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You searched for: Author "Mancino, Marilena" Remove constraint Author: "Mancino, Marilena" Subject cell proliferation Remove constraint Subject: cell proliferation
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1. Modulating eIF6 levels unveils the role of translation in ecdysone biosynthesis during Drosophila development

Author:
Mancino, Marilena,   et al.   ; Russo, Arianna; Gatti, Guido; Alfieri, Roberta; Pesce, Elisa; Soanes, Kelly; Ricciardi, Sara; Cheroni, Cristina; Vaccari, Thomas; Biffo, Stefano; Calamita, Piera;     Show all 11 Authors
Source:
Developmental biology 2019 v.455 no.1 pp. 100-111
ISSN:
0012-1606
Subject:
Drosophila melanogaster; biochemical pathways; biogenesis; biosynthesis; cell proliferation; ecdysone; genes; mammals; models; phenotype; programmed cell death; protein synthesis; ribosomes; signal transduction; transcription factors; yeasts
Abstract:
... During development, ribosome biogenesis and translation reach peak activities, due to impetuous cell proliferation. Current models predict that protein synthesis elevation is controlled by transcription factors and signalling pathways. Developmental models addressing translation factors overexpression effects are lacking. Eukaryotic Initiation Factor 6 (eIF6) is necessary for ribosome biogenesis a ...
DOI:
10.1016/j.ydbio.2019.05.013