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1. 1,4-Benzenediboronic-Acid-Induced Aggregation of Gold Nanoparticles: Application to Hydrogen Peroxide Detection and Biotin–Avidin-Mediated Immunoassay with Naked-Eye Detection

Author:
Yang Ya-Chun; Tseng Wei-Lung
Source:
Analytical chemistry 2016 v.88 no.10 pp. 5355-5362
ISSN:
1520-6882
Subject:
antibodies; antigens; citrates; colorimetry; glucose; glucose oxidase; humans; hydrogen peroxide; immunoassays; immunoglobulin G; nanogold; oxidation; phenol; rabbits; systems engineering
Abstract:
... Hydrogen-peroxide (H₂O₂)-induced growth of small-sized gold nanoparticles (AuNPs) is often implemented for H₂O₂ sensing and plasmonic immunoassay. In contrast, there is little-to-no information in the literature regarding the application of H₂O₂-inhibited aggregation of citrate-capped AuNPs. This study discloses that benzene-1,4-diboronic acid (BDBA) was effective in driving the aggregation of cit ...
DOI:
10.1021/acs.analchem.6b00668

2. 1-Methylmalate from Camu-Camu (Myrciaria dubia) Suppressed D-Galactosamine-Induced Liver Injury in Rats

Author:
Toshiyuki AKACHI; Yasuyuki SHIINA; Takumi KAWAGUCHI; Hirokazu KAWAGISHI; Tatsuya MORITA; Kimio SUGIYAMA
Source:
Bioscience, biotechnology, and biochemistry 2010 v.74 no.3 pp. 573-578
ISSN:
1347-6947
Subject:
Averrhoa carambola; Hylocereus; Myrciaria dubia; acerolas; active ingredients; alanine transaminase; aspartate transaminase; biotechnology; citrates; fractionation; freeze drying; fruits; gel chromatography; liver; malates; solvents
Abstract:
... To evaluate the protective effects of fruit juices against D-galactosamine (GalN)-induced liver injury, lyophilized fruit juices (total 12 kinds) were fed to rats for 7 d, and then we evoked liver injury by injecting GalN. The juice of camu-camu (Myrciaria dubia) significantly suppressed GalN-induced liver injury when the magnitude of liver injury was assessed by plasma alanine aminotransferase an ...
DOI:
10.1271/bbb.90775

3. 13C isotope-based metabolic flux analysis revealing cellular landscape of glucose metabolism in human liver cells exposed to perfluorooctanoic acid

Author:
Ruijia Zhang; Baowei Chen; Li Lin; Hui Zhang; Tiangang Luan
Source:
Science of the total environment 2021 v.770 pp. 145329
ISSN:
0048-9697
Subject:
citrates; environment; glucose; glycolysis; homeostasis; humans; landscapes; liver; lung function; metabolic flux analysis; metabolites; mitochondria; oxygen consumption; perfluorooctanoic acid; pyruvic acid; toxicity; tricarboxylic acid cycle
Abstract:
... Perfluorooctanoic acid (PFOA) is well known to break glucose homeostasis. However, the effects of PFOA on glucose metabolism are difficult to be evaluated because related metabolites may be synthesized from other nutritional substrates. Here, the relative contribution of glucose to metabolites (e.g., pyruvate and citrate) in the PFOA-treated human liver cells (HepG2) was determined using the ¹³C i ...
DOI:
10.1016/j.scitotenv.2021.145329

4. 13C-NMR analysis of glucose metabolism during citric acid production by Aspergillus niger

Author:
Peksel, A.; Torres, N.V.; Liu, J.; Juneau, G.; Kubicek, C.P.
Source:
Applied microbiology and biotechnology 2002 v.58 no.2 pp. 157-163
ISSN:
0175-7598
Subject:
Aspergillus niger; citrates; citric acid; erythritol; fermentation; fructose 6-phosphate; glucose; glyceraldehyde-3-phosphate dehydrogenase; glycerol; glycolysis; mannitol; pyruvate carboxylase; pyruvic acid; trehalose
Abstract:
... The effect of glucose concentration on glycolytic metabolism under conditions of citric acid accumulation by Aspergillus niger was studied with 13C-labelled glucose. The results show that during cultivation at high glucose (14%, w/v), most of the label in citric acid is in C-2/C-4, and is thus due to the pyruvate carboxylase reaction. However, a significant portion is also present in C-1/C-5, whos ...
DOI:
10.1007/s00253-001-0839-x
PubMed:
11876406

5. 13C-metabolic flux analysis of lipid accumulation in the oleaginous fungus Mucor circinelloides

Author:
Lina Zhao; Huaiyuan Zhang; Liping Wang; Haiqin Chen; Yong Q. Chen; Wei Chen; Yuanda Song
Source:
Bioresource technology 2015 v.197 pp. 23-29
ISSN:
0960-8524
Subject:
Mucor circinelloides; NADP (coenzyme); acetyl coenzyme A; adenosine triphosphate; amino acids; citrates; gamma-linolenic acid; gas chromatography-mass spectrometry; glyoxylate cycle; malic enzyme; oleaginous fungi; pentose phosphate cycle; tricarboxylic acid cycle
Abstract:
... The oleaginous fungus Mucor circinelloides is of industrial interest because it can produce high levels of polyunsaturated fatty acid γ-linolenic acid. M. circinelloides CBS 277.49 is able to accumulate less than 15% of cell dry weight as lipids, while M. circinelloides WJ11 can accumulate lipid up to 36%. In order to better understand the mechanisms behind the differential lipid accumulation in t ...
DOI:
10.1016/j.biortech.2015.08.035

6. 141 Positive effects of supplementation in bovine culture medium with 3 cytokines

Author:
L. Spate; B. Redel; S. Ortega; J. Moraes; R. Prather; T. Spencer
Source:
Reproduction, fertility, and development 2019 v.31 no.1 pp. 196
ISSN:
1031-3613
Subject:
Angus; Holstein; blastocyst; bulls; citrates; culture media; cytokines; embryo culture; embryogenesis; fetus; freezing; heart rate; heifers; myo-inositol; oocytes; regression analysis; spermatozoa; swine; thawing; uterus; vitrification; zygote
Abstract:
... Recently, our laboratory has identified that supplementation of 3 cytokines, 40ng mL−1 FGF2, 20ng mL−1 LIF, and 20ng mL−1 IGF1 (termed FLI), to porcine oocyte maturation medium leads to an increase in maturation percentage and embryo development to blastocyst. Similarly, addition of FLI to porcine embryo culture at Day 2 after fertilization increased the number of embryos that became blastocyst. T ...
DOI:
10.1071/RDv31n1Ab141

7. 1H NMR Study on the Short- and Long-Term Impact of Two Training Programs of Sprint Running on the Metabolic Fingerprint of Human Serum

Author:
Pechlivanis Alexandros; Kostidis Sarantos; Saraslanidis Ploutarchos; Petridou Anatoli; Tsalis George; Veselkov Kirill; Mikros Emmanuel; Mougios Vassilis; Theodoridis Georgios A.
Source:
Journal of Proteome Research 2013 v.12 no.1 pp. 470-480
ISSN:
1535-3907
Subject:
acetoacetic acid; acetone; alanine; arginine; blood serum; citrates; exercise; glucose; glycoproteins; histidine; humans; isoleucine; lactic acid; leucine; lipids; long term effects; lysine; men; metabolism; metabolites; metabolomics; models; nuclear magnetic resonance spectroscopy; proteome; pyruvic acid; sports; taurine; trimethylamine; valine
Abstract:
... Metabonomics is an established strategy in the exploration of the effects of various stimuli on the metabolic fingerprint of biofluids. Here, we present an application of ¹H NMR-based metabonomics on the field of exercise biochemistry. Fourteen men were assigned to either of two training programs, which lasted 8 weeks and involved sets of 80-m maximal runs separated by either 10 s or 1 min of rest ...
DOI:
10.1021/pr300846x

8. 1H NMR based pharmacometabolomics analysis of metabolic phenotype on predicting metabolism characteristics of losartan in healthy volunteers

Author:
Chenjie He; Yongbin Liu; Yicheng Wang; Jie Tang; Zhirong Tan; Xi Li; Yao Chen; Yuanfei Huang; Xiaoping Chen; Dongsheng Ouyang; Honghao Zhou; Jingbo Peng
Source:
Journal of chromatography 2018 v.1095 pp. 15-23
ISSN:
1570-0232
Subject:
biomarkers; blood; citrates; clinical trials; creatine; creatinine; drugs; gluconeogenesis; glycolysis; lactic acid; least squares; lipid metabolism; lipids; liquid chromatography; males; mass spectrometry; metabolites; models; nuclear magnetic resonance spectroscopy; oral administration; pharmacokinetics; phenotype; phosphorylcholine; prediction; serine; threonine
Abstract:
... Inter-individual variability in drug metabolism and disposition is common in both preclinical and clinical researches. Losartan and its active metabolite EXP3174 present a high degree of inter-individual differences in blood concentrations that affect drug efficacy and side effect. Pharmacometabolomics has been increasingly applied on predicting the drug responses by analyzing the differences in m ...
DOI:
10.1016/j.jchromb.2018.07.016

9. 1H NMR characterisation of the lipid fraction and the metabolite profiles of Fossa (pit) cheese

Author:
Paola Scano; Laura R. Cagliani; Roberto Consonni
Source:
International dairy journal 2019 v.90 pp. 39-44
ISSN:
0958-6946
Subject:
Fossa; Italian cheeses; butyric acid; cadaverine; cheese ripening; citrates; conjugated linoleic acid; diacylglycerols; ewe milk; free amino acids; glycerol; lactic acid; lipolysis; metabolites; nuclear magnetic resonance spectroscopy; proteolysis; tyramine
Abstract:
... Fossa cheese is a typical Italian cheese characterised by ripening in pits dug in tuffaceous rock. In this work, 1H NMR spectroscopy was applied to characterise the lipid fraction and the metabolite profile of Fossa cheese produced with sheep's milk. Samples were collected before and after ripening in different pit environments. The higher levels of free amino acids (FAAs) found in samples suggest ...
DOI:
10.1016/j.idairyj.2018.10.007

10. 1H NMR-based metabolic profiling approach to identify the geo-authentic Chinese yam (Dioscorea polystachya Turczaninow cv. Tiegun)

Author:
Qiang Wang; Xiaohui Wang; Xujin Wu; Yanli Wang; Yuli Zhang; Yaling Jiang; Chaonan Zhang; Xiaowan Huang; Li An; Huan Ma; Kaihong Xu
Source:
Journal of food composition and analysis 2021 v.98 pp. 103805
ISSN:
0889-1575
Subject:
Dioscorea polystachya; Oriental traditional medicine; adulterated products; arginine; aspartic acid; choline; citrates; color; food composition; fructose; functional foods; glucose; glutamic acid; industry; leucine; metabolites; metabolomics; sucrose; tetrazolium; threonine; China
Abstract:
... Chinese Yams (Dioscorea polystachya Turczaninow) are mainly used as functional food and traditional Chinese medicine in China. Adulteration is a major problem in the food and herbal industry and has affected the commercial use of natural products. Here, a ¹H NMR-based metabolomics approach was used for the identification of the distinguishing metabolites between geo-authentic Chinese yam (D. polys ...
DOI:
10.1016/j.jfca.2021.103805

11. 1H NMR-based metabolite profiling workflow to reduce inter-sample chemical shift variations in urine samples for improved biomarker discovery

Author:
Ryan B. Gil; Rainer Lehmann; Philippe Schmitt-Kopplin; Silke S. Heinzmann
Source:
Analytical and bioanalytical chemistry 2016 v.408 no.17 pp. 4683-4691
ISSN:
1618-2642
Subject:
biomarkers; citrates; clinical trials; data collection; fluorides; human diseases; humans; kidney diseases; metabolites; metabolomics; nuclear magnetic resonance spectroscopy; pH; phosphates; potassium; proteinuria; spectral analysis; statistical analysis; urine
Abstract:
... Metabolite profiling of urine has seen much advancement in recent years, and its analysis by nuclear magnetic resonance (NMR) spectroscopy has become well established. However, the highly variable nature of human urine still requires improved protocols despite some standardization. In particular, diseases such as kidney disease can have a profound effect on the composition of urine and generate a ...
DOI:
10.1007/s00216-016-9552-6

12. 1H NMR-based metabolomic fingerprinting to determine metabolite levels in serrano peppers (Capsicum annum L.) grown in two different regions

Author:
Elvia Becerra-Martínez; Elideth Florentino-Ramos; Nury Pérez-Hernández; L. Gerardo Zepeda-Vallejo; Nemesio Villa-Ruano; Manuel Velázquez-Ponce; Felipe García-Mendoza; Angel E. Bañuelos-Hernández
Source:
Food research international 2017 v.102 pp. 163-170
ISSN:
0963-9969
Subject:
Capsicum annuum; acetates; aspartic acid; citrates; condiments; environmental factors; formates; hot peppers; lactic acid; leucine; markets; metabolites; metabolomics; nuclear magnetic resonance spectroscopy; pyruvic acid; succinic acid; sucrose; Mexico
Abstract:
... Chili pepper (Capsicum annuum) is the most important and emblematic condiment in Mexican food. Serrano pepper is a variety of C. annuum that is traditionally cultivated in Mexico and commercialized in local markets. The aim of this study was to describe the 1H NMR metabolomic profiling of the aqueous phase of serrano peppers harvested from two distinct regions, in the states of Veracruz and Oaxaca ...
DOI:
10.1016/j.foodres.2017.10.005

13. 1H NMR-based metabolomics profiling and taste of boneless dry-cured hams during processing

Author:
Jian Zhang; Yue Yi; Daodong Pan; Guanghong Zhou; Ying Wang; Yali Dang; Jun He; Gang Li; Jinxuan Cao
Source:
Food research international 2019 v.122 pp. 114-122
ISSN:
0963-9969
Subject:
acetates; alanine; citrates; formates; glutamic acid; histidine; hypoxanthine; isoleucine; metabolites; metabolomics; multivariate analysis; nucleic acids; peptides; processing time; raw materials; sugars; taste; vacuum packaging; valine
Abstract:
... Boneless dry-cured hams were processed by raw material treatment (deboned and tumbled), salting (vacuum packed; 4 °C and 60–70% RH for 3.5 months), resting (vacuum packed; 15 °C and 60–70% RH for 1.5 months) and ripening (vacuum packed; 15 °C and 60–70% RH for 1.5 months). To explore the mechanisms that contributed to the taste of boneless dry-cured hams, ¹H NMR-based metabolomics combined with mu ...
DOI:
10.1016/j.foodres.2019.04.005

14. 1H NMR-based metabolomics reveals interactive effects between the carrier solvent methanol and a pharmaceutical mixture in an amphibian developmental bioassay with Limnodynastes peronii

Author:
Steven D. Melvin; Oliver A.H. Jones; Anthony R. Carroll; Frederic D.L. Leusch
Source:
Chemosphere 2018 v.199 pp. 372-381
ISSN:
0045-6535
Subject:
Limnodynastes peronii; acetates; amphibians; arginine; bioassays; biomarkers; citrates; diclofenac; ecotoxicology; glutamine; glycogen; hepatotoxicity; leucine; metabolites; metabolomics; metformin; methanol; nuclear magnetic resonance spectroscopy; purine nucleotides; solubility; solvents; tadpoles; toxicity testing; tyrosine; valproic acid
Abstract:
... Organic carrier solvents are used in aquatic toxicity testing to improve chemical solubility and facilitate the exploration of dose-response relationships. Both water- and solvent-control groups are normally included in these scenarios to ensure that the solvent itself has no effect on the test organism, but this fails to consider possible interactive effects between carrier solvents and contamina ...
DOI:
10.1016/j.chemosphere.2018.02.063

15. 1H NMR-based metabolomics study on repeat dose toxicity of fine particulate matter in rats after intratracheal instillation

Author:
Yannan Zhang; Hejing Hu; Yanfeng Shi; Xiaozhe Yang; Lige Cao; Jing Wu; Collins Otieno Asweto; Lin Feng; Junchao Duan; Zhiwei Sun
Source:
Science of the total environment 2017 pp. -
ISSN:
0048-9697
Subject:
acetates; alanine; allantoin; arginine; atrophy; blood serum; citrates; creatine; edema; formates; histidine; histopathology; kidneys; lactic acid; liver; metabolites; metabolomics; methane; multivariate analysis; nitrogen metabolism; nuclear magnetic resonance spectroscopy; particulates; pollutants; rats; serine; succinic acid; threonine; toxicity; tricarboxylic acid cycle; trimethylamine; urine
Abstract:
... Systemic metabolic effects and toxicity mechanisms of ambient fine particulate matter (PM2.5) remain uncertain. In order to investigate the mechanisms in PM2.5 toxicity, we explored the endogenous metabolic changes and possible influenced metabolic pathways in rats after intratracheal instillation of PM2.5 by using a 1H nuclear magnetic resonance (NMR)-based metabolomics approach. Liver and kidney ...
DOI:
10.1016/j.scitotenv.2017.02.149

16. 1H NMR-based metabonomic study on the effects of Epimedium on glucocorticoid-induced osteoporosis

Author:
Sina Pan; Ali Chen; Zhihui Han; Yaling Wang; Xin Lu; Yongxia Yang
Source:
Journal of chromatography 2016 v.1038 pp. 118-126
ISSN:
1570-0232
Subject:
Epimedium; urine; chromatography; creatinine; dexamethasone; oral administration; glucocorticoids; lactic acid; intestinal microorganisms; multivariate analysis; metabolomics; phospholipids; citrates; metabolism; energy; blood serum; taurine; osteoporosis; rats; nuclear magnetic resonance spectroscopy; creatine; biochemical pathways; Oriental traditional medicine
Abstract:
... Glucocorticoids are widely used in clinical practice for the treatment of many immune-mediated and inflammatory diseases, and glucocorticoid-induced osteoporosis (GIO) is the most common type of secondary osteoporosis. Epimedium is one of the most commonly used traditional Chinese medicines for treating osteoporosis. In the present study, we systematically analysed the metabonomic characteristics ...
DOI:
10.1016/j.jchromb.2016.10.015

17. 1H NMR-based urinary metabonomic study of the antidiabetic effects of Rubus Suavissimus S. Lee in STZ-induced T1DM rats

Author:
Zhiheng Su; Xue Ling; Kewei Ji; Huimin Huang; Xi Liu; Chunli Yin; Hongjia Zhu; Yue Guo; Yiyi Mo; Yating Lu; Yonghong Liang; Hua Zheng
Source:
Journal of chromatography 2020 v.1158 pp. 122347
ISSN:
1570-0232
Subject:
Oriental traditional medicine; Rubus suavissimus; acetates; allantoin; animal models; chromatography; citrates; creatinine; gluconeogenesis; glycemic effect; glycolysis; hyperglycemia; insulin-dependent diabetes mellitus; lactic acid; leaves; metabolites; metabolomics; patients; pyruvic acid; rats; shrubs; succinic acid; therapeutics; tricarboxylic acid cycle
Abstract:
... Long-term hyperglycemia associated with diabetes mellitus (DM) causes damage to various organs and tissues, including the eyes, kidneys, heart, blood vessels and nerves. Rubus Suavissimus S. Lee (RS), a shrub whose leaves are used in traditional Chinese medicine (TCM), has been shown to exert hypoglycemic effects in DM patients. However, the underlying mechanism is unclear. This was investigated i ...
DOI:
10.1016/j.jchromb.2020.122347

18. 1H NMR‐based metabonomic evaluation of the pesticides camptothecin and matrine against larvae of Spodoptera litura

Author:
Li‐shang Dai; Hui‐fei Tian; Yang Hang; Chao‐wei Wen; Ying‐hao Huang; Bin‐feng Wang; Jing‐wei Hu; Jia‐ping Xu; Ming‐jie Deng
Source:
Pest management science 2021 v.77 no.1 pp. 208-216
ISSN:
1526-498X
Subject:
Spodoptera litura; alanine transaminase; citrates; fumarates; glycolysis; hemolymph; hydrolysis; isocitrate dehydrogenase; lactate dehydrogenase; lactic acid; malate dehydrogenase; malates; metabolites; metabolomics; mortality; quantitative polymerase chain reaction; succinic acid; toxicity; toxicity testing; trehalase; trehalose
Abstract:
... BACKGROUND: Camptothecin (CPT) and matrine (MAT) have potential as botanical pesticides against several pest species. However, the mechanisms of metabolic and physiological changes in pests induced by CPT and MAT are unknown. In this study, a toxicological test, an NMR‐based metabolomic study, an enzymatic test, and an RT quantitative PCR (RT‐qPCR) experiment were all conducted to examine the effe ...
DOI:
10.1002/ps.6009

19. 1HNMR-based metabonomic study of sub-chronic hepatotoxicity induced by realgar

Author:
Taoguang Huo; Ying Fang; Longshan Zhao; Zhili Xiong; Yinghua Zhang; Yanlei Wang; Cong Feng; Mingmei Yuan; Shouyun Wang; Mo Chen; Hong Jiang
Source:
Journal of ethnopharmacology 2016 v.192 pp. 1-9
ISSN:
0378-8741
Subject:
Oriental traditional medicine; acetates; alanine; alanine transaminase; alkaline phosphatase; aspartate transaminase; biochemical pathways; cholesterol; cholinesterase; citrates; creatine; dose response; energy metabolism; glutamic acid; hepatotoxicity; histopathology; intestinal microorganisms; lactic acid; liver; low density lipoprotein; males; metabolites; metabolomics; methionine; mice; nuclear magnetic resonance spectroscopy; phenylalanine; poisoning; principal component analysis; protein content; pyruvic acid; rats; succinic acid; taurine; urine; very low density lipoprotein
Abstract:
... Realgar has been used as a traditional Chinese medicine (TCM) for thousands of years. Recently, a number of realgar or realgar-containing medicines poisoning cases have been reported. However, the toxicological mechanism of realgar has not been clearly clarified. In present study, the subchronic hepatotoxicity of realgar on mice was investigated using ¹HNMR-based metabonomic approaches.Twenty-eigh ...
DOI:
10.1016/j.jep.2016.07.003

20. 2,4-Dichlorophenoxyacetic acid (2,4-D) degradation promoted by nanoparticulate zerovalent iron (nZVI) in aerobic suspensions

Author:
Adriana Correia de Velosa; Raquel F. Pupo Nogueira
Source:
Journal of environmental management 2013 v.121 pp. 72-79
ISSN:
0301-4797
Subject:
water pollution; citrates; iron; EDTA (chelating agent); methodology; pH; oxidation; coprecipitation; 2,4-D; oxygen; adsorption
Abstract:
... Reactive species generated by Fe0 oxidation promoted by O2 (catalyzed or not by ligands) are able to degrade contaminant compounds like the herbicide 2,4-dichlorophenoxyacetic acid. The degradation of 2,4-D was influenced by the concentrations of zero valent iron (ZVI) and different ligands, as well as by pH. In the absence of ligands, the highest 2,4-D degradation rate was obtained at pH 3, while ...
DOI:
10.1016/j.jenvman.2013.02.031
PubMed:
23524398