PubAg

Main content area

You searched for: Author wenhan Remove constraint Author: wenhan Subject chemical structure Remove constraint Subject: chemical structure
Start Over

Search

39  Search Results

« Previous | 1 - 20 of 39 |
Number of results to display per page

Search Results

1. DMOA-based meroterpenoids with diverse scaffolds from the sponge-associated fungus Penicillium brasilianum

Author:
Lin, Wenhan,   et al.   ; Zhang, Jianping; Wu, Yifan; Yuan, Bochuan; Liu, Dong; Zhu, Kui; Huang, Jian; Proksch, Peter;     Show all 8 Authors
Source:
Tetrahedron 2019 v.75 no.14 pp. 2193-2205
ISSN:
0040-4020
Subject:
Penicillium brasilianum; X-ray diffraction; actin; bacteria; bioinformatics; chemical structure; chromatography; ethyl acetate; fermentation; fungi; multigene family; polymerization; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; spectral analysis; synthetic genes
Abstract:
... Bioinformatics analysis of the synthetic gene clusters in association with the qRT-PCR detection led to speculate a marine derived fungus, Penicillium brasilianum WZXY-m122-9, to be potential to produce meroterpenoids. Chromatographic separation of the EtOAc extract of this fungal strain on a large-scale fermentation resulted in the isolation of six new DMOA-related meroterpenoids, namely brasilia ...
DOI:
10.1016/j.tet.2019.02.037

2. Eremophilane-type sesquiterpenoids in a deep-sea fungus Eutypella sp. activated by chemical epigenetic manipulation

Author:
Lin, Wenhan,   et al.   ; Niu, Siwen; Liu, Dong; Shao, Zongze; Proksch, Peter;     Show all 5 Authors
Source:
Tetrahedron 2018 v.74 no.51 pp. 7310-7325
ISSN:
0040-4020
Subject:
Eutypella; X-ray diffraction; chemical reactions; chemical structure; chromatography; enzyme inhibitors; epigenetics; fungi; histone deacetylase; lipopolysaccharides; macrophages; metabolites; nitric oxide; nuclear magnetic resonance spectroscopy; sesquiterpenoids
Abstract:
... Cultivation of a deep-sea-derived fungus Eutypella sp. MCCC 3A00281 by a chemical epigenetic manipulation using suberohydroxamic acid (SBHA), a histone deacetylase inhibitor (HDI), resulted in the significant change of the metabolite profile. Chromatographic application of the extended metabolites led to the isolation of a total of 30 eremophilane-type sesquiterpenoids, of which 26 were identified ...
DOI:
10.1016/j.tet.2018.10.056

3. Eutypellazines N−S, new thiodiketopiperazines from a deep sea sediment derived fungus Eutypella sp. with anti-VRE activities

Author:
Lin, Wenhan,   et al.   ; Niu, Siwen; Liu, Dong; Shao, Zongze; Proksch, Peter;     Show all 5 Authors
Source:
Tetrahedron letters 2017
ISSN:
0040-4039
Subject:
Enterococcus; Eutypella; alkaloids; bacteria; chemical reactions; chemical structure; drug resistance; fungi; marine sediments; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... Chemical investigation of a deep sea sediment derived fungus Eutypella sp. MCCC 3A00281 resulted in the isolation of six new thiodiketopiperazine alkaloids, namely eutypellazines N-S (1-6). Their structures were elucidated on the basis of the extensive NMR and mass spectroscopic analysis, including the ECD data for the determination of absolute configuration. The structures of eutypellazines N-P ( ...
DOI:
10.1016/j.tetlet.2017.08.015

4. Inducing new secondary metabolites through co-cultivation of the fungus Pestalotiopsis sp. with the bacterium Bacillus subtilis

Author:
Lin, Wenhan,   et al.   ; Liu, Shuai; Dai, Haofu; Heering, Christian; Janiak, Christoph; Liu, Zhen; Proksch, Peter;     Show all 7 Authors
Source:
Tetrahedron letters 2017 v.58 pp. 257-261
ISSN:
0040-4039
Subject:
Bacillus subtilis; Fabaceae; Pestalotiopsis; axenic culture; bacteria; chemical reactions; chemical structure; coculture; endophytes; fruits; fungi; lactones; nuclear magnetic resonance spectroscopy; secondary metabolites; sesquiterpenoids
Abstract:
... Two new lactones, pestalotiolactones A (1) and B (2), together with three known compounds (3–5) were isolated from the axenic culture of the endophytic fungus Pestalotiopsis sp., obtained from fruits of Drepanocarpus lunatus (Fabaceae). Co-culture of this fungus with Bacillus subtilis afforded two new sesquiterpenoids pestabacillins A (6) and B (7) as well as eight known compounds (8–15). Their st ...
DOI:
10.1016/j.tetlet.2016.12.026

5. Chartarolides A-C, novel meroterpenoids with antitumor activities

Author:
Lin, Wenhan,   et al.   ; Liu, Dong; Li, Yong; Li, Xiaodan; Cheng, Zhongbin; Huang, Jian; Proksch, Peter;     Show all 7 Authors
Source:
Tetrahedron letters 2017
ISSN:
0040-4039
Subject:
Stachybotrys; antineoplastic activity; chemical reactions; chemical structure; cytotoxicity; fibroblast growth factor receptor 3; fungi; humans; neoplasm cells; nuclear magnetic resonance spectroscopy; organic compounds; spectral analysis
Abstract:
... Three phenylspirodrimane-based meroterpenoids with novel scaffolds, namely chartarolides A-C (1-3), were isolated from a sponge (Niphates recondite) associated fungus Stachybotrys chatarum WGC-25C-6. Their structures were determined on the basis of comprehensive analyses of the spectroscopic data (IR, 1D and 2D NMR, HRESIMS), including the TDDFT-ECD calculation for the assignments of absolute conf ...
DOI:
10.1016/j.tetlet.2017.03.079

6. Fragilolides A-Q, norditerpenoid and briarane diterpenoids from the gorgonian coral Junceella fragilis

Author:
Lin, Wenhan,   et al.   ; Cheng, Wei; Ji, Ming; Li, Xiaodan; Ren, Jinwei; Yin, Fuling; van Ofwegen, Leen; Yu, Siwang; Chen, Xiaoguang;     Show all 9 Authors
Source:
Tetrahedron 2017
ISSN:
0040-4020
Subject:
Hepatitis B virus; Junceella; X-ray diffraction; anticarcinogenic activity; chemical reactions; chemical structure; corals; diterpenoids; hepatitis B antigens; macrophages; neoplasm cells; nitric oxide; spectral analysis; transcription factor NF-kappa B
Abstract:
... Chemical investigation of the gorgonian coral Junceella fragilis resulted in the isolation of a new norditerpenoid fragilolide A (1), sixteen new briarane diterpenoids fragilolides B-Q (2–17), together with frajunolides H and N, and three known norcembranoids scabrolide D, sinuleptolide and 5-epi-sinuleptolide. The structures of new compounds were determined on the basis of extensive spectroscopic ...
DOI:
10.1016/j.tet.2017.03.037

7. New amides from the fruits of Piper retrofractum

Author:
Lin, Wenhan,   et al.   ; Muharini, Rini; Liu, Zhen; Proksch, Peter;     Show all 4 Authors
Source:
Tetrahedron letters 2015 v.56 no.19 pp. 2521-2525
ISSN:
0040-4039
Subject:
Cladosporium cladosporioides; Piper retrofractum; amides; antifungal properties; biochemical pathways; chemical reactions; chemical structure; cytotoxicity; fruits; fungi; growth retardation; inhibitory concentration 50; mice; neoplasm cells; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... Three new amides, (2E,14Z)-N-isobutyleicosa-2,14-dienamide (1), dipiperamides F and G (2 and 3), together with 30 known compounds were isolated from the fruits of Piper retrofractum. Their structures were elucidated by extensive spectroscopic analyses including 1D and 2D NMR as well as MS, and by comparison with the literature. A plausible biosynthetic pathway leading to the amides isolated in thi ...
DOI:
10.1016/j.tetlet.2015.03.116

8. Inducing secondary metabolite production by the endophytic fungus Chaetomium sp. through fungal–bacterial co-culture and epigenetic modification

Author:
Lin, Wenhan,   et al.   ; Akone, Sergi Herve; Mándi, Attila; Kurtán, Tibor; Hartmann, Rudolf; Daletos, Georgios; Proksch, Peter;     Show all 7 Authors
Source:
Tetrahedron 2016 v.72 pp. 6340-6347
ISSN:
0040-4020
Subject:
4-hydroxybenzoic acid; Bacillus subtilis; Chaetomium; antibacterial properties; bacteria; chemical reactions; chemical structure; coculture; cytotoxicity; endophytes; epigenetics; esters; fungi; inhibitory concentration 50; lymphoma; mice; polyketides; protocatechuic acid; rice; secondary metabolites
Abstract:
... Co-culturing the fungal endophyte Chaetomium sp. with the bacterium Bacillus subtilis on solid rice medium resulted in an up to 8.3-fold increase in the accumulation of constitutively present metabolites that included a 1:1 mixture of 3- and 4-hydroxybenzoic acid methyl esters (1 and 2, respectively), and the polyketides acremonisol A (3), SB236050 (4), and SB238569 (5). In addition, seven compoun ...
DOI:
10.1016/j.tet.2016.08.022

9. Stylissatins B–D, cycloheptapeptides from the marine sponge Stylissa massa

Author:
Lin, Wenhan,   et al.   ; Sun, Jingyuan; Cheng, Wei; de Voogd, Nicole J.; Proksch, Peter;     Show all 5 Authors
Source:
Tetrahedron letters 2016 v.57 pp. 4288-4292
ISSN:
0040-4039
Subject:
Porifera; amino acids; chemical reactions; chemical structure; chromatography; electrospray ionization mass spectrometry; fractionation; humans; inhibitory concentration 50; methylene chloride; neoplasm cells; nuclear magnetic resonance spectroscopy
Abstract:
... The NMR and LC–MS guided chromatographic fractionation of the CH2Cl2 extract of the sponge Stylissa massa resulted in the isolation of three new cycloheptapeptides, namely stylissatins B–D (1–3), together with ten known cyclopeptides. The structures of stylissatins B–D were established by comprehensive analysis of 2D NMR (COSY, TOCSY, HMQC, HMBC, and ROESY) in association with the ESI-MS/MS fragme ...
DOI:
10.1016/j.tetlet.2016.08.024

10. Diasteltoxins A–C, Asteltoxin-Based Dimers from a Mutant of the Sponge-Associated Emericella variecolor Fungus

Author:
Lin, Wenhan,   et al.   ; Long, Hailin; Cheng, Zhongbin; Huang, Wei; Wu, Qi; Li, Xiaodan; Cui, Jingrong; Proksch, Peter;     Show all 8 Authors
Source:
Organic letters 2016 v.18 no.18 pp. 4678-4681
ISSN:
1523-7052
Subject:
Emericella; chemical structure; circular dichroism spectroscopy; cycloaddition reactions; fungi; mutants; neoplasm cells; organic compounds; spectral analysis; thioredoxins
Abstract:
... Three novel asteltoxin-bearing dimers namely diasteltoxins A–C (1–3) along with asteltoxin were isolated from a mutated strain of a sponge-derived fungus Emericella variecolor XSA-07-2. Their structures were determined by extensive spectroscopic analyses including the computed electronic circular dichroism (ECD) data for the configurational assignment. The biogenetic formation of the dimers throug ...
DOI:
10.1021/acs.orglett.6b02313

11. Polyketides from the Mangrove-derived fungal endophyte Pestalotiopsis clavispora

Author:
Lin, Wenhan,   et al.   ; Pérez Hemphill, Catalina Francis; Daletos, Georgios; Liu, Zhen; Proksch, Peter;     Show all 5 Authors
Source:
Tetrahedron letters 2016 v.57 pp. 2078-2083
ISSN:
0040-4039
Subject:
Neopestalotiopsis clavispora; Rhizophora harrisonii; chemical reactions; chemical structure; cytotoxicity; endophytes; fungi; inhibitory concentration 50; mass spectrometry; metabolites; mice; neoplasm cells; nuclear magnetic resonance spectroscopy; polyketides
Abstract:
... Six new polyketide derivatives, including pestalpolyol I (1), pestapyrones A (2) and B (3), (R)-periplanetin D (6), pestaxanthone (7), norpestaphthalide A (8), and an isolation artifact pestapyrone C (4), were obtained from extracts of the endophytic fungus Pestalotiopsis clavispora isolated from the Mangrove plant Rhizophora harrisonii. In addition, seven known metabolites, including similanpyron ...
DOI:
10.1016/j.tetlet.2016.03.101

12. Secondary metabolites of the lichen-associated fungus Apiospora montagnei

Author:
Lin, Wenhan,   et al.   ; Wang, Hao; Umeokoli, Blessing O.; Eze, Peter; Heering, Christian; Janiak, Christoph; Müller, Werner E.G.; Orfali, Raha S.; Hartmann, Rudolf; Dai, Haofu; Liu, Zhen; Proksch, Peter;     Show all 12 Authors
Source:
Tetrahedron letters 2017 v.58 pp. 1702-1705
ISSN:
0040-4039
Subject:
Apiospora montagnei; Cladonia; X-ray diffraction; ammonium chloride; chemical reactions; chemical structure; cytotoxicity; diterpenoids; fungi; inhibitory concentration 50; lichens; mice; neoplasm cells; nuclear magnetic resonance spectroscopy; rice; secondary metabolites; sodium chloride; xanthone
Abstract:
... The endolichenic fungus Apiospora montagnei isolated from the lichen Cladonia sp. was cultured on solid rice medium, yielding the new diterpenoid libertellenone L (1), the new pyridine alkaloid, 23-O-acetyl-N-hydroxyapiosporamide (2) and the new xanthone derivative 8-hydroxy-3-hydroxymethyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ether (3) together with 19 known compounds (4–22). The structures ...
DOI:
10.1016/j.tetlet.2017.03.052

13. Amicoumacins from the marine-derived bacterium Bacillus sp. with the inhibition of NO production

Author:
Lin, Wenhan,   et al.   ; Bai, Jian; Liu, Dong; Yu, Siwang; Proksch, Peter;     Show all 5 Authors
Source:
Tetrahedron letters 2014 v.55 no.45 pp. 6286-6291
ISSN:
0040-4039
Subject:
Bacillus (bacteria); chemical reactions; chemical structure; culture media; lipopolysaccharides; macrophages; mice; nitric oxide; organic compounds; spectral analysis
Abstract:
... Chemical examination of the fermentation broth of the marine-derived bacterium Bacillus sp. resulted in the isolation of seven new amicoumacin-type isocoumarin derivatives, namely bacillcoumacins A–G (1–7), together with four known analogues. Their structures were elucidated on the basis of extensive spectroscopic analysis, while the absolute configurations of the new compounds were determined by ...
DOI:
10.1016/j.tetlet.2014.09.100

14. Tetrahydroanthraquinone derivatives from the mangrove-derived endophytic fungus Stemphylium globuliferum

Author:
Lin, Wenhan,   et al.   ; Moussa, Mariam; Ebrahim, Weaam; El-Neketi, Mona; Mándi, Attila; Kurtán, Tibor; Hartmann, Rudolf; Liu, Zhen; Proksch, Peter;     Show all 9 Authors
Source:
Tetrahedron letters 2016 v.57 pp. 4074-4078
ISSN:
0040-4039
Subject:
Avicennia marina; Stemphylium; beans; chemical reactions; chemical structure; culture media; endophytes; fungi; mice; neoplasm cells; nuclear magnetic resonance spectroscopy; organic compounds; secondary metabolites
Abstract:
... Two new tetrahydroanthraquinone derivatives, altersolanol Q (1) and 10-methylaltersolanol Q (2), and the new dimer alterporriol X (3), together with 13 known analogues were isolated from white bean solid culture media of the endophytic fungus, Stemphylium globuliferum, obtained from the Egyptian mangrove plant Avicennia marina. The present study resulted in the production of a large diversity of s ...
DOI:
10.1016/j.tetlet.2016.07.091

15. Truncateols A–N, new isoprenylated cyclohexanols from the sponge-associated fungus Truncatella angustata with anti-H1N1 virus activities

Author:
Lin, Wenhan,   et al.   ; Zhao, Yang; Si, Longlong; Liu, Dong; Proksch, Peter; Zhou, Demin;     Show all 6 Authors
Source:
Tetrahedron 2015 v.71 pp. 2708-2718
ISSN:
0040-4020
Subject:
Truncatella; X-ray diffraction; chemical reactions; chemical structure; fungi; organic compounds; spectroscopy; virion; viruses
Abstract:
... Fourteen new isoprenylated cyclohexanols namely truncateols A–N (1–14) were isolated from the solid culture of the sponge-associated fungus Truncatella angustata. Their structures were determined on the basis of extensive spectroscopic analyses, including the modified Mosher's method and ECD, as well as X-ray diffraction for the assignment of absolute configurations. The structures of truncateols ...
DOI:
10.1016/j.tet.2015.03.033

16. Microbacterins A and B, New Peptaibols from the Deep Sea Actinomycete Microbacterium sediminis sp. nov. YLB-01(T)

Author:
Lin, Wenhan,   et al.   ; Liu, Dong; Lin, Hong; Proksch, Peter; Tang, Xixiang; Shao, Zhongze;     Show all 6 Authors
Source:
Organic letters 2015 v.17 no.5 pp. 1220-1223
ISSN:
1523-7052
Subject:
Microbacterium; amino acids; chemical reactions; chemical structure; cytotoxicity; humans; neoplasm cells; nuclear magnetic resonance spectroscopy; organic compounds; spectral analysis
Abstract:
... Two new peptaibols, namely microbacterins A (1) and B (2), were isolated from the deep sea inhabited actinomycete Microbacterium sediminis spp. nov. YLB-01(T). The sequences of the amino acid residues were determined on the basis of intensive NMR and ESI-MS/MS spectroscopic analysis, in addition to the Marfey’s method and CD and optical rotation data for the configurational assignment. Both 1 and ...
DOI:
10.1021/acs.orglett.5b00172

17. Reagent-free synthesis of 2,3,4-polysubstituted tetrahydroquinolines: application to the formal synthesis of (±)-martinellic acid and martinelline

Author:
Lin, Wenhan,   et al.   ; Rong, Zhouting; Li, Qingjiang; Jia, Yanxing;     Show all 4 Authors
Source:
Tetrahedron letters 2013 v.54 pp. 4432-4434
ISSN:
0040-4039
Subject:
aldehydes; chemical reactions; chemical structure
Abstract:
... The simple and one-pot method for the synthesis of polysubstituted tetrahydroquinolines from readily available anilines and aldehydes under reagent-free conditions has been developed. The scope of the transformation has been demonstrated. This method has been successfully applied to the rapid formal synthesis of (±)-martinellic acid and martinelline. ...
DOI:
10.1016/j.tetlet.2013.06.028

18. A new fusarielin analogue from Penicillium sp. isolated from the Mediterranean sponge Ircinia oros

Author:
Lin, Wenhan,   et al.   ; Chen, Huiqin; Aktas, Nihal; Konuklugil, Belma; Mándi, Attila; Daletos, Georgios; Dai, Haofu; Kurtán, Tibor; Proksch, Peter;     Show all 9 Authors
Source:
Tetrahedron letters 2015 v.56 no.39 pp. 5317-5320
ISSN:
0040-4039
Subject:
Ircinia; Penicillium; cell lines; chemical reactions; chemical structure; coculture; curvularin; cytotoxicity; dehydrocurvularin; fungi; griseofulvin; inhibitory concentration 50; lymphoma; mass spectrometry; mice; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... The marine-derived fungus Penicillium sp. (strain IO1) isolated from the Mediterranean sponge Ircinia oros yielded a new fusarielin analogue (1) together with the known compounds griseofulvin (4) and dechlorogriseofulvin (5). The structure of 1 was unambiguously elucidated by comprehensive spectroscopic analysis (1D and 2D NMR, and mass spectrometry) as well as by comparison with the literature, w ...
DOI:
10.1016/j.tetlet.2015.07.072

19. Absolute configuration and anti-tumor activity of torrubiellin B

Author:
Lin, Wenhan,   et al.   ; Pérez Hemphill, Catalina Francis; Daletos, Georgios; Hamacher, Alexandra; Kassack, Matthias Ullrich; Mándi, Attila; Kurtán, Tibor; Proksch, Peter;     Show all 8 Authors
Source:
Tetrahedron letters 2015 v.56 no.30 pp. 4430-4433
ISSN:
0040-4039
Subject:
Acremonium; Sonneratia caseolaris; anthracenes; antineoplastic activity; cell lines; chemical reactions; chemical structure; circular dichroism spectroscopy; cisplatin; endophytes; fungi; inhibitory concentration 50; leaves; neoplasm cells; neoplasms
Abstract:
... The dimeric anthracene derivative torrubiellin B (1) was isolated from the endophytic fungus Acremonium sp. that had been obtained from leaves of the Mangrove plant Sonneratia caseolaris. The absolute configuration of 1 was established as (5′R,10′S,10a′R) for the first time on the basis of its electronic circular dichroism (ECD) spectra aided with TDDFT-ECD calculations. Torrubiellin B (1) exhibit ...
DOI:
10.1016/j.tetlet.2015.03.126

20. Structural revision and absolute configuration of lateritin

Author:
Lin, Wenhan,   et al.   ; Ola, Antonius R.B.; Aly, Amal H.; Wray, Victor; Debbab, Abdessamad;     Show all 5 Authors
Source:
Tetrahedron letters 2014 v.55 no.45 pp. 6184-6187
ISSN:
0040-4039
Subject:
acid hydrolysis; chemical structure; derivatization; gas chromatography-mass spectrometry; nuclear magnetic resonance spectroscopy; organic compounds
Abstract:
... ‘Lateritin’ (1), a morpholine-2,5-dione (depsipeptide), was reinvestigated for its structure and absolute configuration. On the basis of thorough 1D and 2D NMR and mass spectrometrical analyses, the structure of 1 was revised to be identical with beauvericin (8) and confirmed that beauvericin (8) is the trimeric lactone of ‘lateritin’ (1). The absolute configuration was determined by acidic hydrol ...
DOI:
10.1016/j.tetlet.2014.09.048