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- Dou, Tongyi, et al. Show all 8 Authors
- Chemical communications 2019 v.55 no.30 pp. 4311-4314
- catechol O-methyltransferase; chemical reactions; ligands; lysine; mass spectrometry; prediction; receptors
- ... Herein we provide a mass spectrometry-based lysine reactivity profiling strategy to monitor the ligand modulation of protein receptors, which is achieved by active dimethyl labeling of lysine residues and comparison of the alterations of labeling reactivity during ligand binding. The small-molecule ligand modulation patterns on the catechol-O-methyltransferase and the N-methyl-d-aspartate receptor ...
- Dou, Tongyi, et al. Show all 5 Authors
- RSC advances 2018 v.8 no.29 pp. 16278-16284
- New Zealand White rabbit; animal models; catechol O-methyltransferase; dogs; fluorescent dyes; guinea pigs; humans; laboratory animals; liver; metabolites; methylation; mice; miniature swine; monkeys; peripheral nervous system diseases; rats; therapeutics
- ... Catechol-O-methyltransferase (COMT) is a druggable biological target and COMT modulators have been widely applied in the treatment of various central and peripheral nervous system disorders. The interspecies differences of COMT were carefully investigated using 3-BTD (a newly developed fluorescent probe of COMT) methylation as the probe reaction, and liver S9 from humans and seven experimental ani ...