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- Author:
- Arraa M. Saghir Afifeh; Monica Verdoia; Matteo Nardin; Federica Negro; Filippo Viglione; Roberta Rolla; Giuseppe De Luca; Novara Atherosclerosis Study Group (NAS)
- Source:
- Nutrition, metabolism, and cardiovascular diseases 2021 v.31 no.1 pp. 36-43
- ISSN:
- 0939-4753
- Subject:
- C-reactive protein; age; angiography; biomarkers; blood platelets; calcitriol; cardiovascular diseases; chemiluminescence immunoassays; cholecalciferol; correlation; creatinine; diabetes; diuretics; exhibitions; fibrinogen; homocysteine; infection; metabolism; pandemic; patients; prediction; renal failure; risk; uric acid; variability; vitamin D deficiency
- Abstract:
- ... Vitamin D deficiency is a pandemic disorder affecting over 1 billion of subjects worldwide. Calcitriol (1,25(OH)2D) represents the perpetrator of the several systemic effects of vitamin D, including the anti-inflammatory, antithrombotic and anti-atherosclerotic actions, potentially preventing acute cardiovascular ischemic events. Variability in the transformation of vitamin D into 1,25(OH)2D has b ...
- DOI:
- 10.1016/j.numecd.2020.09.021
- https://doi.org/10.1016/j.numecd.2020.09.021
- Author:
- D. Recabarren-Leiva; C.F. Burgos; B. Hernández; F.J. Garcïa-García; R.I. Castro; L. Guzman; E. Fuentes; I. Palomo; M. Alarcón
- Source:
- International journal of biological macromolecules 2021 v.166 pp. 1149-1161
- ISSN:
- 0141-8130
- Subject:
- age; amino acids; blood platelets; cardiovascular diseases; databases; elderly; journals; objectives; platelet aggregation; prediction
- Abstract:
- ... Platelet activity is essential in cardiovascular diseases. Therefore our objective was to evaluate the main effects of activating RAGE in platelets which are still unknown. A search for RAGE expression in different databases showed poor or a nonexistent presence in platelets. We confirmed the expression in platelets and secreted variable of RAGE (sRAGE). Platelets from elderly adults expressed in ...
- DOI:
- 10.1016/j.ijbiomac.2020.10.270
- https://doi.org/10.1016/j.ijbiomac.2020.10.270
- Author:
- Matteo Nardin; Monica Verdoia; Rocco Gioscia; Federica Negro; Giuseppe De Luca
- Source:
- Nutrition, metabolism, and cardiovascular diseases 2021 v.31 no.4 pp. 1276-1285
- ISSN:
- 0939-4753
- Subject:
- angiotensin-converting enzyme inhibitors; blood platelets; cardiovascular diseases; electrodes; homocysteine; metabolism; metabolites; methionine; nutrition; patients; platelet aggregation; renin; renin-angiotensin system; testing; therapeutics
- Abstract:
- ... Dual antiplatelet therapy (DAPT) and Renin-angiotensin system inhibitors (RASi) represent the cornerstone in the treatment of patients undergoing percutaneous coronary interventions (PCI), mainly after an acute ischemic event. However, high-on treatment residual platelet reactivity (HRPR), is not infrequent despite optimal medical treatment. Homocysteine (Hcy) is a metabolite of methionine catabol ...
- DOI:
- 10.1016/j.numecd.2020.12.004
- https://doi.org/10.1016/j.numecd.2020.12.004
- Author:
- Dan Gao; Shan-na Wu; Cong-en Zhang; Rui-sheng Li; Zhen-jie Liu; Xiao-he Xiao; Lin Li; Jia-bo Wang; Lan Zhang; Ming Niu
- Source:
- Journal of ethnopharmacology 2020 v.261 pp. 113078
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; active ingredients; animal models; aorta; aspirin; bioactive compounds; bioassays; biomarkers; blood platelets; blood stasis; cardiovascular diseases; coagulation; epicatechin; fibrinogen; health foods; histopathology; medicinal properties; pharmacodynamics; platelet activation; procyanidins; prothrombin; quality control; rats; rhubarb; risk factors; therapeutics
- Abstract:
- ... Hyperviscosity syndrome (HVS) is a major risk factor for thrombotic diseases. Rhubarb, well-known as a traditional Chinese medicine, exhibits multiple pharmacological activities, especially for promoting blood circulation to remove blood stasis (PBRB), which has been become a functional health food for decreasing the risk of cardiovascular diseases. However, due to the complexity of rhubarb compon ...
- DOI:
- 10.1016/j.jep.2020.113078
- https://doi.org/10.1016/j.jep.2020.113078
- Author:
- Beata Olas
- Source:
- Nutrients 2020 v.12 no.2 pp. -
- ISSN:
- 2072-6643
- Subject:
- Apis mellifera; antioxidants; apigenin; area; blood platelets; caffeic acid; cardiovascular diseases; dietary supplements; honey; honey bees; humans; kaempferol; knowledge; medicine; models; nutrients; oxidative stress; platelet activation; quercetin; syrups
- Abstract:
- ... Honey is a sweet, viscous syrup produced by the honey bee (Apis mellifera). It is probably the first natural sweetener ever discovered, and is currently used as a nutritious food supplement and medicinal agent. The aim of the present mini-review is to summarize and update the current knowledge regarding the role of honey in CVDs based on various experimental models. It also describes the role of i ...
- DOI:
- 10.3390/nu12020283
- https://doi.org/10.3390/nu12020283
- Author:
- Marcelo Alarcón; Michelle Bustos; Diego Mendez; Eduardo Fuentes; Ivan Palomo; Mariane Lutz
- Source:
- Plant foods for human nutrition 2020 v.75 no.2 pp. 215-222
- ISSN:
- 0921-9668
- Subject:
- Chenopodium quinoa; Lupinus albus; Lupinus angustifolius; Lupinus luteus; Lupinus mutabilis; bioactive properties; blood platelets; cardiovascular diseases; chemical composition; food intake; human health; humans; in vitro studies; nutritive value; plant extracts; platelet aggregation; risk factors; Chile
- Abstract:
- ... Cardiovascular disease (CVD) is the leading cause of death throughout the world. A major risk factor for CVD is platelet aggregation. Various plant extracts exhibit anti-aggregatory action in vitro. The dietary intake of traditional plant crops such as quinoa (Chenopodium quinoa Willd) and lupin (Lupinus spp., Fabaceae family), highly recognized for their high nutritional value, is increasing worl ...
- DOI:
- 10.1007/s11130-019-00786-y
- https://doi.org/10.1007/s11130-019-00786-y
- Author:
- Cristina Barale; Katia Bonomo; Chiara Frascaroli; Alessandro Morotti; Angelo Guerrasio; Franco Cavalot; Isabella Russo
- Source:
- Nutrition, metabolism, and cardiovascular diseases 2020 v.30 no.2 pp. 282-291
- ISSN:
- 0939-4753
- Subject:
- aspirin; blood platelets; blood serum; cardiovascular diseases; chemokine CXCL4; hypercholesterolemia; ligands; light transmission; low density lipoprotein cholesterol; metabolism; monoclonal antibodies; patients; platelet aggregation; subtilisin; therapeutics
- Abstract:
- ... In the association between hypercholesterolemia (HC) and thrombotic risk platelet hyper-reactivity plays an important role. The inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) to reduce plasma LDL-cholesterol merges as effective therapeutic strategy to prevent cardiovascular (CV) events. Aim of this study was to verify whether a treatment up to 12 months with the monoclonal ant ...
- DOI:
- 10.1016/j.numecd.2019.09.012
- https://doi.org/10.1016/j.numecd.2019.09.012
- Author:
- Agata Rolnik; Jerzy Żuchowski; Anna Stochmal; Beata Olas
- Source:
- Industrial crops and products 2020 v.152 pp. 112536
- ISSN:
- 0926-6690
- Subject:
- Lens culinaris; aerial parts; anticoagulant activity; antioxidant activity; blood platelets; cardiovascular diseases; humans; kaempferol; lentils; quercetin
- Abstract:
- ... Quercetin and kaempferol show cardioprotective potential. Our preliminary results have demonstrated that the crude extract, phenolic fraction and different flavonoids (including quercetin and kaempferol derivatives) isolated from aerial parts of lentil (Lens culinaris Medik.) have anticoagulant properties and antioxidant activity in human plasma. The objective was to investigate anti-platelet prop ...
- DOI:
- 10.1016/j.indcrop.2020.112536
- https://doi.org/10.1016/j.indcrop.2020.112536
- Author:
- Beata Olas
- Source:
- Advances in nutrition 2019 v.10 no.2 pp. 280-290
- ISSN:
- 2156-5376
- Subject:
- Allium cepa; Allium sativum; Beta vulgaris; Solanum lycopersicum; antioxidant activity; beets; blood platelets; cardiovascular diseases; disease control; epidemiological studies; fruits; garlic; onions; platelet aggregation; risk factors; therapeutics; tomatoes
- Abstract:
- ... Increased blood platelet activation, especially platelet aggregation, plays an important function in cardiovascular disease; however, various dietary components may inhibit platelet activation. Recent clinical and epidemiologic studies indicate that both fruits and vegetables, and their products, contain various phytoprotective substances possessing biological properties such as antiplatelet and a ...
- DOI:
- 10.1093/advances/nmy085
- PubMed:
- 30759176
- PubMed Central:
- PMC6416036
- https://doi.org/10.1093/advances/nmy085
- Author:
- Abdulrahman Yakubu; Azrina Azlan; Su Peng Loh; Sabariah Md Noor
- Source:
- Journal of obesity 2019 v.2019 pp. -
- ISSN:
- 2090-0716
- Subject:
- Selaroides leptolepis; arachidonic acid; blood platelets; cardiovascular diseases; cytokines; docosahexaenoic acid; drug therapy; eicosapentaenoic acid; fatty acid composition; fish fillets; free radicals; inflammation; leukocytes; obesity; omega-3 fatty acids; phospholipids; prospective studies; risk factors; salmon; saturated fats; seafoods; signal transduction
- Abstract:
- ... This review article stresses the effective role of dietary fish fillet docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on overweight as a risk factor of cardiovascular disease (CVD) via platelet phospholipid modification. Several reports have demonstrated that saturated fat in overweight evokes systemic inflammation and more importantly predisposes it to cardiovascular disorder. Prospec ...
- DOI:
- 10.1155/2019/4929131
- PubMed:
- 31354987
- PubMed Central:
- PMC6636454
- https://doi.org/10.1155/2019/4929131
- Author:
- Bernadetta Lis; Agata Rolnik; Dariusz Jedrejek; Agata Soluch; Anna Stochmal; Beata Olas
- Source:
- Journal of functional foods 2019 v.59 pp. 16-24
- ISSN:
- 1756-4646
- Subject:
- Taraxacum officinale; additives; amino acids; blood platelets; cardiovascular diseases; disease control; esters; functional foods; in vitro studies; ingredients; inositols; lipids; models; oxidation; plant organs; protective effect; proteins; superoxide anion
- Abstract:
- ... The effect of dandelion root and its various ingredients on the biological functions of blood platelets has not been well investigated. Thus, the objective of our in vitro study was to examine the five root fractions (A–E), differing in chemical composition, for changes induced in the human platelets’ model using selected hemostatic parameters. As a result, the best anti-platelet potential was sho ...
- DOI:
- 10.1016/j.jff.2019.05.019
- https://doi.org/10.1016/j.jff.2019.05.019
- Author:
- Jana Pourová; Lenka Applová; Kateřina Macáková; Marie Vopršalová; Thomas Migkos; Roger Bentanachs; David Biedermann; Lucie Petrásková; Václav Tvrdý; Marcel Hrubša; Jana Karlíčková; Vladimír Křen; Kateřina Valentová; Přemysl Mladěnka
- Source:
- Nutrients 2019 v.11 no.10 pp. -
- ISSN:
- 2072-6643
- Subject:
- active ingredients; aorta; blood platelets; cardiovascular diseases; diastereomers; dietary supplements; humans; liver; liver diseases; median effective concentration; metabolites; platelet aggregation; rats; silymarin; vasodilator agents
- Abstract:
- ... Silymarin is a traditional drug and food supplement employed for numerous liver disorders. The available studies indicate that its activities may be broader, in particular due to claimed benefits in some cardiovascular diseases, but the contributions of individual silymarin components are unclear. Therefore, we tested silymarin flavonolignans as pure diastereomers as well as their sulfated metabol ...
- DOI:
- 10.3390/nu11102286
- PubMed:
- 31554252
- PubMed Central:
- PMC6836034
- https://doi.org/10.3390/nu11102286
- Author:
- Adil Haimeur; Nadia Meskini; Virginie Mimouni; Lionel Ulmann; Hafida Messaouri; Fabienne Pineau-Vincent; Nezha Abouakil; Gérard Tremblin
- Source:
- Nutrition 2019 v.57 pp. 32-39
- ISSN:
- 0899-9007
- Subject:
- adiposity; antioxidant activity; blood lipids; blood platelets; cardiovascular diseases; dietary supplements; fish oils; high fat diet; hyperlipidemia; insulin resistance; liver; males; oxidative stress; platelet aggregation; polyunsaturated fatty acids; rats; risk factors; tissues
- Abstract:
- ... The aim of this study was to investigate the effects of two different sources of polyunsaturated fatty acid—fish oil (FO) and argan oil (AO)—on some risk factors for cardiovascular disease, such as platelet aggregation, dyslipidemia, and oxidative stress.To explore this, four groups of six male rats were fed with different diets: The first group received a standard diet (control); the second group ...
- DOI:
- 10.1016/j.nut.2018.05.027
- https://doi.org/10.1016/j.nut.2018.05.027
- Author:
- Francesco Finamore; Jean-Luc Reny; Sarah Malacarne; Pierre Fontana; Jean-Charles Sanchez
- Source:
- Journal of proteomics 2019 v.192 pp. 258-266
- ISSN:
- 1874-3919
- Subject:
- acetylation; aspirin; blood platelets; cardiovascular diseases; diabetes; glucose; glycation; hyperglycemia; mass spectrometry; patients; prostaglandin synthase; proteins; risk factors; serine
- Abstract:
- ... Diabetes is a major risk factor for cardiovascular diseases. Although aspirin is considered a cornerstone of the prevention and treatment of atherothrombotic-related ischemic events, this antiplatelet drug appears to be less effective in patients with poorly controlled diabetes. It has been suggested that the glycation of platelet proteins plays a pivotal role in poor responsiveness to aspirin. Ho ...
- DOI:
- 10.1016/j.jprot.2018.09.007
- https://doi.org/10.1016/j.jprot.2018.09.007
- Author:
- Roberto Carnevale; Cristina Nocella; Vittoria Cammisotto; Simona Bartimoccia; Roberto Monticolo; Alessandra D'Amico; Lucia Stefanini; Francesca Pagano; Daniele Pastori; Roberto Cangemi; Francesco Violi
- Source:
- Nutrition 2018 v.55-56 pp. 36-40
- ISSN:
- 0899-9007
- Subject:
- NAD(P)H oxidase (H2O2-forming); NADP (coenzyme); antioxidant activity; blood platelets; cardiovascular diseases; catalase; extra-virgin olive oil; gallic acid; hydrogen; hydrogen peroxide; in vitro studies; polyphenols; vitamin E
- Abstract:
- ... Extra virgin olive oil (EVOO) supplementation is associated with a significant reduction in cardiovascular disease but the underlying mechanism is still unclear.In platelets that were taken from healthy subjects (n = 5), agonist-induced hydrogen peroxide (H2O2) production and NADPH oxidase 2 (NOX2) activation in the presence of or without catalase, which catabolizes H2O2, were investigated. Platel ...
- DOI:
- 10.1016/j.nut.2018.03.045
- https://doi.org/10.1016/j.nut.2018.03.045
- Author:
- Bernadetta Lis; Dariusz Jędrejek; Anna Stochmal; Beata Olas
- Source:
- Food research international 2018 v.107 pp. 605-612
- ISSN:
- 0963-9969
- Subject:
- Taraxacum officinale; adverse effects; aerial parts; anticoagulant activity; antioxidant activity; antioxidants; bladder; blood platelets; cardiovascular diseases; cinnamic acid; coagulation; corolla; coumaric acids; dietary supplements; drugs; flavonoids; hemostasis; humans; in vitro studies; leaves; lipid peroxidation; liver; methanol; polyphenols; prothrombin; roots; spleen; thrombin; thromboplastin; triterpenoids
- Abstract:
- ... Aerial parts and roots of Taraxacum officinale (dandelion) have been found to be rich sources of polyphenols, including cinnamic acid derivatives, flavonoids and triterpenoids, which exert different biological activities, such as anti-inflammatory, anticancer and antimicrobial. Additionally, the whole plant is recognized as safe and well tolerated by humans, with no reported adverse effects. Nowad ...
- DOI:
- 10.1016/j.foodres.2018.03.012
- https://doi.org/10.1016/j.foodres.2018.03.012
- Author:
- Lin-yan Huang; Peng-peng Li; Yu-jie Li; Wen-qian Zhao; Wen-kang Shang; Yan-ling Wang; Dian-shuai Gao; Hong-chun Li; Ping Ma
- Source:
- Biochemical and biophysical research communications 2018 v.503 no.3 pp. 1740-1746
- ISSN:
- 0006-291X
- Subject:
- adenosine diphosphate; adenosine triphosphate; aspirin; blood platelets; blood serum; cAMP-dependent protein kinase; cardiovascular diseases; cell adhesion; chlorides; cyclic AMP; cytosol; patients; phosphorylation; platelet activation; signal transduction
- Abstract:
- ... Decrease of chloride concentration contributes to cardiovascular diseases, however, whether decrease of chloride concentration is involved in platelet activation remains elusive. In the present study, we found that ACI patients had lower serum chloride which would be rescued after Aspirin administration. ADP induced chloride concentration reduction in platelets. Blockade of chloride channel preven ...
- DOI:
- 10.1016/j.bbrc.2018.07.107
- https://doi.org/10.1016/j.bbrc.2018.07.107
- Author:
- Irena Krga; Nevena Vidovic; Dragan Milenkovic; Aleksandra Konic-Ristic; Filip Stojanovic; Christine Morand; Marija Glibetic
- Source:
- Archives of biochemistry and biophysics 2018 v.645 pp. 34-41
- ISSN:
- 0003-9861
- Subject:
- adenosine; blood platelets; cardioprotective effect; cardiovascular diseases; digestive system; ferulic acid; foods; hydroxybenzaldehyde; metabolites; monocytes; myrtillin; neutrophils; platelet activation; protocatechuic acid
- Abstract:
- ... Accumulating evidence suggests that anthocyanins play an important role in the cardioprotective effects associated with consumption of anthocyanin-rich foods. These benefits may partly be attributed to their effects on platelets, significant contributors to cardiovascular disease development. This study aimed to investigate the impact of physiologically relevant concentrations of anthocyanins and ...
- DOI:
- 10.1016/j.abb.2018.03.016
- https://doi.org/10.1016/j.abb.2018.03.016
- Author:
- Spyridon Karkabounas; Nikolaos Papadopoulos; Chryssa Anastasiadou; Chrysoula Gubili; Dimitrios Peschos; Telemachos Daskalou; Nikolaos Fikioris; Yannis V. Simos; Evangelos Kontargiris; Xenophon Gianakopoulos; Vasilios Ragos; Maria Chatzidimitriou
- Source:
- Journal of medicinal food 2018 v.21 no.12 pp. 1197-1203
- ISSN:
- 1557-7600
- Subject:
- adenosine diphosphate; arachidonic acid; blood platelets; blood serum; body weight; cardioprotective effect; cardiovascular diseases; carnosine; collagen; dose response; epinephrine; glucose; humans; insulin; lipoic acid; noninsulin-dependent diabetes mellitus; oxidative stress; pancreas; patients; platelet aggregation; platelet-activating factor; rabbits; thiamin; thrombin
- Abstract:
- ... Type 2 diabetes mellitus (T2DM) is evolving to an epidemic of the modern world. T2DM is associated with a number of pathological complications, including cardiovascular disease that is mostly promoted by the increased oxidative stress in type 2 diabetic patients. We performed a randomized double-blind placebo-controlled trial to investigate the effectiveness of an individualized oral supplementati ...
- DOI:
- 10.1089/jmf.2018.0007
- https://doi.org/10.1089/jmf.2018.0007
- Author:
- Zilong Zhang; Ta-Chien Chan; Cui Guo; Ly-yun Chang; Changqing Lin; Yuan Chieh Chuang; Wun Kai Jiang; Kin Fai Ho; Tony Tam; Kam S. Woo; Alexis K.H. Lau; Xiang Qian Lao
- Source:
- Environmental pollution 2018 v.240 pp. 432-439
- ISSN:
- 0269-7491
- Subject:
- adults; adverse effects; air pollution; blood platelets; cardiovascular diseases; chronic exposure; coagulation; men; models; particulates; regression analysis; risk; satellites; women
- Abstract:
- ... The prothrombotic effects of particulate matter (PM) may underlie the association of air pollution with increased risks of cardiovascular disease. This study aimed to investigate the association between long-term exposure to PM with an aerodynamic diameter ≤2.5 μm (PM2.5) and platelet counts, a marker of coagulation profiles.The study participants were from a cohort consisting of 362,396 Taiwanese ...
- DOI:
- 10.1016/j.envpol.2018.04.123
- https://doi.org/10.1016/j.envpol.2018.04.123
- Author:
- Rohith N. Thota; Jessica J. A. Ferguson; Kylie A. Abbott; Cintia B. Dias; Manohar L. Garg
- Source:
- Food & function 2018 v.9 no.7 pp. 3576-3596
- ISSN:
- 2042-650X
- Subject:
- Inuit; adhesion; adipokines; adipose tissue; anti-inflammatory activity; blood flow; blood lipids; blood platelets; blood pressure; cardioprotective effect; cardiovascular diseases; clinical trials; cytokines; dietary supplements; endothelium; heart health; low density lipoprotein; omega-3 fatty acids; platelet aggregation; seafoods; secretion; triacylglycerols; vascular cell adhesion molecules; Canada; Greenland; Japan
- Abstract:
- ... Lower incidence of cardiovascular disease (CVD) in the Greenland Inuit, Northern Canada and Japan has been attributed to their consumption of seafood rich in long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA). While a large majority of pre-clinical and intervention trials have demonstrated heart health benefits of LCn-3PUFA, some studies have shown no effects or even negative effects. LCn- ...
- DOI:
- 10.1039/c8fo00348c
- https://doi.org/10.1039/c8fo00348c
- Author:
- Evgenios Stylos; Maria V. Chatziathanasiadou; Antonis Tsiailanis; Tahsin F. Kellici; Maria Tsoumani; Androniki D. Kostagianni; Maria Deligianni; Alexandros D. Tselepis; Andreas G. Tzakos
- Source:
- Biochimica et biophysica acta 2017 v.1861 no.11 pp. 2609-2618
- ISSN:
- 0304-4165
- Subject:
- antagonists; aspirin; bioactive compounds; blood platelets; cardiovascular diseases; docosahexaenoic acid; hemorrhage; humans; in vitro studies; ligands; liquid chromatography; naringenin; patients; platelet aggregation; prostaglandin synthase; proteinases; risk; tandem mass spectrometry; therapeutics
- Abstract:
- ... The current standard-of-care antiplatelet therapy in cardiovascular disease patients is consisted of cyclooxygenase-1 (COX-1) inhibitor aspirin, along with a platelet receptor P2Y12 antagonist. Recently, the triple antiplatelet therapy with aspirin, a P2Y12 receptor antagonist and a protease activated receptor-1 (PAR-1) antagonist, has been suggested for the secondary prevention of atherothromboti ...
- DOI:
- 10.1016/j.bbagen.2017.08.018
- https://doi.org/10.1016/j.bbagen.2017.08.018
- Author:
- Gema Baeza; Eva-Maria Bachmair; Sharon Wood; Raquel Mateos; Laura Bravo; Baukje de Roos
- Source:
- Food & function 2017 v.8 no.3 pp. 1333-1342
- ISSN:
- 2042-650X
- Subject:
- adenosine; blood flow; blood platelets; caffeic acid; caffeine; cardiovascular diseases; coffee beans; ferulic acid; fibrinogen; flow cytometry; healthy diet; metabolism; metabolites; methylxanthines; morbidity; mortality; platelet activation; polyphenols; theobromine; yerba mate
- Abstract:
- ... Cardiovascular disease (CVD) is the major cause of morbidity and mortality worldwide. The consumption of a healthy diet rich in polyphenols has been inversely associated with the development of CVD. This study evaluated the effects of green coffee bean extract (GCBE) and yerba mate phenolic extract (YMPE), the main phenolic and methylxanthine constituents (5-caffeoylquinic acid, 3,5-dicaffeoylquin ...
- DOI:
- 10.1039/c6fo01404f
- https://doi.org/10.1039/c6fo01404f
- Author:
- Dongping Long; Yunfei Shang; Youyi Qiu; Bin Zhou; Peihui Yang
- Source:
- Biosensors & bioelectronics 2017 pp. -
- ISSN:
- 0956-5663
- Subject:
- biosensors; blood platelets; cardiovascular diseases; cell adhesion; collagen; electrochemiluminescence; human umbilical vein endothelial cells; models; nanocomposites; nanogold; nanosilver; pathogenesis; quercetin
- Abstract:
- ... A novel single-cell analysis platform (SCA) was developed for the investigation of platelets adhesion to single human umbilical vein endothelial cell (HUVEC) via using the adhesion molecule (E-selectin) on the damaged HUVEC as the marker site, and integrating electrochemiluminescence (ECL) with the ultrasensitive Au@DL-ZnCQDs nanoprobes. The Au@DL-ZnCQDs nanocomposite, a kind of double layer zinc- ...
- DOI:
- 10.1016/j.bios.2017.11.058
- https://doi.org/10.1016/j.bios.2017.11.058
- Author:
- Habib Haybar; Zeinab Deris Zayeri
- Source:
- Frontiers in biology 2017 v.12 no.5 pp. 349-356
- ISSN:
- 1674-7984
- Subject:
- adenosine diphosphate; aspirin; blood platelets; cardiovascular diseases; endothelial cells; genes; hemorrhage; heparan sulfate; hormones; inflammation; ischemia; metabolites; patients; pharmacogenomics; receptors; risk factors; single nucleotide polymorphism; therapeutics; uric acid
- Abstract:
- ... OBJECTIVES AND BACKGROUNDS: Cardiovascular events occure as a result of various risk factors, such as uric acid (UA), inflammation, hormones and other materials that induce C- reactive protein (CRP) expression. These factors lead to complement activation, and endothelial damages. Damaged endothelial cells release heparan sulfate which inhibits tissue factor activity and von Willed brand factor (VW ...
- DOI:
- 10.1007/s11515-017-1456-0
- https://doi.org/10.1007/s11515-017-1456-0
- Author:
- Gang Liu; Wen Xie; Ao‐Di He; Xing‐Wen Da; Ming‐Lu Liang; Guang‐qiang Yao; Ji‐Zhou Xiang; Cun‐ji Gao; Zhang‐Yin Ming
- Source:
- Molecular nutrition & food research 2016 v.60 no.9 pp. 1984-1993
- ISSN:
- 1613-4125
- Subject:
- adenosine diphosphate; bioflavonoids; blood platelets; cardiovascular diseases; chrysin; collagen; fibrinogen; glycoproteins; honey; humans; integrins; mitogen-activated protein kinase; phosphorylation; platelet aggregation; propolis; protein kinase C; secretion; signal transduction; tau-protein kinase; thrombin
- Abstract:
- ... SCOPE: Propolis is thought to help prevent thrombotic and related cardiovascular diseases in humans. Chrysin, a bioflavonoids compound found in high levels in propolis and in honey, has been reported to possess antiplatelet activity. However, the mechanism by which it inhibits platelet function is unclear. METHODS AND RESULTS: The effects of chrysin on agonist‐activated platelet‐aggregation, granu ...
- DOI:
- 10.1002/mnfr.201500801
- https://doi.org/10.1002/mnfr.201500801
- Author:
- Mohammed El Haouari; Juan A. Rosado
- Source:
- Phytotherapy research 2016 v.30 no.7 pp. 1059-1071
- ISSN:
- 0951-418X
- Subject:
- Asteraceae; Fabaceae; Lamiaceae; Liliaceae; Rhamnaceae; Rutaceae; Zingiberaceae; Zygophyllaceae; adenosine diphosphate; bioactive compounds; blood platelets; calcium; cardiovascular diseases; coumarins; flavonoids; mechanism of action; medicinal plants; platelet aggregation; polyphenols; signal transduction; terpenoids
- Abstract:
- ... Blood platelets play an essential role in the hemostasis and wound‐healing processes. However, platelet hyperactivity is associated to the development and the complications of several cardiovascular diseases. In this sense, the search for potent and safer antiplatelet agents is of great interest. This article provides an overview of experimental studies performed on medicinal plants with antiplate ...
- DOI:
- 10.1002/ptr.5619
- https://doi.org/10.1002/ptr.5619
- Author:
- Beata Olas
- Source:
- Food and chemical toxicology 2016 v.97 pp. 199-204
- ISSN:
- 0278-6915
- Subject:
- Hippophae rhamnoides; antioxidant activity; antiviral properties; bioactive compounds; blood platelets; blood pressure; cardioprotective effect; cardiovascular diseases; cholesterol; fatty acids; flavonoids; fruits; leaves; oils; phenolic compounds; phytosterols; platelet aggregation; toxicology; vitamins
- Abstract:
- ... Hippophae rhamnoides (sea buckthorn) offers many health benefits. It has significant cardioprotective activity and exerts many positive healing effects on the cardiovascular system, including inhibiting blood platelet activation (especially platelet aggregation), lowering cholesterol concentration and blood pressure, and providing antioxidant activity. In addition, sea buckthorn has antibacterial ...
- DOI:
- 10.1016/j.fct.2016.09.008
- https://doi.org/10.1016/j.fct.2016.09.008
- Author:
- Jose Bincy; McCluskey Peter; Gilmartin Niamh; Somers Martin; Kenny Dermot; Ricco Antonio J.; Kent Nigel J.; Basabe-Desmonts Lourdes
- Source:
- Langmuir 2016 v.32 no.11 pp. 2820-2828
- ISSN:
- 1520-5827
- Subject:
- adhesion; aspirin; blood flow; blood platelets; blood sampling; cardiovascular diseases; cell adhesion; death; diagnostic techniques; fibrinogen; olefin; patients; polymers
- Abstract:
- ... We report the development of a microfluidic device for the rapid assay in whole blood of interfacial platelet–protein interactions indicative of the efficacy of antiplatelet drugs, for example, aspirin and Plavix, two of the world’s most widely used drugs, in patients with cardiovascular disease (CVD). Because platelet adhesion to surface-confined protein matrices is an interfacial phenomenon modu ...
- DOI:
- 10.1021/acs.langmuir.5b03540
- https://doi.org/10.1021/acs.langmuir.5b03540
- Author:
- F. Raffaelli; L. Nanetti; G. Montecchiani; F. Borroni; E. Salvolini; E. Faloia; G. Ferretti; L. Mazzanti; A. Vignini
- Source:
- Nutrition, metabolism, and cardiovascular diseases 2015 v.25 no.2 pp. 224-229
- ISSN:
- 0939-4753
- Subject:
- Carica papaya; adenosinetriphosphatase; antioxidant activity; antioxidants; blood platelets; cardiovascular diseases; dietary supplements; enzyme activity; fermentation; insulin resistance; insulin secretion; membrane fluidity; noninsulin-dependent diabetes mellitus; oxidative stress; papayas; pathogenesis; patients; protective effect; superoxide dismutase
- Abstract:
- ... Oxidative stress is associated with insulin resistance pathogenesis, insulin secretion deficiency, and complication onset. Fermented papaya preparation (FPP), a dietary supplement obtained by fermentation of the papaya fruit, may be used as an antioxidant in the prevention of diabetic complications.Platelets from 30 patients with type 2 diabetes mellitus (DM 2) and 15 healthy subjects were analyze ...
- DOI:
- 10.1016/j.numecd.2014.10.013
- https://doi.org/10.1016/j.numecd.2014.10.013
- Author:
- Eduardo Fuentes; Marcelo Alarcón; Manuel Fuentes; Gilda Carrasco; Iván Palomo
- Source:
- Nutrients 2014 v.6 no.12 pp. 5839-5852
- ISSN:
- 2072-6643
- Subject:
- Eruca vesicaria subsp. sativa; Western blotting; adenosine diphosphate; animal models; anti-inflammatory activity; arachidonic acid; blood platelets; cAMP-dependent protein kinase; cardiovascular diseases; chemokine CCL5; collagen; epidemiological studies; flow cytometry; hemorrhage; humans; interleukin-1beta; platelet aggregation; thromboxanes; transcription factor NF-kappa B; transforming growth factor beta 1; vegetables
- Abstract:
- ... Background: Epidemiological studies have shown the prevention of cardiovascular diseases through the regular consumption of vegetables. Eruca sativa Mill., commonly known as rocket, is a leafy vegetable that has anti-inflammatory activity. However, its antiplatelet and antithrombotic activities have not been described. Methods: Eruca sativa Mill. aqueous extract (0.1 to 1 mg/mL), was evaluated on ...
- DOI:
- 10.3390/nu6125839
- PubMed:
- 25514563
- PubMed Central:
- PMC4277002
- https://doi.org/10.3390/nu6125839
- Author:
- Laure Bachelet-Violette; Amanda K. A. Silva; Murielle Maire; Aude Michel; Ovidiu Brinza; Phalla Ou; Véronique Ollivier; Antonino Nicoletti; Claire Wilhelm; Didier Letourneur; Christine Ménager; Frédéric Chaubet
- Source:
- RSC advances 2014 v.4 no.10 pp. 4864-4871
- ISSN:
- 2046-2069
- Subject:
- blood platelets; cardiovascular diseases; coatings; flow cytometry; fucoidan; humans; image analysis; iron oxides; ligands; magnetic fields; magnetic resonance imaging; molecular weight; nanoparticles
- Abstract:
- ... Activated platelets play a pivotal role in cardiovascular diseases such as atherothrombosis. Therefore, strategies enabling activated platelet molecular imaging are of great interest. Herein, a chemical protocol was investigated for coating superparamagnetic iron oxide nanoparticles with low molecular weight fucoidan, a ligand of P-selectin expressed on the surface of activated platelets. The phys ...
- DOI:
- 10.1039/c3ra46757k
- https://doi.org/10.1039/c3ra46757k
- Author:
- Lopez-Alonso Ana; Jose Bincy; Somers Martin; Egan Karl; Foley David P.; Ricco Antonio J.; Ramström Sofia; Basabe-Desmonts Lourdes; Kenny Dermot
- Source:
- Analytical chemistry 2013 v.85 no.13 pp. 6497-6504
- ISSN:
- 1520-6882
- Subject:
- adhesion; blood platelets; cardiovascular diseases; cell adhesion; drugs; fibrinogen; flow cytometry; microarray technology; monitoring; patients; therapeutics
- Abstract:
- ... Widespread monitoring of platelet function and the effect of antiplatelet drugs will improve outcomes in cardiovascular patients, but platelet function testing is not routine in clinical practice. We report a rapid, accurate methodology to quantify platelet-protein interactions: a microarray of contact-printed 6-μm fibrinogen dots on a transparent substrate binds platelets from whole blood, one pl ...
- DOI:
- 10.1021/ac401076s
- https://doi.org/10.1021/ac401076s
- Author:
- Joanna Saluk; MichaÅ Bijak; Joanna KoÅodziejczyk-Czepas; MaÅgorzata Posmyk; Krystyna Janas; Barbara Wachowicz
- Source:
- Open life sciences 2012 v.7 no.4 pp. 655-663
- ISSN:
- 2391-5412
- Subject:
- adverse effects; anthocyanins; antioxidant activity; arachidonic acid; blood platelets; cabbage; cardiovascular diseases; leaves; oxidative stress; platelet aggregation; protective effect; proteins
- Abstract:
- ... Red cabbage belongs to cruciferous vegetables recognized as a rich source of anthocyanins. Anthocyanins have a wide range of therapeutic advantages without adverse effects, including cardiovascular protective properties. For development of cardiovascular diseases, platelet activation is crucial; therefore compounds which inhibit platelet activation are sought after. The anti-platelet activity of a ...
- DOI:
- 10.2478/s11535-012-0057-9
- https://doi.org/10.2478/s11535-012-0057-9
- Author:
- Ostertag, Luisa M.; O'Kennedy, Niamh; Kroon, Paul A.; Duthie, Garry G.; de Roos, Baukje
- Source:
- Molecular nutrition & food research 2010 v.54 no.1 pp. 60-81
- ISSN:
- 1613-4125
- Subject:
- beverages; bioavailability; blood platelets; blood vessels; cardiovascular diseases; chronic diseases; diet study techniques; humans; plant-based diet; platelet activation; polyphenols; protective effect; research methods; secondary metabolites
- Abstract:
- ... Cardiovascular disease is a chronic disease influenced by many factors, with activated blood platelets being one of them. Platelets play a central role in the formation of plaques within blood vessels, contributing to early inflammatory events. Consumption of diets rich in plant-based products protects against the development of cardiovascular disease. Polyphenols, which are secondary plant metabo ...
- DOI:
- 10.1002/mnfr.200900172
- PubMed:
- 20058256
- https://doi.org/10.1002/mnfr.200900172
- Author:
- Gawlowski, Thomas; Stratmann, Bernd; Ruetter, Ruth; Buenting, Christina E.; Menart, Barbara; Weiss, Jürgen; Vlassara, Helen; Koschinsky, Theodor; Tschoepe, Diethelm
- Source:
- European journal of nutrition 2009 v.48 no.8 pp. 475-481
- ISSN:
- 1436-6207
- Subject:
- affinity chromatography; antibodies; beverages; blood platelets; cardiovascular diseases; diabetes mellitus; exogenous sources; flow cytometry; glycation; hyperglycemia; pathogenesis; platelet activation; receptors
- Abstract:
- ... Background Diabetes mellitus is characterized by hyperglycemia that plays an important role in the pathogenesis of diabetic complications including cardiovascular diseases. Moreover, hyperglycemia induces increased generation of advanced glycation end products (AGEs). The activation of platelets is associated with the development of cardiovascular diseases. Aim of the study The question whether AG ...
- DOI:
- 10.1007/s00394-009-0038-6
- PubMed:
- 19633966
- https://doi.org/10.1007/s00394-009-0038-6
- Author:
- Cicerale, Sara; Conlan, Xavier A.; Sinclair, Andrew J.; Keast, Russell S.J.
- Source:
- Critical reviews in food science and nutrition 2009 v.49 no.3 pp. 218-236
- ISSN:
- 1040-8398
- Subject:
- antimicrobial properties; blood lipids; atherosclerosis; neoplasms; lipoproteins; olive oil; biomarkers; inflammation; blood platelets; food composition; health foods; oxidative stress; phenolic compounds
- Abstract:
- ... The Mediterranean diet is associated with a lower incidence of atherosclerosis, cardiovascular disease, and certain types of cancer. The apparent health benefits have been partially attributed to the dietary consumption of virgin olive oil by Mediterranean populations. Most recent interest has focused on the biologically active phenolic compounds naturally present in virgin olive oils. Studies (hu ...
- DOI:
- 10.1080/10408390701856223
- https://doi.org/10.1080/10408390701856223
- Author:
- Mattiello, Teresa; Trifirò, Elisabetta; Jotti, Gloria Saccani; Pulcinelli, Fabio M.
- Source:
- Journal of medicinal food 2009 v.12 no.2 pp. 334-339
- ISSN:
- 1096-620X
- Subject:
- chemical concentration; polyphenols; pomegranates; calcium; hydrogen peroxide; blood platelets; plant extracts; platelet aggregation; ion transport; collagen; arachidonic acid; tannins; cultured cells; stroke; dosage; in vitro studies; thromboxanes; fruit juices
- DOI:
- 10.1089/jmf.2007.0640
- PubMed:
- 19459734
- https://doi.org/10.1089/jmf.2007.0640
- Author:
- Dohadwala, Mustali M.; Vita, Joseph A.
- Source:
- Journal of nutrition 2009 v.139 no.9 pp. 1788S-1793S
- ISSN:
- 0022-3166
- Subject:
- diet-related diseases; polyphenols; anti-inflammatory activity; grapes; disease prevention; blood platelets; wines; blood pressure; mechanism of action; atherosclerosis; antihypertensive effect; oxidation; human diseases; platelet aggregation; risk reduction; dietary recommendations; translation (genetics); endothelium; inflammation; low density lipoprotein; diet therapy
- Abstract:
- ... Epidemiological studies suggest that consumption of wine, grape products, and other foods containing polyphenols is associated with decreased risk for cardiovascular disease. The benefits of wine consumption appear to be greater than other alcoholic beverages. Experimental studies indicate that grape polyphenols could reduce atherosclerosis by a number of mechanisms, including inhibition of oxidat ...
- DOI:
- 10.3945/jn.109.107474
- PubMed:
- 19625699
- PubMed Central:
- PMC2728695
- https://doi.org/10.3945/jn.109.107474
- Author:
- Faber, D.R.; de Groot, Ph.G.; Visseren, F.L.J.
- Source:
- Obesity reviews 2009 v.10 no.5 pp. 554-563
- ISSN:
- 1467-7881
- Subject:
- adiponectin; adipose tissue; blood platelets; cardiovascular diseases; coagulation; factor VII; factor VIII; fibrinogen; fibrinolysis; free fatty acids; hemostasis; inflammation; insulin resistance; interleukin-1beta; interleukin-6; leptin; neoplasms; noninsulin-dependent diabetes mellitus; obesity; plasminogen activator inhibitors; risk; tumor necrosis factor-alpha
- Abstract:
- ... Obesity is associated with an increased incidence of insulin resistance (IR), type 2 diabetes mellitus and cardiovascular diseases. The increased risk for cardiovascular diseases could partly be caused by a prothrombotic state that exists because of abdominal obesity. Adipose tissue induces thrombocyte activation by the production of adipose tissue-derived hormones, often called adipokines, of whi ...
- DOI:
- 10.1111/j.1467-789X.2009.00593.x
- PubMed:
- 19460118
- https://doi.org/10.1111/j.1467-789X.2009.00593.x
- Author:
- Natella, F.; Nardini, M.; Belelli, F.; Pignatelli, P.; Di Santo, S.; Ghiselli, A.; Violi, F.; Scaccini, C.
- Source:
- British journal of nutrition 2008 v.100 no.6 pp. 1276-1282
- ISSN:
- 0007-1145
- Subject:
- caffeine; coffee (beverage); men; cardiovascular diseases; women; phenols; adenosine diphosphate; blood platelets; cardioprotective effect; platelet aggregation; collagen; arachidonic acid; agonists
- Abstract:
- ... Epidemiological studies indicate a J-shaped relationship linking coffee consumption and cardiovascular risk, suggesting that moderate coffee consumption can be beneficial. Platelet aggregation is of critical importance in thrombotic events, and platelets play a major role in the aetiology of several CVD. The aim of this study was to evaluate the effect of coffee drinking on platelet aggregation ex ...
- DOI:
- 10.1017/S0007114508981459
- PubMed:
- 18439332
- https://doi.org/10.1017/S0007114508981459
- Author:
- El Haouari, M.; López, J.J.; Mekhfi, H.; Rosado, J.A.; Salido, G.M.
- Source:
- Journal of ethnopharmacology 2007 v.113 no.2 pp. 325-331
- ISSN:
- 0378-8741
- Subject:
- Arbutus unedo; medicinal plants; chemical constituents of plants; plant extracts; medicinal properties; bioassays; human cell lines; blood platelets; anticoagulant activity; anticoagulants; cardiovascular diseases
- Abstract:
- ... Platelet hyperaggregability plays a pivotal role in the pathogenesis of cardiovascular diseases. Thrombin evokes aggregation through Ca2+ mobilization, tyrosine phosphorylation and generation of reactive oxygen species (ROS). We have investigated the antiaggregant properties of Arbutus unedo extracts in human platelets. Changes in cytosolic Ca2+ concentration and intracellular oxidants production ...
- DOI:
- 10.1016/j.jep.2007.06.016
- https://doi.org/10.1016/j.jep.2007.06.016
- Author:
- Sawashita, N.; Naemura, A.; Shimizu, M.; Morimatsu, F.; Ijiri, Y.; Yamamoto, J.
- Source:
- Nutrition 2006 v.22 no.6 pp. 661-667
- ISSN:
- 0899-9007
- Subject:
- pork; high fat diet; blood platelets; potatoes; thrombosis; atherosclerosis; chicken meat; egg albumen; animal disease models; risk factors; platelet aggregation; mice; casein; animal-based foods; long term effects; soybeans; mackerel; plant-based foods
- DOI:
- 10.1016/j.nut.2006.02.002
- PubMed:
- 16567078
- https://doi.org/10.1016/j.nut.2006.02.002
- Author:
- Clarke, Michael W; Ward, Natalie C; Wu, Jason HY; Hodgson, Jonathan M; Puddey, Ian B; Croft, Kevin D
- Source:
- American journal of clinical nutrition 2006 v.83 no.1 pp. 95-102
- ISSN:
- 0002-9165
- Subject:
- vitamin metabolism; urine; blood platelets; alpha-tocopherol; noninsulin-dependent diabetes mellitus; creatinine; thrombosis; biomarkers; cardioprotective effect; nutrient uptake; patients; blood serum; gamma-tocopherol; platelet aggregation; intestinal absorption; vitamin supplements; risk reduction; antioxidant activity; megadose; free radicals; platelet-activating factor; nutrient availability
- Abstract:
- ... BACKGROUND: Some studies have shown potential benefit of vitamin E on platelet function, but several clinical trials failed to show improved cardiovascular outcome with [alpha]-tocopherol supplementation. [gamma]-Tocopherol, a major dietary form of vitamin E, may have protective properties different from those of [alpha]-tocopherol. OBJECTIVE: We compared the effects of supplementation with [alpha ...
- PubMed:
- 16400056
- Author:
- Watkins, T.R.; Lenz, P.H.; Siderits, R.; Struck, M.; Bierenbaum, M.L.
- Source:
- Journal of the American College of Nutrition 1995 v.14 no.2 pp. 176-183
- ISSN:
- 0731-5724
- Subject:
- corn oil; rapeseed oil; cholesterol; blood serum; mustard oil; selenium; lipid peroxidation; vitamin E; cardiovascular diseases; glutathione peroxidase; rats; blood platelets
- Abstract:
- ... A degenerative cardiomyopathy (DCM) has been observed among mustard oil (MUST) users in China who eat 150 ml/week. Though the condition may be a selenium (Se) deficiency, MUST, rich in erucic acid (22:1), may bear a cardiotoxic or pro-oxidant substrate(s). The purpose of this feeding study was to compare the effects of feeding MUST, high erucic acid rape seed oil (HEAR), low erucic acid rape seed ...
- DOI:
- 10.1080/07315724.1995.10718491
- PubMed:
- 7790693
- https://doi.org/10.1080/07315724.1995.10718491
- Author:
- Allen, Kenneth G.D.; Klevay, Leslie M.
- Source:
- Current opinion in lipidology 1994 v.5 no.1 pp. 22-28
- Subject:
- copper; hypercholesterolemia; biomarkers; nutrient deficiencies; lipid peroxidation; blood platelets; cardioprotective effect; risk factors; free radical scavengers; antioxidant activity; prostaglandins; portal hypertension; dietary minerals; oxidative stress
- Abstract:
- ... Dietary copper often is low in the Western diet; low intakes may affect all stages of atherosclerosis adversely. Impaired oxidative defense in copper deficiency contributes to hypercholesterolemia, hypertension, and impaired prostaglandin metabolism. Free copper ion does not exist in vivo; some in-vitro experiments are conducted with millions-fold excesses. ...
- Handle:
- 10113/45196