Jump to Main Content
- Demicheli, Romano, et al. Show all 5 Authors
- Biometrics 2017 v.73 no.1 pp. 260-270
- biometry; breast neoplasms; data collection; developmental stages; dormancy; metastasis; models; mortality; patients; relapse; risk
- ... Frailty models are here proposed in the tumor dormancy framework, in order to account for possible unobservable dependence mechanisms in cancer studies where a non‐negligible proportion of cancer patients relapses years or decades after surgical removal of the primary tumor. Relapses do not seem to follow a memory‐less process, since their timing distribution leads to multimodal hazards. From a bi ...
- Demichelis, Francesca, et al. Show all 18 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.17 pp. 6997-7002
- pathophysiology; androgen receptors; ubiquitination; point mutation; humans; ubiquitin-protein ligase; proteolysis; therapeutics; heterozygosity; transcription (genetics); metastasis; missense mutation; genes; mutants; prostatic neoplasms; zinc finger motif; cell proliferation; breast neoplasms
- ... The p160 steroid receptor coactivators (SRCs) SRC-1, SRC-2 [nuclear receptor coactivator (NCOA)2], and SRC-3 [amplified in breast cancer 1 (AIB1)/NCOA3] are key pleiotropic “master regulators” of transcription factor activity necessary for cancer cell proliferation, survival, metabolism, and metastasis. SRC overexpression and overactivation occur in numerous human cancers and are associated with p ...
- PubMed Central: