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1. Administration of whey protein complexed vitamin D₃ to vitamin D₃-deficient growing Sprague-Dawley rats

Author:
Louise M. Arildsen Jakobsen; Weiwei He; Nicholas Ditzel; Marianne Danielsen; Trine K. Dalsgaard; Niklas Rye Jørgensen; Peter Bollen; Hanne C. Bertram
Source:
Food & function 2022 v.13 no.8 pp. 4691-4698
ISSN:
2042-650X
Subject:
bioavailability; biomechanics; blood serum; bone health; bone metabolism; bone strength; dietary supplements; males; metabolites; microstructure; placebos; rats; vitamin D deficiency; whey; whey protein isolate
Abstract:
... Vitamin D deficiency is a global health issue with consequences for bone health. Complexation of vitamin D₃ with specific whey proteins might increase the bioavailability and enhance the effect of dietary supplementation on health outcomes. The current rat study was set up to investigate if complexation of vitamin D₃ with whey protein isolate (WPI) or β-lactoglobulin (B-LG) increases bioavailabili ...
DOI:
10.1039/d1fo03645a

2. Analysis of the effects of curcumin and symbiotic consumption on bones of rats submitted to the use of dexamethasone

Author:
Julia Aparecida Galdino Torralba de Oliveira; Mariana Daudt Neves; Gleicy Fernanda Soares Sampaio; Carlos José Leopoldo Constantino; Wilson Romero Nakagaki
Source:
Life sciences 2022 v.304 pp. 120690
ISSN:
0024-3205
Subject:
alkaline phosphatase; bone resorption; bone strength; calcium; curcumin; deformation; dexamethasone; females; glucocorticoids; mineralization; modulus of elasticity; osteoporosis; turmeric
Abstract:
... Glucocorticoids have adverse side effects that can compromise bone tissue. There is evidence to show that symbiotics and curcumin can prevent bone loss. The aim of this study was to analyze the effects of curcumin and symbiotic to prevent and/or minimize a possible bone impairment in rats submitted to the use of dexamethasone. Fifty Wistar female rats were divided into five groups: control group ( ...
DOI:
10.1016/j.lfs.2022.120690

3. Bone mineralisation status of broilers fed reduced-protein diets supplemented with L-arginine, guanidinoacetic acid and L-citrulline

Author:
Hiep Thi Dao; Amy F. Moss; Emma J. Bradbury; Robert A. Swick
Source:
Animal production science 2022 v.62 no.6 pp. 539-553
ISSN:
1836-0939
Subject:
animal production; bone mineralization; bone strength; crude protein; digestibility; femur; financial economics; ileum; mineral content; mineralization; poultry industry; tibia; transportation
Abstract:
... Context Mineralisation of the bone matrix is a pivotal factor affecting bone strength in broilers. Reduced bone strength might cause fracture during catching and transportation to slaughterhouses, leading to economic loss. Aims This study was conducted to investigate the effects of l -arginine (Arg), guanidinoacetic acid (GAA), and l -citrulline (Cit) supplementation to Arg-deficient reduced-prote ...
DOI:
10.1071/AN21539

4. Carfilzomib alleviated osteoporosis by targeting PSME1/2 to activate Wnt/β-catenin signaling

Author:
Fan Zhang; Shokouh Attarilar; Kegong Xie; Chao Han; Qingyang liang; Ke Huang; Changgong Lan; Chong Wang; Chengliang Yang; Liqiang Wang; Masoud Mozafari; Kai Li; Jia Liu; Yujin Tang
Source:
Molecular and cellular endocrinology 2022 v.540 pp. 111520
ISSN:
0303-7207
Subject:
bone density; bone formation; bone strength; endocrinology; micro-computed tomography; models; osteoblasts; osteoclasts; osteoporosis; ovariectomy; postmenopause; proteasome endopeptidase complex; proteasome inhibitors; protein content; recombinant proteins
Abstract:
... Osteoporosis (OP) is characterized by decreased bone mineral density and impaired bone strength. Carfilzomib (CFZ) is a new-generation proteasome inhibitor and has been found to affect bone metabolism. However, the effect and mechanism of CFZ on OP has not been investigated systematically. In this study, we found that protein levels of proteasome activator subunit 1/2 (PSME1/2) increased in OP, an ...
DOI:
10.1016/j.mce.2021.111520

5. Dietary protein levels during the pullet phase (8–18 week) influence the mortality during laying stage

Author:
C.T. Oluwabiyi; J. Zhao; H. Jiao; X. Wang; H. Lin
Source:
Journal of applied poultry research 2022 v.31 no.1 pp. 100223
ISSN:
1056-6171
Subject:
blood serum; body composition; body weight; calcitonin; crude protein; dietary protein; egg production; egg quality; feed intake; femur; growth performance; high protein diet; low protein diet; mortality; nutritional intervention; pullets; research; tibia
Abstract:
... An experiment was conducted to evaluate the effects of dietary crude protein levels on growth performance, serum and bone parameters, production performance, and egg quality of Hy-Line brown chicken. A total of 384 pullets were randomly allotted to one of 3 groups with 8 replicates of 16 birds each and were fed with a diet containing 14% crude protein (CP), 16% CP, or 18% CP from 8 to 18 wk. At 18 ...
DOI:
10.1016/j.japr.2021.100223

6. Early life vitamin D depletion and mechanical loading determine methylation changes in the RUNX2, RXRA, and osterix promoters in mice

Author:
Nevena Krstic; Nick Bishop; Beth Curtis; Cyrus Cooper; Nick Harvey; Karen Lilycrop; Robert Murray; Robert Owen; Gwen Reilly; Tim Skerry; Steph Borg
Source:
Genes & nutrition 2022 v.17 no.1 pp. 7
ISSN:
1555-8932
Subject:
DNA methylation; bone density; bone strength; diet; epigenome; growth and development; mice; osteoblasts; pregnancy; tibia
Abstract:
... BACKGROUND: Early life vitamin D exposure is linked to later skeletal health with maternal vitamin D status in pregnancy associated with neonatal bone mass. The MAVIDOS study has demonstrated that vitamin D supplementation leads to reduced RXRA DNA methylation. Mice exposed to early life vitamin D deficiency have reduced bone mass and bone accrual in response to mechanical loading. Using the tibia ...
DOI:
10.1186/s12263-022-00711-0

7. Effect of limestone particle size on performance, eggshell quality, bone strength, and in vitro/in vivo solubility in laying hens: a meta-analysis approach

Author:
F. Hervo; A. Narcy; Y. Nys; M.-P. Létourneau-Montminy
Source:
Poultry science 2022 v.101 no.4 pp. 101686
ISSN:
0032-5791
Subject:
bone mineralization; bone strength; egg shell; egg shell thickness; gizzard; limestone; meta-analysis; particle size; solubility; solubilization; specific gravity; tibia
Abstract:
... Numerous publications over the past 5 decades have investigated the effect of limestone particle size (LmPS) on production performance, bone mineralization, and limestone solubilization in laying hens. Coarse limestone particles have been shown to improve eggshell quality and bone mineralization. However, there is a large variability of responses in birds to this factor, indicating the need to bet ...
DOI:
10.1016/j.psj.2021.101686

8. Effects of 12 Months Consumption of 100 g Dried Plum (Prunes) on Bone Biomarkers, Density, and Strength in Men

Author:
Shirin Hooshmand; Danielle Gaffen; Ashley Eisner; Jonnatan Fajardo; Mark Payton; Mark Kern
Source:
Journal of medicinal food 2022 v.25 no.1 pp. 40-47
ISSN:
1557-7600
Subject:
alkaline phosphatase; biomarkers; blood; bone density; bone health; bone strength; collagen; computed tomography; diet; dual-energy X-ray absorptiometry; functional foods; hips; humans; males; plums; prunes; tibia; ulna
Abstract:
... Several male animal studies have demonstrated bone-protective effects of dried plum; however, no human male study has evaluated the effect of dried plum on bone health. We conducted a randomized controlled clinical study to test if daily inclusion of 100 g of dried plum in the diet positively influenced bone mineral density (BMD), bone strength, and bone biomarkers in men. Sixty-six men were rando ...
DOI:
10.1089/jmf.2021.0080

9. Effects of Creatine Supplementation on Properties of Muscle, Bone, and Brain Function in Older Adults: A Narrative Review

Author:
Scott C. Forbes; Darren G. Candow; Luis H. B. Ferreira; Tacito P. Souza-Junior
Source:
Journal of dietary supplements 2022 v.19 no.3 pp. 318-335
ISSN:
1939-022X
Subject:
bone density; bone strength; brain; creatine; lifestyle; muscle tissues; muscles; nitrogen
Abstract:
... Aging is associated with reductions in muscle and bone mass and brain function, which may be counteracted by several lifestyle factors, of which exercise appears to be most beneficial. However, less than 20% of older adults (> 55 years of age) adhere to performing the recommended amount of resistance training (≥ 2 days/week) and less than 12% regularly meet the aerobic exercise guidelines (≥ 150 m ...
DOI:
10.1080/19390211.2021.1877232

10. Evolutionary Genetic Signatures of Selection on Bone-Related Variation within Human and Chimpanzee Populations

Author:
Daryn A. Stover; Genevieve Housman; Anne C. Stone; Michael S. Rosenberg; Brian C. Verrelli
Source:
Genes 2022 v.13 no.2 pp. -
ISSN:
2073-4425
Subject:
Pan troglodytes; amino acids; bone strength; collagen; data collection; gene expression regulation; genetic analysis; genetic variation; haplotypes; humans; introns; linkage disequilibrium; natural selection; structural proteins
Abstract:
... Bone strength and the incidence and severity of skeletal disorders vary significantly among human populations, due in part to underlying genetic differentiation. While clinical models predict that this variation is largely deleterious, natural population variation unrelated to disease can go unnoticed, altering our perception of how natural selection has shaped bone morphologies over deep and rece ...
DOI:
10.3390/genes13020183

11. Growth performance, carcass and meat quality, bone strength, and immune response of broilers fed low-calcium diets supplemented with marine mineral complex and phytase

Author:
Zafer Hakami; Ali R. Al Sulaiman; Abdulrahman S. Alharthi; Ronan Casserly; Meike A. Bouwhuis; Alaeldein M. Abudabos
Source:
Poultry science 2022 v.101 no.6 pp. 101849
ISSN:
0032-5791
Subject:
Infectious bronchitis virus; ash content; bone strength; breast meat; calcium; feed conversion; femur; geometry; growth performance; immune response; intestines; limestone; meat quality; nutritional intervention; pH; phytases; temperature; tibia
Abstract:
... Influence of marine mineral complex (CeltiCal) as a partial substitute for limestone on growth efficiency, carcass traits, meat quality, bone strength, calcium (Ca) retention, and immune response was investigated in broilers fed low-Ca diets with or without phytase (PHY) addition for a 35-d trial period. A total of 300 one-day-old Ross 308 straight-run broilers were randomly allocated to: T1 (posi ...
DOI:
10.1016/j.psj.2022.101849

12. In pursuit of a better broiler: tibial morphology, breaking strength, and ash content in conventional and slower-growing strains of broiler chickens

Author:
Midian N. Santos; Tina M. Widowski; Elijah G. Kiarie; Michele T. Guerin; A. Michelle Edwards; Stephanie Torrey
Source:
Poultry science 2022 v.101 no.4 pp. 101755
ISSN:
0032-5791
Subject:
ash content; bone strength; mineralization; morphometry; tibia
Abstract:
... This study was conducted to determine the differences in bone traits in 14 strains of broiler chickens differing in growth rate. The strains encompassed 2 conventional (CONV; ADG₀₋₄₈ >60 g/d) and 12 slower-growing (SG) strains classified as FAST (ADG₀₋₆₂ = 53–55 g/d), MOD (ADG₀₋₆₂ = 50–51 g/d), and SLOW (ADG₀₋₆₂ <50 g/d), with 4 strains represented in each SG category. A total of 7,216 mixed-sex b ...
DOI:
10.1016/j.psj.2022.101755

13. Influence of dietary dacitic tuff breccia on laying hen performance and egg quality parameters and bone structure at 85 weeks of age after a non-anorexic molt program at 73 to 77 weeks

Author:
R.D. Malheiros; V.M.B. Moraes; K.E. Anderson; F.L.S. Castro; J.E. Ferrel
Source:
Poultry science 2022 v.101 no.4 pp. 101718
ISSN:
0032-5791
Subject:
body weight; bone health; bone strength; calcium; color; diet; digestibility; egg production; egg shell; egg shell thickness; egg weight; feed intake; ileum; metabolizable energy; mineral content; molting; nitrogen retention; phosphorus; tuff
Abstract:
... The objective of the study was to assess the efficacy of AZOMITE (AZM), a dacitic tuff breccia, in laying hens through egg quality and production parameters. A total of ninety six 73-wk-old Hy-Line W-36 commercial laying hens were randomly assigned to 2 dietary treatments, a control diet and the same diet containing 0.25% AZM, with 24 replicates of 2 hens/replication. From 73 to 77 wk, hens went t ...
DOI:
10.1016/j.psj.2022.101718

14. Integument, mortality, and skeletal strength in extended production cycles for laying hens – effects of genotype and dietary zinc source

Author:
H. Wall; M. Boyner; D. J. de Koning; A. Kindmark; H. A. McCormack; R. H. Fleming; F. Lopes Pinto; R. Tauson
Source:
British poultry science 2022 v.63 no.2 pp. 115-124
ISSN:
1466-1799
Subject:
body weight; claws; diet; genotype; hybrids; keel bone; mortality; plumage; pododermatitis; tibia; zinc
Abstract:
... 1. This study on long-life layers, covering the period 20–100 weeks of age, investigated longitudinal effects on mortality, layer integument, and skeletal properties in Bovans White (BoW) and Lohmann Selected Leghorn Classic (LSL), with or without supplementation with dietary organic zinc (Zn). 2. Two experiments, using 1440 layers in furnished small group cages (FC) and 1836 layers in a tradition ...
DOI:
10.1080/00071668.2021.1955329

15. Living near greenness is associated with higher bone strength: A large cross-sectional epidemiological study in China

Author:
Ye Jiang; Bai Ma Kang Zhuo; Bing Guo; Pei-Bin Zeng; Yu-Ming Guo; Gong-Bo Chen; Jing Wei; Rui-Feng He; Zhi-Feng Li; Xue-Hui Zhang; Zi-Yun Wang; Xuan Li; Lei Wang; Chun-Mei Zeng; Lin Chen; Xiong Xiao; Xing Zhao; on behalf of the China Multi-Ethnic Cohort (CMEC) collaborative group
Source:
Science of the total environment 2022 v.831 pp. 155393
ISSN:
0048-9697
Subject:
air pollution; bone strength; confidence interval; cross-sectional studies; environment; epidemiological studies; household income; nationalities and ethnic groups; normalized difference vegetation index; particulates; physical activity; regression analysis; ultrasonics
Abstract:
... Living near green spaces may benefit various health outcomes. However, no studies have investigated the greenness-bone linkage in the general population. Moreover, to which extent ambient air pollution (AAP), physical activity (PA), and body mass index (BMI) mediate this relationship remains unclear. We aimed to explore the association between greenness and bone strength and the potential mediatin ...
DOI:
10.1016/j.scitotenv.2022.155393

16. Performance, carcass yield and cuts of male broilers fed with canthaxanthin and 25-hydroxycholecalciferol in the diet

Author:
Douglas Vanderlei Bonamigo; Alexandre Pires Rosa; Sandro José Paixão; Flavia Santi Stefanello; Angélica Londero; Alexandre Bonadiman Mariani; Letícia Cardoso Bittencourt
Source:
Animal feed science and technology 2022 v.283 pp. 115173
ISSN:
0377-8401
Subject:
25-hydroxycholecalciferol; body weight changes; bone strength; breast meat; calcium; canthaxanthin; carcass yield; color; diet; feed conversion; feed intake; feeds; gait; lipid peroxidation; males; pH; phosphorus; pigmentation; tibia; variance; weight loss
Abstract:
... The objective of this study was to evaluate the effect of canthaxanthin (CTX) associated with 25-hydroxycholecalciferol (25-OH-D3) in the feed of male broilers. A total of 1500 one-day-old Cobb-500TM males were used, distributed in a completely randomized design, totaling two treatments with fifteen replicates of 50 birds each. The treatments were: CD - control diet and CTX+ 25-OH-D3 - control die ...
DOI:
10.1016/j.anifeedsci.2021.115173

17. The Influence of Nesfatin-1 on Bone Metabolism Markers Concentration, Densitometric, Tomographic and Mechanical Parameters of Skeletal System of Rats in the Conditions of Established Osteopenia

Author:
Grzegorz Tymicki; Iwona Puzio; Marta Pawłowska-Olszewska; Marek Bieńko; Radosław Piotr Radzki
Source:
Animals 2022 v.12 no.5 pp. -
ISSN:
2076-2615
Subject:
alkaline phosphatase; blood serum; body weight; bone density; bone resorption; bone strength; collagen; crosslinking; densitometry; enzyme-linked immunosorbent assay; females; osteocalcin; osteopenia; ovariectomy; resorption; skeleton; tomography
Abstract:
... Our study aimed to evaluate the impact of nesfatin-1 administration on bone metabolism and properties in established osteopenia in ovariectomized female rats. In total, 21 female Wistar rats were assigned to two groups: sham-operated (SHAM, n = 7) and ovariectomized (OVA, n = 14). After 12 weeks of osteopenia induction in the OVA females, the animals were given i.p. physiological saline (OVA, n = ...
DOI:
10.3390/ani12050654

18. The action of oxytocin on the bone of senescent female rats

Author:
Luís Fernando Gadioli Santos; Fernanda Fernandes-Breitenbach; Rafael Augusto Santos Silva; Damáris Raíssa Santos; Melise Jacon Peres-Ueno; Edilson Ervolino; Antonio Hernandes Chaves-Neto; Rita Cássia Menegati Dornelles
Source:
Life sciences 2022 v.297 pp. 120484
ISSN:
0024-3205
Subject:
acid phosphatase; alkaline phosphatase; bone density; bone strength; females; femur; gait; osteocalcin; oxytocin; peroxidation; porosity; superoxide dismutase
Abstract:
... This study verified the action of oxytocin (OT) as a preventive measure to control bone damage during aging in female rats. Wistar rats received saline (0.15 mol/L/IP; Vehicle Group), Atosiban/AT (300 μg/Kg/IP; At Group), OT (134 μg/Kg/IP; Ot Group), or AT+OT (OT injections 5 min after AT; At+Ot Group), at 19 and 20 months of age. A functional test was performed immediately before and 30 days afte ...
DOI:
10.1016/j.lfs.2022.120484

19. Agastache rugosa ethanol extract suppresses bone loss via induction of osteoblast differentiation with alteration of gut microbiota

Author:
Soyeon Hong; Kwang Hyun Cha; Do Yeon Kwon; Yang Ju Son; Sang Min Kim; Jung-Hye Choi; Gyhye Yoo; Chu Won Nho
Source:
Phytomedicine 2021 v.84 pp. 153517
ISSN:
0944-7113
Subject:
Agastache rugosa; bone formation; bone marrow; bone resorption; bone strength; calcium; collagen; digestive system; ethanol; femur; genes; intestinal microorganisms; mice; micro-computed tomography; microbiome; osteoblasts; osteoporosis; ovariectomy; postmenopause; risk; transcription factors
Abstract:
... Osteoporosis is a metabolic skeletal disease characterized by bone loss and an increased risk of fractures. This study aimed to investigate the therapeutic effect of Agastache rugosa on postmenopausal osteoporosis and elucidate its mechanisms in modulating the bone status.In the osteoblast differentiation process with MC3T3-E1 pre-osteoblasts, ethanol extract of Agastache rugosa (EEAR) and its com ...
DOI:
10.1016/j.phymed.2021.153517

20. Bioavailability of Calcium from Chia (Salvia hispanica L.) in Ovariectomized Rats Fed a High Fat Diet

Author:
Marcella Duarte Villas Mishima; Bárbara Pereira da Silva; Renata Celi Lopes Toledo; Neuza Maria Brunoro Costa; Hércia Stampini Duarte Martino
Source:
Journal of the American College of Nutrition 2021 v.40 no.5 pp. 454-464
ISSN:
1541-1087
Subject:
Salvia hispanica; adiposity; bioavailability; blood serum; body mass index; bone health; bone resorption; bone strength; calcium; females; high fat diet; inflammation; morphometry; nutritive value; ovariectomy; porosity; waist circumference
Abstract:
... Skeletal abnormalities such as bone loss occur when there is an imbalance in bone matrix synthesis and bone resorption. This imbalance is also caused by hormonal changes and inflammation. Chia (Salvia hispanica L.) has a high nutritional value and is an excellent source of calcium. Evaluate the bioavailability of calcium from chia, and its effect on bone metabolism when consumed as part of a stand ...
DOI:
10.1080/07315724.2020.1790441