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- Zhou, Chi, et al. Show all 9 Authors
- Phytomedicine 2017 v.28 pp. 27-35
- Atractylodes; Western blotting; bioactive compounds; biochemical pathways; calcium; cell movement; cell proliferation; chemical constituents of plants; epithelial cells; flow cytometry; high performance liquid chromatography; inflammatory bowel disease; intestinal mucosa; medicinal properties; messenger RNA; peptic ulcers; polyamines; protein synthesis; quantitative polymerase chain reaction; rhizomes; sesquiterpenoid lactones; signal transduction; therapeutics; tissue repair
- ... An impairment of the integrity of the mucosal epithelial barrier can be observed in the course of various gastrointestinal diseases. The migration and proliferation of the intestinal epithelial (IEC-6) cells are essential repair modalities to the healing of mucosal ulcers and wounds. Atractylenolide I (AT-I), one of the major bioactive components in the rhizome of Atractylodes macrocephala Koidz. ...
- Zhou, Chi, et al. Show all 5 Authors
- Journal of ethnopharmacology 2015 v.159 pp. 23-35
- Atractylodes macrocephala; Oriental traditional medicine; Western blotting; alpha-difluoromethylornithine; antibodies; cell movement; computer software; confocal microscopy; derivatization; digestive system diseases; drugs; high performance liquid chromatography; immunity; intestinal mucosa; messenger RNA; models; myosin; patients; polystyrenes; protein synthesis; spermidine
- ... Atractylodes macrocephala Koidz (AMK), a valuable traditional Chinese herbal medicine, has been widely used in clinical practice for treating patients with disorders of the digestive system. AMK has shown noteworthy promoting effect on improving gastrointestinal function and immunity, which might represent a promising candidate for the treatment of intestinal mucosa injury. The aim of this study w ...