PubAg

Main content area

You searched for: Author offord Remove constraint Author: offord Subject chemokines Remove constraint Subject: chemokines
Start Over

Search

3  Search Results

1 - 3 of 3
Number of results to display per page

Search Results

1. Vaginal rings with exposed cores for sustained delivery of the HIV CCR5 inhibitor 5P12-RANTES

Author:
Offord, Robin E.,   et al.   ; McBride, John W.; Boyd, Peter; Dias, Nicola; Cameron, David; Hartley, Oliver; Kett, Vicky L.; Malcolm, R. Karl;     Show all 8 Authors
Source:
Journal of controlled release 2019 v.298 pp. 1-11
ISSN:
0168-3659
Subject:
CCR5 receptor; Human immunodeficiency virus; chemokines; drugs; freeze drying; inhibitory concentration 50; lipophilicity; models; molecular weight; permeability; pharmacokinetics; sheep; silicone; thermoplastics; vagina
Abstract:
... Antiretroviral-releasing vaginal rings are at the forefront of ongoing efforts to develop microbicide-based strategies for prevention of heterosexual transmission of the human immunodeficiency virus (HIV). However, traditional ring designs are generally only useful for vaginal administration of relatively potent, lipophilic, and small molecular weight drug molecules that have sufficient permeabili ...
DOI:
10.1016/j.jconrel.2019.02.003
PubMed:
30731150
PubMed Central:
PMC6414755

2. Potential evidence for biotype-specific chemokine profile following BVDV infection of bovine macrophages

Author:
Offord, Victoria,   et al.   ; Burr, Stephen; Thomas, Carole; Brownlie, Joe; Coffey, Tracey J.; Werling, Dirk;     Show all 6 Authors
Source:
Veterinary immunology and immunopathology 2012 v.150 no.1-2 pp. 123-127
ISSN:
0165-2427
Subject:
bovine viral diarrhea; cattle; chemokines; gene expression; immune response; macrophages; messenger RNA; monocytes
Abstract:
... Chemokines play a key role in initiating the innate and subsequently adaptive immune response by recruiting immune cells to the site of an infection. Monocytes/macrophages (MØ) are part of the first line of defence against invading pathogens, and have been shown to release a variety of chemokines in response to infection. Here, we reveal the early transcriptional response of MØ to infection with c ...
DOI:
10.1016/j.vetimm.2012.08.009
PubMed:
22985634
PubMed Central:
PMC3778901

3. Highly potent, fully recombinant anti-HIV chemokines: Reengineering a low-cost microbicide

Author:
Offord, Robin,   et al.   ; Gaertner, Hubert; Cerini, Fabrice; Escola, Jean-Michel; Kuenzi, Gabriel; Melotti, Astrid; Rossitto-Borlat, Irène; Nedellec, Rebecca; Salkowitz, Janelle; Gorochov, Guy; Mosier, Donald; Hartley, Oliver;     Show all 12 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.46 pp. 17706-17711
ISSN:
0027-8424
Subject:
CCR5 receptor; Human immunodeficiency virus 1; agonists; amino acids; antiretroviral agents; bacteriophages; chemokines; developing countries; inflammation; models; production costs; synthesis; topical application
Abstract:
... New prevention strategies for use in developing countries are urgently needed to curb the worldwide HIV/AIDS epidemic. The N-terminally modified chemokine PSC-RANTES is a highly potent entry inhibitor against R5-tropic HIV-1 strains, with an inhibitory mechanism involving long-term intracellular sequestration of the HIV coreceptor, CCR5. PSC-RANTES is fully protective when applied topically in a m ...
DOI:
10.1073/pnas.0805098105
PubMed:
19004761
PubMed Central:
PMC2584686