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1. Development of a three dimensional (3D) knitted scaffold for myocardial tissue engineering. Part II: biological performance of the knitted scaffolds

Author:
Derya Haroglu; Ahmet Eken; Zeynep Burçin Gönen; Dilek Bahar
Source:
The journal of the Textile Institute 2025 v.113 no.5 pp. 895-905
ISSN:
1754-2340
Subject:
adhesion; anisotropy; cell adhesion; cell lines; fabrics; fibronectins; humans; interleukin-11; medicine; mice; myoblasts; myocardial infarction; myocardium; polyethylene terephthalates; porosity; therapeutics
Abstract:
... Cardiac patch has been proposed as an alternative therapeutic tissue engineering strategy to treat damaged heart for patients who survive the acute myocardial infarction (MI). To that end, studies have focused on designing an ideal cardiac patch assisting myocardium to repair itself. The engineering of three dimensional (3 D) anisotropic knitted scaffolds could be an efficient and effective strate ...
DOI:
10.1080/00405000.2021.1907990

2. 3D direct printing of composite bone scaffolds containing polylactic acid and spray dried mesoporous bioactive glass-ceramic microparticles

Author:
Azadeh Saberi; Aliasghar Behnamghader; Behzad Aghabarari; Aliakbar Yousefi; Dorota Majda; Maria Victoria Martinez Huerta; Masoud Mozafari
Source:
International journal of biological macromolecules 2022 v.207 pp. 9-22
ISSN:
0141-8130
Subject:
apatite; bioactive properties; biocompatibility; biocompatible materials; biomineralization; bones; cell adhesion; compression strength; humans; polylactic acid; porosity; porous media; storage modulus; viability
Abstract:
... In this study, a three-dimensional composite scaffold is proposed consisting of polylactic acid and spray dried glass-ceramic microparticles (SGCMs). The compositional and structural characterization showed that the obtained spray dried powder formed as glass-ceramic (GC) with a completely interconnected porosity structure. Before direct printing of scaffolds, the rheological behavior of polylacti ...
DOI:
10.1016/j.ijbiomac.2022.02.067

3. A bioinspired Janus polyurethane membrane for potential periodontal tissue regeneration

Author:
Yushui He; Xiao Wang; Yuanyuan He; Xin Zhao; Jingjing Lin; Yuan Feng; Jie Chen; Feng Luo; Zhen Li; Jiehua Li; Hong Tan
Source:
Journal of materials chemistry B 2022 v.10 no.14 pp. 2602-2616
ISSN:
2050-7518
Subject:
ammonium salts; antibacterial properties; antioxidants; biocompatibility; bones; cell adhesion; dopamine; epithelium; fibroblasts; mineralization; models; polyurethanes; quaternary ammonium compounds; rats; therapeutics; tissue repair; topology
Abstract:
... Guided tissue regeneration (GTR) is the main therapeutic method for periodontal tissue regeneration. The key to the GTR strategy is the membrane which can assist the reconstruction of bone tissue in the periodontal defect and prevent the migration of epithelium and fibroblasts to the defect. However, the existing periodontal membrane cannot effectively promote periodontal tissue regeneration due t ...
DOI:
10.1039/d1tb02068d

4. A chalcone-syringaldehyde hybrid inhibits triple-negative breast cancer cell proliferation and migration by inhibiting CKAP2-mediated FAK and STAT3 phosphorylation

Author:
Xiang-xiang Jin; Ya-nan Mei; Zhe Shen; Ju-fan Zhu; Sun-hui Xing; Hua-mao Yang; Guang Liang; Xiao-hui Zheng
Source:
Phytomedicine 2022 v.101 pp. 154087
ISSN:
0944-7113
Subject:
DNA damage; DNA replication; adhesion; antineoplastic activity; apoptosis; breast neoplasms; cell adhesion; cell cycle checkpoints; cell proliferation; chalcone; cytotoxicity; drugs; flow cytometry; fluorescence microscopy; hybrids; neoplasm cells; non-specific protein-tyrosine kinase; phosphorylation; relapse; sequence analysis; signal transduction; transactivators; transcriptome
Abstract:
... Although triple-negative breast cancer (TNBC) accounts for only 15% of breast cancer cases, it is associated with a high relapse rate and poor outcome after standard treatment. Currently, the effective drugs and treatment strategies for TNBC remain limited, and thus, developing effective treatments for TNBC is pressing. Several studies have demonstrated that both chalcone and syringaldehyde have a ...
DOI:
10.1016/j.phymed.2022.154087

5. A hybrid oxygen-generating wound dressing based on chitosan thermosensitive hydrogel and decellularized amniotic membrane

Author:
Fatemeh Dadkhah Tehrani; Iman Shabani; Azadeh Shabani
Source:
Carbohydrate polymers 2022 v.281 pp. 119020
ISSN:
0144-8617
Subject:
adhesion; blood; cell adhesion; cell growth; chitosan; encapsulation; hemolysis; hydrogels; oxygen; polylactic acid; porosity; thermosensitivity
Abstract:
... Amniotic membrane (AM) has been utilized as a wound dressing extensively. Given the importance of oxygen in wound healing, here we have reported the fabrication and characterization of an oxygen-generating wound dressing based on AM. This construct was composed of H₂O₂-loaded polylactic acid (PLA) microparticles embedded within a chitosan/β-glycerophosphate (β-GP) thermosensitive hydrogel covered ...
DOI:
10.1016/j.carbpol.2021.119020

6. A new insight into sex-specific non-coding RNAs and networks in response to SARS-CoV-2

Author:
Nahid Askari; Morteza Hadizadeh; Maryam Rashidifar
Source:
Infection, genetics, and evolution 2022 v.97 pp. 105195
ISSN:
1567-1348
Subject:
COVID-19 infection; Internet; Severe acute respiratory syndrome coronavirus 2; bioinformatics; biomarkers; cell adhesion; complement; databases; evolution; gene expression regulation; genes; humans; immune response; infection; microRNA; nucleotide sequences; pathophysiology; phagosomes; prognosis; therapeutics
Abstract:
... SARS-CoV-2 is the RNA virus responsible for COVID-19, the prognosis of which has been found to be slightly worse in men. The present study aimed to analyze the expression of different mRNAs and their regulatory molecules (miRNAs and lncRNAs) to consider the potential existence of sex-specific expression patterns and COVID-19 susceptibility using bioinformatics analysis. The binding sites of all hu ...
DOI:
10.1016/j.meegid.2021.105195

7. Activation of α7 nicotinic acetylcholine receptors attenuates monocyte–endothelial adhesion through FUT7 inhibition

Author:
Chia-Hsien Wu; Tsuyoshi Inoue; Yasuna Nakamura; Rie Uni; Sho Hasegawa; Hiroshi Maekawa; Mai Sugahara; Youichiro Wada; Tetsuhiro Tanaka; Masaomi Nangaku; Reiko Inagi
Source:
Biochemical and biophysical research communications 2022 v.590 pp. 89-96
ISSN:
0006-291X
Subject:
acetylcholine; adhesion; agonists; cell adhesion; cell lines; cytokines; genes; inflammation; ligands; macrophages; monocytes; nicotinic receptors; research; sequence analysis
Abstract:
... Cholinergic anti-inflammatory pathway (CAP) describes a neuronal-inflammatory reflex centered on systemic cytokine regulation by α7 nicotinic acetylcholine receptor (α7nAChR) activation of spleen-residue macrophage. However, the CAP mechanism attenuating distal tissue inflammation, inducing a low level of systemic inflammation, is lesser known. In this study, we hypothesized that CAP regulates mon ...
DOI:
10.1016/j.bbrc.2021.12.094

8. Alginate/polycaprolactone composite fibers as multifunctional wound dressings

Author:
Wei-Wen Hu; Yu-Ting Lin
Source:
Carbohydrate polymers 2022 v.289 pp. 119440
ISSN:
0144-8617
Subject:
absorbents; alginates; calcium; cell adhesion; collagen; electrostatic interactions; hemostasis; ion exchange; nanosilver; plasmids; polyethyleneimine
Abstract:
... We developed a composite wound dressing that provides multifunctional wound care. Alginate and polycaprolactone (PCL) were coelectrospun as composite fibers. Highly absorbent alginate provided a moist environment for wounds and PCL increased cell adhesion. Silver nanoparticles embedded in PCL fibers for long-term release inhibited the growth of microorganisms. In addition, plasmid DNA encoding pla ...
DOI:
10.1016/j.carbpol.2022.119440

9. Alternagin-C, an alpha2beta1 integrin ligand, attenuates collagen-based adhesion, stimulating the metastasis suppressor 1 expression in triple-negative breast tumor cells

Author:
Milene Nóbrega de Oliveira Moritz; Bruna Carla Casali; Uliana Sbeguen Stotzer; Patty Karina dos Santos; Heloisa Sobreiro Selistre-de-Araujo
Source:
Toxicon 2022 v.210 pp. 1-10
ISSN:
0041-0101
Subject:
Bothrops; adhesion; angiogenesis; breast neoplasms; breasts; cell adhesion; cell lines; cell movement; collagen; disease course; extracellular matrix; gene expression; inflammation; integrins; ligands; metalloproteinases; metastasis; neoplasm cells; neoplasm progression; risk; snake venoms; snakes
Abstract:
... Triple-negative breast cancer has an aggressive clinical course and its treatment has been challenging due to high metastatic risk. Molecular targets have been sought to provide better strategies for this type of cancer. Integrins are cell adhesion receptors involved in tumor progression and α₂β₁ integrin, a collagen receptor, has a key role in breast metastasis. Disintegrins, a family of proteins ...
DOI:
10.1016/j.toxicon.2022.02.001

10. An integrin alpha 4 (ChIntα 4) from oyster Crassostrea hongkongensis mediates the hemocytes phagocytosis towards Vibrio alginolyticus

Author:
Yao-Wu Fu; Wei-Feng Chen; Meng-Han He; Lei Tang; Shu-Quan Guo; Qi-Zhong Zhang
Source:
Fish & shellfish immunology 2022 v.122 pp. 246-256
ISSN:
1050-4648
Subject:
Crassostrea hongkongensis; Escherichia coli; Vibrio alginolyticus; antibodies; apoptosis; cell adhesion; fish; gene expression; hemocytes; integrins; oysters; phagocytosis; plasmids; polypeptides; rabbits; shellfish; transfection
Abstract:
... Integrins, a family of cell adhesion transmembrane receptors, mediate cell adhesion, migration, proliferation, apoptosis, and phagocytosis. In the present study, an integrin ChIntα 4 from Crassostrea hongkongensis was characterized to investigate its role in defensing against pathogenic bacterium Vibrio alginolyticus. The full-length cDNA sequence of ChIntα 4 was 3572 bp with an open reading frame ...
DOI:
10.1016/j.fsi.2022.02.015

11. Anti-Adhesion and Antibiofilm Activity of Eruca sativa Miller Extract Targeting Cell Adhesion Proteins of Food-Borne Bacteria as a Potential Mechanism: Combined In Vitro-In Silico Approach

Author:
Amir Mahgoub Awadelkareem; Eyad Al-Shammari; AbdElmoneim O. Elkhalifa; Mohd Adnan; Arif Jamal Siddiqui; Danish Mahmood; Z. R. Azaz Ahmad Azad; Mitesh Patel; Khalid Mehmood; Corina Danciu; Syed Amir Ashraf
Source:
Plants 2022 v.11 no.5 pp. -
ISSN:
2223-7747
Subject:
Eruca vesicaria subsp. sativa; Escherichia coli; active sites; adhesion; agar; antibacterial properties; biofilm; cell adhesion; computer simulation; food contamination; phytochemicals; plankton; sortase A; viability
Abstract:
... Bacterial cells have the ability to form biofilm onto the surfaces of food matrixes and on food processing equipment, leading to a source of food contamination posing serious health implications. Therefore, our study aimed to determine the effect of Eruca sativa Miller (E. sativa) crude extract against biofilms of food-borne bacteria along with in silico approaches to investigate adhesion proteins ...
DOI:
10.3390/plants11050610

12. Antibacterial and antibiofilm activity of essential oil of clove against Listeria monocytogenes and Salmonella Enteritidis

Author:
Mariem Somrani; Hajer Debbabi; Alfredo Palop
Source:
Food science and technology international 2022 v.28 no.4 pp. 331-339
ISSN:
1532-1738
Subject:
Listeria monocytogenes; Salmonella Enteritidis; antimicrobial properties; bioactive compounds; biofilm; biomass; cell adhesion; cloves; disk diffusion antimicrobial test; essential oils; eugenol; food science; gas chromatography-mass spectrometry; gentian violet; minimum inhibitory concentration; oils; technology
Abstract:
... The antibacterial and antibiofilm activity of essential oil of clove against Listeria monocytogenes and Salmonella Enteritidis were investigated. The chemical composition of the oil was characterized by gas chromatography–mass spectrometry. Stock solution of the essential oil of clove was prepared in 95% (v/v) ethanol (EOC). The antibacterial assays were performed by disk diffusion assay and minim ...
DOI:
10.1177/10820132211013273

13. Anticancer potential of corilagin on T24 and TSGH 8301 bladder cancer cells via the activation of apoptosis by the suppression of NF‐κB‐induced P13K/Akt signaling pathway

Author:
Xiaodong Yu; Tao Wu; Bo Liao; Zhongbo Du; Pingyu Zhu
Source:
Environmental toxicology 2022 v.37 no.5 pp. 1152-1159
ISSN:
1520-4081
Subject:
4',6-diamidino-2-phenylindole; adhesion; apoptosis; cell adhesion; cell movement; cytotoxicity; death; ecotoxicology; inflammation; metastasis; mortality; toxicity testing; urinary bladder neoplasms; viability
Abstract:
... Bladder cancer (BC) is a primary source of malignancy‐associated death, and the mortality rate is high due to its prevalence of metastasis. Corilagin (CLG), a bioactive constituent of numerous medicinal plants, exerts assorted pharmacological actions comprising anti‐cancer, apoptotic, anti‐inflammatory, and hepatoprotective. CLG possesses a substantial anti‐tumor prospective and less noxiousness i ...
DOI:
10.1002/tox.23472

14. Assessing Aedes aegypti candidate genes during viral infection and Wolbachia‐mediated pathogen blocking

Author:
Leah T. Sigle; Matthew Jones; Mario Novelo; Suzanne A. Ford; Nadya Urakova; Konstantinos Lymperopoulos; Richard T. Sayre; Zhiyong Xi; Jason L. Rasgon; Elizabeth A. McGraw
Source:
Insect molecular biology 2022 v.31 no.3 pp. 356-368
ISSN:
0962-1075
Subject:
Aedes aegypti; Chikungunya virus; Dengue virus; RNA interference; Wolbachia; adhesion; artificial selection; cell adhesion; gene expression; genes; glycosylation; immunity; insects; mechanism of action; midgut; molecular biology; pathogens; symbionts; transcription (genetics); virus transmission; viruses
Abstract:
... One approach to control dengue virus transmission is the symbiont Wolbachia, which limits viral infection in mosquitoes. Despite plans for its widespread use in Aedes aegypti, Wolbachia's mode of action remains poorly understood. Many studies suggest that the mechanism is likely multifaceted, involving aspects of immunity, cellular stress and nutritional competition. A previous study from our grou ...
DOI:
10.1111/imb.12764

15. Bi-layered carboxymethyl cellulose-collagen vitrigel dual-surface adhesion-prevention membrane

Author:
Yue Wang; Kei Kanie; Toshiaki Takezawa; Miki Horikawa; Kyoshiro Kaneko; Ayako Sugimoto; Aika Yamawaki-Ogata; Yuji Narita; Ryuji Kato
Source:
Carbohydrate polymers 2022 v.285 pp. 119223
ISSN:
0144-8617
Subject:
adhesion; adhesion inhibition assay; carboxymethylcellulose; cell adhesion; collagen; crosslinking; hydrogels; vitrification
Abstract:
... During wound regeneration, both cell adhesion and adhesion-inhibitory functions must be controlled in parallel. We developed a membrane with dual surfaces by merging the properties of carboxymethyl cellulose (CMC) and collagen using vitrification. A rigid membrane was formed by vitrification of a bi-layered CMC and collagen hydrogel without using cross-linking reagents, thus providing dual functio ...
DOI:
10.1016/j.carbpol.2022.119223

16. Bio-based poly (γ-glutamic acid)-gelatin double-network hydrogel with high strength for wound healing

Author:
Chunyan Dou; Zheng Li; Ying Luo; Jixian Gong; Qiujin Li; Jianfei Zhang; Qingsong Zhang; Changsheng Qiao
Source:
International journal of biological macromolecules 2022 v.202 pp. 438-452
ISSN:
0141-8130
Subject:
biocompatibility; cell adhesion; chemical bonding; crosslinking; gelatin; hydrogels; models
Abstract:
... Building bio-based hydrogels with high strength and biocompatibility is still a challenge. Herein, we successfully constructed a hybrid double-network (DN) full biological hydrogel with excellent mechanical properties and biocompatibility by introducing a physically cross-linked gelatin (GEL) network in a covalently cross-linked poly (γ-glutamic acid) (γ-PGA) network. The γ-PGA-GEL DN hydrogel dem ...
DOI:
10.1016/j.ijbiomac.2022.01.057

17. Biofilm formation potential of Bacillus toyonensis and Pseudomonas aeruginosa on the stainless steel test surfaces in a model dairy batch system

Author:
Dilay Kütük; Ayhan Temiz
Source:
Folia microbiologica 2022 v.67 no.3 pp. 405-417
ISSN:
0015-5632
Subject:
Bacillus toyonensis; Gram-negative bacteria; Gram-positive bacteria; Pseudomonas aeruginosa; adhesion; batch systems; biofilm; cell adhesion; cell walls; culture media; dairies; disinfection; electron microscopy; fluorescence microscopy; milk; stainless steel
Abstract:
... Bacillus toyonensis (a Gram-positive bacterium) and Pseudomonas aeruginosa (a Gram-negative bacterium) isolated from the different surfaces of a dairy plant in our previous study were selected as the test bacteria for the present study. These two test bacteria were investigated in terms of their attachment on the stainless steel test surfaces in a model dairy batch system. After incubation at 5 °C ...
DOI:
10.1007/s12223-021-00940-7

18. Biomimetic multifactor stimulation method for analyzing the synergism of matrix stiffness and inorganic polyphosphates on cellular behaviors

Author:
Xiaonan Zheng; Yucheng Sun; Haifang Li; Nan Li; Xueji Zhang; Jin-Ming Lin
Source:
Talanta 2022 v.241 pp. 123222
ISSN:
0039-9140
Subject:
biomechanics; biomimetics; carcinogenesis; cell adhesion; cell culture; drugs; energy; extracellular matrix; glioma; metabolism; phagocytosis; polyphosphates; synergism
Abstract:
... In the process of tumorigenesis and development, cancer cells must integrate and respond to complex and dynamic signals in the tumor microenvironment. Nevertheless, simulating the original biomechanical and biochemical microenvironment of different cells in vitro is a fundamental challenge in studying synergistic effects. To address this issue, we have proposed a biomimetic multi-factor stimulatio ...
DOI:
10.1016/j.talanta.2022.123222

19. Biomimetic polypyrrole/hyaluronic acid electrodes integrated with hyaluronidase inhibitors offer persistent electroactivity and resistance to cell binding

Author:
Jongdarm Yi; Sanghun Lee; Jae Young Lee
Source:
Journal of materials chemistry B 2022 v.10 no.10 pp. 1591-1600
ISSN:
2050-7518
Subject:
biocompatibility; biofouling; biomimetics; cell adhesion; cell culture; cytotoxicity; glycyrrhizin; hyaluronic acid; hyaluronoglucosaminidase; microelectrodes; moieties; pyrroles
Abstract:
... Conductive polymers, including polypyrrole (PPy), have garnered much attention as bioelectrodes because of their high conductivity, low interfacial resistance, environmental stability, and biocompatibility. In particular, the introduction of high-molecular weight hyaluronic acid (HA) into PPy enables the fabrication of biomimetic and biocompatible electrodes (i.e., PPy/HA) characterized by low bio ...
DOI:
10.1039/d1tb02849a

20. Bone tissue engineering: Anionic polysaccharides as promising scaffolds

Author:
Ponnurengam Malliappan Sivakumar; Abuzer Alp Yetisgin; Sevilay Burcu Sahin; Ebru Demir; Sibel Cetinel
Source:
Carbohydrate polymers 2022 v.283 pp. 119142
ISSN:
0144-8617
Subject:
biocompatible materials; biomimetics; bones; calcium phosphates; cell adhesion; glycosaminoglycans; homeostasis; inflammation; mammals; porosity; viscoelasticity
Abstract:
... Bone repair is a self-healing process. However, critical-sized bone defects need bone augmentation where bone tissue engineering plays vital role. Bone tissue Engineering (BTE) requires unique combinations of scaffolds, cells, and bio-signal molecules. Bone scaffold materials should be biocompatible, bioresorbable and exhibit biomimetic properties. Natural polymers, acquiring cell binding motives, ...
DOI:
10.1016/j.carbpol.2022.119142