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1. False-negative result of serum cryptococcal antigen lateral flow assay in an HIV-infected patient with culture-proven cryptococcaemia

Author:
Borges, Moara Alves Santa Bárbara,   et al.   ; Araújo Filho, João Alves de; Soares, Renata de Bastos Ascenço; Vidal, José Ernesto; Turchi, Marília Dalva;     Show all 5 Authors
Source:
Medical mycology case reports 2019 v.26 pp. 64-66
ISSN:
2211-7539
Subject:
Cryptococcus neoformans; HIV infections; antigens; blood serum; case studies; cerebrospinal fluid; clinical examination; false negative results; mycoses; patients
Abstract:
... The detection of cryptococcal capsular antigen (CrAg) is very sensitive and specific, however false-negative results have been reported, mostly in cerebrospinal fluid. We report the case of an HIV-infected patient with CD4 = 42 cells/mL, asthenic, negative serum CrAg lateral flow assay (LFA) and culture-proven cryptococcaemia. Despite the high accuracy of LFA, false-negative result is possible. Ca ...
DOI:
10.1016/j.mmcr.2019.10.009
PubMed:
31737475
PubMed Central:
PMC6849355