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1. 3-Hydroxy-3-methylbutyrate administration diminishes fundectomy-induced osteopenia of the lumbar spine in pigs

Author:
Tatara, Marcin R.; Śliwa, Ewa; Krupski, Witold; Worzakowska, Marta
Source:
Nutrition 2008 v.24 no.7-8 pp. 753-760
ISSN:
0899-9007
Subject:
diet-related diseases; chemical concentration; human diseases; leucine; vertebrae; hydroxyapatite; osteopenia; surgery; bone density; animal models; human nutrition; bone mineralization; bone strength; metabolites; swine
Abstract:
... Objective: The aim of the study was to test the hypothesis that oral administration with 3-hydroxy-3-methylbutyrate (HMB) positively influences bone metabolism and diminishes fundectomy-induced osteopenia of the axial skeleton in pigs. The pig model was chosen because of its recognized physiologic and anatomic similarities of the gastrointestinal tract and skeletal system to those of humans. Metho ...
DOI:
10.1016/j.nut.2008.03.009
PubMed:
18490141

2. Accuracy and precision of dual-energy x-ray absorptiometry for ex vivo determination of mineral content in turkey poult bones

Author:
Zotti, Alessandro; Rizzi, Chiara; Chiericato, Gianmaria; Bernardini, Daniele
Source:
Veterinary radiology & ultrasound 2003 v.44 no.1 pp. 49-52
ISSN:
1058-8183
Subject:
ash content; bone density; bone strength; correlation; dual-energy X-ray absorptiometry; equations; humerus; linear models; mineral content; poults
Abstract:
... The right humerus was removed from 30 20-week-old male turkey poults for humerus strength analysis using dual-energy x-ray absorptiometry and humerus-breaking strength. Specimens were cleaned and dried before scanning. To determine the most precise and accurate protocol of bone densitometry analysis for avian long bones, we scanned each specimen using five different techniques, all aimed to simula ...
DOI:
10.1111/j.1740-8261.2003.tb01448.x
PubMed:
12620050

3. Achyranthes bidentata root extract prevent OVX-induced osteoporosis in rats

Author:
Rong Zhang; Shi-Jie Hu; Chen Li; Feng Zhang; Hong-Quan Gan; Qi-Bing Mei
Source:
Journal of ethnopharmacology 2012 v.139 no.1 pp. 12-18
ISSN:
0378-8741
Subject:
Achyranthes japonica; alkaline phosphatase; alternative medicine; biomarkers; bone density; bone resorption; bone strength; calcium; dual-energy X-ray absorptiometry; excretion; micro-computed tomography; oral administration; osteocalcin; osteoporosis; ovariectomy; phosphorus; rats; uterus; weight gain
Abstract:
... AIM: The objective of the present study was to systematically investigate the effects of Achyranthes bidentata root extract (ABRE) on postmenopausal osteoporosis. MATERIALS AND METHODS: Eighty 3-month-old female Sprague–Dawley rats were used and randomly assigned into sham-operated group (SHAM) and five ovariectomy (OVX) subgroups, i.e. OVX with vehicle (OVX); OVX with 17β-ethinylestradiol (E₂, 25 ...
DOI:
10.1016/j.jep.2011.05.034
PubMed:
21669273

4. Anti-osteoporotic effects of mixed compositions of extracellular polymers isolated from Aureobasidium pullulans and Textoria morbifera in ovariectomized mice

Author:
Chang-Soo Cho; Hye-Seong Jeong; In-Young Kim; Go-Woon Jung; Bon-Hwa Ku; Dong-Chan Park; Seung-Bae Moon; Hyung-Rae Cho; Khawaja Muhammad Imran Bashir; Sae Kwang Ku; Jae-Suk Choi
Source:
BMC complementary and alternative medicine 2018 v.18 no.1 pp. 295
ISSN:
1472-6882
Subject:
Aureobasidium pullulans; Dendropanax; active ingredients; alkaline phosphatase; alternative medicine; animal models; blood chemistry; bone density; bone resorption; bone strength; calcium; femur; functional foods; histology; humans; inorganic phosphorus; menopause; mice; mineral content; osteocalcin; osteoporosis; ovariectomy; polymers; tea; traditional medicine; trees; women
Abstract:
... BACKGROUND: Extracellular polymeric substances isolated from Aureobasidium pullulans (EAP), containing specifically 13% β-1,3/1,6-glucan, have shown various favorable bone-preserving effects. Textoria morbifera Nakai (TM) tree has been used as an ingredient in traditional medicine and tea for various pharmacological purposes. Thus, the present study was aimed to examine the synergistic anti-osteop ...
DOI:
10.1186/s12906-018-2362-y
PubMed:
30400922
PubMed Central:
PMC6220464

5. Antiosteoporotic activity of Davallia formosana

Author:
Yu-Jen Ko; Jin-Bin Wu; Hui-Ya Ho; Wen-Chuan Lin
Source:
Journal of ethnopharmacology 2012 v.139 no.2 pp. 558-565
ISSN:
0378-8741
Subject:
Davallia; alkaline phosphatase; body weight; bone density; bone metabolism; bone strength; calcium; in vitro studies; microcomputers; oral administration; osteoporosis; quality control; rats; tomography; traditional medicine
Abstract:
... ETHANOPHARMACOLOGICAL RELEVANCE: In Taiwanese folk medicine, Davallia formosana is used to treat bone diseases, including osteoporosis. AIM: This study evaluated the anti-osteoporotic effect of ethanolic extract derived from Davallia formosana (DFE). MATERIALS AND METHODS: In this in vitro study, we investigated the inhibitory action of DFE on RANKL-stimulated osteoclastogenesis. The in vivo effec ...
DOI:
10.1016/j.jep.2011.11.050
PubMed:
22155390

6. Antiosteoporotic effects of 3:1 (g/g) mixed formulation of exopolymers purified from Aureobasidium pullulans SM‐2001 and Dendropanax morbifera leaf extracts in ovariectomized rats

Author:
Chang‐Soo Cho; Hye‐Seong Jeong; In‐Young Kim; Go‐Woon Jung; Bon‐Hwa Ku; Dong‐Chan Park; Seung‐Bae Moon; Hyung‐Rae Cho; Sae Kwang Ku; Jae‐Suk Choi
Source:
Journal of food biochemistry 2018 v.42 no.5 pp. e12548
ISSN:
0145-8884
Subject:
Aureobasidium pullulans; Dendropanax morbifer; biochemistry; blood chemistry; body weight; bone density; bone strength; developmental orthopedic disease; dose response; femur; histology; ingredients; leaf extracts; menopause; oral administration; osteoporosis; ovariectomy; rats; resorption; risk; tibia; urine; vertebrae; weight gain; women
Abstract:
... The dose‐dependent antiosteoporotic potentials of the exopolymers from Aureobasidium pullulans (EAP): Dendropanax morbifera (DM) 3:1 (g/g) were observed in bilateral ovariectomized (OVX) rats. Twenty‐eight days after bilateral OVX surgery, 200 mg/kg EAP or DM, and 400, 200, and 100 mg/kg EAP : DM (3:1) were orally administered, once a day for 56 days. We measured changes in body weight and weight ...
DOI:
10.1111/jfbc.12548

7. Antioxidative peptide from milk exhibits antiosteopenic effects through inhibition of oxidative damage and bone-resorbing cytokines in ovariectomized rats

Author:
Sanusi Bello Mada; Srinu Reddi; Naveen Kumar; Rohit Kumar; Suman Kapila; Rajeev Kapila; Ritu Trivedi; Anirudha Karvande; Naseer Ahmad
Source:
Nutrition 2017 v.43-44 pp. 21-31
ISSN:
0899-9007
Subject:
animal models; antioxidant activity; antioxidants; atrophy; blood serum; body weight changes; bone density; bone resorption; bone strength; buffalo milk; calcium; catalase; cytokines; endometrium; enzyme activity; femur; glutathione; human diseases; malondialdehyde; milk; osteoporosis; ovariectomy; oxidative stress; phosphorus; postmenopause; protective effect; rats; superoxide dismutase; tibia; transforming growth factor beta; weight loss
Abstract:
... Oxidative stress has been implicated as a crucial pathogenic factor in the development of postmenopausal osteoporosis. Milk-derived antioxidative peptides are gaining much attention toward the development of prodrugs for alleviating several human diseases, including osteoporosis. The aim of the present study was to determine whether antioxidant peptides are good candidates for alleviating postmeno ...
DOI:
10.1016/j.nut.2017.06.010

8. Arachidonic acid exacerbates diet-induced obesity and reduces bone mineral content without impacting bone strength in growing male rats

Author:
Ivy L Mak; Paula Lavery; Sherry Agellon; Frank Rauch; Monzur Murshed; Hope A Weiler
Source:
Journal of nutritional biochemistry 2019 v.73 pp. 108226
ISSN:
0955-2863
Subject:
adipocytes; adiposity; analysis of variance; arachidonic acid; blood serum; bone density; bone resorption; bone strength; dual-energy X-ray absorptiometry; energy intake; erythrocytes; fatty acid composition; femur; gas chromatography; high fat diet; laboratory animals; leptin; long chain polyunsaturated fatty acids; males; metabolism; micro-computed tomography; mineral content; obesity; rats; visceral fat
Abstract:
... Long-chain polyunsaturated fatty acids modulate bone mass and adipocyte metabolism. Arachidonic acid (AA, C20:4 n-6) is elevated in obesity and postulated to stimulate bone resorption. This study aimed to determine the effect of AA on bone mass, quality, and adiposity in diet-induced obesity during growth. Male Sprague–Dawley rats (n=42, 4-week) were randomized into groups fed a control diet (CTRL ...
DOI:
10.1016/j.jnutbio.2019.108226

9. Assessing bone mineral density in vivo: digitized fluoroscopy and ultrasound

Author:
Fleming, R.H.; Korver, D.; McCormack, H.A.; Whitehead, C.C.
Source:
Poultry science 2004 v.83 no.2 pp. 207-214
ISSN:
0032-5791
Subject:
laying hens; osteoporosis; bone density; humerus; ulna; ultrasonography; radiography; digital images; battery cages; extensive farming; image analysis; tibia; bone strength; shear strength; bending strength; heritability; quantitative traits; genetic correlation; phenotypic correlation; body weight; cholecalciferol; 25-hydroxycholecalciferol; free range husbandry
Abstract:
... The genetic component of osteoporosis in caged laying hens is large, and a method for detecting hens susceptible to fracture could be useful in breeding programs. A radiographic absorptiometry film method was modified by video digitization from an image intensifier and computer analysis and termed digitized fluoroscopy (DF). Humeral and ulnar DF values were measured in 165 hens during lay. Relatio ...
DOI:
10.1093/ps/83.2.207
PubMed:
14979571

10. Assessing bone mineral density in vivo: dual energy x-ray absorptiometry

Author:
Hester, P.Y.; Schreiweis, M.A.; Orban, J.I.; Mazzuco, H.; Kopka, M.N.; Ledur, M.C.; Moody, D.E.
Source:
Poultry science 2004 v.83 no.2 pp. 215-221
ISSN:
0032-5791
Subject:
dual-energy X-ray absorptiometry; laying hens; broiler breeders; humerus; bone density; animal age; nondestructive methods; mineral content; bone strength; weight; densitometry; tibia; fibula; osteoporosis; egg shell; egg shell thickness; rapid methods; ash content; selection criteria
Abstract:
... Dual-energy X-ray absorptiometry can be used as a noninvasive tool to monitor the skeletal integrity of live birds. A pDexa X-ray bone densitometer was used to determine bone mineral densities (BMD) of the left tibia together with the fibula and the humerus of live, unanesthetized birds. Densitometry effectively detected changes in bone integrity of live birds fed varying levels of dietary calcium ...
DOI:
10.1093/ps/83.2.215
PubMed:
14979572

11. Association of CYP19 Gene Polymorphism with Vertebral Fractures in Japanese Postmenopausal Women

Author:
Yasuko Koudu; Tsuneko Onouchi; Takayuki Hosoi; Toshiyuki Horiuchi
Source:
Biochemical genetics 2012 v.50 no.5-6 pp. 389-396
ISSN:
0006-2928
Subject:
bone density; bone strength; gender differences; genes; genetic polymorphism; postmenopause; risk; testosterone; women
Abstract:
... This study investigates aromatase gene polymorphism, which might influence bone strength in terms of mineral density and quality. We explored the relationship between CYP19 polymorphisms and vertebral fractures in postmenopausal Japanese women. In addition, we compared estrogen and testosterone levels in Japanese postmenopausal women with and without fractures. Osteoporotic postmenopausal women sh ...
DOI:
10.1007/s10528-011-9483-z
PubMed:
22160249

12. Association of Dairy Food Intake with Measures of Bone Microarchitecture in Men and Women from the Framingham Study (OR18-08-19)

Author:
Shivani Sahni; Douglas Kiel; Marian Hannan
Source:
Current developments in nutrition 2019 v.3 no.Supplement_1 pp. -
ISSN:
2475-2991
Subject:
bone density; bone strength; calcium; cheeses; computed tomography; cream; cross-sectional studies; elderly; energy intake; food frequency questionnaires; longitudinal studies; men; milk; milk consumption; physical activity; progeny; regression analysis; tibia; vitamin D; vitamin supplements; women; yogurt
Abstract:
... Previous studies reported that dairy foods are associated with higher areal bone mineral density (BMD) in older adults. However, data on bone strength and bone microarchitecture are lacking. The objective of this study was to determine the association of milk, yogurt, cheese, cream, milk + yogurt and milk + yogurt + cheese intakes with high resolution peripheral quantitative computed tomography (H ...
DOI:
10.1093/cdn/nzz028.OR18-08-19

13. Beneficial effects of paeoniflorin on osteoporosis induced by high-carbohydrate, high-fat diet-associated hyperlipidemia in vivo

Author:
Yanmao Wang; Yu Zhu; Shengdi Lu; Chengfang Hu; Wanrun Zhong; Yimin Chai
Source:
Biochemical and biophysical research communications 2018 v.498 no.4 pp. 981-987
ISSN:
0006-291X
Subject:
adverse effects; biomechanics; blood lipids; blood serum; bone density; bone metabolism; bone strength; chemical constituents of plants; femur; high fat diet; hyperlipidemia; lipid composition; low density lipoprotein cholesterol; medicinal properties; micro-computed tomography; osteoblasts; osteoporosis; protective effect; rats; risk factors; triacylglycerols
Abstract:
... Osteoporosis is linked to reduced bone mineral density (BMD) as a major risk factor for fragility fractures. Recent studies indicated an association between BMD and abnormally elevated lipid levels in blood as common indicators for hyperlipidemia. In this study, we assessed the protective effect of paeoniflorin, a phytochemical compound with multiple pharmacological activities, against hyperlipide ...
DOI:
10.1016/j.bbrc.2018.03.093

14. Blueberry prevents bone loss in ovariectomized rat model of postmenopausal osteoporosis

Author:
Devareddy, Latha; Hooshmand, Shirin; Collins, Julie K.; Lucas, Edralin A.; Chai, Sheau C.; Arjmandi, Bahram H.
Source:
Journal of nutritional biochemistry 2008 v.19 no.10 pp. 694-699
ISSN:
0955-2863
Subject:
osteocalcin; bone density; bone mineralization; blood chemistry; biomarkers; bone strength; functional foods; messenger RNA; collagen; ovariectomy; osteoporosis; rats; bone resorption; acid phosphatase; dosage; animal models; skeleton; blueberries; femur; alkaline phosphatase
Abstract:
... The objective of the present study was to explore the bone protective role of blueberry in an ovariectomized rat model. Thirty 6-month-old female Sprague-Dawley rats were either sham-operated (Sham) or ovariectomized (Ovx) and divided into three groups: Sham, Ovx (control), Ovx+blueberry (5% blueberry w/w). After 100 days of treatment, rats were euthanized, and blood and tissues were collected. Bo ...
DOI:
10.1016/j.jnutbio.2007.09.004
PubMed:
18328688

15. Bone Strength in Growing Rats Treated with Fluoride: a Multi-dose Histomorphometric, Biomechanical and Densitometric Study

Author:
Brenda Lorena Fina; Maela Lupo; Eugenia Rocío Da Ros; Mercedes Lombarte; Alfredo Rigalli
Source:
Biological trace element research 2018 v.185 no.2 pp. 375-383
ISSN:
0163-4984
Subject:
adults; biomechanics; bone density; bone strength; children; deformation; densitometry; femur; fluorides; fluorosis; laboratory animals; modulus of elasticity; multivariate analysis; rats; tibia
Abstract:
... Bone deformation and fragility are common signs of skeletal fluorosis. Disorganisation of bone tissue and presence of inflammatory foci were observed after fluoride (F⁻) administration. Most information about F⁻ effects on bone has been obtained in adult individuals. However, in fluorosis areas, children are a population very exposed to F⁻ and prone to develop not only dental but also skeletal flu ...
DOI:
10.1007/s12011-017-1229-2

16. Bone breaking strength and apparent metabolisability of calcium and phosphorus in selected and unselected broiler chicken genotypes

Author:
McDevitt, R.M.; McEntee, G.M.; Rance, K.A.
Source:
British poultry science 2006 v.47 no.5 pp. 613-621
ISSN:
0007-1668
Subject:
broiler chickens; broiler feeding; genotype; genetic variation; calcium; phosphorus; dietary minerals; nutritional status; mineral metabolism; bone strength; bone density; artificial selection; selection criteria; limb bones; body weight; chemical composition; nutrient intake; feed quality
Abstract:
... 1. The present study examined the bone strength and apparent mineral metabolisability of a selected broiler chicken compared with those of a relatively unselected genotype. 2. Selected (SB) and unselected genotypes (UB) were reared under standard conditions and were fed on either a high quality (HQ) or a low quality (LQ) diet. Tibiotarsi samples were collected at 42 d from SB and compared to tibio ...
DOI:
10.1080/00071660600963560
PubMed:
17050107

17. Bone densitometry as an indicator of percentage tibia ash in broiler chicks fed varying dietary calcium and phosphorus levels

Author:
Onyango, E.M.; Hester, P.Y.; Stroshine, R.; Adeola, O.
Source:
Poultry science 2003 v.82 no.11 pp. 1787-1791
ISSN:
0032-5791
Subject:
bone density; phosphorus; chicks; broiler chickens; dose response; liveweight gain; mineral content; broiler feeding; bone strength; shear strength; densitometry; tibia; calcium; nutrient deficiencies; feed conversion; equations; feed intake; prediction; nutritional status; dosage; ash content; dietary minerals
Abstract:
... The relative sensitivity of tibia bone mineral content (BMC) and density (BMD), percentage ash (ash), and shear force as indicators for dietary Ca and P was compared in 3-wk-old broiler chicks. One hundred eight 7-d-old chicks were grouped by weight into 6 blocks of 3 cages each with 6 birds per cage. Three corn-soybean meal-based diets were randomly assigned to cages within each block. The diets ...
DOI:
10.1093/ps/82.11.1787
PubMed:
14653474

18. Bone mineral density QTL at sexual maturity and end of lay

Author:
B.K. Podisi; S.A. Knott; I.C. Dunn; D.W. Burt; P.M. Hocking
Source:
British poultry science 2012 v.53 no.6 pp. 763-769
ISSN:
1466-1799
Subject:
White Leghorn; alleles; bone density; bone strength; chromosomes; crossing; laying hens; mutation; quantitative trait loci; selection criteria; sexual maturity
Abstract:
... 1. An F₂ cross of a broiler male line and a White Leghorn layer line was used to identify quantitative trait loci (QTL) for bone density at the onset of lay and at the end of the laying period. A total of 686 measures of humeral bone density were available for analysis.2. There was no evidence for epistasis.3. Genome-wide significant QTL for bone density at the onset of lay were identified on chro ...
DOI:
10.1080/00071668.2012.747674
PubMed:
23398420

19. Bone strength of caged layers as affected by dietary calcium and phosphorus concentrations, reconditioning, and ash content

Author:
Wilson, J.H.
Source:
British poultry science 1991 v.32 no.3 pp. 501-508
ISSN:
0007-1668
Subject:
hens; bone strength; shear strength; body weight; bone density
DOI:
10.1080/00071669108417374
PubMed:
1893262

20. Bone structure and breaking strength in laying hens housed in different husbandry systems

Author:
Fleming, R.H.; Whitehead, C.C.; Alvey, D.; Gregory, N.G.; Wilkins, L.J.
Source:
British poultry science 1994 v.35 no.5 pp. 651-662
ISSN:
0007-1668
Subject:
perches (animal housing); battery husbandry; radiography; tibia; humerus; bone fractures; physical activity; battery cages; bone formation; bone density; osteoporosis; hens; bone strength
Abstract:
... 1. Bone structure and breaking strength were measured in hens that had been housed throughout a laying year in battery cages or in Perchery, Naturel or Litter and Wire husbandry systems. 2. Battery caged hens had the poorest bones, as assessed by measurements of cancellous bone volume, radiographic density, cortical thickness and three-point breaking strength. 3. Humeri from birds in the Litter an ...
DOI:
10.1080/00071669408417731
PubMed:
7719730

21. Bone-protective effects of bioactive fractions and ingredients in Sambucus williamsii HANCE

Author:
Hui-Hui Xiao; Yi Dai; Hoi-Ying Wan; Man-Sau Wong; Xin-Sheng Yao
Source:
British journal of nutrition 2011 v.106 no.12 pp. 1802-1809
ISSN:
1475-2662
Subject:
Sambucus; bioactive properties; biomechanics; bone density; bone strength; cell proliferation; ethanol; femur; high performance liquid chromatography; ingredients; lignans; mice; models; phenolic acids; rats; tibia; uterus
Abstract:
... Our previous study demonstrated that 60 % ethanol crude extract of Sambucus williamsii HANCE (SWH) improved bone mass, bone strength and bone micro-structure in both ovariectomised (OVX) rats and mice. The present study aims to identify the bioactive fractions and ingredients in SWH that account for its osteoprotective effects. Bilateral sham-operated mice acted as controls. OVX C57BL/6J mice, age ...
DOI:
10.1017/S0007114511002546
PubMed:
21736773

22. Boron and fish oil have different beneficial effects on strength and trabecular microarchitecture of bone

Author:
Nielsen, Forrest H.; Stoecker, Barbara J.
Source:
Journal of trace elements in medicine and biology 2009 v.23 no.3 pp. 195-203
Subject:
nutrient intake; skeletal development; food intake; linoleic acid; vertebrae; nutrient availability; boron; bone density; rats; safflower oil; bone strength; femur; menhaden oil
Abstract:
... An experiment was performed to determine whether boron deprivation would adversely affect vertebra (trabecular) bone microarchitecture, and whether any adverse effect would be modified by dietary fatty acid composition. Female rats were fed diets containing 0.1 mg (9 μmol) boron/kg in a factorial arrangement with variables of supplemental boron at 0 (boron-deprived) or 3 (boron-adequate) mg (278 μ ...
Handle:
10113/46624
DOI:
10.1016/j.jtemb.2009.03.003

23. Calcium Requirements of Growing Rats Based on Bone Mass, Structure, or Biomechanical Strength Are Similar

Author:
Hunt, Janet R.; Hunt, Curtiss D.; Zito, Carol Ann; Idso, Joseph P.; Johnson, LuAnn K.
Source:
Journal of nutrition 2008 v.138 no.8 pp. 1462-1468
ISSN:
0022-3166
Subject:
calcium; dietary minerals; nutrient requirements; animal models; animal growth; bone density; bone fractures; bone strength; animal morphology; tibia; rats; food intake; experimental diets
Abstract:
... Although calcium (Ca) supplementation increases bone density, the increase is small and the effect on bone strength and fracture risk is uncertain. To investigate if bone mass, morphology, and biomechanical properties are affected by deficient to copious dietary Ca concentrations, the long bones (tibia and femur) of growing female Sprague-Dawley rats (8/group) were assessed after 13 wk of consumin ...
Handle:
10113/23503
PubMed:
18641192

24. Calcium Supplement Derived from Gallus gallus domesticus Promotes BMP-2/RUNX2/SMAD5 and Suppresses TRAP/RANK Expression through MAPK Signaling Activation

Author:
Han Seok Yoo; Gyung-Ji Kim; Da Hye Song; Kang-Hyun Chung; Kwon-Jai Lee; Dong-Hee Kim; Jeung Hee An
Source:
Nutrients 2017 v.9 no.5 pp. -
ISSN:
2072-6643
Subject:
Gallus gallus; bone density; bone formation; bone morphogenetic proteins; bone resorption; bone strength; calcium; cathepsin K; chickens; diet; genes; genetic markers; micro-computed tomography; mitogen-activated protein kinase; mothers against decapentaplegic homolog proteins; osteoblasts; osteocalcin; osteoclasts; ovariectomy; rats; tibia; transcription factor NF-kappa B
Abstract:
... The present study evaluated the effects of a calcium (Ca) supplement derived from Gallus gallus domesticus (GD) on breaking force, microarchitecture, osteogenic differentiation and osteoclast differentiation factor expression in vivo in Ca-deficient ovariectomized (OVX) rats. One percent of Ca supplement significantly improved Ca content and bone strength of the tibia. In micro-computed tomography ...
DOI:
10.3390/nu9050504
PubMed:
28513557
PubMed Central:
PMC5452234

25. Carfilzomib alleviated osteoporosis by targeting PSME1/2 to activate Wnt/β-catenin signaling

Author:
Fan Zhang; Shokouh Attarilar; Kegong Xie; Chao Han; Qingyang liang; Ke Huang; Changgong Lan; Chong Wang; Chengliang Yang; Liqiang Wang; Masoud Mozafari; Kai Li; Jia Liu; Yujin Tang
Source:
Molecular and cellular endocrinology 2022 v.540 pp. 111520
ISSN:
0303-7207
Subject:
bone density; bone formation; bone strength; endocrinology; micro-computed tomography; models; osteoblasts; osteoclasts; osteoporosis; ovariectomy; postmenopause; proteasome endopeptidase complex; proteasome inhibitors; protein content; recombinant proteins
Abstract:
... Osteoporosis (OP) is characterized by decreased bone mineral density and impaired bone strength. Carfilzomib (CFZ) is a new-generation proteasome inhibitor and has been found to affect bone metabolism. However, the effect and mechanism of CFZ on OP has not been investigated systematically. In this study, we found that protein levels of proteasome activator subunit 1/2 (PSME1/2) increased in OP, an ...
DOI:
10.1016/j.mce.2021.111520

26. Causal assessment of dietary acid load and bone disease: a systematic review & meta-analysis applying Hill's epidemiologic criteria for causality

Author:
Tanis R Fenton; Suzanne C Tough; Andrew W Lyon; Misha Eliasziw; David A Hanley
Source:
Nutrition journal 2011 v.10 no.1 pp. 371
ISSN:
1475-2891
Subject:
acid ash diet; adults; balance studies; biopsy; bone density; bone strength; calcium; dietary supplements; estrogens; excretion; grain foods; in vitro studies; meta-analysis; milk; osteoporosis; pH; phosphates; prospective studies; risk factors; systematic review; urine; weight loss
Abstract:
... BACKGROUND: Modern diets have been suggested to increase systemic acid load and net acid excretion. In response, alkaline diets and products are marketed to avoid or counteract this acid, help the body regulate its pH to prevent and cure disease. The objective of this systematic review was to evaluate causal relationships between dietary acid load and osteoporosis using Hill's criteria. METHODS: S ...
DOI:
10.1186/1475-2891-10-41
PubMed:
21529374
PubMed Central:
PMC3114717

27. Changes in bone mass, biomechanical properties, and microarchitecture of calcium- and iron-deficient rats fed diets supplemented with inulin-type fructans

Author:
Lobo, Alexandre R.; Cocato, Maria Lucia; Jorgetti, Vanda; de Sá, Lílian R.M.; Nakano, Eduardo Y.; Colli, Célia
Source:
Nutrition research 2009 v.29 no.12 pp. 873-881
ISSN:
0271-5317
Subject:
bone density; bone mineralization; transferrin; males; binding proteins; bone strength; microstructure; dietary fiber; blood serum; tibia; calcium; nutrient deficiencies; histology; iron deficiency anemia; rats; inulin; bone resorption; heme iron; osteoclasts; liver; mineral metabolism; nutritional status; experimental diets; nutrient availability; hemoglobin; magnesium; animal models
Abstract:
... Feeding mineral-deficient diets enhances absorptive efficiency as an attempt of the body to compensate for the lack of an essential nutrient. Under certain circumstances, it does not succeed; and nutritional deficiency is produced. Our hypothesis was that inulin-type fructans (ITF), which are known to affect mineral absorption, could increase Ca and Fe bioavailability in Ca- and Fe-deficient rats. ...
DOI:
10.1016/j.nutres.2009.10.012
PubMed:
19963161

28. Changes in bone structure of Corriedale sheep with inherited rickets: A peripheral quantitative computed tomography assessment

Author:
Keren E. Dittmer; Elwyn C. Firth; Keith G. Thompson; Jonathan C. Marshall; Hugh T. Blair
Source:
veterinary journal 2011 v.187 no.3 pp. 369-373
ISSN:
1090-0233
Subject:
Corriedale; bone density; bone strength; computed tomography; mineral content; rickets; sheep; tibia; New Zealand
Abstract:
... An inherited skeletal disease with gross and microscopic features of rickets has been diagnosed in Corriedale sheep in New Zealand. The aim of this study was to quantify the changes present in tibia from sheep with inherited rickets using peripheral quantitative computed tomography. In affected sheep, scans in the proximal tibia, where metaphysis becomes diaphysis, showed significantly greater tra ...
DOI:
10.1016/j.tvjl.2009.12.025

29. Changes of lipid and bone metabolism in broilers with spontaneous femoral head necrosis

Author:
Kangping Liu; Kuanbo Wang; Leguo Wang; Zhenlei Zhou
Source:
Poultry science 2021 v.100 no.3 pp. 100808
ISSN:
0032-5791
Subject:
alanine transaminase; alkaline phosphatase; apoptosis; aspartate transaminase; blood chemistry; bone density; bone metabolism; bone strength; cartilage; chondrocytes; comparative study; etiology; femur; growth plate; high density lipoprotein; homeostasis; hyperlipidemia; lipid metabolism; liver; liver function; necrosis; tibia; triacylglycerols
Abstract:
... Blood biochemistry and bone metabolism were evaluated to investigate the etiology and mechanism of spontaneous femoral head necrosis (FHN) in broilers. According to the femoral head score of the fourth, fifth, and sixth week old FHN-affected broilers, they were divided into 3 groups, namely Normal group, femoral head separation group, and femoral head separation with growth plate lacerations group ...
DOI:
10.1016/j.psj.2020.10.062

30. Characteristics of kyphotic vertebrae in the cultured yellowtail Seriola quinqueradiata

Author:
Daichi Hayashi; Chiemi Miura; Takeshi Miura
Source:
Aquaculture 2019 v.506 pp. 380-386
ISSN:
0044-8486
Subject:
Seriola quinqueradiata; X-radiation; ash content; bone density; bone strength; farmers; financial economics; fish; histology; image analysis; muscles; porosity; spermatogenesis; vertebrae
Abstract:
... Vertebral deformities, including kyphosis, of the cultured yellowtail Seriola quinqueradiata resulted in a decrease in product value, and consequently economic loss for fish farmers. Hence, in order to resolve this problem, it is important to examine the characteristics of kyphotic vertebrae in fish. In this study, we focused on the comparison between kyphotic and non-kyphotic two-year old yellowt ...
DOI:
10.1016/j.aquaculture.2019.03.071

31. Citrus juice modulates bone strength in male senescent rat model of osteoporosis

Author:
Deyhim, F.; Garcia, K.; Lopez, E.; Gonzalez, J.; Ino, S.; Garcia, M.; Patil, B.S.
Source:
Nutrition 2006 v.22 no.5 pp. 559-563
ISSN:
0899-9007
Subject:
bone metabolism; disease prevention; males; orange juice; bone density; animal models; osteoporosis; rats; Citrus; antioxidant activity; bone strength; grapefruit juice; antioxidants; oxidative stress
DOI:
10.1016/j.nut.2005.12.002
PubMed:
16472977

32. Comparative Activities of the S-Enantiomer and Racemic Forms of Equol on Bone Fragility in Ovariectomized Mice

Author:
Yoshifumi KIMIRA; Shin-ichi KATSUMATA; Kazuharu SUZUKI; Yoshiko ISHIMI; Tomomi UENO; Shigeto UCHIYAMA; Herman ADLERCREUTZ; Mariko UEHARA
Source:
Bioscience, biotechnology, and biochemistry 2012 v.76 no.5 pp. 1018-1021
ISSN:
1347-6947
Subject:
biochemistry; biotechnology; blood serum; bone density; bone strength; femur; ovariectomy; urine
Abstract:
... We compared the effects of the S-enantiomer and racemic forms of equol on bone using ovariectomized (OVX) mice. Femoral bone mineral density and bone strength decreased in the OVX mice, but not in OVX mice administered 0.5 mg/d S-equol. This, however, did not hold for racemic equol. Serum and urine S-equol concentrations were higher in the mice administered S-equol than in those administered racem ...
DOI:
10.1271/bbb.110973

33. Comparative differences in the composition and biomechanical properties of tibiae of seven- and seventy-two-week-old male and female broiler breeder chickens

Author:
Rath, N.C.; Balog, J.M.; Huff, W.E.; Huff, G.R.; Kulkarani, G.B.; Tierce, J.F.
Source:
Poultry science 1999 v.78 no.8 pp. 1232-1239
ISSN:
0032-5791
Subject:
broiler chickens; hens; roosters; gender differences; tibia; epiphyses; bone density; histology; blood glucose; blood lipids; calcium; phosphorus; blood serum; alkaline phosphatase; creatine kinase; lactate dehydrogenase; bone strength; collagen; proteoglycans; fluorescence
Abstract:
... Skeletal problems are common in both young and old poultry and are often related to bone weakness. They affect mortality on the farm and condemnations within processing plant and thus raise both welfare and economic concerns. To understand the basis of bone strength, the metaphyseal histology, composition, and the biomechanical properties of tibiae from 7- and 72-wk-old male and female broiler bre ...
DOI:
10.1093/ps/78.8.1232
PubMed:
10472852

34. Comparison of bones of 4 strains of laying hens kept in conventional cages and floor pens

Author:
F. G. Silversides; R. Singh; K. M. Cheng; D. R. Korver
Source:
Poultry science 2012 v.91 no.1 pp. 1-7
ISSN:
0032-5791
Subject:
Plymouth Rock; Rhode Island Red; White Leghorn; animal health; animal pens; animal welfare; bone density; bone strength; cages; crossbreds; genetic background; laying hens; mechanical loads; nest boxes; radius (bone); restraint of animals; strain differences; tibia; wings
Abstract:
... The maintenance of bone strength has been an important issue in the debate over cage use for laying hens. Bone strength depends on adequate mechanical load and cages restrict movement. Four laying crosses (Lohmann White, Lohmann Brown, H&N White, and Rhode Island Red x Barred Plymouth Rock cross hens) were housed in conventional cages or in floor pens equipped with perches and nest boxes to measur ...
DOI:
10.3382/ps.2011-01453
PubMed:
22184423

35. Comprehensive evaluation of the combined extracts of Epimedii Folium and Ligustri Lucidi Fructus for PMOP in ovariectomized rats based on MLP-ANN methods

Author:
Zitong Ma; Xiaoxi Li; Yuheng Chen; Xiufeng Tang; Yingying Gao; Han Wang; Renhui Liu
Source:
Journal of ethnopharmacology 2021 v.268 pp. 113563
ISSN:
0378-8741
Subject:
Oriental traditional medicine; bone density; bone strength; estrogens; humans; immunity; kidneys; metabolism; microstructure; models; nerve tissue; osteoporosis; ovariectomy; pathogenesis; postmenopause
Abstract:
... Kidney deficiency is the main pathogenesis of osteoporosis based on the theory of “kidney governing bones” in traditional Chinese medicine (TCM). Osteoporosis is a systemic disease; kidney deficiency influences the growth, aging and reproduction of human body, reflecting in endocrine, nerve, immunity, metabolism and other functions. Multi-target drugs composed of natural non-toxic products from ki ...
DOI:
10.1016/j.jep.2020.113563

36. Cortical bone development, maintenance and porosity: genetic alterations in humans and mice influencing chondrocytes, osteoclasts, osteoblasts and osteocytes

Author:
Tsuyoshi Isojima; Natalie A. Sims
Source:
Cellular and molecular life sciences 2021 v.78 no.15 pp. 5755-5773
ISSN:
1420-682X
Subject:
bone density; bone mineralization; bone resorption; bone strength; chondrocytes; cortex; humans; mice; mineralization; osteoblasts; osteoclasts; porosity; skeletal development; wnt proteins
Abstract:
... Cortical bone structure is a crucial determinant of bone strength, yet for many years studies of novel genes and cell signalling pathways regulating bone strength have focused on the control of trabecular bone mass. Here we focus on mechanisms responsible for cortical bone development, growth, and degeneration, and describe some recently described genetic-driven modifications in humans and mice th ...
DOI:
10.1007/s00018-021-03884-w

37. Dairy Food Intake Is Not Associated with Measures of Bone Microarchitecture in Men and Women: The Framingham Osteoporosis Study

Author:
Courtney L. Millar; Douglas P. Kiel; Marian T. Hannan; Shivani Sahni
Source:
Nutrients 2021 v.13 no.11 pp. -
ISSN:
2072-6643
Subject:
bone density; bone strength; cheeses; computed tomography; cross-sectional studies; dairy consumption; energy; food frequency questionnaires; milk; osteoporosis; regression analysis; tibia; yogurt
Abstract:
... Previous studies reported that dairy foods are associated with higher areal bone mineral density (BMD) in older adults. However, data on bone strength and bone microarchitecture are lacking. We determined the association of dairy food intake (milk, yogurt, cheese, milk + yogurt, and milk + yogurt + cheese, servings/week) with high resolution peripheral quantitative computed tomography (HR-pQCT) me ...
DOI:
10.3390/nu13113940

38. Dietary Advanced Glycation End-Products (dAGEs) Intake and Bone Health: A Cross-Sectional Analysis in the Rotterdam Study

Author:
Komal Waqas; Jinluan Chen; Bram C. J. van der Eerden; M. Arfan Ikram; André G. Uitterlinden; Trudy Voortman; M. Carola Zillikens
Source:
Nutrients 2020 v.12 no.8 pp. -
ISSN:
2072-6643
Subject:
advanced glycation end products; age; bone density; bone health; bone strength; cross-sectional studies; diabetes; energy intake; femur; food intake; food quality; frequency; glycation; hips; humans; humerus; lumbar spine; odds ratio; physical activity; regression analysis; renal function
Abstract:
... Animal studies suggest a role for dietary advanced glycation end-products (dAGEs) in bone health, but human studies on dAGEs in relation to bone are lacking. We aimed to study whether dAGEs intake is associated with the parameters of bone strength namely, bone mineral density (BMD), prevalent vertebral (VFs), and major osteoporotic fractures (MOFs = hip, wrist, proximal humerus, and clinical VFs). ...
DOI:
10.3390/nu12082377

39. Dietary Calcium Restriction Affects Mesenchymal Stem Cell Activity and Bone Development in Neonatal Pigs

Author:
Mahajan, Avanika; Alexander, Lindsey S.; Seabolt, Brynn S.; Catrambone, Daniel E.; McClung, James P.; Odle, Jack; Pfeiler, T. Wayne; Loboa, Elizabeth G.; Stahl, Chad H.
Source:
Journal of nutrition 2011 v.141 no.3 pp. 373-379
ISSN:
0022-3166
Subject:
bone density; bone strength; calcium; diet; dietary restriction; in vitro studies; long term effects; neonatal development; parathyroid hormone; phosphates; skeletal development; stem cells; swine
Abstract:
... The effects of dietary calcium (Ca) deficiency on skeletal integrity are well characterized in growing and mature mammals; however, less is known about Ca nutrition during the neonatal period. In this study, we examined the effects of neonatal Ca nutrition on bone integrity, endocrine hormones, and mesenchymal stem cell (MSC) activity. Neonatal pigs (24 ± 6 h of age) received either a Ca-adequate ...
DOI:
10.3945/jn.110.131193
PubMed:
21248192

40. Dietary Protein Derived from Dried Bonito Fish Improves Type‐2 Diabetes Mellitus‐Induced Bone Frailty in Goto‐Kakizaki Rats

Author:
Masaru Ochiai; Takashi Kuroda; Shoichi Gohtani; Tatsuhiro Matsuo
Source:
Journal of food science 2015 v.80 no.4 pp. H848
ISSN:
0022-1147
Subject:
bonito; food intake; young animals; blood chemistry; blood serum; polyunsaturated fatty acids; absorption; calcium; bone density; casein; noninsulin-dependent diabetes mellitus; rats; femur; bone strength; alkaline phosphatase
Abstract:
... Type‐2 diabetes mellitus (T2DM) induces bone frailty. Protein and polyunsaturated fatty acids (PUFA) contained in fish can be effective in enhancing bone quality, but the bone developing effect of fish protein containing less PUFA has not been evaluated in young animals with T2DM. We prepared a bonito fish (BF) and defatted BF (DBF) and hypothesized that protein contained in BF and DBF would be ef ...
DOI:
10.1111/1750-3841.12797

41. Dietary betaine reduces plasma homocysteine concentrations and improves bone strength in laying hens

Author:
M. B. M. Maidin; H. A. McCormack; P. W. Wilson; S. D. Caughey; N. Whenham; I. C. Dunn
Source:
British poultry science 2021 v.62 no.4 pp. 573-578
ISSN:
1466-1799
Subject:
betaine; bone density; bone mineralization; bone strength; egg production; homocysteine; phosphorus; phytases; tibia
Abstract:
... 1. This study tested the hypothesis that the methyl-donor properties of betaine could reduce homocysteine concentrations, which has been recognised in a previous genetics study to be linked to bone quality. This was combined with phytase treatment, as phosphorus is critical for bone mineralisation. 2. Using a 2 × 2 factorial arrangement, a total of 1920 Lohmann LSL-lite chickens housed as 24 repli ...
DOI:
10.1080/00071668.2021.1883550

42. Dietary non-phytate phosphorus requirement of broilers fed a conventional corn-soybean meal diet from 1 to 21 d of age

Author:
S.B. Liu; X.D. Liao; L. Lu; S.F. Li; L. Wang; L.Y. Zhang; Y. Jiang; X.G. Luo
Source:
Poultry science 2017 v.96 no.1 pp. 151-159
ISSN:
0032-5791
Subject:
blood serum; bone density; bone strength; cages; calcium; calcium hydrogen phosphate; diet; duodenum; gene expression; genes; growth performance; inorganic phosphorus; males; sodium phosphate; symporters; tibia; weight gain
Abstract:
... An experiment was conducted to investigate the effect of dietary non-phytate phosphorus (NPP) level on growth performance, bone characteristics and phosphorus metabolism-related gene expressions, so as to evaluate the dietary NPP requirement of broiler chicks fed a conventional corn-soybean meal diet from 1 to 21 d of age. A total of 540 day-old Arbor Acres male chicks were randomly allocated to o ...
DOI:
10.3382/ps/pew212

43. Dietary patterns and incident low-trauma fractures in postmenopausal women and men aged ≥50 y: a population-based cohort study

Author:
Langsetmo, Lisa; Hanley, David A.; Prior, Jerilynn C.; Barr, Susan I.; Anastassiades, Tassos; Towheed, Tanveer; Goltzman, David; Morin, Suzanne; Poliquin, Suzette; Kreiger, Nancy
Source:
American journal of clinical nutrition 2011 v.93 no.1 pp. 192-199
ISSN:
0002-9165
Subject:
vegetables; bone fractures; energy density; age; bone density; French fries; food frequency questionnaires; potato chips; bone mineralization; meat products; sweets; women; menopause; bone strength; men; nutrient density; osteoporosis; body mass index; soft drinks; whole grain foods
Abstract:
... BACKGROUND: Previous research has shown that dietary patterns are related to the risk of several adverse health outcomes, but the relation of these patterns to skeletal fragility is not well understood. OBJECTIVE: Our objective was to determine the relation between dietary patterns and incident fracture and possible mediation of this relation by body mass index, bone mineral density, or falls. DES ...
DOI:
10.3945/ajcn.110.002956
PubMed:
21068350
PubMed Central:
PMC5101071

44. Dietary supplementation with dried plum prevents ovariectomy-induced bone loss while modulating the immune response in C57BL/6J mice

Author:
Elizabeth Rendina; Yin F. Lim; Denver Marlow; Yan Wang; Stephen L. Clarke; Solo Kuvibidila; Edralin A. Lucas; Brenda J. Smith
Source:
Journal of nutritional biochemistry 2012 v.23 no.1 pp. 60-68
ISSN:
0955-2863
Subject:
animal ovaries; bone density; bone marrow; bone resorption; bone strength; dietary supplements; immune response; mice; necrosis; plums; tibia; tumor necrosis factors
Abstract:
... This study was designed to investigate the effects of dried plum on the changes in bone metabolism and the immune response associated with ovarian hormone deficiency. Adult female C57BL/6J mice were either sham-operated (Sham) and fed AIN-93 diet (control) or ovariectomized (OVX) and fed a control diet with 0%, 5%, 15% or 25% dried plum (w/w), corresponding to control, low- (LDP), medium- (MDP) an ...
DOI:
10.1016/j.jnutbio.2010.10.010
PubMed:
21414765

45. Dioscorea improves the morphometric and mechanical properties of bone in ovariectomised rats

Author:
Chen, Jian-Horng; Wu, James Shih-Shyn; Lin, Hsiao-Che; Wu, Shey-Lin; Wang, Wen-Fu; Huang, Shu-Kuei; Ho, Ying-Jui
Source:
Journal of the science of food and agriculture 2008 v.88 no.15 pp. 2700-2706
ISSN:
0022-5142
Subject:
food intake; Dioscorea alata; porosity; mineral content; ovariectomy; mechanical properties; bone density; animal models; osteoporosis; rats; bone strength; oral administration; roots; femur; yams
Abstract:
... BACKGROUND: The aim of this work was to determine the effects of oral administration of dioscorea on the morphometric and mechanical properties of the femur in ovariectomised (OVX) rats. Female Wistar rats that had undergone surgery for ovariectomy were used as a model of menopause and osteoporosis. Four weeks after surgery the animals were given oral dioscorea (0, 250, 750 or 1500 mg kg⁻¹ day⁻¹) ...
DOI:
10.1002/jsfa.3396

46. Disruption of bone morphogenetic protein type IA receptor in osteoblasts impairs bone quality and bone strength in mice

Author:
Quanwei Bao; Ang Li; Sixu Chen; Jianquan Feng; Huayu Liu; Hao Qin; Junfeng Li; Daocheng Liu; Yue Shen; Zhaowen Zong
Source:
Cell and tissue research 2018 v.374 no.2 pp. 263-273
ISSN:
0302-766X
Subject:
bone density; bone morphogenetic proteins; bone strength; collagen; culture media; femur; immunohistochemistry; in vivo studies; mice; mineralization; osteoblasts; osteocalcin
Abstract:
... In recent years, several studies have found that the disruption of type IA receptor of bone morphogenetic proteins (BMPR1A) could increase bone mass. However, whether disruption of BMPR1A could have an effect on bone quality and bone strength is currently unknown. Osteoblast-targeted conditional knockout (cKO) of BMPRIA by crossing 3.2-kb Col1-CreER™ mice with BMPR1A fx +/+ mice was conducted. The ...
DOI:
10.1007/s00441-018-2873-3

47. Drynaria fortunei J. Sm. improves the bone mass of ovariectomized rats through osteocalcin-involved endochondral ossification

Author:
Yong-Eng Lee; Hwa-Chang Liu; Yi-Ling Lin; Shing-Hwa Liu; Rong-Sen Yang; Ruei-Ming Chen
Source:
Journal of ethnopharmacology 2014 v.158 pp. 94-101
ISSN:
0378-8741
Subject:
Drynaria fortunei; bioactive compounds; biomechanics; biosynthesis; blood serum; body weight; bone density; bone formation; bone strength; chondrocytes; estradiol; growth plate; immunoblotting; immunohistochemistry; mineral content; naringin; osteoblasts; osteocalcin; ovariectomy; rats; traditional medicine; translation (genetics)
Abstract:
... Our previous study showed that Drynaria fortunei J. Sm. (Kunze), a traditional Chinese medical herb, can promote osteoblast differentiation and maturation. This study was further aimed to confirm the traditional effects of Kunze on the bone mass of ovariectomized rats.Female Wistar rats were given an ovariectomy and then administered the water extract of Kunze (WEK). Systemic and tissue toxicities ...
DOI:
10.1016/j.jep.2014.10.016

48. Early life vitamin D depletion and mechanical loading determine methylation changes in the RUNX2, RXRA, and osterix promoters in mice

Author:
Nevena Krstic; Nick Bishop; Beth Curtis; Cyrus Cooper; Nick Harvey; Karen Lilycrop; Robert Murray; Robert Owen; Gwen Reilly; Tim Skerry; Steph Borg
Source:
Genes & nutrition 2022 v.17 no.1 pp. 7
ISSN:
1555-8932
Subject:
DNA methylation; bone density; bone strength; diet; epigenome; growth and development; mice; osteoblasts; pregnancy; tibia
Abstract:
... BACKGROUND: Early life vitamin D exposure is linked to later skeletal health with maternal vitamin D status in pregnancy associated with neonatal bone mass. The MAVIDOS study has demonstrated that vitamin D supplementation leads to reduced RXRA DNA methylation. Mice exposed to early life vitamin D deficiency have reduced bone mass and bone accrual in response to mechanical loading. Using the tibia ...
DOI:
10.1186/s12263-022-00711-0

49. Effect of 12 months of creatine supplementation and whole-body resistance training on measures of bone, muscle and strength in older males

Author:
Darren G Candow; Philip D Chilibeck; Julianne Gordon; Emelie Vogt; Tim Landeryou; Mojtaba Kaviani; Lisa Paus-Jensen
Source:
Nutrition and health 2021 v.27 no.2 pp. 151-159
ISSN:
2047-945X
Subject:
bone density; bone resorption; creatine; femur; geometry; muscle strength; muscles; nutrition; placebos
Abstract:
... The combination of creatine supplementation and resistance training (10–12 weeks) has been shown to increase bone mineral content and reduce a urinary indicator of bone resorption in older males compared with placebo. However, the longer-term effects (12 months) of creatine and resistance training on bone mineral density and bone geometric properties in older males is unknown. To assess the effect ...
DOI:
10.1177/0260106020975247

50. The Effect of Dietary Probiotic Supplementation on Tibial Bone Characteristics and Strength in Broilers

Author:
Mutus, R.; Kocabagli, N.; Alp, M.; Acar, N.; Eren, M.; Gezen, S.S.
Source:
Poultry science 2006 v.85 no.9 pp. 1621-1625
ISSN:
0032-5791
Subject:
broiler chickens; probiotics; tibia; bone strength; bone density; phosphorus; feed additives
Abstract:
... A 6-wk study with 50 birds was conducted to investigate the effects of a dietary supplemental probiotic on morphometric parameters and yield stress of the tibia. Twenty-five 1-d-old broiler chicks were assigned to a control or an experimental diet containing Bacillus licheniformis and Bacillus subtilis (BioPlus 2B, CHR Hansen BioSystems, Denmark, Ugur Ecza Deposu, Turkiye Distributoru, Adapazari 4 ...
DOI:
10.1093/ps/85.9.1621
PubMed:
16977848