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1. Human exposure to a mixture of endocrine disruptors and serum levels of thyroid hormones: A cross-sectional study

Author:
Bing Yue; Shangyong Ning; Hongjian Miao; Congrong Fang; Jingguang Li; Lei Zhang; Yan Bao; Sai Fan; Yunfeng Zhao; Yongning Wu
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 641-649
ISSN:
1001-0742
Subject:
Bayesian theory; bisphenol A; bisphenol F; bisphenol S; blood serum; chemical species; confidence interval; cross-sectional studies; dose response; homeostasis; humans; metabolites; occupational exposure; perchlorates; phthalates; regression analysis; thiocyanates; thyroid function; triiodothyronine; China
Abstract:
... Exposure to endocrine disruptors (EDCs) could disrupt thyroid hormone homeostasis. However, human epidemiological studies reported inconsistent observations, and scarce information on the effect of a mixture of chemicals. The aim of the present study was to examine the associations of multiple chemicals with thyroid hormones among adults from China. We measured serum levels of thyroid hormones and ...
DOI:
10.1016/j.jes.2022.01.017

2. A CdSe/ZnS core/shell competitive quantum dot-based fluorescence-linked immunosorbent assay for the sensitive and accurate detection of aflatoxin B1 in corn sample

Author:
Yanbing Lv; Yifan Yang; Ruili Wu; Yanxia Xu; Jinjie Li; Ning Li; Huaibin Shen; Yujuan Chai; Lin Song Li
Source:
Journal of food measurement & characterization 2022 v.16 no.1 pp. 857-866
ISSN:
2193-4126
Subject:
aflatoxin B1; analytical kits; antibodies; chemical species; commercialization; corn; detection limit; enzyme-linked immunosorbent assay; food contamination; inhibitory concentration 50; measurement; metabolites; quantum dots; toxicity
Abstract:
... Aflatoxin B1 (AFB1), as the main metabolite, found in aflatoxin contaminated food is highly toxic and strictly controlled in many countries. Aiming to construct a simplified, highly sensitive, and accurate quantitative detection platform of AFB1 in ordinary conditions, a one-step competitive quantum dot-labeled immunosorbent assay (cQLISA) was developed using biocompatible CdSe/ZnS core/shell quan ...
DOI:
10.1007/s11694-021-01223-y

3. A Joint Technology Combining the Advantages of Capillary Microsampling with Mass Spectrometry Applied to the Trans-Resveratrol Pharmacokinetic Study in Mice

Author:
Ying Xu; Song-xia Zhang; Jing Guo; Li-jie Chen; Yu-ligh Liou; Tai Rao; Jing-bo Peng; Ying Guo; Wei-hua Huang; Zhi-rong Tan; Dong-sheng Ou-yang; Hong-hao Zhou; Wei Zhang; Yao Chen
Source:
Journal of Analytical Methods in Chemistry (Online) 2022 v.2022 pp. -
ISSN:
2090-8873
Subject:
blood; blood sampling; chemical species; chemistry; drugs; metabolites; mice; pharmacokinetics; quantitative analysis; sample size; tandem mass spectrometry
Abstract:
... Mice are the most frequently used animals in pharmacokinetic studies; however, collecting series of blood samples from mice is difficult because of their small sizes and tiny vessels. In addition, due to the small sample size, it is problematic to perform high required quantification. Thus, present work aims to find an effective strategy for overcoming these challenges using trans-resveratrol as a ...
DOI:
10.1155/2022/5952436

4. A QuEChERS-based UPLC-MS/MS method for rapid determination of organophosphate flame retardants and their metabolites in human urine

Author:
Zhi-Feng Chen; Ying-Tao Tang; Xiao-Liang Liao; Jie-Ru Jiang; Zenghua Qi; Zongwei Cai
Source:
Science of the total environment 2022 v.826 pp. 153989
ISSN:
0048-9697
Subject:
biphenyl; chemical species; environment; excretion; fire spread; humans; metabolites; organophosphorus compounds; phosphates; rapid methods; risk; urine
Abstract:
... Organophosphate flame retardants (OPFRs) have been widely used in consumer products to prevent fire spread. However, once released into the atmospheric environment, they may accumulate in humans and undergo metabolic transformation and excretion by urine. In order to clarify the human exposure to OPFRs, a quick, easy, cheap, effective, rugged, and safe method for the simultaneous determination of ...
DOI:
10.1016/j.scitotenv.2022.153989

5. A Rapid LC-MS/MS Method for Simultaneous Determination of Ten Flavonoid Metabolites of Naringin in Rat Urine and Its Application to an Excretion Study

Author:
Xuan Zeng; Yuying Zheng; Yan He; Wei Peng; Weiwei Su
Source:
Foods 2022 v.11 no.3 pp. -
ISSN:
2304-8158
Subject:
acetonitrile; chemical species; excretion; formic acid; metabolism; metabolites; methanol; naringin; rats; urine
Abstract:
... Naringin is a dietary flavonoid glycoside with multiple bioactivities. It has been involved in numerous metabolism and excretion studies, and its metabolic properties are clear. However, information concerning the excretion profile of its original metabolites are still scarce, and few methods for simultaneous determination of multiple original metabolites of naringin in biological samples have bee ...
DOI:
10.3390/foods11030316

6. A clinically validated method to separate and quantify underivatized acylcarnitines and carnitine metabolic intermediates using mixed-mode chromatography with tandem mass spectrometry

Author:
Carolina Luna; Chandler Griffin; Marcus J. Miller
Source:
Journal of chromatography 2022 v.1663 pp. 462749
ISSN:
0021-9673
Subject:
amino acid metabolism; beta oxidation; biomarkers; carnitine; chemical species; derivatization; humans; liquid chromatography; metabolites; mitochondria; patients; tandem mass spectrometry
Abstract:
... Acylcarnitines are intermediate metabolites of the mitochondria that serve as biomarkers for inherited disorders of fatty acid oxidation and amino acid metabolism. The prevailing clinical method used to quantify acylcarnitines involves flow-injection tandem mass spectrometry, an approach with a number of limitations; foremost the inability to separate and therefore distinguish key isobaric acylcar ...
DOI:
10.1016/j.chroma.2021.462749

7. A novel LC-MS/MS method for simultaneous estimation of acalabrutinib and its active metabolite acalabrutinib M₂₇ in human plasma and application to a human pharmacokinetic study

Author:
Venkat Rao Valluri; Naresh Kumar Katari; Chirag Khatri; Pankaj Kasar; Srinivasa Rao Polagani; Sreekanth Babu Jonnalagadda
Source:
RSC advances 2022 v.12 no.11 pp. 6631-6639
ISSN:
2046-2069
Subject:
acetonitrile; ammonium; chemical species; drugs; formates; formic acid; humans; liquid chromatography; liquid-liquid extraction; metabolites; pharmacokinetics; tandem mass spectrometry
Abstract:
... A simple, specific, selective and accurate bioanalytical method was developed and validated for simultaneous estimation of acalabrutinib and its active metabolite in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Deuterated analogs of both the analytes were used as internal standards. The extraction of analytes and internal standards were evaluated from the human pla ...
DOI:
10.1039/d1ra09026g

8. A novel electrochemical sensor for the detection of fipronil and its toxic metabolite fipronil sulfone using TiO2-polytriazine imide submicrostructured composite as an efficient electrocatalyst

Author:
Suzan El-Akaad; Roman Morozov; Mikhail Golovin; Oleg Bol'shakov; Sarah De Saeger; Natalia Beloglazova
Source:
Talanta 2022 v.238 pp. 123025
ISSN:
0039-9140
Subject:
carbon nitride; chemical species; composite materials; crystal structure; detection limit; electrochemistry; electrodes; fipronil; hot water treatment; metabolites; oxidation; pH; sensors (equipment); titanium dioxide; toxicity; voltammetry
Abstract:
... For the first time, a simple and sensitive electrochemical sensor based on a screen printed electrode (SPE) modified with titanium dioxide (TiO₂) and polytriazine imide submicrostructured composite (TiO₂-PTI) has been developed for the simultaneous detection of fipronil (FIP) and its toxic metabolite fipronil sulfone (FIP-S). The submicrostructured composite material based on TiO₂ and PTI was obta ...
DOI:
10.1016/j.talanta.2021.123025

9. A rapid HPLC–MS/MS method for the simultaneous determination of luteolin, resveratrol and their metabolites in rat plasma and its application to pharmacokinetic interaction studies

Author:
Wenying Wu; Kexin Li; Chen Zhao; Xiaohua Ran; Yu Zhang; Tianhong Zhang
Source:
Journal of chromatography 2022 v.1191 pp. 123118
ISSN:
1570-0232
Subject:
ammonium acetate; bioavailability; chemical species; daidzein; electrospray ionization mass spectrometry; formic acid; liver; luteolin; metabolites; methanol; naringenin; pharmacokinetics; polyphenols; rats; resveratrol; therapeutics; uridine
Abstract:
... Both luteolin (LUT) and resveratrol (RES) are natural polyphenols that exert therapeutic effects on liver injuries. Extensive glucuronidation by uridine diphosphate-glucuronosyltransferases 1As (UGT1As) results in poor bioavailability of LUT, which limits its clinical application. As an inhibitor of UGT1A1 and UGT1A9, RES may affect the bioavailability of LUT. The purpose of this study was to deve ...
DOI:
10.1016/j.jchromb.2022.123118

10. A rapid and robust method for amino acid quantification using a simple N-hydroxysuccinimide ester derivatization and liquid chromatography-ion mobility-mass spectrometry

Author:
Taylor M. Domenick; Austin L. Jones; Robin H. J. Kemperman; Richard A. Yost
Source:
Analytical and bioanalytical chemistry 2022 v.414 no.18 pp. 5549-5559
ISSN:
1618-2642
Subject:
acetic acid; amino acids; analytical chemistry; chemical species; derivatization; mass spectrometry; metabolites; metabolomics; neuroglia; reversed-phase liquid chromatography; yeast extract
Abstract:
... The vast majority of mass spectrometry (MS)-based metabolomics studies employ reversed-phase liquid chromatography (RPLC) to separate analytes prior to MS detection. Highly polar metabolites, such as amino acids (AAs), are poorly retained by RPLC, making quantitation of these key species challenging across the broad concentration ranges typically observed in biological specimens, such as cell extr ...
DOI:
10.1007/s00216-022-03993-w

11. A simple method for simultaneous determination of organophosphate esters and their diester metabolites in dairy products and human milk by using solid-phase extraction coupled to liquid chromatography-tandem mass spectrometry

Author:
Xuelei Chen; Nan Zhang; Liping Li; Rong Zhao; Ning Chen; Sai Fan; Zhixiong Shi
Source:
Analytical and bioanalytical chemistry 2022 v.414 no.14 pp. 4255-4265
ISSN:
1618-2642
Subject:
acetonitrile; analytical chemistry; breast milk; chemical species; enzymatic hydrolysis; esters; exposure assessment; freeze drying; humans; liquid chromatography; metabolites; milk; organophosphorus compounds; solid phase extraction; standard deviation; tandem mass spectrometry
Abstract:
... Organophosphate esters (OPEs) and their diester metabolites have been frequently found in various environmental matrices and regarded as emerging environmental pollutants, whereas data on their occurrence in foods and human matrices are still limited. In this study, a novel and simple procedure was developed to simultaneously determine 14 OPEs and 6 diester metabolites in dairy products and human ...
DOI:
10.1007/s00216-022-04079-3

12. Analysis of synthetic cannabinoids in wastewater of major cities in China

Author:
Xiaolin Fan; Jianhe Zhang; Xiaofang Fu; Bo Zhou; Zeqiong Xu; Hongmei Huang; Sheng Han; Xiqing Li
Source:
Science of the total environment 2022 v.827 pp. 154267
ISSN:
0048-9697
Subject:
ambient temperature; cannabinoids; chemical species; epidemiology; liquid chromatography; metabolites; tandem mass spectrometry; wastewater; China
Abstract:
... Synthetic cannabinoids (SCs) could pose serious health risks to its users. It is necessary to monitor its community consumption. Wastewater-based epidemiology is a potentially useful approach in this regard. However, limited research has been conducted to investigate the occurrence of SCs in wastewater. In this study, liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was optimized t ...
DOI:
10.1016/j.scitotenv.2022.154267

13. Analysis of tamoxifen and its main metabolites in plasma samples of breast cancer survivor female athletes: Multivariate and chemometric optimization

Author:
Tahereh Sadeghcheh; Mohammad Saber Tehrani; Hakim Faraji; Parviz Aberoomand Azar; Masoumeh Helalizadeh
Source:
Journal of separation science 2022 v.45 no.7 pp. 1362-1373
ISSN:
1615-9306
Subject:
breast neoplasms; chemical species; chemometrics; diodes; females; humans; hydrophobicity; ionic strength; liquid chromatography; liquid-phase microextraction; metabolites; multivariate analysis; pharmacodynamics; pharmacokinetics; separation; solvents; tamoxifen; therapeutics
Abstract:
... A sensitive method based on liquid chromatography combined with a diode array detector was developed and validated to simultaneously determine tamoxifen, and its active metabolites N‐desmethyltamoxifen, 4‐hydroxytamoxifen, and endoxifen in human plasma samples. The green and sustainable vortex‐assisted dispersive liquid‐phase microextraction technique based on the natural hydrophobic deep eutectic ...
DOI:
10.1002/jssc.202100899

14. Analytical method for sequential determination of persistent herbicides and their metabolites in fish tissues by UPLC–MS/MS

Author:
Cuifang Zhang; Zhuang Wang; Sheng Liu; Huihua Tan; Dongqiang Zeng; Xuesheng Li
Source:
Chemosphere 2022 v.288 pp. 132591
ISSN:
0045-6535
Subject:
acetochlor; atrazine; bioaccumulation; biotransformation; chemical species; deethylatrazine; fish; liver; metabolites; metolachlor; raw fish; tandem mass spectrometry; China
Abstract:
... A novel and accurate liquid chromatography–tandem mass spectrometry method was developed to sequentially determine three persistent herbicides (atrazine (ATZ), acetochlor (ACE), and metolachlor (MET)) and seven characteristic metabolites (desethylatrazine (DEA), deisopropylatrazine (DIA), diaminochlorotriazine (DACT), MET–oxanilic acid (MET-OA), MET-ethanesulfonic acid (MET-ESA), ACE-ESA, and ACE- ...
DOI:
10.1016/j.chemosphere.2021.132591

15. Aptapaper─An Aptamer-Functionalized Glass Fiber Paper Platform for Rapid Upconcentration and Detection of Small Molecules

Author:
Sandra Martínez-Jarquín; Alina Begley; Yin-Hung Lai; Giovanni Luca Bartolomeo; Adam Pruška; Christian Rotach; Renato Zenobi
Source:
Analytical chemistry 2022 v.94 no.14 pp. 5651-5657
ISSN:
1520-6882
Subject:
adsorption; analytical chemistry; chemical species; fluorescence microscopy; glass fibers; ionization; mass spectrometry; metabolites; oligonucleotides; paper; quinine; serotonin
Abstract:
... We tested a paper-based platform (“Aptapaper”) for the upconcentration and analysis of small molecules from complex matrices for two well-characterized aptamers, quinine and serotonin binding aptamers (QBA and SBA, respectively). After incubating the aptapaper under conditions that ensure correct aptamer folding, the aptapaper was used to upconcentrate target analytes from complex matrices. Aptapa ...
DOI:
10.1021/acs.analchem.2c00035

16. Au@PtPd enhanced immunoassay with 3D printed smartphone device for quantification of diaminochlorotriazine (DACT), the major atrazine biomarker

Author:
Xiaofan Ruan; Victoria Hulubei; Yijia Wang; Qiurong Shi; Nan Cheng; Limin Wang; Zhaoyuan Lyu; William C. Davis; Jordan N. Smith; Yuehe Lin; Dan Du
Source:
Biosensors & bioelectronics 2022 v.208 pp. 114190
ISSN:
0956-5663
Subject:
absorbance; antigens; atrazine; biomarkers; biosensors; chemical species; color; detection limit; humans; immunoaffinity chromatography; immunoassays; metabolites; mobile telephones; porous media; rapid methods; three-dimensional printing
Abstract:
... Increased use of pesticides in agriculture requires new advanced techniques to monitor both environmental levels and human exposure of pesticides to avoid potential adverse health outcomes in sensitive populations. Atrazine is widely used to control broadleaf weeds, and here we developed a new sensor capable of detecting diaminochlorotriazine (DACT), the major metabolite and biomarker of atrazine ...
DOI:
10.1016/j.bios.2022.114190

17. CE‐DAD‐MS/MS in the simultaneous determination and identification of selected antibiotic drugs and their metabolites in human urine samples

Author:
Katarzyna Pauter; Małgorzata Szultka‐Młyńska; Michał Szumski; Anna Król‐Górniak; Paweł Pomastowski; Bogusław Buszewski
Source:
Electrophoresis 2022 v.43 no.9-10 pp. 978-989
ISSN:
0173-0835
Subject:
amoxicillin; capillary electrophoresis; cefotaxime; chemical species; ciprofloxacin; clindamycin; diketopiperazines; electrolytes; humans; linezolid; metabolites; metronidazole; pH; sulfoxides; tandem mass spectrometry; temperature; urine
Abstract:
... In this study, a new analytical method was developed and validated for the simultaneous analysis of antibiotic drugs (amoxicillin, cefotaxime, ciprofloxacin, clindamycin, linezolid, metronidazole) and their metabolites (amoxycilloic acid, amoxicillin diketopiperazine, 3‐desacetyl cefotaxime lactone, clindamycin sulfoxide, ciprofloxacin piperazinyl‐N4‐sulfate, linezolid N‐oxide, metronidazole‐OH) i ...
DOI:
10.1002/elps.202100190

18. Capillary electrophoresis applied for the determination of acidity constants and limiting electrophoretic mobilities of ionizable herbicides including glyphosate and its metabolites and for their simultaneous separation

Author:
Hannes Georg Graf; Sonja Maria Biebl; Linda Müller; Christina Breitenstein; Carolin Huhn
Source:
Journal of separation science 2022 v.45 no.5 pp. 1128-1139
ISSN:
1615-9306
Subject:
acidity; beers; capillary electrophoresis; chemical species; computer software; glyoxylic acid; glyphosate; ionic strength; metabolites; pH; phosphates; phosphorous acid; sarcosines; separation; thermodynamics
Abstract:
... Thermodynamic acidity constants and limiting ionic mobilities were determined for polyprotic non‐chromophore analytes using capillary electrophoresis with capacitively coupled contactless conductivity detection. It was not necessary to work with buffers of identical ionic strength as ionic strength effects on effective electrophoretic mobilities were corrected by modeling during data evaluation (s ...
DOI:
10.1002/jssc.202100952

19. Comprehensive metabolic study of nicotine in equine plasma and urine using liquid chromatography/high-resolution mass spectrometry for the identification of unique biomarkers for doping control

Author:
Hideaki Ishii; Gary Ngai-Wa Leung; Shozo Yamashita; Shun-ichi Nagata; Asuka Kushiro; Satoshi Sakai; Kota Toju; Jun Okada; Kazumi Kawasaki; Kanichi Kusano; Isao Kijima-Suda
Source:
Journal of chromatography 2022 v.1190 pp. 123100
ISSN:
1570-0232
Subject:
Thoroughbred; biomarkers; chemical species; electrospray ionization mass spectrometry; liquid chromatography; liquids; metabolic studies; metabolism; metabolites; nicotine; risk; smoke; urine
Abstract:
... Nicotine is classified as a stimulant, and its use is banned in horse racing and equestrian sports by the International Federation of Horseracing Authorities and the Fédération Équestre Internationale, respectively. Because nicotine is a major alkaloid of tobacco leaves, there is a potential risk that doping control samples may be contaminated by tobacco cigarettes or smoke during sample collectio ...
DOI:
10.1016/j.jchromb.2022.123100

20. Determination of Daphnetin and its 8-O-Methylated Metabolite in Rat Plasma by UFLC-MS/MS: Application to a Pharmacokinetic Study

Author:
Zhongqiong Wang; Chengyi Wang; Bing He; Wei Zhang; Li Liu; Mingming Deng; Muhan Lü; Xiaoyi Qi; Sicheng Liang
Source:
Chromatographia 2022 v.85 no.4 pp. 333-341
ISSN:
0009-5893
Subject:
chemical species; drugs; intragastric administration; metabolites; pharmacokinetics; rats; spectrometers; stereoselectivity; tandem mass spectrometry; ultrafast liquid chromatography; vasculitis
Abstract:
... Daphnetin, which has been developed as a drug against obliterative vasculitis, can be rapidly and stereoselectively metabolized to an active 8-O-methylated metabolite, namely daphnetin 8-methyl ether (daphnetin-Me). Herein, a rapid, sensitive and reliable ultrafast liquid chromatography tandem mass spectrometry (UFLC-MS/MS) method was developed and validated to simultaneously determine daphnetin a ...
DOI:
10.1007/s10337-022-04131-5

21. Determination of atrazine and propazine metabolites deemed endocrine disruptors in human seminal plasma by LC–ESI-MS/MS

Author:
Virginia Rodríguez-Robledo; Alberto Vendrell; Alicia García-Cifuentes; Noemí Villaseca-González; Carmen Guiberteau-Cabanillas; Lydia Luque Martínez; José Julián Garde; María Rocío Fernández-Santos
Source:
Chemical and biological technologies in agriculture 2022 v.9 no.1 pp. 22
ISSN:
2196-5641
Subject:
agriculture; atrazine; bioaccumulation; chemical species; detection limit; electric potential difference; humans; male sterility; metabolites; propazine; seminal plasma; sperm quality; temperature
Abstract:
... BACKGROUND: The increasing prevalence of male infertility and the declining trend in sperm quality has been associated to compounds known as “endocrine-disruptors”. The proven endocrine-disrupting effects of atrazine and propazine herbicides led us to conduct long-term research based on highly accurate specific analytical methods with a view to confirming the suspected association. Among the propo ...
DOI:
10.1186/s40538-022-00285-4

22. Determination of fipronil and its metabolites in edible oil by pollen based solid-phase extraction combined with gas chromatography-electron capture detection

Author:
Yi-Lian Zhou; Shi-Wen Yue; Bing-Wei Cheng; Qin Zhao
Source:
Food chemistry 2022 v.377 pp. 132021
ISSN:
0308-8146
Subject:
absorption; chemical species; cooking fats and oils; detection limit; fipronil; food chemistry; gas chromatography; hydrogen bonding; markets; metabolites; particle size; pine pollen; solid phase extraction; sorbents
Abstract:
... In this study, a convenient and economic method for the determination of fipronil and its three metabolites in edible oil was developed based on pollen grain solid-phase extraction (SPE). As a natural material, pollen grains exhibit well absorption capacity for some polar compounds due to their special functional structures. Their stable composition and appropriate particle size also make them sui ...
DOI:
10.1016/j.foodchem.2021.132021

23. Development and Validation for Simultaneous Determination of Disulfoton and Its Five Metabolites in Seven Agro-Products Using Liquid Chromatography-Tandem Mass Spectrometry Combined with QuEChERS Extraction Method

Author:
Hui Li; Lingyi Pan; Chunsheng Yu; Xukun Zhang; Xueyan Cui; Ting Luo; Zhen Cao; Jing Wang; Qingxiao Li
Source:
Chromatographia 2022 v.85 no.6 pp. 529-537
ISSN:
0009-5893
Subject:
acaricides; chemical species; chickens; corn; disulfoton; food safety; liquid chromatography; markets; metabolites; milk; oats; peas; rice; sorbents; spectrometers; tandem mass spectrometry
Abstract:
... Disulfoton is highly toxic insecticide and acaricide. Food safety requires analysis of disulfoton and its five metabolites (disulfoton-sulfoxide, disulfoton-sulfone, demeton-S, demeton-S-sulfoxide, and demeton-S-sulfone). However, simultaneous determination of disulfoton and its metabolites in agro-products was not established, and the limits of quantification (LOQs) of reported methods could hard ...
DOI:
10.1007/s10337-022-04151-1

24. Development and evaluation of a simultaneous strategy for pyrimidine metabolome quantification in multiple biological samples

Author:
Feng Xu; Yuanyuan Pang; Qixing Nie; Zhipeng Zhang; Chuan Ye; Changtao Jiang; Yuan Wang; Huiying Liu
Source:
Food chemistry 2022 v.373 pp. 131405
ISSN:
0308-8146
Subject:
apoptosis; biosynthesis; brain; carbohydrates; chemical species; food chemistry; lipid metabolism; metabolites; metabolome; metabolomics; nucleic acids; pyrimidines; tandem mass spectrometry
Abstract:
... Pyrimidines are critical nutrients and key biomolecules in nucleic acid biosynthesis and carbohydrate and lipid metabolism. Here, we proposed the concept of the pyrimidine metabolome, which covers 14 analytes in pyrimidine de novo and salvage synthetic pathways, and established a novel analytical strategy with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to efficie ...
DOI:
10.1016/j.foodchem.2021.131405

25. Development and validation of a UHPLC-HRMS-QTOF method for the detection of 132 New Psychoactive Substances and synthetic opioids, including fentanyl, in Dried Blood Spots

Author:
Marta Massano; Carola Incardona; Enrico Gerace; Pierre Negri; Eugenio Alladio; Alberto Salomone; Marco Vincenti
Source:
Talanta 2022 v.241 pp. 123265
ISSN:
0039-9140
Subject:
acetonitrile; blood; blood sampling; chemical species; fentanyl; forensic sciences; mass spectrometry; metabolites; methanol; narcotics; toxicology
Abstract:
... Dried Blood Spots (DBS) represents a promising micro-sampling technique in the field of forensic toxicology to carry out minimally invasive blood sample collection. In DBS, cheap, fast and easy sampling is combined with effortless store and transport. These properties aimed us to develop and validate a quick and easy procedure for the detection of a large and diverse range of emerging and alarming ...
DOI:
10.1016/j.talanta.2022.123265

26. Development and validation of a new liquid chromatography-tandem mass spectrometry assay for the simultaneous quantification of afatinib, dacomitinib, osimertinib, and the active metabolites of osimertinib in human serum

Author:
Emi Ishikawa; Yuta Yokoyama; Haruna Chishima; Ouki Kuniyoshi; Itaru Sato; Naoki Nakaya; Hideo Nakajima; Motonori Kimura; Jun Hakamata; Naoya Suehiro; Hideo Nakada; Shinnosuke Ikemura; Aya Jibiki; Hitoshi Kawazoe; Hiroshi Muramatsu; Sayo Suzuki; Tomonori Nakamura
Source:
Journal of chromatography 2022 v.1199 pp. 123245
ISSN:
1570-0232
Subject:
Food and Drug Administration; blood serum; chemical species; drugs; epidermal growth factor; humans; liquid chromatography; lung neoplasms; metabolites; tandem mass spectrometry; therapeutics
Abstract:
... Reports on the therapeutic drug monitoring (TDM) of second- and third-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) in non-small cell lung cancer patients are limited and are required to improve the safety of EGFR-TKI therapy. Some EGFR-TKIs have active metabolites with similar or higher potency compared with the parent compounds; thus, monitoring the parent co ...
DOI:
10.1016/j.jchromb.2022.123245

27. Development and validation of a quantitative method for 15 antiviral drugs in poultry muscle using liquid chromatography coupled to tandem mass spectrometry

Author:
Clément Douillet; Mary Moloney; Melissa Di Rocco; Christopher Elliott; Martin Danaher
Source:
Journal of chromatography 2022 v.1665 pp. 462793
ISSN:
0021-9673
Subject:
antiviral agents; chemical species; chickens; ducks; electrospray ionization mass spectrometry; hydrophilic interaction chromatography; influenza; markets; metabolites; methanol; multiresidue analysis; muscles; poultry meat; quails; quantitative analysis; spectrometers; tandem mass spectrometry
Abstract:
... The objective of this work was to develop a quantitative multi-residue method for analysing antiviral drug residues and their metabolites in poultry meat samples. Antiviral drugs are not licensed for the treatment of influenza in food producing animals. However, there have been some reports indicating their illegal use in poultry. In this study, a method was developed for the analysis of 15 antivi ...
DOI:
10.1016/j.chroma.2021.462793

28. Development and validation of a rapid LC–MS/MS method for the confirmatory analysis of the bound residues of eight nitrofuran drugs in meat using microwave reaction

Author:
Gemma Regan; Mary Moloney; Melissa Di Rocco; Padraig McLoughlin; Wesley Smyth; Steven Crooks; Christopher Elliott; Martin Danaher
Source:
Analytical and bioanalytical chemistry 2022 v.414 no.3 pp. 1375-1388
ISSN:
1618-2642
Subject:
analytical chemistry; animal tissues; chemical species; derivatization; furaltadone; furazolidone; laws and regulations; liquid-liquid extraction; meat; metabolites; microwave treatment; monitoring; nitrofurantoin
Abstract:
... A rapid analytical method was developed and validated for the analysis of eight bound nitrofurans in animal tissue, shortening laboratory turnaround times from 4 to 2 days. The majority of methodologies for nitrofuran analysis focus on the detection of only four drugs (nitrofurantoin, furazolidone, furaltadone and nitrofurazone), and is time-consuming given the 16-h overnight derivatisation step a ...
DOI:
10.1007/s00216-021-03763-0

29. Development and validation of ultra-performance liquid chromatography-tandem mass spectrometric methods for simultaneous and rapid determination of contezolid and its major metabolite M2 in plasma and urine samples and its application to a study in subjects with moderate liver impairment

Author:
Yu Wang; Hailan Wu; Junzhen Wu; Yaxin Fan; Xiaofen Liu; Yi Li; Jiali Hu; Jing Zhang; Beining Guo
Source:
Journal of chromatography 2022 v.1191 pp. 123129
ISSN:
1570-0232
Subject:
acetonitrile; antibacterial properties; automation; chemical species; humans; liquid-liquid extraction; liver; metabolites; methicillin-resistant Staphylococcus aureus; pharmacokinetics; quality control; solid phase extraction; urine
Abstract:
... Contezolid is a novel oxazolidinone antibiotic with good antibacterial activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus. For the purpose to further characterize the pharmacokinetics of contezolid and its major metabolite M2, accurate and rapid ultra-performance liquid chromatography-tandem mass spectrometric assays (UPLC-MS/MS) were developed and valida ...
DOI:
10.1016/j.jchromb.2022.123129

30. Development of an analytical method based on solid-phase extraction and LC-MS/MS for the monitoring of current-use pesticides and their metabolites in human urine

Author:
Beibei Gao; Giulia Poma; Govindan Malarvannan; Catalina Dumitrascu; Michiel Bastiaensen; Minghua Wang; Adrian Covaci
Source:
Journal of environmental sciences (China) 2022 v.111 pp. 153-163
ISSN:
1001-0742
Subject:
acetamiprid; bifenthrin; chemical species; chlorpyrifos; chlorpyrifos-methyl; cyfluthrin; cypermethrin; deltamethrin; dicarboxylic acids; environmental monitoring; fipronil; humans; imidacloprid; liquid chromatography; malathion; metabolites; permethrin; pyrethrins; solid phase extraction; tandem mass spectrometry; thiacloprid; triazoles; urine; China
Abstract:
... Pyrethroids, organophosphorus pesticides and fipronil have been listed as priority chemicals in human biomonitoring studies because of their wide use and potential health effects in humans. The determination of 13 pesticides, including pyrethroids (deltamethrin, cypermethrin, permethrin, cyfluthrin, bifenthrin), organophosphorus (chlorpyrifos, chlorpyrifos-methyl, and malathion), fipronil, neonico ...
DOI:
10.1016/j.jes.2021.03.029

31. Development of analytical method for the determination of methylphenidate, the analog ethylphenidate and their metabolite ritalinic acid in oral fluid samples by micro-QuEChERS and liquid chromatography–tandem mass spectrometry

Author:
Kauê de Oliveira Chinaglia; Ana Carolina Furiozo Arantes; Kelly Francisco da Cunha; Eduardo Geraldo de Campos; Júlia Martinelli Magalhães Kahl; Leonardo Costalonga Rodrigues; Jose Luiz Costa
Source:
Journal of chromatography 2022 v.1205 pp. 123330
ISSN:
1570-0232
Subject:
calibration; chemical species; forensic sciences; freezers; liquid chromatography; metabolites; music; quantitative analysis; refrigerators; tandem mass spectrometry; toxicology; Brazil
Abstract:
... The aim of this study was to develop a quantitative method for the analysis of methylphenidate, the analog ethylphenidate and their metabolite ritalinic acid in oral fluid, using micro-QuEChERS extraction and liquid chromatography–tandem mass spectrometry (LC–MS/MS). Oral fluid samples were collected with Quantisal™ device, extracted by micro-QuEChERS technique and analyzed by LC–MS/MS. The develo ...
DOI:
10.1016/j.jchromb.2022.123330

32. Dietary Betaine and Fatty Acids Change Circulating Single-Carbon Metabolites and Fatty Acids in the Dog

Author:
Dennis E. Jewell; Matthew I. Jackson
Source:
Animals 2022 v.12 no.6 pp. -
ISSN:
2076-2615
Subject:
adults; alpha-linolenic acid; betaine; blood serum; carnitine; chemical species; docosahexaenoic acid; dogs; eicosapentaenoic acid; fish oils; flax; menhaden; metabolites; metabolomics; methionine; omega-3 fatty acids; sulfates; xenobiotics
Abstract:
... In order to evaluate the interaction of betaine and n-3 PUFA in foods consumed by the dog, six extruded dry foods were formulated. The control food had no specific source of added betaine or n-3 fatty acids, while the test foods were supplemented with betaine, flax or fish oil in a 2 × 3 factorial design (no added n-3 source, added flax, added menhaden fish oil, and all with or without added betai ...
DOI:
10.3390/ani12060768

33. Embossed Paper Platform for Whole Blood Collection, Room Temperature Storage, and Direct Analysis by Pinhole Paper Spray Mass Spectrometry

Author:
Benjamin S. Frey; Derik R. Heiss; Abraham K. Badu-Tawiah
Source:
Analytical chemistry 2022 v.94 no.10 pp. 4417-4425
ISSN:
1520-6882
Subject:
ambient temperature; analytical chemistry; blood; blood sampling; chemical species; cocaine; electrospray ionization mass spectrometry; health services; hydrophilicity; hydrophobicity; ionization; liquid chromatography; liquid-liquid extraction; metabolites; paper
Abstract:
... Dry-state microsampling techniques are convenient and advantageous for sample collection in resource-limited settings, including healthcare systems designed for the underserved population. In this work, a microsampling platform based on an embossed hydrophobic paper substrate is introduced together with three-dimensional (3D) printed cartridges that offer opportunities for rapid (<30 min) drying o ...
DOI:
10.1021/acs.analchem.1c05340

34. Enantioseparation and dissipation of acephate and its highly toxic metabolite methamidophos in pakchoi by supercritical fluid chromatography tandem mass spectrometry

Author:
Linjie Jiang; Yue Geng; Lu Wang; Yi Peng; Wei Jing; Yaping Xu; Xiaowei Liu
Source:
Journal of separation science 2022 v.45 no.10 pp. 1806-1817
ISSN:
1615-9306
Subject:
Brassica rapa subsp. chinensis; acephate; chemical species; enantiomers; enantioselectivity; metabolites; methamidophos; separation; supercritical fluid chromatography; tandem mass spectrometry; temperature; toxicity
Abstract:
... Acephate is widely used in crops as racemate. However, the enantioselective dissipation of acephate enantiomers has not been investigated in pakchoi. A sensitive and effective approach was established for determining residues of acephate and its highly toxic metabolite methamidophos enantiomers by supercritical fluid chromatography tandem mass spectrometry. Baseline separations for their enantiome ...
DOI:
10.1002/jssc.202200006

35. Evaluation of rapid and standard tandem mass spectrometric methods to analyse veterinary drugs and their metabolites in antemortem bodily fluids from food animals

Author:
Weilin L. Shelver; Shubhashis Chakrabarty; Jennifer M. Young; Christopher J. Byrd; David J. Smith
Source:
Food additives & contaminants 2022 v.39 no.3 pp. 462-474
ISSN:
1944-0057
Subject:
acetonitrile; calibration; cattle; chemical species; clenbuterol; electrospray ionization mass spectrometry; erythromycin; flunixin; fluorescence; hydrolysis; meloxicam; metabolites; ractopamine; slaughter; swine; tylosin; urine; zilpaterol hydrochloride
Abstract:
... Antemortem bodily fluids can serve as an indicator of veterinary medicine exposure prior to food animal slaughter. A multi-residue, rapid screen electrospray ionisation mass spectrometric (RS-ESI-MS) method was developed to analyse 10 veterinary drugs or metabolites (clenbuterol, erythromycin, flunixin, 5-hydroxyflunixin, meloxicam, ractopamine, ractopamine-glucuronide, salbutamol, tylosin, and zi ...
DOI:
10.1080/19440049.2021.2006801

36. Exposure to neonicotinoid insecticides and their characteristic metabolites: Association with human liver cancer

Author:
Hua Zhang; Renwen Zhang; Xujia Zeng; Xiao Wang; Desheng Wang; Hongling Jia; Weiguo Xu; Yunfei Gao
Source:
Environmental research 2022 v.208 pp. 112703
ISSN:
0013-9351
Subject:
acetamiprid; blood; chemical species; clothianidin; confidence interval; dinotefuran; guanidines; hepatotoxicity; hospitals; human health; humans; imidacloprid; liver neoplasms; metabolites; odds ratio; pest control; research; thiacloprid; thiamethoxam; urea; China
Abstract:
... Neonicotinoid insecticides (NEOs) are commonly applied for pest control in China and around the world. Previous studies reported that NEOs are hepatotoxic to mammals. However, limited studies have explored the associations between NEOs exposure and liver disease. In the present study, we detected six parent NEOs (p-NEOs), including acetamiprid, thiacloprid, dinotefuran, clothianidin, imidacloprid, ...
DOI:
10.1016/j.envres.2022.112703

37. Glutathione-Triggered catalytic response of Copper-Iron mixed oxide Nanoparticles. Leveraging tumor microenvironment conditions for chemodynamic therapy

Author:
Javier Bonet-Aleta; Maria Sancho-Albero; Javier Calzada-Funes; Silvia Irusta; Pilar Martin-Duque; Jose L. Hueso; Jesus Santamaria
Source:
Journal of colloid and interface science 2022 v.617 pp. 704-717
ISSN:
0021-9797
Subject:
analytical methods; antioxidants; apoptosis; catalytic activity; chemical species; glutathione; metabolism; metabolites; nanocatalysts; neoplasms; therapeutics; toxicity
Abstract:
... Heterogeneous catalysis has emerged as a promising alternative for the development of new cancer therapies. In addition, regarding the tumor microenvironment as a reactor with very specific chemical features has provided a new perspective in the search for catalytic nanoarchitectures with specific action against chemical species playing a key role in tumor metabolism. One of these species is gluta ...
DOI:
10.1016/j.jcis.2022.03.036

38. Human exposure to BTEX emitted from a typical e-waste recycling industrial park: External and internal exposure levels, sources, and probabilistic risk implications

Author:
Ranran Liu; Shengtao Ma; Daijin Chen; Guiying Li; Yingxin Yu; Ruifang Fan; Taicheng An
Source:
Journal of hazardous materials 2022 v.437 pp. 129343
ISSN:
0304-3894
Subject:
air; benzene; carcinogenicity; chemical species; electronic wastes; ethylbenzene; humans; metabolites; pollution; remediation; risk; toluene; xylene
Abstract:
... Benzene, toluene, ethylbenzene, and xylene (BTEX) can be released during extensive activities associated with the disposal of electronic waste (e-waste), which might pose deleterious health effects on workers. In this study, pollution profiles of BTEX in air and their urinary excretive profiles in occupational workers were investigated in a typical e-waste recycling industrial park. The results sh ...
DOI:
10.1016/j.jhazmat.2022.129343

39. Improvement of the QuEChERS extraction step by matrix-dispersion effect and application on beta-lactams analysis in wastewater sludge by LC-MS/MS

Author:
Alexandre Guironnet; Laure Wiest; Emmanuelle Vulliet
Source:
Talanta 2022 v.237 pp. 122923
ISSN:
0039-9140
Subject:
amoxicillin; cefoperazone; ceftiofur; chemical species; cloxacillin; liquid chromatography; medicine; metabolites; sand; sewage treatment; sludge; solvents; tandem mass spectrometry; wastewater
Abstract:
... In the last decade, beta-lactams use in veterinary and human medicine increased to represent today about 15% of the overall consumption. Beta-lactams tend to degrade and metabolize in the environment. Therefore, analytical methods must be sensitive enough to quantify low concentrations of the parent molecules and also allow detection of metabolites. This study presents the development of a modifie ...
DOI:
10.1016/j.talanta.2021.122923

40. Improvement on recovery and reproducibility for quantifying urinary mono-hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs)

Author:
Khue Nguyen; Masha Pitiranggon; Hui-Chen Wu; Esther M. John; Regina M. Santella; Mary Beth Terry; Beizhan Yan
Source:
Journal of chromatography 2022 v.1192 pp. 123113
ISSN:
1570-0232
Subject:
acetonitrile; chemical species; environmental monitoring; epidemiology; hydroxylation; metabolites; methanol; polymers; quality control; sodium acetate; solid phase extraction; solvents; urine; variance; New York
Abstract:
... Efficient and reproducible measurements of multiple polycyclic aromatic hydrocarbon (PAH) metabolites in urinary samples are required to evaluate the complex health effects of PAH exposure. Here, we demonstrate a highly practical, automated off-line solid-phase extraction (SPE) of deconjugated hydroxylated PAHs followed by LC-MS/MS to simultaneously measure eight mono-hydroxylated PAH compounds: 1 ...
DOI:
10.1016/j.jchromb.2022.123113

41. Improving the specificity of E. coli acetate/propionate exclusion biosensors via iterative engineering

Author:
Joseph B. Sweeney; Kevin McDonnell; Cormac D. Murphy
Source:
Enzyme and microbial technology 2022 pp. 110091
ISSN:
0141-0229
Subject:
Escherichia coli; Saccharomyces cerevisiae; acetates; acetyl coenzyme A; bacteriophages; biosensors; catabolism; chemical species; formate dehydrogenase; formates; gas production (biological); leachates; lignocellulose; metabolites; propionic acid; technology
Abstract:
... Real-time monitoring of key performance indicator analytes such as acetate and propionate within anaerobic digestors (AD) is required for optimum biogas production. In this paper the further refinement of acetate and propionate whole cell (E. coli) exclusion biosensors is reported following an iterative process in which key metabolites that might interfere with O₂-uptake measurements are identifie ...
DOI:
10.1016/j.enzmictec.2022.110091

42. In Silico Method Development of Achiral and Chiral Tandem Column Reversed-phase Liquid Chromatography for Multicomponent Pharmaceutical Mixtures

Author:
Imad A. Haidar Ahmad; Alaina Kiffer; Rodell C. Barrientos; Gioacchino Luca Losacco; Andrew Singh; Vladimir Shchurik; Heather Wang; Ian Mangion; Erik L. Regalado
Source:
Analytical chemistry 2022 v.94 no.9 pp. 4065-4071
ISSN:
1520-6882
Subject:
analytical chemistry; chemical species; computer simulation; computer software; cost effectiveness; cyclic peptides; landscapes; metabolites; reversed-phase liquid chromatography
Abstract:
... Tandem column liquid chromatography (LC) is a convenient, cost-effective approach to resolve multicomponent mixtures by serially coupling columns on readily available one-dimensional separation systems without specialized user training. Yet, adoption of this technique remains limited, mainly due to the difficulty in identifying optimal selectivity out of many possible tandem column combinations. A ...
DOI:
10.1021/acs.analchem.1c05551

43. LC-MS/MS Method for Determination of Hydroxychloroquine and Metabolites: Application in a Pharmacokinetic Study

Author:
Lili Cui; Zhipeng Wang; Shi Qiu; Mengwei Zhang; Yanping Liu; Fengjing Xu; Xinhua Song; Shouhong Gao; Wansheng Chen
Source:
Journal of Analytical Methods in Chemistry (Online) 2022 v.2022 pp. -
ISSN:
2090-8873
Subject:
animal models; antimalarials; blood; chemical species; half life; humans; immunomodulation; liquid chromatography; metabolites; pharmacokinetics; rats; tandem mass spectrometry
Abstract:
... Hydroxychloroquine (HCQ) was originally used as an antimalarial and immunomodulation drug. We developed and validated a simple and sensitive ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for simultaneous quantitation of HCQ and its three metabolites in rat blood, and reported their pharmacokinetic parameters. The chromatographic separation and detection ...
DOI:
10.1155/2022/6058445

44. Liquid Chromatography Method for Simultaneous Quantification of ATP and its Degradation Products Compatible with both UV-Vis and Mass Spectrometry

Author:
Andrew S. Law; Paul S. Hafen; Jeffrey J. Brault
Source:
Journal of chromatography 2022 pp. 123351
ISSN:
1570-0232
Subject:
ammonium acetate; chemical species; high performance liquid chromatography; hindlimbs; mass spectrometry; metabolites; mice; phosphates; ultra-performance liquid chromatography
Abstract:
... ATP and its degradation products are essential metabolic and signaling molecules. Traditionally, they have been quantified via high-performance liquid chromatography (HPLC) with UV-Vis detection while utilizing phosphate buffer mobile phase, but this approach is incompatible with modern mass detection. The goal of this study was to develop an ultra-performance liquid chromatography (UPLC) method f ...
DOI:
10.1016/j.jchromb.2022.123351

45. Measurement of 5- fluorouracil, capecitabine and its metabolite concentrations in blood using volumetric absorptive microsampling technology and LC-MS/MS

Author:
Mirjana Radovanovic; Jennifer J. Schneider; Mohsen Shafiei; Jennifer H. Martin; Peter Galettis
Source:
Journal of chromatography 2022 v.1188 pp. 123075
ISSN:
1570-0232
Subject:
acetonitrile; ambient temperature; blood sampling; cancer therapy; chemical species; electrospray ionization mass spectrometry; fluorouracil; formic acid; health services; isotope labeling; liquid chromatography; metabolites; pharmacokinetics; toxicity
Abstract:
... 5-fluorouracil (5-FU) and its oral formulation, capecitabine, are widely used in treating a range of malignancies, either alone or in combination with other antineoplastic drugs. Body surface area-based dosing is used for these agents, despite this approach leading to substantial variability in drug exposure and often resulting in either toxicity or treatment failure. Tailoring therapeutic regimen ...
DOI:
10.1016/j.jchromb.2021.123075

46. Microbial selenate detoxification linked to elemental sulfur oxidation: Independent and synergic pathways

Author:
Liuliu Li; Baogang Zhang; Lei Li; Alistair G.L. Borthwick
Source:
Journal of hazardous materials 2022 v.422 pp. 126932
ISSN:
0304-3894
Subject:
Thiobacillus; bioprocessing; chemical species; human health; hydrogen; metabolites; methane; mixed culture; oxidation; selenates; selenites; selenium; sulfur
Abstract:
... Elevated selenium levels in the environment, with soluble selenate [Se(VI)] as the common chemical species, pose a severe threat to human health. Anaerobic Se(VI) bioreduction is a promising approach for selenium detoxification, and various organic/inorganic electron donors have proved effective in supporting this bioprocess. Nevertheless, autotrophic Se(VI) bioreduction driven by solid inorganic ...
DOI:
10.1016/j.jhazmat.2021.126932

47. Minimum variance optimized Fisher ratio analysis of comprehensive two-dimensional gas chromatography / mass spectrometry data: Study of the pacu fish metabolome

Author:
Sonia Schöneich; Grant S. Ochoa; Celina M. Monzón; Robert E. Synovec
Source:
Journal of chromatography 2022 v.1667 pp. 462868
ISSN:
0021-9673
Subject:
Piaractus mesopotamicus; algorithms; automation; chemical species; comprehensive two-dimensional gas chromatography; derivatization; farmed fish; metabolites; metabolome; rice; variance; Argentina
Abstract:
... Integration of rice and fish farming, eg., pacu fish in Argentina, has raised concern that herbicides used for rice paddies may adversely affect the fish metabolome. To study this issue, tile-based Fisher ratio (F-ratio) analysis was applied to comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC × GC-TOFMS) data of pacu fish raised in an integrated rice-fish ...
DOI:
10.1016/j.chroma.2022.462868

48. NIR-I fluorescence imaging tumorous methylglyoxal by an activatable nanoprobe based on peptide nanotubes by FRET process

Author:
Jin Liu; Min Li; Yijing Dang; Haiming Lou; Zhiai Xu; Wen Zhang
Source:
Biosensors & bioelectronics 2022 v.204 pp. 114068
ISSN:
0956-5663
Subject:
bioimaging; biosensors; chemical species; detection limit; energy transfer; fluorescence; glycolysis; metabolites; nanotubes; neoplasms; peptides; water solubility; wavelengths
Abstract:
... Methylglyoxal (MGO), a glycolysis metabolite with high reactivity, can nonenzymatically modify proteins, lipids and nucleic acids etc., and it is closely related to the development of tumors. The accurate detection and high-performance optical imaging of MGO from deep tumor issues is of great significance for understanding their roles in tumor initiation and progression. Herein, we have presented ...
DOI:
10.1016/j.bios.2022.114068

49. Nanoconfined liquid phase nanoextraction combined with in-fiber derivatization for simultaneous quantification of seventy amino-containing metabolites in plasma by LC-MS/MS: Exploration of lung cancer screening model

Author:
Chunyu Yu; Qian Zhang; Liyuan Wang; Yiwen Zhang; Meiyu Cui; Kaishun Bi; Donghao Li; Qing Li
Source:
Talanta 2022 v.245 pp. 123452
ISSN:
0039-9140
Subject:
biomarkers; carbon nanofibers; chemical species; chlorides; cost effectiveness; derivatization; desorption; drugs; liquids; lung neoplasms; metabolites; metabolomics; models; nucleosides; regression analysis; response surface methodology; solvents
Abstract:
... Targeted metabolomics with absolute quantification is widely applied in biomarker identification and drug screening. However, due to the complexity of biological matrix and trace amount of metabolites in plasma, simultaneous quantification of highly polar metabolites in plasma with broad coverage in short time is still challenging. Herein, we proposed a nanoconfined liquid phase nanoextraction (NL ...
DOI:
10.1016/j.talanta.2022.123452

50. Nitrous oxide abuse in the emergency practice, and Review of toxicity mechanisms and potential markers

Author:
Marie Joncquel Chevalier-Curt; Guillaume Grzych; Céline Tard; Julien Lannoy; Sylvie Deheul; Riyad Hanafi; Claire Douillard; Joseph Vamecq
Source:
Food and chemical toxicology 2022 v.162 pp. 112894
ISSN:
0278-6915
Subject:
DNA; RNA; S-adenosylmethionine; arginine; betaine; chemical species; cobalt; cystathionine; folic acid; glutathione; homocysteine; metabolites; methionine synthase; methylation; methylmalonyl-coenzyme A; nitrous oxide; oxidation; pathogenesis; protein arginine methyltransferases; retrospective studies; sarcosines; toxicity; toxicology; tricarboxylic acid cycle; vitamin B12
Abstract:
... Nitrous oxide (N₂O) toxicity is a concern common to several medical fields. Here, retrospective study of four N₂O abuses with neurological signs in the emergency practice provides a preliminary basis for a metabolic Discussion/Review. This latter highlights N₂O abuse as pathology of DNA/RNA/protein methylations, for instance consistent with impairments of protein arginine methyltransferases involv ...
DOI:
10.1016/j.fct.2022.112894