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1. Removal of pharmaceutical in a biogenic/chemical manganese oxide system driven by manganese-oxidizing bacteria with humic acids as sole carbon source

Author:
Tingming Ye; Huijuan Liu; Weixiao Qi; Jiuhui Qu
Source:
Journal of environmental sciences (China) 2023 v.126 pp. 734-741
ISSN:
1001-0742
Subject:
Pseudomonas; bacteria; caffeine; carbon; decaffeination; filtration; manganese dioxide; manganese monoxide; quartz; sand; synergism; China
Abstract:
... Bioaugmented sand filtration has attracted considerable attention because it can effectively remove contaminants in drinking water without additional chemical reagent addition. In this study, a synthesized chemical manganese dioxide (MnO₂)-coated quartz sand (MnQS) and biogenic manganese oxide (BioMnOₓ) composite system was proposed to simultaneously remove typical pharmaceutical contaminants and ...
DOI:
10.1016/j.jes.2022.05.035

2. ATP-binding cassette (ABC) drug transporters in the developing blood–brain barrier: role in fetal brain protection

Author:
Margaret E. Eng; Guinever E. Imperio; Enrrico Bloise; Stephen G. Matthews
Source:
Cellular and molecular life sciences 2022 v.79 no.8 pp. 415
ISSN:
1420-682X
Subject:
P-glycoproteins; antiretroviral agents; at-risk population; blood-brain barrier; brain; caffeine; glucocorticoids; homeostasis; interleukins; morphine; neuroprotective effect; permeability; pregnancy outcome; toxins; tumor necrosis factors; xenobiotics
Abstract:
... The blood–brain barrier (BBB) provides essential neuroprotection from environmental toxins and xenobiotics, through high expression of drug efflux transporters in endothelial cells of the cerebral capillaries. However, xenobiotic exposure, stress, and inflammatory stimuli have the potential to disrupt BBB permeability in fetal and post-natal life. Understanding the role and ability of the BBB in p ...
DOI:
10.1007/s00018-022-04432-w

3. Abundance, fate, and effects of pharmaceuticals and personal care products in aquatic environments

Author:
Adeyemi S. Adeleye; Jie Xue; Yixin Zhao; Alicia A. Taylor; Jenny E. Zenobio; Yian Sun; Ziwei Han; Omobayo A. Salawu; Yurong Zhu
Source:
Journal of hazardous materials 2022 v.424 pp. 127284
ISSN:
0304-3894
Subject:
analgesics; burden of disease; caffeine; demography; excretion; ibuprofen; municipal wastewater; population density; wastewater treatment
Abstract:
... Pharmaceuticals and personal care products (PPCPs) are found in wastewater, and thus, the environment. In this study, current knowledge about the occurrence and fate of PPCPs in aquatic systems—including wastewater treatment plants (WWTPs) and natural waters around the world—is critically reviewed to inform the state of the science and highlight existing knowledge gaps. Excretion by humans is the ...
DOI:
10.1016/j.jhazmat.2021.127284

4. Acetylcholinesterase Activity Monitoring and Natural Anti-neurological Disease Drug Screening via Rational Design of Deep Eutectic Solvents and CeO₂-Co(OH)₂ Nanosheets

Author:
Yun Liu; Xing Wei; Jia Chen; Yong-Liang Yu; Jian-Hua Wang; Hongdeng Qiu
Source:
Analytical chemistry 2022 v.94 no.15 pp. 5970-5979
ISSN:
1520-6882
Subject:
acetylcholinesterase; analytical chemistry; aqueous solutions; berberine; caffeine; catalytic activity; colorimetry; nanosheets; neostigmine; oxygen; proline; solvents; therapeutics
Abstract:
... The activity monitoring of acetylcholinesterase (AChE) and the screening of its inhibitors are critical for the diagnosis and therapy of neurological diseases. Herein, CeO₂-Co(OH)₂ nanosheets were synthesized for the first time in a newly designed deep eutectic solvent (DES) composed of l-proline and Ce(NO₃)₃·6H₂O, and a colorimetric assay was developed for quantitative detection of AChE and anti- ...
DOI:
10.1021/acs.analchem.2c00428

5. Acute Effects of Caffeine Supplementation on Physical Performance, Physiological Responses, Perceived Exertion, and Technical-Tactical Skills in Combat Sports: A Systematic Review and Meta-Analysis

Author:
Slaheddine Delleli; Ibrahim Ouergui; Hamdi Messaoudi; Khaled Trabelsi; Achraf Ammar; Jordan M. Glenn; Hamdi Chtourou
Source:
Nutrients 2022 v.14 no.14 pp. -
ISSN:
2072-6643
Subject:
anaerobiosis; blood; caffeine; exercise; hand strength; heart rate; lactic acid; meta-analysis; systematic review
Abstract:
... Although the effects of caffeine supplementation on combat sports performance have been extensively investigated, there is currently no consensus regarding its ergogenic benefits.This systematic review with meta-analysis aimed to summarize the studies investigating the effects of caffeine supplementation on different aspects of performance in combat sports and to quantitatively analyze the results ...
DOI:
10.3390/nu14142996

6. Acute Effects of Low Dose of Caffeine Ingestion Combined with Conditioning Activity on Psychological and Physical Performances of Male and Female Taekwondo Athletes

Author:
Ibrahim Ouergui; Nourhene Mahdi; Slaheddine Delleli; Hamdi Messaoudi; Hamdi Chtourou; Zouheir Sahnoun; Anissa Bouassida; Ezdine Bouhlel; Hadi Nobari; Luca Paolo Ardigò; Emerson Franchini
Source:
Nutrients 2022 v.14 no.3 pp. -
ISSN:
2072-6643
Subject:
caffeine; cross-over studies; emotions; females; ingestion; males; placebos
Abstract:
... This study investigated low-dose caffeine ingestion, conditioning activity (CA) effects on psycho-physical performances in young taekwondo athletes. In a randomized, double-blind, counterbalanced, crossover design, 20 athletes (10 males; 17.5 ± 0.7 yrs) performed taekwondo-specific agility test (TSAT), 10 s/multiple frequency speed of kick test (FSKT-10s/FSKT-mult) after ingesting 3 mg·kg⁻¹ caffei ...
DOI:
10.3390/nu14030571

7. Acute effects of two caffeine doses on bar velocity during the bench press exercise among women habituated to caffeine: a randomized, crossover, double-blind study involving control and placebo conditions

Author:
Aleksandra Filip-Stachnik; Michal Krzysztofik; Juan Del Coso; Michal Wilk
Source:
European journal of nutrition 2022 v.61 no.2 pp. 947-955
ISSN:
1436-6207
Subject:
body weight; caffeine; exercise; ingestion; nutrition; placebos
Abstract:
... PURPOSE: The main goal of this study was to evaluate the effectiveness of two different doses of caffeine (3 and 6 mg/kg) to enhance bar velocity during the bench press in women habituated to caffeine. METHODS: Twelve recreationally trained women (age: 23.3 ± 0.8 years, body mass: 60.7 ± 5.7 kg, bench press one-repetition maximum (1RM): 44.3 ± 7.8 kg, daily caffeine ingestion: 5.7 ± 2.0 mg/kg/day) ...
DOI:
10.1007/s00394-021-02708-8

8. Adaptive potential of Coffea canephora from Uganda in response to climate change

Author:
Sinara Oliveira de Aquino; Catherine Kiwuka; Rémi Tournebize; Clément Gain; Pierre Marraccini; Cédric Mariac; Kévin Bethune; Marie Couderc; Philippe Cubry; Alan C. Andrade; Maud Lepelley; Olivier Darracq; Dominique Crouzillat; Niels Anten; Pascal Musoli; Yves Vigouroux; Alexandre de Kochko; Stéphanie Manel; Olivier François; Valérie Poncet
Source:
Molecular ecology 2022 v.31 no.6 pp. 1800-1819
ISSN:
0962-1083
Subject:
Coffea canephora; biodiversity; biosynthesis; caffeine; climate change; ex situ conservation; genes; genetic variation; landscapes; metagenomics; pests; Lake Victoria; Uganda
Abstract:
... Understanding vulnerabilities of plant populations to climate change could help preserve their biodiversity and reveal new elite parents for future breeding programmes. To this end, landscape genomics is a useful approach for assessing putative adaptations to future climatic conditions, especially in long‐lived species such as trees. We conducted a population genomics study of 207 Coffea canephora ...
DOI:
10.1111/mec.16360

9. Advances in bioconversion of spent tea leaves to value-added products

Author:
Taru Negi; Yogesh Kumar; Ranjna Sirohi; Shikhangi Singh; Ayon Tarafdar; Sunil Pareek; Mukesh Kumar Awasthi; Narashans Alok Sagar
Source:
Bioresource technology 2022 v.346 pp. 126409
ISSN:
0960-8524
Subject:
anaerobic digestion; aspirin; batteries; biochar; biofuels; biopolymers; biotransformation; caffeine; catechin; dyes; fermentation; insulating materials; nanocatalysts; peptides; rutin; silage making; tea; theaflavins; theobromine; value added; vermicomposting; wastes
Abstract:
... Spent tea leaves (STL) are generated after the extraction of liquor from processed tea leaves and are regarded as an underutilized waste. STL are rich in essential amino acids, ω-6 and ω-3 fatty acids, alkaloids (theobromine and caffeine), polyphenols (catechin, theaflavins and rutin) and minerals (Ca, P, K, Mg, Mn) that could be utilized for the production of industrially important products. Verm ...
DOI:
10.1016/j.biortech.2021.126409

10. Aidi injection altered the activity of CYP2D4, CYP1A2, CYP2C19, CYP3A2, CYP2E1 and CYP2C11 in normal and diethylnitrosamine-induced hepatocellular carcinoma in rats

Author:
Yuan Lu; Yanli Wang; Yan He; Jie Pan; Yang Jin; Lin Zheng; Yong Huang; Yongjun Li; Wen Liu
Source:
Journal of ethnopharmacology 2022 v.286 no. pp. 114930
ISSN:
0378-8741
Subject:
Oriental traditional medicine; blood sampling; caffeine; caudal vein; cytochrome P-450; diethylnitrosamine; drug therapy; enzymes; hepatoma; liver; metabolism; tandem mass spectrometry; tolbutamide; ultra-performance liquid chromatography
Abstract:
... Aidi injection (ADI), a traditional Chinese medicine preparation, is widely used in combination with chemotherapy for the treatment of various malignant tumors, such as hepatocellular carcinoma (HCC). Studies have shown that changes in cytochrome P450 (CYP450) activity in disease states would affect the metabolism of drugs in vivo, especially liver diseases. However, the changes of Aidi injection ...
DOI:
10.1016/j.jep.2021.114930

11. Analysis of Sport Supplement Consumption by Competitive Swimmers According to Sex and Competitive Level

Author:
Berta Moreno; Santiago Veiga; Antonio J. Sánchez-Oliver; Raúl Domínguez; Esther Morencos
Source:
Nutrients 2022 v.14 no.15 pp. -
ISSN:
2072-6643
Subject:
ascorbic acid; caffeine; females; males; questionnaires; sports
Abstract:
... Sports supplements (SS) are commonly used by athletes to improve their performance. SS use by competitive swimmers is reported to be prevalent but there is no evidence of such use by elite swimmers, either male or female. The objective of this research was to study the patterns of SS use by competitive swimmers based on sex and competitive levels (national and international); Methods: Using the ca ...
DOI:
10.3390/nu14153218

12. Analytical method to monitor contaminants of emerging concern in water and soil samples from a non-conventional wastewater treatment system

Author:
Blanca Huidobro-López; Isabel López-Heras; Covadonga Alonso-Alonso; Virtudes Martínez-Hernández; Leonor Nozal; Irene de Bustamante
Source:
Journal of chromatography 2022 v.1671 pp. 463006
ISSN:
0021-9673
Subject:
acetaminophen; anticonvulsants; antihypertensive agents; aquifers; beta-adrenergic antagonists; caffeine; chemical species; electrospray ionization mass spectrometry; groundwater; lifestyle; lipids; liquid chromatography; soil; solid phase extraction; vegetation; wastewater; wastewater treatment
Abstract:
... Nonconventional wastewater treatments, such as vegetation filters (VFs), are propitious systems to attenuate contaminants of emerging concern (CECs) in small municipalities. The development of standardised multiresidue and multimatrix methods suitable for measuring a reliable number of CEC in environmental samples is crucial for monitoring infiltrating concentrations and for ensuring these systems ...
DOI:
10.1016/j.chroma.2022.463006

13. Androgenic haploid plant development via embryogenesis with simultaneous determination of bioactive metabolites in Cambod tea (Camellia assamica ssp. lasiocalyx)

Author:
Vijay Kumar Mishra; Ruchira Bajpai; Rakhi Chaturvedi
Source:
Plant cell, tissue, and organ culture 2022 v.148 no.3 pp. 515-531
ISSN:
0167-6857
Subject:
Camellia sinensis var. assamica; androgenesis; benzyladenine; caffeine; callus; cultivars; cytokinins; flow cytometry; genome; germination; glutamine; haploidy; homozygosity; metabolites; organ culture; plant development; plantlets; root tips; serine; sucrose; tea; theophylline
Abstract:
... This pioneering work reports successful androgenic plant development via embryogenesis from microspore calluses in anther cultures and estimation of bioactive metabolites in in vitro regenerants and parent plant (control) of Cambod tea, Camellia assamica ssp. lasiocalyx (Planch MS) cultivar TV19. Anthers bearing microspores at early-to-late uni-nucleate stage were selected to initiate androgenesis ...
DOI:
10.1007/s11240-021-02203-2

14. Another perspective to explain green tea cream: Utilizing engineered catechin-caffeine complex

Author:
Gang Zhang; Yanyan Cao; Sifan Mei; Yating Guo; Shuying Gong; Qiang Chu; Ping Chen
Source:
Food research international 2022 v.158 pp. 111542
ISSN:
0963-9969
Subject:
Fourier transform infrared spectroscopy; X-ray diffraction; aqueous solutions; caffeine; flavanols; flavor; food research; green tea; guanidines; high performance liquid chromatography; hydrogen bonding; spectral analysis
Abstract:
... Green tea cream, the precipitate formed in cooled green tea infusion, appears a negative effect on flavor. To explain the mechanism of green tea cream, complexations between four catechins (CATs) and caffeine (CAF) were engineered and characterized. Dynamic light scattering, high performance liquid chromatography, scanning electron microscopy, fourier-transform infrared spectroscopy, UV–visible ab ...
DOI:
10.1016/j.foodres.2022.111542

15. Antibiotic and analgesic residues in the environment – Occurrence and ecological risk study from the Sunyani municipality, Ghana

Author:
Bernice Araba Otoo; Ivy Anima Amoabeng; Godfred Darko; Lawrence Sheringham Borquaye
Source:
Toxicology reports 2022 v.9 pp. 1491-1500
ISSN:
2214-7500
Subject:
acetaminophen; amoxicillin; caffeine; chloramphenicol; ciprofloxacin; diclofenac; doxycycline; ecosystems; environmental assessment; hospitals; ibuprofen; liquids; metronidazole; remediation; risk; rivers; soil; solid phase extraction; toxicology; waste disposal sites; water utilities; Ghana
Abstract:
... The presence of five antibiotics (metronidazole, ciprofloxacin, amoxicillin, doxycycline, and chloramphenicol) and four analgesics (diclofenac, ibuprofen, paracetamol, and caffeine) were investigated in water and soil samples from the Sunyani municipality, Ghana. Liquid samples were collected from hospital effluents, sachet drinking water, municipal waterworks, river Tano, and dumpsite leachates, ...
DOI:
10.1016/j.toxrep.2022.07.003

16. Antiinflammatory and antiinfective effect of caffeine in a mouse model of disseminated salmonellosis

Author:
Betty Mancebo Dorvigny; Lethicia Souza Tavares; Ingrydt Alcântara de Almeida; Lucas Nunes Santana; Esther de Souza Silva; Juliana Kelly Urtigas de Souza; Anísio Francisco Soares; Valdemiro Amaro da Silva Júnior; José Vitor Lima‐Filho
Source:
Phytotherapy research 2022 v.36 no.4 pp. 1652-1663
ISSN:
0951-418X
Subject:
Salmonella Typhimurium; bacteria; blood flow; caffeine; cell viability; dexamethasone; inducible nitric oxide synthase; interleukin-6; intravenous injection; liver; macrophages; mice; microbial load; phagocytosis; phytotherapy; research; salmonellosis; spleen; tumor necrosis factor-alpha; virulence
Abstract:
... Caffeine has been reported for its antiinflammatory properties by stimulating phagocytosis. In this study, we investigated the antiinflammatory and antiinfective potential of caffeine in murine macrophage cell cultures and Swiss mice infected with virulent Salmonella enterica serotype typhimurium. Peritoneal macrophages (pMØ) were treated with caffeine on 96‐well plates for 24 hr and then infected ...
DOI:
10.1002/ptr.7349

17. Antioxidant and sensory evaluation of cocoa (Theobroma cacao L.) tea formulated with cocoa bean hull of different origins

Author:
Cai San Siow; Eric Wei Chiang Chan; Chen Wai Wong; Chee Wai Ng
Source:
Future foods 2022 v.5 pp. 100108
ISSN:
2666-8335
Subject:
Theobroma cacao; byproducts; caffeine; chocolate; cocoa beans; flavonoids; flavor; free radicals; green tea; ingredients; ochratoxin A; sensory evaluation; surveys; temperature; theobromine; Malaysia; Venezuela
Abstract:
... Cocoa nibs are the main ingredient for chocolate production while cocoa bean hulls are the major by-product. Uniqueness of this study is that we investigate the antioxidant content and activity of single origin cocoa bean hulls compared to nibs based on their total phenolic content (TPC), total flavonoid content (TFC), free radical scavenging activity (DPPH Assay), ferric reducing powder (FRAP), a ...
DOI:
10.1016/j.fufo.2021.100108

18. Anti‐Alzheimer's disease potential of Arabian coffee versus Date palm seed extract in male rats

Author:
Nahla S. Zidan; Awatif M. E. Omran; Samar M. Rezk; Hebatallah H. Atteia; Mohamed I. Sakran
Source:
Journal of food biochemistry 2022 v.46 no.1 pp. e14017
ISSN:
0145-8884
Subject:
Alzheimer disease; Phoenix dactylifera; aluminum chloride; animal models; beverages; blood serum; caffeine; cognitive disorders; decaffeination; flavonoids; males; memory disorders; seed extracts; therapeutics
Abstract:
... Coffee is among the most commonly consumed beverage all over the world. Studies have increasingly suggested caffeine and coffee as effective therapeutic interventions against Alzheimer's disease (AD). We have therefore utilized the aluminum chloride rat model for AD to compare the influence of moderately caffeinated (Arabian) and decaffeinated (Date palm seed) coffee on cognitive impairment and pa ...
DOI:
10.1111/jfbc.14017

19. Application of electrostatic dry powder coating technology on capsules to achieve sustained release

Author:
Zhehao Jing; Yingliang Ma; Jesse Zhu
Source:
Powder technology 2022 pp. 117786
ISSN:
0032-5910
Subject:
adhesion; aspirin; caffeine; gelatin; liquids; methylcellulose; polymers; stickiness; technology; weight gain
Abstract:
... This study introduces an electrostatic dry powder coating process to coat hard gelatin capsules and hydroxypropyl methylcellulose capsules directly in a coating pan to achieve sustained release. The process overcomes many difficulties in the capsule liquid coating process, such as stickiness and poor adhesion. According to the results of SEM, the coating process required more polymer powder to sea ...
DOI:
10.1016/j.powtec.2022.117786

20. Application of multispectral imaging combined with machine learning models to discriminate special and traditional green coffee

Author:
Winston Pinheiro Claro Gomes; Luís Gonçalves; Clíssia Barboza da Silva; Wanessa R. Melchert
Source:
Computers and electronics in agriculture 2022 v.198 pp. 107097
ISSN:
0168-1699
Subject:
agriculture; caffeine; catechin; data collection; electronics; fluorescence; fluorescent dyes; food analysis; food industry; reflectance
Abstract:
... Non-destructive techniques aided by machine learning models are widely implemented in food analysis. To discriminate between ‘special’ and ‘traditional’ classes of green coffee beans, an advanced multispectral imaging technique based on reflectance and autofluorescence data was employed in combination with four machine learning algorithms (SVM, RF, XGBoost, and CatBoost). Of the four algorithms, S ...
DOI:
10.1016/j.compag.2022.107097

21. Applying acceptability and emotion to understand the consumer's consumption habits and involvement with coffee

Author:
Ari Lynn Kenney; Uyen Thuy Xuan Phan; Koushik Adhikari
Source:
Journal of sensory studies 2022 v.37 no.1 pp. e12713
ISSN:
0887-8250
Subject:
beverage industry; beverages; caffeine; markets; sensation; surveys
Abstract:
... The current study determined the hedonic perception and emotion response during coffee consumption, and also aimed to understand the coffee drinkers' involvement and consumption habits related to this beverage. An acceptability and an emotions test followed by an attitudinal survey on consumption habits and coffee involvement were performed with three coffees samples. Results suggest that coffee d ...
DOI:
10.1111/joss.12713

22. Are taste variations associated with the liking of sweetened and unsweetened coffee?

Author:
Catamo Eulalia; Navarini Luciano; Gasparini Paolo; Robino Antonietta
Source:
Physiology & behavior 2022 v.244 pp. 113655
ISSN:
0031-9384
Subject:
alleles; behavior; bitterness; caffeine; coffee (beverage); gender; genotyping; hedonic scales; introns; phenotype; questionnaires; regression analysis; sweetness; taste sensitivity
Abstract:
... In this study, we evaluated the influence of taste phenotypes and genotypes on the hedonics of sweetened and unsweetened coffee.Liking of espresso coffee from food questionnaire and of a ready-to-drink unsweetened coffee beverage was measured using a 9-point hedonic scale in 1551 Italian individuals. Perception and liking for different bitter and sweet compounds were also collected. Genotyping of ...
DOI:
10.1016/j.physbeh.2021.113655

23. Artisanal fortified beers: Brewing, enrichment, HPLC-DAD analysis and preliminary screening of antioxidant and enzymatic inhibitory activities

Author:
Giuseppe Scioli; Alice Della Valle; Gokhan Zengin; Marcello Locatelli; Angela Tartaglia; Angelo Cichelli; Azzurra Stefanucci; Adriano Mollica
Source:
Food bioscience 2022 v.48 pp. 101721
ISSN:
2212-4292
Subject:
antioxidant activity; antioxidants; beers; caffeine; enzyme inhibition; ethanol; flavonoids; nutritive value; phenol; resveratrol; taurine; traditional technology
Abstract:
... In this study an artisanal “Porter style” beer has been enriched with diverse natural bioactive substances, following all-grain brewing method. Common beer generally contains a poor content of phenolic acids which confers a low antioxidant power and nutritional value, also due to the presence of ethanol. However in this work we aimed to enrich beer with different flavonoids and other food suppleme ...
DOI:
10.1016/j.fbio.2022.101721

24. Assessing Caffeine and Linear Alkylbenzene Sulfonate Effects on Molting and Reproduction of Daphnia magna by Quantitative and Qualitative Approaches

Author:
Mara R. de Lima e Silva; Aline C. Bernegossi; Gleyson B. Castro; Allan P. Ogura; Juliano J. Corbi; Mayara C. Felipe
Source:
Water, air, and soil pollution 2022 v.233 no.3 pp. 98
ISSN:
0049-6979
Subject:
Daphnia magna; air; caffeine; humans; keystone species; progeny; soil pollution; sulfonates; water
Abstract:
... Caffeine (CAF) and linear alkylbenzene sulfonate (LAS) are human activity indicators, classified as contaminants of emerging concern (CECs). The long-term effects of these CECs on keystone species are still scarce in the literature. In this study, the molting and reproduction of Daphnia magna were evaluated over chronicle experiments by quantitative and qualitative approaches. The reported environ ...
DOI:
10.1007/s11270-022-05554-4

25. Assessment of a wide array of organic micropollutants of emerging concern in wastewater treatment plants in Greece: Occurrence, removals, mass loading and potential risks

Author:
Anna Ofrydopoulou; Christina Nannou; Eleni Evgenidou; Aikaterini Christodoulou; Dimitra Lambropoulou
Source:
Science of the total environment 2022 v.802 pp. 149860
ISSN:
0048-9697
Subject:
UV filters; acetaminophen; caffeine; diclofenac; ecotoxicology; environment; fish; mass spectrometry; methotrexate; monitoring; organophosphorus compounds; pollutants; relative risk; risk assessment; solid phase extraction; surveys; telmisartan; toxicity; ultra-performance liquid chromatography; wastewater; wastewater treatment; Greece
Abstract:
... Exploring the contamination profile of multi-class emerging contaminants (ECs) in wastewater is highly desirable. To this end, the occurrence, removal, mass loading and risks associated with a large panel of pharmaceuticals and personal care products, illicit drugs, perfluorinated compounds and organophosphate flame retardants in two wastewater treatment plants (WWTPs) in the region of Thessalonik ...
DOI:
10.1016/j.scitotenv.2021.149860

26. Associations between sleep duration and Mediterranean diet score in Costa Rican adults

Author:
Kashvi Gupta; Erica C. Jansen; Hannia Campos; Ana Baylin
Source:
Appetite 2022 v.170 pp. 105881
ISSN:
0195-6663
Subject:
Mediterranean diet; adults; appetite; caffeine; case-control studies; education; food frequency questionnaires; hypertension; models; noninsulin-dependent diabetes mellitus; physical activity; regression analysis; sleep; Latin America
Abstract:
... Both insufficient and excessive sleep duration have been associated with lower-quality diets in adult populations. However, investigations in Latin America, where different sleep norms may exist (e.g., daily napping), are scarce. Therefore, we examined whether weekday sleep duration and inconsistencies between weekday and weekend sleep duration were related to adherence to the Mediterranean diet a ...
DOI:
10.1016/j.appet.2021.105881

27. Associations of Blood Caffeine and Genetically Predicted Coffee Consumption with Anthropometric Measures of Obesity: A Two Sample Mendelian Randomization Study

Author:
Vikram P. Narayan; S. Y. Yoon
Source:
journal of nutrition, health & aging 2022 v.26 no.2 pp. 190-196
ISSN:
1279-7707
Subject:
ancestry; blood serum; caffeine; hip circumference; issues and policy; metabolites; nutrition; obesity; pleiotropy; risk; waist circumference; waist-to-hip ratio
Abstract:
... OBJECTIVES: In observational studies, caffeine has been associated with a lower risk of obesity. However, whether the associations are causal and apply to coffee, which is a mixture of chemical compounds is unclear. DESIGN: Two sample Mendelian randomization study. SETTING AND PARTICIPANTS: Genetic instruments predicting caffeine were extracted from an existing GWAS of serum metabolites in 1960 in ...
DOI:
10.1007/s12603-022-1736-5

28. Auditing the Representation of Female Versus Male Athletes in Sports Science and Sports Medicine Research: Evidence-Based Performance Supplements

Author:
Ella S. Smith; Alannah K. A. McKay; Megan Kuikman; Kathryn E. Ackerman; Rachel Harris; Kirsty J. Elliott-Sale; Trent Stellingwerff; Louise M. Burke
Source:
Nutrients 2022 v.14 no.5 pp. -
ISSN:
2072-6643
Subject:
beets; caffeine; creatine; evidence-based practice; females; glycerol; males; nitrates; sodium bicarbonate; women
Abstract:
... Although sports nutrition guidelines promote evidence-based practice, it is unclear whether women have been adequately included in the underpinning research. In view of the high usage rates of performance supplements by female athletes, we conducted a standardised audit of the literature supporting evidence-based products: β-alanine, caffeine, creatine, glycerol, nitrate/beetroot juice and sodium ...
DOI:
10.3390/nu14050953

29. Biological Role of Nutrients, Food and Dietary Patterns in the Prevention and Clinical Management of Major Depressive Disorder

Author:
Miguel A. Ortega; Óscar Fraile-Martínez; Cielo García-Montero; Miguel Angel Alvarez-Mon; Guillermo Lahera; Jorge Monserrat; Maria Llavero-Valero; Luis Gutiérrez-Rojas; Rosa Molina; Roberto Rodríguez-Jimenez; Javier Quintero; Melchor Alvarez De Mon
Source:
Nutrients 2022 v.14 no.15 pp. -
ISSN:
2072-6643
Subject:
Mediterranean diet; S-adenosylmethionine; brain; caffeine; carnitine; creatine; eating habits; fermentation; fish; lifestyle; malnutrition; mental depression; polyphenols; tea
Abstract:
... Major Depressive Disorder (MDD) is a growing disabling condition affecting around 280 million people worldwide. This complex entity is the result of the interplay between biological, psychological, and sociocultural factors, and compelling evidence suggests that MDD can be considered a disease that occurs as a consequence of an evolutionary mismatch and unhealthy lifestyle habits. In this context, ...
DOI:
10.3390/nu14153099

30. Bottom-up and top-down drivers of herbivory on Arabica coffee along an environmental and management gradient

Author:
H.F. Burger; K. Hylander; B. Ayalew; N.M. van Dam; E. Mendesil; A. Schedl; T. Shimales; B. Zewdie; A.J.M. Tack
Source:
Basic and applied ecology 2022 v.59 pp. 21-32
ISSN:
1439-1791
Subject:
Coffea arabica; applied ecology; birds; caffeine; canopy; center of origin; chemistry; chlorogenic acid; forests; herbivores; pest control; pests; predation; sustainable agriculture; Ethiopia
Abstract:
... While sustainable agriculture relies on natural pest control, we lack insights into the relative importance of bottom-up and top-down factors on pest levels, especially along broad environmental and management gradients. To this aim, we focused on bottom-up and top-down control of herbivore damage in sixty sites in the centre of origin of Arabica coffee in southwestern Ethiopia, where coffee grows ...
DOI:
10.1016/j.baae.2021.12.009

31. CCDB: A database for exploring inter-chemical correlations in metabolomics and exposomics datasets

Author:
Dinesh Kumar Barupal; Priyanka Mahajan; Sadjad Fakouri-Baygi; Robert O. Wright; Manish Arora; Susan L. Teitelbaum
Source:
Environment international 2022 v.164 pp. 107240
ISSN:
0160-4120
Subject:
National Health and Nutrition Examination Survey; acetaminophen; caffeine; data collection; databases; environment; exposome; humans; metabolites; metabolomics; phthalates; smoke; tobacco; xenobiotics
Abstract:
... Inter-chemical correlations in metabolomics and exposomics datasets provide valuable information for studying relationships among chemicals reported for human specimens. With an increase in the number of compounds for these datasets, a network graph analysis and visualization of the correlation structure is difficult to interpret. We have developed the Chemical Correlation Database (CCDB), as a sy ...
DOI:
10.1016/j.envint.2022.107240

32. Caffeine Ameliorates AKT-Driven Nonalcoholic Steatohepatitis by Suppressing De Novo Lipogenesis and MyD88 Palmitoylation

Author:
Xiangyun Tan; Yi Sun; Liang Chen; Junjie Hu; Yan Meng; Ming Yuan; Qi Wang; Shan Li; Guohua Zheng; Zhenpeng Qiu
Source:
Journal of agricultural and food chemistry 2022 v.70 no.20 pp. 6108-6122
ISSN:
1520-5118
Subject:
anti-inflammatory activity; caffeine; fatty liver; food chemistry; hepatoma; humans; interleukin-6; lipogenesis; mice; oncogenes; palmitoylation; therapeutics; thymoma
Abstract:
... Dysregulated hepatic lipogenesis represents a promising druggable target for treating nonalcoholic steatohepatitis (NASH). This work aims to evaluate the therapeutic efficacy of caffeine in a NASH mouse model displaying increased hepatic lipogenesis driven by constitutive hepatic overexpression of the active v-akt murine thymoma viral oncogene homolog (AKT). Caffeine was administered in the AKT mi ...
DOI:
10.1021/acs.jafc.2c01013

33. Caffeine Consumption among Various University Students in the UAE, Exploring the Frequencies, Different Sources and Reporting Adverse Effects and Withdrawal Symptoms

Author:
Zelal Kharaba; Nour Sammani; Samar Ashour; Rose Ghemrawi; Ahmad Z. Al Meslamani; Ahmad Al-Azayzih; Manal Ali Buabeid; Yassen Alfoteih
Source:
Journal of nutrition and metabolism 2022 v.2022 pp. -
ISSN:
2090-0732
Subject:
average daily intake; beverages; caffeine; cognition; cross-sectional studies; males; metabolism; nutrition; overdose; questionnaires; social sciences; surveys; tea
Abstract:
... Background. Caffeine is widely consumed among students due to its cognitive and physical enhancing effects. However, little is known about the consumption pattern of different caffeinated products among university students in the United Arab Emirates (UAE). Aim. To investigate the frequency of caffeine consumption among the young population of students, assess types of caffeinated products consume ...
DOI:
10.1155/2022/5762299

34. Caffeine Encapsulation in Metal Organic Framework MIL-53(Al) at Pilot Plant Scale for Preparation of Polyamide Textile Fibers with Cosmetic Properties

Author:
Beatriz Zornoza; César Rubio; Elena Piera; Miguel A. Caballero; Daniel Julve; Jorge Pérez; Carlos Téllez; Joaquín Coronas
Source:
ACS applied materials & interfaces 2022 v.14 no.19 pp. 22476-22488
ISSN:
1944-8252
Subject:
adsorption; caffeine; coordination polymers; fabrics; markets; microencapsulation; polyamides; porosity; temperature
Abstract:
... Currently in the marketplace, we can find clothing items able to release skin-friendly ingredients while wearing them. These innovative products with high-added value are based on microencapsulation technology. In this work, due to its lightness, flexibility, porosity, chemical affinity and adsorption capacity, metal–organic framework (MOF) MIL-53(Al) was the selected microcapsule to be synthesize ...
DOI:
10.1021/acsami.2c04293

35. Caffeine Enhances the Toxicity of Platinum-Based Drugs at the Molecular Level Even Outside of the Intracellular Environment: A Single-Molecule Force Spectroscopy Study

Author:
Rayane M. de Oliveira; Tiago A. Moura; Márcio S. Rocha
Source:
Journal of physical chemistry 2022 v.126 no.17 pp. 3291-3299
ISSN:
1520-5207
Subject:
DNA; DNA repair; caffeine; catalysts; cisplatin; drug therapy; phosphates; physical chemistry; platinum; spectroscopy; toxicity
Abstract:
... It is well reported in the literature that caffeine, the most consumed alkaloid around the world, enhances the anticancer effects of the drug cisplatin by inhibiting DNA repair by the cellular machinery. Here, we perform single-molecule force spectroscopy assays with optical tweezers to show that caffeine enhances the toxicity not only of cisplatin but also of various different platinum-based drug ...
DOI:
10.1021/acs.jpcb.2c01553

36. Caffeine Ingestion Affects Performance in Different Parts of a Novel Multidirectional High-Intensity Intermittent Exercise in Futsal Athletes

Author:
Gerdiel John dos Santos Bezerra; Emmanuel Damasceno Silva Gomes; Carlos Rafaell Correia-Oliveira
Source:
Journal of the American Nutrition Association 2022 v.41 no.2 pp. 149-156
ISSN:
2769-707X
Subject:
body fat; body mass index; caffeine; cellulose; exercise; heart rate; ingestion; nutrition; placebos
Abstract:
... Objective: No study has analyzed the effects of caffeine ingestion on performance during a multidirectional high-intensity intermittent exercise. Thus, we aimed to investigate the effects of caffeine ingestion during a novel repeated agility test in futsal athletes. Methods: Using a double-blind, counterbalanced, and repeated-measures design, ten athletes (mass 71.2 ± 8.7 kg, height 1.77 ± 0.05 m, ...
DOI:
10.1080/07315724.2020.1852450

37. Caffeine Inhibits Growth of Temozolomide-Treated Glioma via Increasing Autophagy and Apoptosis but Not via Modulating Hypoxia, Angiogenesis, or Endoplasmic Reticulum Stress in Rats

Author:
Jin-Cherng Chen; Juen-Haur Hwang
Source:
Nutrition and cancer 2022 v.74 no.3 pp. 1090-1096
ISSN:
1532-7914
Subject:
angiogenesis; apoptosis; autophagy; caffeine; caspase-3; endoplasmic reticulum stress; glioma; hypoxia; nutrition; vascular endothelial growth factors
Abstract:
... Thirty rats with glioma were divided into control group, temozolomide (TMZ) group (TMZ 30 mg/kg once daily for 5 day), and TMZ plus Caffeine group (TMZ 30 mg/kg once daily for 5 day and caffeine 100 mg/kg once daily for 2 weeks). The relative tumor fold and expression of hypoxia-induced factor-1α (HIF-1α), vascular endothelial growth factor (VEGF), neuropilin-1 (NRP-1), CCAAT/enhancer-binding prot ...
DOI:
10.1080/01635581.2021.1931361

38. Caffeine Intake and Its Sex-Specific Association with General Anxiety: A Cross-Sectional Analysis among General Population Adults

Author:
Indira Paz-Graniel; Junko Kose; Nancy Babio; Serge Hercberg; Pilar Galan; Mathilde Touvier; Jordi Salas-Salvadó; Valentina A. Andreeva
Source:
Nutrients 2022 v.14 no.6 pp. -
ISSN:
2072-6643
Subject:
anxiety; caffeine; confidence interval; cross-sectional studies; food intake; inventories; odds ratio; regression analysis; sugars
Abstract:
... (1) Background: Caffeine is one of the most consumed psychoactive stimulants worldwide. It has been suggested that caffeine intake at large doses can induce anxiety, whereas evidence of the role of low to moderate caffeine intake is scarce and inconsistent. Therefore, we aimed to assess the association between caffeine intake and general anxiety in adults recruited from the general population. (2) ...
DOI:
10.3390/nu14061242

39. Caffeine and Paraxanthine as Tracers of Anthropogenic Wastewater in Coastal Lagoons in Yucatan, Mexico

Author:
Yazmín Martínez-Casales; Karina León-Aguirre; Elizabeth Lamas-Cosío; E. Noreña-Barroso; Jorge Herrera-Silveira; Flor Arcega-Cabrera
Source:
Bulletin of environmental contamination and toxicology 2022 v.108 no.2 pp. 182-189
ISSN:
0007-4861
Subject:
aquifers; bedrock; caffeine; groundwater; metabolites; toxicology; wastewater; wastewater treatment; water pollution; water quality; Mexico
Abstract:
... Due to karstic bedrock geology and poor wastewater management practices, anthropogenic activities are impacting water quality in Yucatan’s aquatic systems. Specifically, raw wastewater inputs to the aquifer subsequently flow to coastal lagoons through groundwater fluxes. This study establishes the presence of anthropogenic wastewater by measuring caffeine and its metabolite, paraxanthine, in four ...
DOI:
10.1007/s00128-021-03428-9

40. Caffeine and canopy cover interact to alter biofilm nutrient content, benthic invertebrates, and insect emergence

Author:
Melanie M. Marshall; Gabrielle K. Metzner; Kevin E. McCluney
Source:
River research and applications 2022 v.38 no.5 pp. 863-872
ISSN:
1535-1459
Subject:
biofilm; biomass; caffeine; canopy; food webs; freshwater; insects; macroinvertebrates; nutrient content; research; rivers
Abstract:
... The addition of trace contaminants to surface waters is recognized as a rising environmental concern and caffeine is among those most commonly detected. Classic toxicological analyses of single organisms have described some of the impacts of caffeine on freshwater organisms, but few have examined ecological interactions, food webs, or aquatic‐terrestrial linkages, especially in natural aquatic sys ...
DOI:
10.1002/rra.3954

41. Caffeine and ethanol in nectar interact with flower color impacting bumblebee behavior

Author:
Patricia Jones; Anurag A. Agrawal
Source:
Behavioral ecology and sociobiology 2022 v.76 no.7 pp. 103
ISSN:
0340-5443
Subject:
Bombus impatiens; bees; caffeine; chemistry; color; ecology; ethanol; flower color; flowers; humans; nectar; pollination; pollinators; social behavior; sociobiology; toxicity
Abstract:
... Caffeine and ethanol are naturally occurring compounds in floral nectar. We examined how these compounds influenced pollinator behaviors including floral preference, floral constancy, and social behavior using bumblebees, Bombus impatiens, which were given prior experience foraging on either human blue or human white (hereafter blue and white) artificial flowers. Because flower color influenced be ...
DOI:
10.1007/s00265-022-03208-3

42. Caffeine as a contaminant of concern: A review on concentrations and impacts in marine coastal systems

Author:
L.R. Vieira; A.M.V.M. Soares; R. Freitas
Source:
Chemosphere 2022 v.286 pp. 131675
ISSN:
0045-6535
Subject:
aquatic environment; bioaccumulation; biochemical pathways; caffeine; corals; energy; human health; lipid peroxidation; microalgae; mortality; neurotoxicity; oxidative stress; pollutants; pollution; psychotropic agents; reproduction; risk assessment; seawater
Abstract:
... Caffeine has been identified as emerging contaminant of concern due to its widespread occurrence in the aquatic environment and potential to be biologically active. Recently, these concerns have been translated in an increasing research on its occurrence and effects on biota. However, there is still a limited knowledge on seawater matrices and the implications of caffeine presence in coastal and m ...
DOI:
10.1016/j.chemosphere.2021.131675

43. Caffeine consumption and mortality in populations with different weight statuses: An analysis of NHANES 1999–2014

Author:
Ping Lin; Zongan Liang; Maoyun Wang
Source:
Nutrition 2022 v.102 pp. 111731
ISSN:
0899-9007
Subject:
National Health and Nutrition Examination Survey; caffeine; confidence interval; hazard ratio; mortality; nutrition; overweight; risk
Abstract:
... The association between caffeine consumption and mortality in different weight statuses is unclear. This study aimed to explore the effects of caffeine consumption on mortality in different weight statuses. Data from the National Health and Nutrition Examination Survey (1999–2014) was used in this study. We used multivariable Cox proportional hazards models with appropriate sampling weight to asse ...
DOI:
10.1016/j.nut.2022.111731

44. Caffeine increases exercise intensity and energy expenditure but does not modify substrate oxidation during 1 h of self-paced cycling

Author:
Carlos Ruiz-Moreno; Francisco J. Amaro-Gahete; Jaime González-García; Verónica Giráldez-Costas; Asier Mañas; Jorge Gutiérrez-Hellín; Juan Del Coso
Source:
European journal of nutrition 2022 v.61 no.6 pp. 3285-3292
ISSN:
1436-6207
Subject:
autoregulation; caffeine; calorimetry; carbohydrates; energy expenditure; exercise; ingestion; lipid metabolism; nutrition; oxidation; placebos
Abstract:
... AIM: Oral caffeine intake has been deemed as an effective supplementation strategy to enhance fat oxidation during aerobic exercise with a steady-state intensity. However, in real exercise scenarios, individuals habitually train with autoregulation of exercise intensity. This study aimed to analyze the effect of oral caffeine intake during self-paced cycling on autoregulated exercise intensity and ...
DOI:
10.1007/s00394-022-02894-z

45. Caffeine intake and its influences on heart rate variability recovery in healthy active adults after exercise: A systematic review and meta-analysis

Author:
Andrey Alves Porto; Cicero Jonas R. Benjamim; Luana Almeida Gonzaga; Mariana Luciano de Almeida; Carlos Roberto Bueno Júnior; David M. Garner; Vitor Engrácia Valenti
Source:
Nutrition, metabolism, and cardiovascular diseases 2022 v.32 no.5 pp. 1071-1082
ISSN:
0939-4753
Subject:
acute effects; caffeine; confidence interval; exercise; heart rate; ingestion; meta-analysis; metabolism; nutrition; risk analysis; standard deviation; systematic review
Abstract:
... Results regarding the effects of caffeine (CAF) intake on the autonomic control of heart rate recovery exercise remain inconclusive. Thus far, no study has used effect measures to pool the results of different experiments. We aim to assess the acute effect of CAF intake before exercise on the recovery of heart rate variability (HRV) after exercise through a systematic review and meta-analysis. Ran ...
DOI:
10.1016/j.numecd.2022.01.015

46. Caffeine intake increases countermovement jump performance in well-trained high jumpers

Author:
Ana C. Santos-Mariano; Gislaine Cristina-Souza; Pâmela Souza Santos; Pablo Ramon Domingos; Pedro De-Oliveira; Romulo Bertuzzi; Cintia Rodacki; Adriano E. Lima-Silva
Source:
PharmaNutrition 2022 v.21 pp. 100305
ISSN:
2213-4344
Subject:
body weight; caffeine; cellulose; ingestion
Abstract:
... Caffeine (CAF) has been shown to be an efficient ergogenic in improving the performance of countermovement jump tests (CMJ). However, it has not been evaluated whether this improvement reproduces itself in well-trained high jumpers. To determine the effect of caffeine ingestion on CMJ performance, eight (5 men and 3 women) well-trained high-jumpers performed three CMJ one hour after the ingestion ...
DOI:
10.1016/j.phanu.2022.100305

47. Caffeine photocatalytic degradation using composites of NiO/TiO2–F and CuO/TiO2–F under UV irradiation

Author:
Claudia Castañeda; José J. Martínez; Laura Santos; Hugo Rojas; Sameh M. Osman; Ricardo Gómez; Rafael Luque
Source:
Chemosphere 2022 v.288 pp. 132506
ISSN:
0045-6535
Subject:
caffeine; crystallites; energy; mineralization; nickel oxide; photocatalysis; surface area; titanium dioxide; ultraviolet radiation
Abstract:
... The interest in the removal of emerging contaminants has increased in the last decade. Photocatalytic degradation using p-n heterojunctions could effectively provide the degradation of these type of substances that are persistent in the environment. In this work, the synthesis, characterization, and photocatalytic evaluation of TiO₂–F as well as CuO/TiO₂–F and NiO/TiO₂–F composite materials were s ...
DOI:
10.1016/j.chemosphere.2021.132506

48. Calibration and field validation of POCIS passive samplers for tracking artificial sweeteners as indicators of municipal wastewater contamination in surface waters

Author:
Tamanna Sultana; Chris D. Metcalfe
Source:
Environmental monitoring and assessment 2022 v.194 no.8 pp. 564
ISSN:
0167-6369
Subject:
acesulfame potassium; anion exchange resins; caffeine; coasts; ibuprofen; municipal wastewater; pH; saccharin; sewage; sorbents; sucralose; surface water; water pollution; Lake Ontario
Abstract:
... Polar organic chemical integrative samplers (POCIS) are widely used to track contaminants in surface waters. However, POCIS have not been used previously to monitor for artificial sweeteners as an indicator of wastewater pollution. In this study, we report for the first time the POCIS sampling rates (Rscₐₗ) for four artificial sweetener compounds, acesulfame (0.001 L/day), sucralose (0.114 L/day), ...
DOI:
10.1007/s10661-022-10150-4

49. Cascading effects of caffeine intake by primary consumers to the upper trophic level

Author:
Kévin Tougeron; Thierry Hance
Source:
Bulletin of entomological research 2022 v.112 no.2 pp. 197-203
ISSN:
1475-2670
Subject:
caffeine; diet; evolution; fecundity; food chain; herbivores; longevity; nectar; parasitism; parasitoids; research; sap; secondary metabolites; tea; trophic levels
Abstract:
... Secondary metabolites are central to understanding the evolution of plant–animal interactions. Direct effects on phytophagous animals are well-known, but how secondary consumers adjust their behavioural and physiological responses to the herbivore's diet remains more scarcely explored for some metabolites. Caffeine is a neuroactive compound that affects both the behaviour and physiology of several ...
DOI:
10.1017/S0007485321000687

50. Changes in Non-Volatile and Volatile Metabolites Associated with Heterosis in Tea Plants (Camellia sinensis)

Author:
Pengjie Wang; Mengya Gu; Shuxian Shao; Xiaomin Chen; Binghao Hou; Naixing Ye; Xingtan Zhang
Source:
Journal of agricultural and food chemistry 2022 v.70 no.9 pp. 3067-3078
ISSN:
1520-5118
Subject:
Camellia sinensis; adenosine; adipic acid; caffeine; cultivars; flavanols; food chemistry; gallic acid; guanosine; heterosis; inosine; metabolites; metabolomics; nucleotides; odors; oolong tea; succinic acid; terpenoids
Abstract:
... Heterosis or hybrid vigor is extensively used in plant breeding. However, the contribution of metabolites to heterosis is still elusive. Here, we systematically identified the non-volatile and volatile metabolites of two hybrids and their parents in Camellia sinensis. The metabolomics analysis showed prevalent non-additive accumulation in hybrids, among which the non-additive nucleotides, alkaloid ...
DOI:
10.1021/acs.jafc.1c08248