Author: "Beales, Jeremy T." / Subject: chemical reactions and free radical scavengers

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Author:: Beales, Jeremy T., et al. ; Mangum, Cathy L.; Munford, Mica B.; Sam, Alyssa B.; Young, Sandra K.; Subedi, Yagya Prasad; Mangum, Chad D.; Allen, Tanner J.; Liddell, Miranda S.; Merrell, Andrew I.; Saavedra, Diana I.; Williams, Becky J.; Evans, Nicole; Beales, Joseph L.; Christiansen, Michael A.; Show all 15 Authors
Source:: Tetrahedron letters 2019
ISSN:: 0040-4039
Subject:: chemical reactions; chemical structure; cytotoxicity; free radical scavengers; humans; inhibitory concentration 50; lung neoplasms; neoplasm cells; polyphenols
Abstract:: ... We here disclose the total syntheses of the natural polyphenol JBIR-94 and two nonnatural analogs, whose structures are of interest for their bioactivity potential as radical scavengers. Although we initially attempted this by dually acylating both of putrecine’s amine nitrogens in a single pot, our endeavors with this method (which has been successfully reported by other groups) proved ineffectua ...
DOI:: 10.1016/j.tetlet.2019.151360
: https://dx.doi.org/10.1016/j.tetlet.2019.151360