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You searched for: Subject term cell lines Remove constraint Subject term: cell lines Subject term Oriental traditional medicine Remove constraint Subject term: Oriental traditional medicine
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1. Antiparasitic potential of ethanolic extracts of Carpesii Fructus against Miamiensis avidus in hirame natural embryo cell line and their effects on immune response- and biotransformation-related genes

Author:
Soo Ji Woo; Min Gyeong Jeong; Eun Ji Jeon; Mi Young Do; Na Young Kim
Source:
Comparative biochemistry and physiology 2022 v.251 pp. 109214
ISSN:
1532-0456
Subject:
Carpesium abrotanoides; Miamiensis avidus; Oriental traditional medicine; Paralichthys olivaceus; antiparasitic agents; antiparasitic properties; aquaculture industry; cell lines; concanavalin A; dried fruit; interleukin-8; parasitoses; physiology; shrinkage; toxicity; viability
Abstract:
... Scuticociliatosis, caused by Miamiensis avidus, is a severe parasitic disease affecting marine organisms, particularly Paralichthys olivaceus. The aim of this study was to assess the antiparasitic potential of ethanolic extracts of Carpesii Fructus (EECF), the dried fruit of Carpesium abrotanoides L., which is used in traditional Chinese medicine, in vitro. We found that 50%, 70%, and 100% EECF in ...
DOI:
10.1016/j.cbpc.2021.109214

2. Artemisia capillaris Thunb. water extract attenuates adriamycin‐induced renal injury by regulating apoptosis through the ROS/MAPK axis

Author:
Guoshun Huang; Yiye Zhu; Chen Yong; Fang Tian; Li Liu; Qijing Wu; Yang Shu; Min Yao; Chenquan Tang; Xiaofang Wang; Wei Chen; Enchao Zhou
Source:
Journal of food biochemistry 2022 v.46 no.2 pp. e14065
ISSN:
0145-8884
Subject:
Artemisia capillaris; Oriental traditional medicine; acetylcysteine; antioxidants; apoptosis; cell lines; cell viability; doxorubicin; food plants; freeze drying; kidneys; oxidative stress; phosphorylation; renal function; renoprotective effect; signal transduction; superoxide dismutase
Abstract:
... Artemisia capillaris Thunb. is widely used in the treatment of kidney diseases, but the underlying mechanism remain elusive. Therefore, this study aimed to elucidate the mechanism of Artemisia capillaris Thunb. in alleviating renal injury. And renoprotective effects of freeze‐dried powder of Artemisia capillaris Thunb. water extract (WAC) were assessed using adriamycin (ADR)‐induced renal injury t ...
DOI:
10.1111/jfbc.14065

3. Glycyrrhiza uralensis root extract ameliorates high glucose‐induced renal proximal tubular fibrosis by attenuating tubular epithelial‐myofibroblast transdifferentiation by targeting TGF‐β1/Smad/Stat3 pathway

Author:
Henry Cherng‐Han Lin; Catherine Reena Paul; Chia‐Hua Kuo; Yung‐Hsien Chang; William Shao‐Tsu Chen; Tsung‐Jung Ho; Cecilia‐Hsuan Day; Bharath Kumar Velmurugan; Yuhsin Tsai; Chih‐Yang Huang
Source:
Journal of food biochemistry 2022 v.46 no.5 pp. e14041
ISSN:
0145-8884
Subject:
Glycyrrhiza uralensis; Oriental traditional medicine; acarbose; cell lines; diabetic nephropathy; epithelial cells; fibrosis; fructose; glucose; herbal medicines; renoprotective effect; root extracts
Abstract:
... Growing evidences indicate that high glucose toxicity‐associated fibrotic effects play a pivotal role in diabetic nephropathy (DN). Tubular epithelial‐myofibroblast transdifferentiation is a major hallmark of renal fibrosis event under diabetic stress. Roots of Glycyrrhiza uralensis (Radix glycyrrhizae) used as a sweetener and traditional Chinese medicine possess high potential for renal protectio ...
DOI:
10.1111/jfbc.14041

4. Makatoxin-3, a thermostable Nav1.7 agonist from Buthus martensii Karsch (BmK) scorpion elicits non-narcotic analgesia in inflammatory pain models

Author:
Yonggen Chen; Erjin Xu; Ming Sang; Zhiheng Wang; Yuxin Zhang; Juan Ye; Qian Zhou; Chenglei Zhao; Chunping Hu; Wuguang Lu; Peng Cao
Source:
Journal of ethnopharmacology 2022 v.288 pp. 114998
ISSN:
0378-8741
Subject:
Buthus martensii; Oriental traditional medicine; Western blotting; agonists; analgesia; analgesic effect; antibodies; arthritis; cell lines; circular dichroism spectroscopy; enzyme-linked immunosorbent assay; ganglia; health services; high performance liquid chromatography; ion channels; morphine; mutants; naloxone; narcotics; pain; scorpion venoms; thermal stability; toxins
Abstract:
... Chronic pain management represents a serious healthcare problem worldwide. The use of opioid analgesics for pain has always been hampered by their side effects; in particular, the addictive liability associated with chronic use. Finding a morphine replacement has been a long-standing goal in the field of analgesia. In traditional Chinese medicine, processed Buthus martensii Karsch (BmK) scorpion h ...
DOI:
10.1016/j.jep.2022.114998

5. Trillin inhibits myoblast differentiation via increasing autophagy

Author:
Weilong Dai; Ke Liu; Rongyang Li; Yan Cao; Ming Shen; Jingli Tao; Honglin Liu
Source:
Phytomedicine 2022 v.99 pp. 153962
ISSN:
0944-7113
Subject:
Oriental traditional medicine; Trillium tschonoskii; Western blotting; active ingredients; autophagy; cell lines; dose response; models; myoblasts; skeletal muscle
Abstract:
... Trillin, an active ingredient in traditional Chinese medicine Trillium tschonoskii, is a potential small molecule compound candidate that affecting myoblast differentiation, which predicting by AI technology in our previous study. Autophagy modulating myoblast differentiation has also been studied. In addition, Trillin was shown to regulate mTOR signaling pathway, a highly conserved kinase importa ...
DOI:
10.1016/j.phymed.2022.153962

6. A preparation of Ginkgo biloba L. leaves extract inhibits the apoptosis of hippocampal neurons in post-stroke mice via regulating the expression of Bax/Bcl-2 and Caspase-3

Author:
Zhixiong Li; Guangxu Xiao; Huanyi Wang; Shuang He; Yan Zhu
Source:
Journal of ethnopharmacology 2021 v.280 pp. 114481
ISSN:
0378-8741
Subject:
Ginkgo biloba; Oriental traditional medicine; Western blotting; apoptosis; brain damage; caspase-3; cell lines; hippocampus; immunocytochemistry; immunohistochemistry; mice; models; myocardial infarction; neurons; prognosis; stroke; therapeutics
Abstract:
... Shuxuening injection (SXNI) is a Chinese medicine of Ginkgo biloba L. leaves extract (GBE), which is widely used clinically for cardiovascular diseases such as stroke and myocardial infarction, but the pharmacological mechanism of its therapeutic effect is not fully understood.Preclinical studies suggested that inhibition of neuronal apoptosis effectively improves brain damage after ischemic strok ...
DOI:
10.1016/j.jep.2021.114481

7. A traditional herbal formula, Deng-Shi-Qing-Mai-Tang, regulates TLR4/NF-κB signaling pathway to reduce inflammatory response in PM2.5-induced lung injury

Author:
You Zhou; Jianbo Liu; Cheng Jiang; Jiaming Chen; Xilian Feng; Weiyan Chen; Jiechun Zhang; Hongzhen Dong; Wei Zhang
Source:
Phytomedicine 2021 v.91 pp. 153665
ISSN:
0944-7113
Subject:
DNA; Oriental traditional medicine; Western blotting; animal models; cell lines; cough; fluorescent antibody technique; gel electrophoresis; inflammation; interleukin-10; interleukin-6; lungs; particulates; quantitative polymerase chain reaction; therapeutics
Abstract:
... Studies revealed that particulate matter 2.5 (PM2.5) enters the lung through the respiratory tract and can damage lung tissue resulting in lung injury primarily via imbalance between pro-inflammatory and anti-inflammatory responses. Moreover, TLR4/NF-κB signaling pathways are reported to play a role in PM2.5-induced inflammation and lung injury, which is closely related to the inflammatory respons ...
DOI:
10.1016/j.phymed.2021.153665

8. Anti-inflammatory effect of traditional Chinese medicine preparation Penyanling on pelvic inflammatory disease

Author:
Wei Zou; Linna Gong; Fenghua Zhou; Yao Long; Zhen Li; Zuoqi Xiao; Bo Ouyang; Menghua Liu
Source:
Journal of ethnopharmacology 2021 v.266 pp. 113405
ISSN:
0378-8741
Subject:
Angelica sinensis; Corydalis yanhusuo; Cyperus rotundus; Glycyrrhiza uralensis; Lindera; Oriental traditional medicine; Paeonia lactiflora; Patrinia; Salvia miltiorrhiza; Sargentodoxa cuneata; Sparganium eurycarpum; Western blotting; animal models; anti-inflammatory activity; cell lines; chemotaxis; cytoplasm; flavonoids; histology; inflammation; interleukin-6; interleukin-8; lipopolysaccharides; mass spectrometry; monocytes; neutrophils; peptide receptors; phenolic compounds; rats; rhizomes; saponins; signal transduction; transcription factor NF-kappa B
Abstract:
... Penyanling is made up of Smilacis Glabrae Rhizoma (SG, from Smilar glabra Roxb.), Angelicae Sinensis Radix (AS, from Angelica sinensis (Oliv.) Diels), Salviae Miltiorrhizae Radix et Rhizoma (SM, from Salvia miltiorrhiza Bunge), Sargentodoxae Caulis (SC, from Sargentodoxa cuneata (Oliv.) Rehd.et Wils.), Linderae Radix (LR, from Lindera aggregata (Sims) Kosterm.), Paeoniae Radix Rubra (PR, from Paeo ...
DOI:
10.1016/j.jep.2020.113405

9. Botanical formulation, TADIOS, alleviates lipopolysaccharide (LPS)-Induced acute lung injury in mice via modulation of the Nrf2-HO-1 signaling pathway

Author:
Wonwoo Lee; Chang Hyung Lee; Jungkyu Lee; Yoonseon Jeong; Jong-Hyung Park; In-Jeong Nam; Doo Suk Lee; Hyun Myung Lee; Jaehyun Lee; Nayoung Yun; Jisun Song; Sooyeon Choi; Sunyoung Kim
Source:
Journal of ethnopharmacology 2021 v.270 pp. 113795
ISSN:
0378-8741
Subject:
Dioscorea polystachya; Oriental traditional medicine; RNA; Schizonepeta tenuifolia; Taraxacum officinale; Western blotting; acute respiratory distress syndrome; antioxidant activity; cell lines; dose response; eosin; ethanol; high performance liquid chromatography; interleukin-6; lipopolysaccharides; luciferase; lungs; macrophages; mice; myeloperoxidase; neutrophils; oxidative stress; plasmids; protein content; quality control; reactive oxygen species; Asia
Abstract:
... TADIOS is an herbal formulation prepared from a mixture of Taraxacum officinale (L.) Weber ex F.H.Wigg, Dioscorea batatas Decaisne and Schizonepeta tenuifolia (Benth.) Briquet. These plants have traditionally been used in Asia to treat a variety of respiratory diseases. A bulk of literature on traditional Korean medicine describe their activities and functions for respiratory problems. Therefore, ...
DOI:
10.1016/j.jep.2021.113795

10. Comparative two-dimensional GPC3 overexpressing SK-Hep1 cell membrane chromatography /C18/ time-of-flight mass spectrometry for screening selective GPC3 inhibitor components from Scutellariae Radix

Author:
Chun Chen; Yanqiu Gu; Rong Wang; Xinyi Chai; Shuya Jiang; Shaozhan Wang; Zhenyu Zhu; Xiaofei Chen; Yongfang Yuan
Source:
Journal of chromatography 2021 v.1163 pp. 122492
ISSN:
1570-0232
Subject:
Oriental traditional medicine; carcinoma; cell lines; cell membranes; cell proliferation; chromatography; hepatoma; ligands; mass spectrometry; neoplasm cells; surface plasmon resonance
Abstract:
... Screening active components targeting membrane proteins is important for drug discovery from traditional Chinese medicine. Cell membrane chromatography (CMC) has achieved a wide application in screening active components on pathological cells due to its high sensitivity and effectiveness. However, it is hard to clarify the specific target protein through simply using pathological and normal cells. ...
DOI:
10.1016/j.jchromb.2020.122492

11. Curcuma oil ameliorates benign prostatic hyperplasia through suppression of the nuclear factor-kappa B signaling pathway in rats

Author:
Shanshan Wang; Yun Li; Wenzhi Li; Kun Zhang; Zhengqiang Yuan; Yina Cai; Kuncheng Xu; Jinrong Zhou; Zhiyun Du
Source:
Journal of ethnopharmacology 2021 v.279 pp. 113703
ISSN:
0378-8741
Subject:
Curcuma longa; Oriental traditional medicine; antioxidants; apoptosis; cell lines; cell viability; dihydrotestosterone; eosin; hyperplasia; immunohistochemistry; interleukin-6; lipophilicity; oils; phosphorylation; propionic acid; protein synthesis; testosterone; therapeutics; transcription factor NF-kappa B
Abstract:
... Curcuma longa L is traditionally used as an anti-inflammatory remedy in Chinese traditional medicine. Curcuma oil (CO), a lipophilic fraction from Curcuma longa L. has been reported to have anti-proliferative, anti-inflammatory and anti-oxidant activities. However, CO has never been investigated for its possible therapeutic effects on benign prostatic hyperplasia (BPH).The study is thus to determi ...
DOI:
10.1016/j.jep.2020.113703

12. Ethnopharmacological analysis from Thai traditional medicine called prasachandaeng remedy as a potential antipyretic drug

Author:
Nuntika Prommee; Arunporn Itharat; Sumalee Panthong; Sunita Makchuchit; Buncha Ooraikul
Source:
Journal of ethnopharmacology 2021 v.268 pp. 113520
ISSN:
0378-8741
Subject:
Oriental traditional medicine; acetaminophen; cell lines; ethanol; fever; herbal medicines; hydrolysis; lipopolysaccharides; maceration; macrophages; mice; nitric oxide; prostaglandins; quality control; shelf life; taste; Thailand
Abstract:
... Prasachandaeng (PSD) remedy is a famous antipyretic drug for adults and children in Thai traditional medicine used and is described in Thailand's National List of Essential Medicine. Relationship between the taste of this herbal medicine, ethnopharmacological used and its pharmacological properties was reviewed.Since there has been no scientific report on the antipyretic activity of PSD, aim of th ...
DOI:
10.1016/j.jep.2020.113520

13. Fucoxanthin extracted from Laminaria Japonica inhibits metastasis and enhances the sensitivity of lung cancer to Gefitinib

Author:
Jia Xiong Ming; Zhao Cong Wang; Yi Huang; Hifumi Ohishi; Rong Ji Wu; Yan Shao; Hui Wang; Ming Yang Qin; Ze Liang Wu; Yi Yong Li; Shun Chang Zhou; Hui Chen; Hui Liu; Rong Xu
Source:
Journal of ethnopharmacology 2021 v.265 pp. 113302
ISSN:
0378-8741
Subject:
Oriental traditional medicine; RNA interference; Saccharina japonica; Western blotting; antineoplastic activity; cadherins; cell lines; cell proliferation; cell viability; drugs; fibronectins; fluorescent antibody technique; gene expression; human diseases; immunohistochemistry; lung neoplasms; lungs; metastasis; models; neoplasm cells; phenotype; phosphatidylinositol 3-kinase; staining; tissue repair; transcription factor NF-kappa B; xenotransplantation
Abstract:
... Laminaria japonica, a brown seaweed, has been used in Traditional Chinese Medicine (TCM) to treat a variety of diseases including lung cancer.To demonstrate the effects of Fucoxanthin (FX), a major active component extracted from Laminaria japonica on metastasis and Gefitinib (Gef) sensitivity in human lung cancer cells both in vitro and in vivo.Invasion and migration of lung cancer cells were det ...
DOI:
10.1016/j.jep.2020.113302

14. Sargassum horneri (Turner) C. Agardh containing polyphenols attenuates particulate matter-induced inflammatory response by blocking TLR-mediated MYD88-dependent MAPK signaling pathway in MLE-12 cells

Author:
Kalahe Hewage Iresha Nadeeka Madushani Herath; Hyo Jin Kim; Ju Hee Lee; Jun Geon Je; Hak-Sun Yu; You-Jin Jeon; Hyun Jung Kim; Youngheun Jee
Source:
Journal of ethnopharmacology 2021 v.265 pp. 113340
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Sargassum horneri; Toll-like receptor 2; algae; anti-inflammatory activity; breathing; cell lines; chemokine CCL2; chemokine CCL5; epithelial cells; ethanol; gene expression; immunomodulators; inflammation; interleukin-6; interleukin-8; ligands; lungs; medicinal plants; messenger RNA; mitogen-activated protein kinase; particulates; phosphorylation; polyphenols; respiratory tract diseases; signal transduction; therapeutics; tumor necrosis factor-alpha
Abstract:
... Sargassum horneri (Turner) C. Agardh (S. horneri), an edible brown marine algae, is known to have immunomodulatory effects and has been used in oriental medicine to treat inflammatory diseases. It is well known that ambient particulate matter (PM) is closely related to increased respiratory diseases inducing lung inflammation.Considering the use of Sargassum horneri in traditional medicine to trea ...
DOI:
10.1016/j.jep.2020.113340

15. Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome

Author:
Heng Zhang; Lingkang Li; Miao Hao; Keyan Chen; Yongping Lu; Jing Qi; Wei Chen; Lu Ren; Xintong Cai; Chen Chen; Zhuang Liu; Bin Zhao; Zhishuang Li; Ping Hou
Source:
Journal of ethnopharmacology 2021 v.277 pp. 114254
ISSN:
0378-8741
Subject:
Astragalus; Ophiopogon japonicus; Oreocome striata; Oriental traditional medicine; Panax; Salvia absconditiflora; Schisandra; apoptosis; bioinformatics; cell lines; dihydroethidium; electrocardiography; fibrosis; fluorescent antibody technique; heart rate; histone deacetylase; metastasis; mice; models; myocytes; nucleotidyltransferases; oxidative stress; peroxidation; protective effect; protein synthesis; toxicity; wood
Abstract:
... Yixin-Fumai granules (YXFMs)—composed of Ginseng quinquefolium (L.) Alph. Wood, Ophiopogon japonicus (Thunb.) Ker Gawl, Schisandra arisanensis Hayata, Astragalus aaronsohnianus Eig, Salvia cryptantha Montbret & Aucher ex Benth, and Ligusticum striatum DC—are compound granules used in traditional Chinese medicine to increase heart rate and thus treat bradyarrhythmia. It may be effective in treating ...
DOI:
10.1016/j.jep.2021.114254

16. α-Cyperone inhibitory effects on tumor-derived DNA trigger microglia by STING pathway

Author:
Peng Gao; Ning Ding; Jiaxin Lv; Muhammad Noman Ramzan; Qingping Wen
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113246
ISSN:
0378-8741
Subject:
Cyperus rotundus; DNA; Oriental traditional medicine; active ingredients; analgesic effect; cell lines; gene expression regulation; genes; interferon regulatory factor-3; interferons; neuroglia; signal transduction; small interfering RNA; transcription factor NF-kappa B; China
Abstract:
... Cyperus rotundus L. (Cyperaceae) is a widespread herbal in China and widely used in Traditional Chinese Medicine for multiple effects such as anti-arthritic, anti-genotoxic, anti-mutagenic, anti-bacterial effects, and analgesic. α-Cyperone is an active compound in Cyperus rotundus and has analgesic effects, but the exact molecular mechanisms require further investigations.Tumor-derived DNA isolate ...
DOI:
10.1016/j.jep.2020.113246

17. Actinidia Chinensis Planch Root extract attenuates proliferation and metastasis of hepatocellular carcinoma by inhibiting the DLX2/TARBP2/JNK/AKT pathway

Author:
Tingting Fang; Zhiying Zhao; Feifei Yuan; Mingyan He; Jialei Sun; Mengzhou Guo; Peixin Huang; Biwei Yang; Jinglin Xia
Source:
Journal of ethnopharmacology 2020 v.251 pp. 112529
ISSN:
0378-8741
Subject:
Actinidia chinensis; Oriental traditional medicine; Western blotting; antineoplastic activity; cell lines; cytotoxicity; genes; hepatoma; messenger RNA; metastasis; mitogen-activated protein kinase; patients; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; root extracts; signal transduction; transcription factors
Abstract:
... Many studies have confirmed that traditional Chinese herbs exert potential anti-tumor effects. Actinidia Chinensis Planch root has been used as a traditional Chinese medicine (TCM) for thousands of years. However, the mechanism of anti-tumor effects of Actinidia Chinensis Planch root has not been clearly clarified.To explore the molecular biological mechanisms underlying the inhibitory effect of A ...
DOI:
10.1016/j.jep.2019.112529

18. Anti-tumor effects and mechanisms of Astragalus membranaceus (AM) and its specific immunopotentiation: Status and prospect

Author:
Shanshan Li; Yi Sun; Jin Huang; Bin Wang; Yinan Gong; Yuxin Fang; Yangyang Liu; Shenjun Wang; Yi Guo; Hong Wang; Zhifang Xu; Yongming Guo
Source:
Journal of ethnopharmacology 2020 v.258 pp. 112797
ISSN:
0378-8741
Subject:
Astragalus membranaceus; Oriental traditional medicine; T-lymphocytes; active ingredients; adverse effects; antineoplastic activity; apoptosis; cell lines; drug therapy; herbal medicines; immunosuppression; macrophages; metastasis; models; neoplasm cells; neoplasms; pathophysiology; patients; risk; surgery
Abstract:
... With cancer deaths increasing, the initiation, pathophysiology and curative management of cancer is receiving increasing attention. Traditional therapies such as surgery and chemoradiotherapy are often accompanied by suppression of host immunity, which increase the risk of metastasis. Astragalus membranceus (AM) is commonly utilized as one herbal medicine of traditional Chinese medicines (TCMs) wi ...
DOI:
10.1016/j.jep.2020.112797

19. Antiviral activity of a polysaccharide from Radix Isatidis (Isatis indigotica Fortune) against hepatitis B virus (HBV) in vitro via activation of JAK/STAT signal pathway

Author:
Tianbao Wang; Xinwei Wang; Ya Zhuo; Changyun Si; Lu Yang; Lijun Meng; Bin Zhu
Source:
Journal of ethnopharmacology 2020 v.257 pp. 112782
ISSN:
0378-8741
Subject:
DNA; Hepatitis B virus; Isatis tinctoria; Oriental traditional medicine; Western blotting; adverse effects; antiviral properties; antiviral proteins; bacterial infections; cell lines; chronic hepatitis; cytotoxicity; dose response; enzyme-linked immunosorbent assay; hepatitis B; hepatitis B antigens; human health; in vitro studies; interferon-alpha; models; polysaccharides; protein synthesis; quantitative polymerase chain reaction; signal transduction; therapeutics; toxicity testing; vaccines
Abstract:
... Hepatitis B virus (HBV) infection frequently results in both acute and chronic hepatitis and poses serious threats to human health worldwide. Despite the availability of effective HBV vaccine and anti-HBV drugs, apparently inevitable side effects and resistance have limited its efficiency, thus prompt the search for new anti-HBV agents. The traditional Chinese medicine Radix Isatidis has been used ...
DOI:
10.1016/j.jep.2020.112782

20. Chromones and coumarins from Saposhnikovia divaricata (Turcz.) Schischk. Growing in Buryatia and Mongolia and their cytotoxicity

Author:
Bayarma M. Urbagarova; Elvira E. Shults; Vasilii V. Taraskin; Larisa D. Radnaeva; Tatyana N. Petrova; Tatyana V. Rybalova; Tatyana S. Frolova; Andrey G. Pokrovskii; Jamsranjav Ganbaatar
Source:
Journal of ethnopharmacology 2020 v.261 pp. 112517
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Saposhnikovia divaricata; X-ray diffraction; antineoplastic activity; antineoplastic agents; antioxidants; bergapten; cell lines; chemical composition; chemical constituents of plants; cytotoxicity; ethanol; ethyl acetate; ethyl ether; fractionation; glycosides; hemolysis; high performance liquid chromatography; homeopathic drugs; medicinal plants; models; neoplasm cells; neoplasms; petroleum; roots; scopoletin; silica gel; therapeutics; China; Mongolia; Siberia
Abstract:
... Saposhnikovia divaricata (family Apiaceae) a traditional medicinal plant distributed in many provinces of China, is well known for the pharmaceutical value and has been used for rheumatic arthritis, and anxiety in children. Antiviral, antioxidant and antiproliferative activities were also mentioned. The application of this plant are recorded in the Chinese Medicine (CM) classical text the Shen Non ...
DOI:
10.1016/j.jep.2019.112517

21. Exploring the ‘cold/hot’ properties of traditional Chinese medicine by cell temperature measurement

Author:
Suyun Yu; Can Li; Yushi Ding; Shuai Huang; Wei Wang; Yuanyuan Wu; Fangxu Wang; Aiyun Wang; Yuexia Han; Zhiguang Sun; Yin Lu; Ning Gu
Source:
Pharmaceutical biology 2020 v.58 no.1 pp. 208-218
ISSN:
1744-5116
Subject:
Oriental traditional medicine; baicalin; calcium; cell lines; cold; ginger root; leaves; molecular biology; neoplasm cells; temperature; transient receptor potential vanilloid channels
Abstract:
... It is common sense that chewing a mint leaf can cause a cooling feeling, while chewing ginger root will produce a burning feeling. In Traditional Chinese Medicine (TCM), this phenomenon is referred to as ‘cold/hot’ properties of herbs. Herein, it is reported that TCM with different “cold/hot” properties have different effects on the variation of cells. To explore the intrinsic ‘cold/hot’ propertie ...
DOI:
10.1080/13880209.2020.1732429

22. Gano oil: A novel antinociceptive agent extracted from Ganoderma lucidum inhibits paw oedema and relieves pain by hypnotic and analgesic actions of fatty acid amides

Author:
Xiaoning Chen; Ravindran Kalathil Veena; Haridas Ramya; Kainoor Krishnankutty Janardhanan; Varughese George
Source:
Journal of ethnopharmacology 2020 v.263 pp. 113144
ISSN:
0378-8741
Subject:
2,2-diphenyl-1-picrylhydrazyl; Ganoderma lucidum; Oriental traditional medicine; acetic acid; albino; amides; analgesic effect; analgesics; antioxidant activity; cell lines; dose response; edema; enzyme activity; enzymes; fatty acids; flow cytometry; fluorescence; free radical scavengers; hot plate test; image analysis; laboratory animals; liquid chromatography; mass spectrometry; medicinal fungi; mice; oils; oral administration; pain; topical application; transcription factor NF-kappa B; writhing test
Abstract:
... Lingzhi or Reishi - Ganoderma lucidum (Fr.) P. Karst is an extensively used medicinal mushroom in folklore and traditional medicine in south East Asia to treat a number of diseases. Lingzhi is known as ‘mushroom of immortality’ in Chinese folklore. In Traditional Chinese Medicine it is considered as a panacea to cure all diseases.Aim of the study: This study aims to evaluate antinociceptive effect ...
DOI:
10.1016/j.jep.2020.113144

23. Inhibition of human liver cancer cell growth by evodiamine involves apoptosis and deactivation of PI3K/AKT pathway

Author:
Jia Jia; Xigang Kang; Yanfang Liu; Jianwei Zhang
Source:
Applied biological chemistry 2020 v.63 no.1 pp. 67
ISSN:
2468-0834
Subject:
4',6-diamidino-2-phenylindole; Euodia; Oriental traditional medicine; alkaloids; antineoplastic activity; apoptosis; assays; cell growth; cell lines; cell movement; cytotoxicity; decline; exhibitions; humans; liver neoplasms; neoplasm cells; phosphatidylinositol 3-kinase; phosphorylation; proteins; staining; therapeutics; tissue repair
Abstract:
... Evodiamine is an active alkaloid member found in Traditional Chinese Herb (TCH) Evodia rutaecarpa. It has been reported to exhibit remarkable biological and medicinal activities including anticancer and anti-inflammatory. This study was designed to investigate the anticancer effects of evodiamine against human liver cancer and evaluate its effects on cell migration, cell invasion, cellular apoptos ...
DOI:
10.1186/s13765-020-00551-9

24. Lignans from Schisandra chinensis ameliorate alcohol and CCl4-induced long-term liver injury and reduce hepatocellular degeneration via blocking ETBR

Author:
Jin-Biao Xu; Guang-Chun Gao; Ming-Jing Yuan; Xuan Huang; Hong-Yu Zhou; Yang Zhang; Ya-Xin Zheng; Zhe Wu; Jun-Miao Feng; Ji-Ming Wu
Source:
Journal of ethnopharmacology 2020 v.258 pp. 112813
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Schisandra chinensis; Western blotting; antioxidants; apoptosis; blood serum; cell lines; computer simulation; disease severity; endoplasmic reticulum; endothelin receptors; enzymes; ethanol; fibrosis; genes; glutathione; hepatitis; hepatocytes; hepatoprotective effect; hepatotoxicity; histology; lignans; liver; liver cirrhosis; liver neoplasms; mice; microarray technology; middle-aged adults; models; patients; prediction; secretion; transforming growth factor beta 1; vines
Abstract:
... Chemical hepatotoxicity, especially alcoholic liver injury (ALI), commonly occurs in young and middle-aged people who drink heavily. ALI is extremely harmful and can induce severe disease states, such as hepatitis, liver fibrosis, cirrhosis, or liver cancer, which are similar to CCl₄-induced liver disease states in animals. In recent studies, the pathological changes of hepatocytes and the hepatic ...
DOI:
10.1016/j.jep.2020.112813

25. Lipidomics-based study on the neuroprotective effect of geissoschizine methyl ether against oxidative stress-induced cytotoxicity

Author:
Jiahong Sun; Fajing He; Yue Gao; Yanying Zhou; Huizhen Zhang; Min Huang; Huichang Bi
Source:
Journal of ethnopharmacology 2020 v.253 pp. 112636
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Uncaria; alkaloids; cardiolipins; cell death; cell lines; cytotoxicity; fatty acids; genes; glucose; glutamic acid; homeostasis; ingredients; lipid metabolism; lipid peroxidation; lipotoxicity; lysophosphatidylcholine; metabolomics; methyl ethers; mice; mitochondria; models; neurodegenerative diseases; neurodevelopment; neurons; neuroprotective effect; oxidative stress; oxidative toxicity; reactive oxygen species; sphingomyelins; synaptic transmission; triacylglycerols
Abstract:
... Lipid homoeostasis is important for neurodevelopment, cell signaling and neurotransmission. Alteration of lipid metabolism has been demonstrated in many neurological disorders and neurodegenerative diseases. Geissoschizine methyl ether (GM) is an active alkaloid ingredient in the traditional Chinese medicine Uncaria hook. It has been shown that GM has strong potency in neuroprotective activity and ...
DOI:
10.1016/j.jep.2020.112636

26. Matrine inhibits the growth of natural killer/T-cell lymphoma cells by modulating CaMKIIγ-c-Myc signaling pathway

Author:
Jianyou Gu; Yu Zhang; Xiao Wang; Jingjing Xiang; Shu Deng; Dijiong Wu; Junfa Chen; Lihong Yu; Yan Zhou; Yaokun Wang; Jianping Shen
Source:
BMC complementary medicine and therapies 2020 v.20 no.1 pp. 214
ISSN:
2662-7671
Subject:
Oriental traditional medicine; Sophora flavescens; alkaloids; alternative medicine; apoptosis; cell lines; cell proliferation; half life; phosphorylation; prognosis
Abstract:
... BACKGROUND: C-Myc overexpression is associated with poor prognosis and aggressive progression of natural killer/T-cell lymphoma (NKTCL). Matrine, a main alkaloid of the traditional Chinese herb Sophora flavescens Ait, has been shown to inhibit cellular proliferation and induce apoptosis of various cancer cells. The present study investigated the effects and possible mechanisms of matrine inhibitin ...
DOI:
10.1186/s12906-020-03006-2

27. Notopterygium incisum extract (NRE) rescues cognitive deficits in APP/PS1 Alzhneimer's disease mice by attenuating amyloid-beta, tau, and neuroinflammation pathology

Author:
Xiao-wen Jiang; Wen-wu Liu; Yu-ting Wu; Qiong Wu; Hong-yuan Lu; Zi-hua Xu; Hui-yuan Gao; Qing-chun Zhao
Source:
Journal of ethnopharmacology 2020 v.249 pp. 112433
ISSN:
0378-8741
Subject:
Alzheimer disease; Hansenia weberbaueriana; Lentivirus; Oriental traditional medicine; Western blotting; cell lines; cognition; cognitive disorders; dose response; elderly; enzyme inhibitors; enzyme-linked immunosorbent assay; hippocampus; interleukin-1beta; kidneys; liver; mice; models; paralysis; plant extracts; protein kinase C; psoralens; secretion; tau-protein kinase; tumor necrosis factor-alpha
Abstract:
... Alzheimer's disease (AD) is a frequently occurring disease of the elderly, and “deficiency” is the root of AD. Most famous experts of traditional Chinese medicine believe that the disease is based on deficiency, and the deficiency of kidney essence is the basis. Notopterygium incisum (Qiang huo) is beneficial to bladder, liver, and kidneys. It is used to treat liver and kidney deficiency, language ...
DOI:
10.1016/j.jep.2019.112433

28. Sophorasubprosrate polysaccharide suppress the inflammatory reaction of RAW264.7 cells infected with PCV2 via regulation NF-κB/MAPKs/c-Jun signal pathway and histone acetylation modification

Author:
Jian Yang; Mi-xia Cao; Wen-yue Hu; Ying-yi Wei; Ting-jun Hu
Source:
International journal of biological macromolecules 2020 v.159 pp. 957-965
ISSN:
0141-8130
Subject:
Oriental traditional medicine; Porcine circovirus-2; acetylation; cell lines; gene expression; histones; inflammation; interleukin-10; interleukin-6; macrophages; mice; phosphorylation; polysaccharides; secretion; signal transduction
Abstract:
... The purpose of this study was to investigate the regulation of Sophorasubprosrate polysaccharide (SSP) on inflammatory response and histone acetylation modification of RAW264.7 cells (mouse mononuclear macrophage cell line) infected with porcine circovirus type 2 (PCV2). We further explored the role of inflammatory response and histone acetylation modification on the basis of the original study. T ...
DOI:
10.1016/j.ijbiomac.2020.05.128

29. Structural characterization of centipede cyclic peptides and apoptosis induction potency evaluation in human gastric cancer cells

Author:
Feng Wang; Wei Li; Xiaolei Liu; Hongpeng Zhao; Jie Liu
Source:
Phytochemistry letters 2020 v.40 pp. 156-165
ISSN:
1874-3900
Subject:
Chilopoda; Oriental traditional medicine; antineoplastic activity; apoptosis; caspases; cell cycle; cell lines; cyclic peptides; cytotoxicity; humans; membrane potential; mitochondrial membrane; neoplasm cells; plant biochemistry; stomach neoplasms; therapeutics; thioredoxins; toxicity testing
Abstract:
... Centipede is a traditional Chinese medicine preparation widely used for gastrointestinal cancers. In this study, the structures of four novel and sixteen known centipede cyclic peptides (CCPs) were identified and their antigastrointestinal cancer potency elucidated. MTT assay demonstrated that CCP-1 [Cyclo-(L-Lys-L-His-L-Leu-L-Trp)] had excellent antitumor activity against the human tumor cell lin ...
DOI:
10.1016/j.phytol.2020.09.015

30. Transcriptional regulation of G2/M regulatory proteins and perturbation of G2/M Cell cycle transition by a traditional Chinese medicine recipe

Author:
Su Su Thae Hnit; Mu Yao; Chanlu Xie; Guangbo Ge; Ling Bi; Shenyi Jin; Lijing Jiao; Ling Xu; Lina Long; Hong Nie; Yu Jin; Linda Rogers; Natalka Suchowerska; Matthew Wong; Tao Liu; Paul De Souza; Zhong Li; Qihan Dong
Source:
Journal of ethnopharmacology 2020 v.251 pp. 112526
ISSN:
0378-8741
Subject:
DNA; DNA damage; Oldenlandia diffusa; Oriental traditional medicine; Scutellaria barbata; animals; cell lines; cyclins; disease prevention; herbal medicines; mechanism of action; messenger RNA; mitosis; neoplasm cells; neoplasm progression; oral administration; phase transition; promoter regions; prostatic neoplasms; reverse transcriptase polymerase chain reaction; transcription (genetics)
Abstract:
... Hedyotis diffusa Willd. (H) and Scutellaria barbata D.Don (S) are ancient anti-cancer Chinese herb medicines. When combined, known as HS, it is one of the most commonly prescribed Chinese Medicines for cancer patients today in China.The prevention of disease progression is a dominant concern for the growing number of men with prostate cancer. The purpose of this work is to evaluate the action and ...
DOI:
10.1016/j.jep.2019.112526

31. A metabolic investigation of anticancer effect of G. glabra root extract on nasopharyngeal carcinoma cell line, C666-1

Author:
Chaopan Zheng; Ling Han; Shihai Wu
Source:
Molecular biology reports 2019 v.46 no.4 pp. 3857-3864
ISSN:
0301-4851
Subject:
Glycyrrhiza glabra; Oriental traditional medicine; alanine; antineoplastic activity; apoptosis; aspartic acid; biomarkers; biosynthesis; carcinoma; cell lines; cysteine; drugs; gas chromatography-mass spectrometry; glutamic acid; glutamine; glutathione; lipid metabolism; metabolites; metabolome; metabolomics; methionine; neoplasm cells; patients; serine; stearic acid; therapeutics; threonine
Abstract:
... Although a majority of nasopharyngeal carcinoma (NPC) are undifferentiated and strongly radiosensitive, many NPC patients still have troubles in recurrence. Traditional Chinese medicine (TCM) is considered as potential therapeutic drugs in NPC. However, the effect of Glycyrrhiza glabra on NPC is limited. The present study shows the decreased proliferation and high apoptosis in G. glabra root extra ...
DOI:
10.1007/s11033-019-04828-1

32. Celastrol induces vincristine multidrug resistance oral cancer cell apoptosis by targeting JNK1/2 signaling pathway

Author:
Fu-Zhen Lin; Shih-Chung Wang; Yi-Ting Hsi; Yu-Sheng Lo; Chia-Chieh Lin; Yi-Ching Chuang; Shu-Hui Lin; Ming-Ju Hsieh; Mu-Kuan Chen
Source:
Phytomedicine 2019 v.54 pp. 1-8
ISSN:
0944-7113
Subject:
Oriental traditional medicine; apoptosis; caspase-3; caspase-8; caspase-9; cell cycle checkpoints; cell lines; drug therapy; herbal medicines; mortality; mouth neoplasms; multiple drug resistance; neoplasm cells; patients; proteins; signal transduction; surgery; triterpenoids; vincristine; Asia
Abstract:
... Oral cancers are one of the most aggressive malignancies, with high mortality rates globally. Patients with these cancers are treated using combination therapies including surgery, chemotherapy, and radiotherapy.Traditional Chinese medicines and other herbal medicines have been used to treat various diseases in Asia. Celastrol is a pentacyclic triterpenoid isolated from the Chinese herbal medicine ...
DOI:
10.1016/j.phymed.2018.09.181

33. Effects of traditional Chinese medicine formula Le-Cao-Shi on hepatitis B: In vivo and in vitro studies

Author:
Qing Zhao; Xia Ren; Min Chen; Shi-Jun Yue; Meng-Qi Zhang; Kai-Xian Chen; Yue-Wei Guo; Chang-Lun Shao; Chang-Yun Wang
Source:
Journal of ethnopharmacology 2019 v.244 pp. 112132
ISSN:
0378-8741
Subject:
Oriental traditional medicine; alanine transaminase; aspartate transaminase; biomarkers; cell lines; ducks; hepatitis B; hepatitis B antigens; histology; histopathology; in vitro studies; liver; models; poultry diseases; secretion; China
Abstract:
... Formula Le-Cao-Shi (LCS) is a traditional Chinese medicine (TCM), which has long been used as a folk remedy against hepatitis B in China. The present study was conducted to evaluate the anti-hepatitis B effects of aqueous extract of LCS in vivo and in vitro.we investigated the anti-HBV effects of LCS in vivo and in vitro with duck hepatitis B model and HepG2.2.15 cell line model, respectively. The ...
DOI:
10.1016/j.jep.2019.112132

34. Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

Author:
Cheng-Yao MA; Jia-Hui LU; Xiang LI; Xiao LIU; Jian-Wei CHEN
Source:
Chinese journal of natural medicines 2019 v.17 no.4 pp. 291-297
ISSN:
1875-5364
Subject:
Annona squamosa; Oriental traditional medicine; acetogenins; cell lines; cytotoxicity; multiple drug resistance; seeds; spectral analysis
Abstract:
... Eight new annonaceous acetogenins, squamotin A-D (1–4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compoun ...
DOI:
10.1016/S1875-5364(19)30032-9

35. Ethanolic extract of Cordyceps cicadae exerts antitumor effect on human gastric cancer SGC-7901 cells by inducing apoptosis, cell cycle arrest and endoplasmic reticulum stress

Author:
Hongqing Xie; Xiaotong Li; Yajie Chen; Mingzi Lang; Zhangfei Shen; Liangen Shi
Source:
Journal of ethnopharmacology 2019 v.231 pp. 230-240
ISSN:
0378-8741
Subject:
Cordyceps; Oriental traditional medicine; Western blotting; adenine; adenosine; antineoplastic activity; antineoplastic agents; apoptosis; calcium; caspase-12; caspase-3; caspase-6; caspase-8; caspase-9; cell cycle checkpoints; cell lines; cyclin-dependent kinase; cyclins; cytochrome c; cytosol; dose response; endoplasmic reticulum; endoplasmic reticulum stress; flow cytometry; fluorescent dyes; high performance liquid chromatography; humans; interphase; membrane potential; mitochondria; mitochondrial membrane; neoplasm cells; staining; stomach neoplasms; therapeutics; toxicity; toxicity testing; uridine
Abstract:
... Cordyceps cicadae (Miq.) Massee is a traditional Chinese medicine that has been used for approximately 1600 years in China. C. cicadae, a member of the Cordyceps genus, exerts a therapeutic effect on many diseases, such as cancer.This study aimed to evaluate the antineoplasmic activity of C. cicadae and to identify its molecular mechanism of cell death.The toxicity of the ethanolic extract of C. c ...
DOI:
10.1016/j.jep.2018.11.028

36. Ginseng extracts modulate mitochondrial bioenergetics of live cardiomyoblasts: a functional comparison of different extraction solvents

Author:
Yun Huang; Kenneth Kin Leung Kwan; Ka Wing Leung; Ping Yao; Huaiyou Wang; Tina Tingxia Dong; Karl Wah Keung Tsim
Source:
Journal of Ginseng Research 2019 v.43 no.4 pp. 517-526
ISSN:
1226-8453
Subject:
Oriental traditional medicine; Panax ginseng; cardiomyocytes; cell lines; energy metabolism; ethanol; functional foods; herbal medicines; mitochondria; oxidative stress; oxygen consumption; rats; research; Asia
Abstract:
... The root of Panax ginseng, a member of Araliaceae family, has been used as herbal medicine and functional food in Asia for thousands of years. According to Traditional Chinese medicine, ginseng is the most widely used “Qi-invigorating” herbs, which provides tonic and preventive effects by resisting oxidative stress, influencing energy metabolism, and improving mitochondrial function. Very few repo ...
DOI:
10.1016/j.jgr.2018.02.002

37. Investigation into perturbed nucleoside metabolism and cell cycle for elucidating the cytotoxicity effect of resveratrol on human lung adenocarcinoma epithelial cells

Author:
Zheng LI; Qian-Qian CHEN; Christopher Wai Kei LAM; Jian-Ru GUO; Wei-Jia ZHANG; Cai-Yun WANG; Vincent Kam Wai WONG; Mei-Cun YAO; Wei ZHANG
Source:
Chinese journal of natural medicines 2019 v.17 no.8 pp. 608-615
ISSN:
1875-5364
Subject:
DNA replication; Oriental traditional medicine; adenocarcinoma; antineoplastic activity; cell cycle checkpoints; cell lines; cytotoxicity; epithelial cells; humans; hydroxyurea; interphase; liquid chromatography; lungs; mass spectrometry; metabolism; metabolomics; nucleosides; resveratrol
Abstract:
... In an effort to understand the molecular events contributing to the cytotoxicity activity of resveratrol (RSV), we investigated its effects on human lung adenocarcinoma epithelial cell line A549 at different concentrations. Cellular nucleoside metabolic profiling was determined by an established liquid chromatography-mass spectrometry method in A549 cells. RSV resulted in significant decreases and ...
DOI:
10.1016/S1875-5364(19)30063-9

38. Mechanistic and therapeutic study of novel anti-tumor function of natural compound imperialine for treating non-small cell lung cancer

Author:
Qing Lin; Mengke Qu; Hirak K. Patra; Shanshan He; Luyao Wang; Xun Hu; Linyu Xiao; Yu Fu; Tao Gong; Qin He; Ling Zhang; Xun Sun; Zhirong Zhang
Source:
Journal of ethnopharmacology 2019 pp. -
ISSN:
0378-8741
Subject:
Fritillaria cirrhosa; Oriental traditional medicine; Western blotting; active ingredients; adverse effects; animal models; antineoplastic activity; antineoplastic agents; blood cell counts; cancer therapy; case studies; cell lines; cytotoxicity; drug delivery systems; enzyme-linked immunosorbent assay; films (materials); herbal medicines; histopathology; immunohistochemistry; in vivo studies; inflammation; lung neoplasms; mice; transcription factor NF-kappa B
Abstract:
... Bulbus Fritillaria cirrhosa D. Don (BFC) is a Chinese traditional herbal medicine that has long been used as an indispensable component in herbal prescriptions for bronchopulmonary diseases due to its well-established strong anti-inflammation and pulmonary harmonizing effects. Interestingly, there are few case reports in traditional Chinese medicine available where they found it to contribute in a ...
DOI:
10.1016/j.jep.2019.112283

39. Phenolic Acids from the Seeds of Sophora alopecuroides

Author:
Ping Song; Hao Chen; Yun Huang; Yanzhang Wen; Ji Hao; Yibing Lv; Shihao Deng; Xinzhou Yang
Source:
Chemistry of natural compounds 2019 v.55 no.5 pp. 835-838
ISSN:
0009-3130
Subject:
Oriental traditional medicine; Sophora alopecuroides; anticarcinogenic activity; cell lines; cytotoxicity; ethyl acetate; hepatoma; nuclear magnetic resonance spectroscopy; phenolic acids; seeds; spectral analysis
Abstract:
... Chemical profiling of the EtOAc extract from a traditional Chinese medicine Sophora alopecuroides yielded a new phenolic acid, (3S,2R)-methyl 2-(4-hydroxybenzyl)tartrate (1), along with four known compounds, eucomic acid (2), methyl eucomate (3), piscidic acid (4), and ethyl 2-(4-hydroxybenzyl)tartrate (5). The structure of 1 was determined by extensive spectral analyses including 1D and 2D NMR an ...
DOI:
10.1007/s10600-019-02826-0

40. Stability Designs of Cell Membrane Cloaked Magnetic Carbon Nanotubes for Improved Life Span in Screening Drug Leads

Author:
Qi Hu; Yusi Bu; Ruiqi Cao; Gao Zhang; Xiaoyu Xie; Sicen Wang
Source:
Analytical chemistry 2019 v.91 no.20 pp. 13062-13070
ISSN:
1520-6882
Subject:
Aconitum carmichaelii; Oriental traditional medicine; binding capacity; biomimetics; carbon nanotubes; cell growth; cell lines; cell membranes; longevity; magnetism; neoplasm cells; neoplasms; receptors; screening
Abstract:
... Convenient strategies to provide natural cell membranes (CMs)-camouflaged nanomaterials with enhanced stability would prompt the advancement of CMs-coated biomimetic technology and expand the application of these emerging nanomaterials. Herein, we have developed stability-enhanced CMs-camouflaged magnetic carbon nanotubes (MCNTs) to screen drug leads from traditional Chinese medicine (TCMs) that t ...
DOI:
10.1021/acs.analchem.9b03268

41. Synergistic Anticancer Effect of a Combination of Paclitaxel and 5-Demethylnobiletin Against Lung Cancer Cell Line In Vitro and In Vivo

Author:
Kok-Tong Tan; Shiming Li; Yi Rong Li; Shih-Lung Cheng; Sheng-Hao Lin; Yu-Tang Tung
Source:
Applied biochemistry and biotechnology 2019 v.187 no.4 pp. 1328-1343
ISSN:
0273-2289
Subject:
Oriental traditional medicine; active ingredients; adverse effects; antineoplastic activity; antineoplastic agents; apoptosis; caspase-3; caspase-8; caspase-9; cell lines; cell viability; drug synergism; drug therapy; flavones; herbs; lung neoplasms; mice; models; neoplasm cells; orange peels; paclitaxel; propidium
Abstract:
... Lung cancer remains a highly prevalent disease and a leading cause of cancer-related deaths worldwide. Currently, exploring antitumor drugs derived from herbs used in traditional Chinese medicine is increasingly becoming an attractive area of research. Paclitaxel (PTX), a highly effective chemotherapeutic drug, is widely used for treating different cancers; however, the clinical use of PTX is dose ...
DOI:
10.1007/s12010-018-2869-1

42. Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum

Author:
Peng-Cheng LIN; Lin-Lin JI; Xiang-Jian ZHONG; Jin-Jie LI; Xin WANG; Xiao-Ya SHANG; Sheng LIN
Source:
Chinese journal of natural medicines 2019 v.17 no.1 pp. 22-26
ISSN:
1875-5364
Subject:
Cirsium arvense; Oriental traditional medicine; animal ovaries; antineoplastic activity; cell lines; chemical structure; colorectal neoplasms; cytotoxicity; food plants; humans; inhibitory concentration 50; ovarian neoplasms; secretion; spectral analysis; triterpenoids; tumor necrosis factor-alpha
Abstract:
... Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD d ...
DOI:
10.1016/S1875-5364(19)30005-6

43. The Zuo Jin Wan Formula increases chemosensitivity of human primary gastric cancer cells by AKT mediated mitochondrial translocation of cofilin-1

Author:
Meng-Yao SUN; Dan-Dan WANG; Jian SUN; Xiao-Hua ZHAO; Si CAI; Qiu-Xue WU; Tao JIE; Zhen-Hua NI; Jian-Yue SUN; Qing-Feng TANG
Source:
Chinese journal of natural medicines 2019 v.17 no.3 pp. 198-208
ISSN:
1875-5364
Subject:
Oriental traditional medicine; Western blotting; apoptosis; cell lines; cell proliferation; cisplatin; drug therapy; flow cytometry; humans; mitochondria; models; neoplasm cells; patients; protein synthesis; staining; stomach neoplasms
Abstract:
... Resistance to cisplatin (DDP)-based chemotherapy is a major cause of treatment failure in human gastric cancer (GC). It is necessary to identify the drugs to re-sensitize GC cells to DDP. In our previous research, Zuo Jin Wan Formula (ZJW) has been proved could increase the mitochondrial apoptosis via cofilin-1 in a immortalized cell line, SGC-7901/DDP. Due to the immortalized cells may still diff ...
DOI:
10.1016/S1875-5364(19)30022-6

44. Two novel anthraquinones with cytotoxicity from Hedyotis caudatifolia

Author:
Yi Jing; Hai-Jiang Zhang; Kui-Wu Wang; Xiao-Xin Wang; Ming-Long Chen; Hong Wang; Bin Wu
Source:
Phytochemistry letters 2019 v.29 pp. 134-137
ISSN:
1874-3900
Subject:
Hedyotis; Oriental traditional medicine; anthraquinones; cell lines; chemotaxonomy; cytotoxicity; inhibitory concentration 50; neoplasm cells; nuclear magnetic resonance spectroscopy; physicochemical properties
Abstract:
... Seven anthraquinones, including two new natural products, hedyanthraquinones A and B (1, 2), were isolated from Hedyotis caudatifolia. The structures were elucidated based on NMR, MS data and physico-chemical properties. Compounds 1 and 2 displayed moderate cytotoxic activities against a panel of cultured tumor cell lines (HL-60, Bcap37, SMMC7721) with IC50 values of 13.71 ∼ 26.29 μM. The result s ...
DOI:
10.1016/j.phytol.2018.11.026

45. Venenum bufonis: An overview of its traditional use, natural product chemistry, pharmacology, pharmacokinetics and toxicology

Author:
Wen-Long Wei; Jin-Jun Hou; Xia Wang; Yang Yu; Hao-Jv Li; Zhen-Wei Li; Zi-Jin Feng; Hua Qu; Wan-Ying Wu; De-An Guo
Source:
Journal of ethnopharmacology 2019 v.237 pp. 215-235
ISSN:
0378-8741
Subject:
Bufo; Oriental traditional medicine; adverse effects; anesthetics; animals; antimicrobial properties; antineoplastic activity; bioavailability; biochemical pathways; bufadienolides; cardiotoxicity; cell lines; clinical trials; databases; diarrhea; heat stroke; hydroxylation; indole alkaloids; metabolites; neoplasm cells; neoplasms; new drugs; pain; pharmacodynamics; pharmacokinetics; secretion; toxicology; vomiting
Abstract:
... The animal medicine of Venenum Bufonis (VB), a product of the secretions of Bufo gargarizans Cantor or B. melanostictus Schneider, has long been used as a traditional Chinese medicine (TCM) for the treatment of sunstroke and faint, acute filthy disease - abdominal pain or vomiting and diarrhea, etc.This review is aimed at providing the comprehensive and up-to-date information of VB as regards its ...
DOI:
10.1016/j.jep.2019.03.042

46. A novel dual-luciferase assay for anti-HIV drug screening based on the CCR5/CXCR4 promoters

Author:
Long Feng; Wuhao Lu; Yunyun Ma; Wentao Guo; Yuanyuan Wang; Qianqian Sun; Jianbo Wu; Guoqiang Zhao; Xiaoli Zhang
Source:
Journal of virological methods 2018 v.256 pp. 17-23
ISSN:
0166-0934
Subject:
CCR5 receptor; CXCR4 receptor; Human immunodeficiency virus 1; Lampyridae; Oriental traditional medicine; T-lymphocytes; acquired immunodeficiency syndrome; antiretroviral agents; cell lines; clinical trials; dose response; drugs; luciferase; neoplasm cells; screening
Abstract:
... Acquired immunodeficiency syndrome (AIDS) is a serious worldwide disease caused by infection with the human immunodeficiency virus (HIV). C-C chemokine receptor 5 (CCR5) and C-X-C chemokine receptor 4 (CXCR4) are important coreceptors mediating HIV-1 cell entry. Many new anti-HIV drugs are currently in preclinical and clinical trials; however, drug development has proceeded slowly partly because o ...
DOI:
10.1016/j.jviromet.2018.02.016

47. Anti-hepatitis B virus effects of the traditional Chinese herb Artemisia capillaris and its active enynes

Author:
Chang-An Geng; Tong-Hua Yang; Xiao-Yan Huang; Jing Yang; Yun-Bao Ma; Tian-Ze Li; Xue-Mei Zhang; Ji-Jun Chen
Source:
Journal of ethnopharmacology 2018 v.224 pp. 283-289
ISSN:
0378-8741
Subject:
Artemisia capillaris; DNA replication; Oriental traditional medicine; cell lines; chromatography; chronic hepatitis; fractionation; hepatitis B antigens; inhibitory concentration 50; moieties; spectral analysis; structure-activity relationships; toxicity; viruses; China
Abstract:
... Artemisia capillaris (Yin-Chen) is a famous traditional Chinese medicine (TCM) for treating acute and chronic hepatitis in China. Enynes are one type of characteristic constituents in this herb, while their anti-hepatitis B virus (anti-HBV) properties have not been systemically investigated.This study is to reveal the active part of A. capillaris, and systemically investigate the enynes and their ...
DOI:
10.1016/j.jep.2018.06.005

48. Antiproliferative, antimigratory, and anticlonogenic effects of Hedyotis diffusa, Panax ginseng, and their combination on colorectal cancer cell lines

Author:
KetLi Ho; Ai Peng Lew; Yee Ching Ong; Yun Qian Lew; Zhi Hang Wong
Source:
Journal of herbs, spices & medicinal plants 2018 v.24 no.2 pp. 185-198
ISSN:
1540-3580
Subject:
Oldenlandia diffusa; Oriental traditional medicine; Panax ginseng; cell lines; cell proliferation; colorectal neoplasms; herbs; neoplasm cells; therapeutics
Abstract:
... Combinations of herbs are often used in traditional Chinese medicine (TCM) as the complex constituents of herbs could synergize in producing greater therapeutic efficacy. The combination of Hedyotis diffusa and Panax ginseng is commonly used to treat colorectal cancer in TCM. This study compared the antiproliferative, antimigratory, and anticlonogenic effects of these herbs when used individually ...
DOI:
10.1080/10496475.2018.1428919

49. Cell shape can be uncoupled from formononetin induction in a novel cell line from Callerya speciosa

Author:
Fei Qiao; Xue-fei Jiang; Han-qing Cong; Hua-peng Sun; Li Li; Peter Nick
Source:
Plant cell reports 2018 v.37 no.4 pp. 665-676
ISSN:
0721-7714
Subject:
Oriental traditional medicine; auxins; benzyladenine; cell culture; cell division; cell lines; cytokinins; elicitors; flagellin; formononetin; ingredients; jasmonic acid; medicinal plants; methyl jasmonate; necrosis; oryzalin; picloram
Abstract:
... KEY MESSAGE: It is the first time that formononetin produced by cell culture and its accumulation was shown to be triggered by specific stress signalling linked jasmonate pathway. Callerya speciosa, an endangered traditional Chinese medicine plant, is intensively used in traditional folk medicine. To develop sustainable alternatives for the overexploitation of natural resources, a suspension cell ...
DOI:
10.1007/s00299-018-2259-8

50. Chemical composition, in vitro anti-tumor activities and related mechanisms of the essential oil from the roots of Potentilla discolor

Author:
Jing Zhang; Ri-Zhen Huang; Hong-Jie Cao; An-Wei Cheng; Cheng-Shi Jiang; Zhi-Xin Liao; Chao Liu; Jin-Yue Sun
Source:
Industrial crops and products 2018 v.113 pp. 19-27
ISSN:
0926-6690
Subject:
DNA replication; Oriental traditional medicine; Potentilla; antineoplastic activity; antineoplastic agents; apoptosis; carbon dioxide; cell cycle; cell growth; cell lines; essential oils; gas chromatography-mass spectrometry; ingredients; inhibitory concentration 50; neoplasm cells; neoplasms; pharmaceutical industry; roots; supercritical fluid extraction
Abstract:
... Potentilla discolor has been used as the Traditional Chinese Medicine ingredient in prescription for over 400 years, and scientific evidences have confirmed its effectiveness as an anticancer agent. The present study is undertaken to assess, for the first time, the chemical composition, potential in vitro anti-tumor activities and related mechanisms of the essential oil, which was extracted from P ...
DOI:
10.1016/j.indcrop.2017.12.071