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1. ATP Hydrolysis Mechanism in a Maltose Transporter Explored by QM/MM Metadynamics Simulation B

Author:
Hsu, Wei-Lin; Furuta, Tadaomi; Sakurai, Minoru
Source:
The Journal of physical chemistry 2016 v.120 no.43 pp. 11102-11112
ISSN:
1520-5207
Subject:
ABC transporters; Gibbs free energy; adenosine; adenosine diphosphate; adenosine triphosphate; catalytic activity; cell membranes; dissociation; energy; heat production; hydrolysis; maltose; models; nitrogen; phosphates; physical chemistry
Abstract:
... Translocation of substrates across the cell membrane by adenosine 5′-triphosphate (ATP)-binding cassette (ABC) transporters depends on the energy provided by ATP hydrolysis within the nucleotide-binding domains (NBDs). However, the detailed mechanism remains unclear. In this study, we focused on maltose transporter NBDs (MalK₂) and performed a quantum mechanical/molecular mechanical (QM/MM) well-t ...
DOI:
10.1021/acs.jpcb.6b07332

2. Development of new chromatographic tools based on A2A adenosine receptor subtype for ligand characterization and screening by FAC-MS

Author:
Temporini, Caterina; Massolini, Gabriella; Marucci, Gabriella; Lambertucci, Catia; Buccioni, Michela; Volpini, Rosaria; Calleri, Enrica
Source:
Analytical and bioanalytical chemistry 2013 v.405 no.2-3 pp. 837-845
ISSN:
1618-2642
Subject:
adenosine; cell membranes; humans; ligands; liquid chromatography; receptors; screening; silica
Abstract:
... A liquid chromatographic stationary phase containing immobilized membranes from cells expressing A₂Aadenosine receptor (A₂AAR) is firstly described. Cellular membranes from CHO cells stably transfected with human A₂AAR vector (A₂A(+)) and from the same cell line transfected with the corresponding empty vector (A₂A(−)) were entrapped on immobilized artificial membrane (IAM) support and packed into ...
DOI:
10.1007/s00216-012-6353-4

3. Adenosine A₂B receptor antagonist suppresses differentiation to regulatory T cells without suppressing activation of T cells

Author:
Nakatsukasa, Hiroko; Tsukimoto, Mitsutoshi; Harada, Hitoshi; Kojima, Shuji
Source:
Biochemical and biophysical research communications 2011 v.409 no.1 pp. 114-119
ISSN:
0006-291X
Subject:
T-lymphocytes; adenosine; antagonists; cell membranes; immunity; interleukin-10; mice; receptors
Abstract:
... Extracellular adenosine activates P1 receptors (A₁, A₂A, A₂B, A₃) on cellular membranes. Here, we investigated the involvement of P1 receptor-mediated signaling in differentiation to regulatory T cells (Treg). Treg were induced in vitro by incubating isolated CD4⁺CD62L⁺ naïve murine T cells under Treg-skewing conditions. Antagonists of A₁ and A₂B receptors suppressed the expression of Foxp3, a spe ...
DOI:
10.1016/j.bbrc.2011.04.125

4. The Legionella Effector Protein DrrA AMPylates the Membrane Traffic Regulator Rab1b

Author:
Müller, Matthias P.; Peters, Heide; Blümer, Julia; Blankenfeldt, Wulf; Goody, Roger S.; Itzen, Aymelt
Source:
Science 2010 v.329 no.5994 pp. 946-949
ISSN:
0036-8075
Subject:
Legionella pneumophila; Legionnaires' disease; adenosine; bacteria; cell membranes; eukaryotic cells; guanosine diphosphate; guanosine triphosphate; guanosinetriphosphatase; phosphorylation; physiological transport; proteins; tyrosine; vacuoles
Abstract:
... In the course of Legionnaires' disease, the bacterium Legionella pneumophila affects the intracellular vesicular trafficking of infected eukaryotic cells by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole. In order to accomplish this, the Legionella protein DrrA contains a specific guanine nucleotide exchange activity for Rab1 ...
DOI:
10.1126/science.1192276

5. Characteristics of taurine release induced by free radicals in mouse hippocampal slices

Author:
Saransaari, P.; Oja, S. S.
Source:
Amino acids 2004 v.26 no.1 pp. 91-98
ISSN:
0939-4451
Subject:
adenosine; adults; agonists; antagonists; cell membranes; glutamic acid; hippocampus; hydrogen peroxide; hydroxylamine; ischemia; mice; neuroprotective effect; nitric oxide; receptors; taurine; transporters; tritium
Abstract:
... The release of the inhibitory neuromodulator taurine in the hippocampus is markedly enhanced under various neural cell-damaging conditions, including ischemia and exposure to free radicals. The properties and regulation of the release evoked by a medium containing free radicals was investigated in hippocampal slices from adult (3-month-old) and developing (7-day-old) mice, using a superfusion syst ...
DOI:
10.1007/s00726-003-0004-1

6. Possible therapeutic benefits of adenosine-potentiating drugs in reducing age-related degenerative disease in dogs and cats

Author:
Scaramuzzi, R.J.; Baker, D.J.
Source:
Journal of veterinary pharmacology and therapeutics 2003 v.26 no.5 pp. 327-335
ISSN:
0140-7783
Subject:
adenosine; central nervous system; smooth muscle; antagonists; cats; dogs; drugs; skeletal muscle; gonads; spaying; heart; cell membranes; pets; quality of life; immune system; receptors; agonists; enzyme inhibition; castration
Abstract:
... Adenosine is a ubiquitous, biologically important molecule that is a precursor of other biologically active molecules. It also is a component of some co-factors and has distinct physiological actions in its own right. Levels are maintained by synthesis from dietary precursors and re-cycling. The daily turnover of adenosine is very high. Adenosine can act either as a hormone by binding to adenosine ...
DOI:
10.1046/j.1365-2885.2003.00527.x
PubMed:
14633184