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1. Results of the Multicenter Spaniel Trial (MUST): Taurine‐and Carnitine‐Responsive Dilated Cardiomyopathy in American Cocker Spaniels With Decreased Plasma Taurine Concentration

Author:
Mark D. Kittleson; Bruce Keene; Paul D. Pion; Carroll G. Loyer
Source:
Journal of veterinary internal medicine 1997 v.11 no.4 pp. 204-211
ISSN:
0891-6640
Subject:
Cocker Spaniel; cardiomyopathy; carnitine; clinical examination; death; digoxin; dogs; drug therapy; echocardiography; furosemide; heart failure; heart valve diseases; patients; placebos; quality of life; taurine
Abstract:
... Fourteen American Cocker Spaniels (ACS) with dilated cardiomyopathy (DCM) were studied to determine if individuals of this breed with DCM are systemically taurine‐or carnitine‐deficient and to determine if they are responsive to taurine and carnitine supplementation. American Cocker Spaniels with DCM were identified using echocardiography, and plasma was analyzed for taurine and carnitine concentr ...
DOI:
10.1111/j.1939-1676.1997.tb00092.x

2. Differential diagnosis of ascites in cats

Author:
Tasker, S.; Gunn-Moore, D.
Source:
In practice 2000 v.22 no.8 pp. 472-479
ISSN:
0263-841X
Subject:
cardiomyopathy; hepatitis; neoplasms; cats; ascites; hemorrhage; body fluids; small animal practice; peritoneum; kidney diseases; clinical examination
DOI:
10.1136/inpract.22.8.472

3. Practical approach to the dyspnoeic cat

Author:
Mackay, A.
Source:
In practice 2001 v.23 no.4 pp. 198-207
ISSN:
0263-841X
Subject:
vasodilator agents; cardiomyopathy; drug therapy; radiography; bronchodilators; laboratory techniques; cats; thoracic cavity; echocardiography; clinical examination; asthma; glucocorticoids; dyspnea; oxygen; disease course
DOI:
10.1136/inpract.23.4.198

4. Clinical, echocardiographic, and electrocardiographic abnormalities in Boxers with cardiomyopathy and left ventricular systolic dysfunction: 48 cases (1985-2003)

Author:
Baumwart, R.D.; Meurs, K.M.; Atkins, C.E.; Bonagura, J.D.; DeFrancesco, T.C.; Keene, B.W.; Koplitz, S.; Fuentes, V.L.; Miller, M.W.; Rausch, W.
Source:
Journal of the American Veterinary Medical Association 2005 v.226 no.7 pp. 1102-1104
ISSN:
0003-1488
Subject:
heart ventricle; heart sounds; cardiomyopathy; diastolic blood pressure; dog diseases; dogs; gender differences; electrocardiography; systolic blood pressure; arrhythmia; clinical examination; animal age; echocardiography
DOI:
10.2460/javma.2005.226.1102

5. Pulsus alternans in English cocker spaniels with dilated cardiomyopathy

Author:
Moneva-Jordan, A.; Fuentes, V. Luis; Corcoran, B.M.; French, A.; Dukes-McEwan, J.
Source:
journal of small animal practice 2007 v.48 no.5 pp. 258-263
ISSN:
0022-4510
Subject:
pathophysiology; heart sounds; cardiomyopathy; heart failure; dog diseases; dogs; echocardiography; heart valves; clinical examination; case studies; signs and symptoms (animals and humans)
Abstract:
... To report the clinical findings associated with pulsus alternans in English cocker spaniels with dilated cardiomyopathy and to review the phenomenon of mechanical alternans, usually found in patients with severe left ventricular systolic dysfunction. The case records of 10 English cocker spaniels with dilated cardiomyopathy and pulsus alternans were reviewed. All dogs had been referred in moderate ...
DOI:
10.1111/j.1748-5827.2006.00258.x
PubMed:
17433080

6. Detection of Congestive Heart Failure in Dogs by Doppler Echocardiography

Author:
Schober, K.E.; Hart, T.M.; Stern, J.A.; Li, X.; Samii, V.F.; Zekas, L.J.; Scansen, B.A.; Bonagura, J.D.
Source:
Journal of veterinary internal medicine 2010 v.24 no.6 pp. 1358-1368
ISSN:
0891-6640
Subject:
cardiomyopathy; clinical examination; cohort studies; dogs; echocardiography; heart failure; medicine; natriuretic peptides; prediction; radiography; respiratory rate
Abstract:
... Background: Echocardiographic prediction of congestive heart failure (CHF) in dogs has not been prospectively evaluated. Hypothesis: CHF can be predicted by Doppler echocardiographic (DE) variables of left ventricular (LV) filling in dogs with degenerative mitral valve disease (MVD) and dilated cardiomyopathy (DCM). Animals: Sixty-three client-owned dogs. Methods: Prospective clinical cohort study ...
DOI:
10.1111/j.1939-1676.2010.0592.x

7. Genome-wide association identifies a deletion in the 3' untranslated region of striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy

Author:
Kathryn M. Meurs; Evan Mauceli; Sunshine Lahmers; Gregory M. Acland; Stephen N. White; Kerstin Lindblad-Toh
Source:
Human genetics 2010 v.128 no.3 pp. 315-324
ISSN:
0340-6717
Subject:
genes; arrhythmia; 3' untranslated regions; gene deletion; tissue distribution; disease severity; gene expression; pathogenesis; clinical examination; animal disease models; sequence analysis; human diseases; cardiomyopathy; humans; cardiac arrest; chromosomes; dogs; electrocardiography; chromosome mapping; fluorescent antibody technique; single nucleotide polymorphism; penetrance; heart ventricle; proteins
Abstract:
... Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease characterized by ventricular arrhythmias and sudden cardiac death. It is most frequently inherited as an autosomal dominant trait with incomplete and age-related penetrance and variable clinical expression. The human disease is most commonly associated with a causative mutation in one of several genes encoding des ...
Handle:
10113/56611
DOI:
10.1007/s00439-010-0855-y
PubMed:
20596727
PubMed Central:
PMC2962869

8. Arterial Thromboembolism : Risks, realities and a rational first-line approach

Author:
Virginia Luis Fuentes
Source:
Journal of feline medicine and surgery v.14 no.7 pp. 459-470
ISSN:
1532-2750
Subject:
analgesia; aorta; aspirin; blood stasis; cardiomyopathy; cats; clinical examination; euthanasia; fentanyl; furosemide; heart failure; hyperthyroidism; ischemia; methadone; neoplasms; observational studies; pain; patients; platelet activation; prognosis; risk; thrombosis
Abstract:
... Practical relevance: Feline arterial thromboembolism (ATE) is a common but devastating complication of myocardial disease, often necessitating euthanasia. A combination of endothelial dysfunction and blood stasis in the left atrium leads to local platelet activation and thrombus formation. Embolisation of the thrombus results in severe ischaemia of the affected vascular bed. With the classic ‘sadd ...
DOI:
10.1177/1098612X12451547

9. Echocardiographic and electrocardiographic findings in client-owned ferrets: 95 cases (1994–2009)

Author:
Rebecca L. Malakoff; Nancy J. Laste; Connie J. Orcutt
Source:
Journal of the American Veterinary Medical Association 2012 v.241 no.11 pp. 1484-1489
ISSN:
0003-1488
Subject:
ascites; cardiomyopathy; clinical examination; echocardiography; edema; electrocardiography; ferrets; heart failure; radiography; syncope
Abstract:
... Objective—To characterize echocardiographic and ECG findings in ferrets (Mustela putorius furo) evaluated at a clinical practice. Design—Retrospective case series. Animals—95 client-owned ferrets. Procedures—Medical records of all ferrets that had a cardiac evaluation (echocardiogram with or without ECG) performed between January 1994 and November 2009 were reviewed. Data analyzed included signalm ...
DOI:
10.2460/javma.241.11.1484

10. Prospective echocardiographic and tissue Doppler screening of a large Sphynx cat population: Reference ranges, heart disease prevalence and genetic aspects

Author:
Valerie Chetboul; Amandine Petit; Vassiliki Gouni; Emilie Trehiou-Sechi; Charlotte Misbach; David Balouka; Carolina Carlos Sampedrano; Jean-Louis Pouchelon; Renaud Tissier; Marie Abitbol
Source:
Journal of veterinary cardiology 2012 v.14 no.4 pp. 497-509
ISSN:
1760-2734
Subject:
adults; body weight; cardiomyopathy; cats; clinical examination; disease prevalence; echocardiography; heart; image analysis; inheritance (genetics); pedigree; penetrance; prospective studies; screening
Abstract:
... OBJECTIVES: (1) To investigate heart morphology and function using echocardiography and tissue Doppler imaging (TDI), (2) to determine heart disease prevalence and characteristics, and (3) to assess potential genetic features in a population of Sphynx cats presented for cardiovascular screening. ANIMALS: A total of 147 echocardiographic examinations, including 33 follow-ups, were performed by trai ...
DOI:
10.1016/j.jvc.2012.08.001
PubMed:
23131204

11. Doppler Echocardiographic Evaluation of Midventricular Obstruction in Cats with Hypertrophic Cardiomyopathy

Author:
H.B. MacLea; J.A. Boon; J.M. Bright
Source:
Journal of veterinary internal medicine 2013 v.27 no.6 pp. 1416-1420
ISSN:
0891-6640
Subject:
cardiomyopathy; cats; clinical examination; color; echocardiography; hypertension; hypertrophy; muscles; people; systolic blood pressure; turbulent flow; Colorado
Abstract:
... BACKGROUND: Hypertrophic cardiomyopathy (HCM) is heterogeneous in both people and cats, with variability in the distribution of hypertrophy, hemodynamic characteristics, and Doppler echocardiographic findings. OBJECTIVES: To document the Doppler echocardiographic characteristics of midventricular obstruction in some cats with HCM. ANIMALS: Eight cats with hypertrophic cardiomyopathy. MATERIALS AND ...
DOI:
10.1111/jvim.12175

12. A Randomized Study Assessing the Effect of Diet in Cats with Hypertrophic Cardiomyopathy

Author:
L.M. Freeman; J.E. Rush; S.M. Cunningham; B.J. Bulmer
Source:
Journal of veterinary internal medicine 2014 v.28 no.3 pp. 847-856
ISSN:
0891-6640
Subject:
blood; body weight; cardiomyopathy; cats; cholesterol; clinical examination; diet; echocardiography; enzymes; ingredients; lipid content; liver; medicine; triacylglycerols
Abstract:
... BACKGROUND: Diet might influence progression of hypertrophic cardiomyopathy (HCM). OBJECTIVE: To investigate whether diet composition could alter clinical, biochemical, or echocardiographic variables in cats with HCM. ANIMALS: Twenty‐nine cats with HCM (International Small Animal Cardiac Health Council stage 1b) examined at a university teaching hospital. METHODS: Randomized, placebo‐controlled tr ...
DOI:
10.1111/jvim.12352
PubMed:
24697827
PubMed Central:
PMC4895464

13. Cardiac Biomarkers in Hyperthyroid Cats

Author:
J.K. Sangster; D.L. Panciera; J.A. Abbott; K.C. Zimmerman; A.C. Lantis
Source:
Journal of veterinary internal medicine 2014 v.28 no.2 pp. 465-472
ISSN:
0891-6640
Subject:
biomarkers; blood pressure; blood serum; cardiomyopathy; cats; clinical examination; hyperthyroidism; hypertrophy; monitoring; urinalysis
Abstract:
... BACKGROUND: Hyperthyroidism has substantial effects on the circulatory system. The cardiac biomarkers NT‐proBNP and troponin I (cTNI) have proven useful in identifying cats with myocardial disease but have not been extensively investigated in hyperthyroidism. HYPOTHESIS: Plasma NT‐proBNP and cTNI concentrations are higher in cats with primary myocardial disease than in cats with hyperthyroidism an ...
DOI:
10.1111/jvim.12259
PubMed:
24350989
PubMed Central:
PMC4857992

14. Case-control study of the effects of pimobendan on survival time in cats with hypertrophic cardiomyopathy and congestive heart failure

Author:
Yamir Reina-Doreste; Joshua A. Stern; Bruce W. Keene; Sandra P. Tou; Clarke E. Atkins; Teresa C. DeFrancesco; Marisa K. Ames; Timothy E. Hodge; Kathryn M. Meurs
Source:
Journal of the American Veterinary Medical Association 2014 v.245 no.5 pp. 534-539
ISSN:
0003-1488
Subject:
blood serum; body weight; cardiomyopathy; case-control studies; cats; clinical examination; echocardiography; heart failure
Abstract:
... Objective-To assess survival time and adverse events related to the administration of pimobendan to cats with congestive heart failure (CHF) secondary to hypertrophic cardiomyopathy (HCM) or hypertrophic obstructive cardiomyopathy (HOCM). Design-Retrospective case-control study. Animals-27 cats receiving treatment with pimobendan and 27 cats receiving treatment without pimobendan. Procedures-Medic ...
DOI:
10.2460/javma.245.5.534

15. Diagnosis and treatment of congestive heart failure secondary to dilated cardiomyopathy in a hedgehog

Author:
K. W. Delk; D. Eshar; E. Garcia; K. Harkin
Source:
journal of small animal practice 2014 v.55 no.3 pp. 174-177
ISSN:
0022-4510
Subject:
Atelerix albiventris; cardiomyopathy; carnitine; clinical examination; distress; edema; furosemide; heart; heart failure; patients; radiography
Abstract:
... A one‐year‐old African pygmy hedgehog (Atelerix albiventris) was evaluated for severe respiratory distress. Physical examination findings included marked dyspnoea, cyanosis and tachypnoea. Radiographic findings included an enlarged heart and pulmonary oedema, and dilated cardiomyopathy was confirmed via echocardiogram. The patient was treated for congestive heart failure because of dilated cardiom ...
DOI:
10.1111/jsap.12169
PubMed:
24372164

16. Evaluation of red blood cell distribution width in cats with hypertrophic cardiomyopathy

Author:
G. Stanzani; R. Cowlam; K. English; D.J. Connolly
Source:
Journal of veterinary cardiology 2015 v.17 pp. S233
ISSN:
1760-2734
Subject:
cardiomyopathy; cats; clinical examination; death; echocardiography; erythrocytes; heart; heart failure; hematocrit; hematology; hospitals; human diseases; mortality; prognosis; veterinarians
Abstract:
... Red blood cell distribution width (RDW) is a measurement of variability in circulating erythrocytes size, and has recently been shown to correlate with prognosis in a variety of human diseases, including acute and chronic heart failure.To determine if RDW differs between healthy controls, cats with hypertrophic cardiomyopathy (HCM) without congestive heart failure (CHF) and cats with HCM and CHF, ...
DOI:
10.1016/j.jvc.2015.09.001

17. Relationship of Body Size to Metabolic Markers and Left Ventricular Hypertrophy in Cats

Author:
L.M. Freeman; J.E. Rush; A. Feugier; I. Hoek
Source:
Journal of veterinary internal medicine 2015 v.29 no.1 pp. 150-156
ISSN:
0891-6640
Subject:
adults; arrhythmia; body condition; body size; body weight; cardiomyopathy; case-control studies; cats; clinical examination; echocardiography; females; glucose; head; hypertrophy; insulin; insulin-like growth factor I; males; multivariate analysis; natriuretic peptides; prospective studies
Abstract:
... BACKGROUND: Cats with hypertrophic cardiomyopathy (HCM) are larger and have higher insulin‐like growth factor‐1 (IGF‐1) concentrations than cats without HCM. HYPOTHESIS/OBJECTIVES: The aim of this study was to assess echocardiographic findings in a colony of adult cats to determine the relationship between early growth and left ventricular hypertrophy (LVH). ANIMALS: Twenty‐eight neutered adult ca ...
DOI:
10.1111/jvim.12503
PubMed:
25411091
PubMed Central:
PMC4858099

18. Cardiomyopathy in a Harris hawk (Parabuteo unicinctus)

Author:
Joao Brandao; Caryn A. Reynolds; Hugues Beaufrere; Jacqueline Serio; Robert V. Blair; Lorrie Gaschen; James G. III Johnson; Fabieo Del Piero; Steven A. Barker; Javier G. Nevarez; Thomas N. Tully
Source:
Journal of the American Veterinary Medical Association 2016 v.249 no.2 pp. 221-227
ISSN:
0003-1488
Subject:
Parabuteo unicinctus; adults; air sacs; birds of prey; cardiomyopathy; clinical examination; death; echocardiography; education programs; females; fungi; furosemide; hawks; hematologic tests; hospitals; microbial culture; necropsy; patients; poisoning; radiography; wildlife
Abstract:
... CASE DESCRIPTION An adult sexually intact female Harris hawk (Parabuteo unicinctus) housed at a wildlife hospital was evaluated because of acute collapse during an educational exhibition. CLINICAL FINDINGS Physical examination and hematologic analysis revealed no abnormalities; radiography revealed findings consistent with a previous tibiotarsal fracture. Coelioscopy with histologic examination an ...
DOI:
10.2460/javma.249.2.221

19. Hypovolemia induced systolic anterior motion of the mitral valve in two dogs

Author:
K. Hammes; J. Novo Matos; M. Baron Toaldo; T. Glaus
Source:
Journal of veterinary cardiology 2016 v.18 no.4 pp. 367-371
ISSN:
1760-2734
Subject:
cardiomyopathy; catecholamines; cats; clinical examination; dogs; echocardiography; geometry; humans; hypovolemic shock; tachycardia
Abstract:
... Systolic anterior (septal) motion of the mitral valve (SAM) is a common secondary phenomenon in hypertrophic cardiomyopathy (HCM) in people and cats. In humans, it is increasingly recognized that SAM may be found in other cardiac and non-cardiac disease states. In small animal cardiology, SAM unassociated with HCM has been described in dogs with mitral valve dysplasia and right ventricular pressur ...
DOI:
10.1016/j.jvc.2016.06.003

20. Ambulatory electrocardiogram recordings in cats with primary asymptomatic hypertrophic cardiomyopathy

Author:
Sofia Hanås; Anna Tidholm; Bodil S Holst
Source:
Journal of feline medicine and surgery v.19 no.2 pp. 158-164
ISSN:
1532-2750
Subject:
arrhythmia; blood pressure; cardiomyopathy; cats; clinical examination; echocardiography; electrocardiography; heart rate
Abstract:
... The aims of the study were to determine the heart rate, rhythm, number of ventricular premature complexes (VPCs) and atrial premature complexes (APCs) in unsedated cats with asymptomatic hypertrophic cardiomyopathy (HCM), using 24 h ambulatory electrocardiogram (ECG) (Holter) in the home environment and to compare the results with those from healthy control cats. Fifteen privately owned cats with ...
DOI:
10.1177/1098612X15618702

21. Investigation of an N‐Terminal Prohormone of Brain Natriuretic Peptide Point‐of‐Care ELISA in Clinically Normal Cats and Cats With Cardiac Disease

Author:
A.N. Harris; S.S. Beatty; A.H. Estrada; B. Winter; M. Bohannon; I. Sosa; J. Hanscom; C.A. Mainville; A.E. Gallagher
Source:
Journal of veterinary internal medicine 2017 v.31 no.4 pp. 994-999
ISSN:
0891-6640
Subject:
brain; cardiomyopathy; cats; clinical examination; echocardiography; enzyme-linked immunosorbent assay; natriuretic peptides; point-of-care systems; Florida
Abstract:
... BACKGROUND: N‐terminal prohormone of brain natriuretic peptide (NT‐proBNP) concentrations may be increased in cats with various cardiac disorders. The point‐of‐care (POC) ELISA assay uses the same biologic reagents as the quantitative NT‐proBNP ELISA. Previous studies have evaluated the sensitivity and specificity of the POC ELISA in cats with cardiac disease. OBJECTIVES: To prospectively evaluate ...
DOI:
10.1111/jvim.14776
PubMed:
28617995
PubMed Central:
PMC5508306

22. A novel TNNI3 gene mutation (c.235C>T/ p.Arg79Cys) found in a thirty-eight-year-old women with hypertrophic cardiomyopathy

Author:
Qin Tao; Junhua Yang; Weili Cheng; Shenghua Yu; Xu Fang; Pingping He; Yuqing Zhang
Source:
Open life sciences 2018 v.13 no.1 pp. 374-378
ISSN:
2391-5412
Subject:
cardiomyopathy; chest; clinical examination; daughters; distress; echocardiography; fibrosis; genes; heterozygosity; hospitals; hypertrophy; magnetic resonance imaging; mutation; phenotype; siblings; troponin I; women
Abstract:
... We report the case of a thirty-eight-year-old woman admitted to our hospital due to palpitation and chest distress. ST-T segment change was found in her ECG. She was then diagnosed with hypertrophic cardiomyopathy by two-dimensional echocardiography. Physical examination showed no obvious abnormal signs and all laboratory examinations were within the normal range. Myocardial fibrosis was detected ...
DOI:
10.1515/biol-2018-0045

23. Effects of sedation with dexmedetomidine and buprenorphine on echocardiographic variables, blood pressure and heart rate in healthy cats

Author:
Einar Johard; Anna Tidholm; Ingrid Ljungvall; Jens Häggström; Katja Höglund
Source:
Journal of feline medicine and surgery v.20 no.6 pp. 554-562
ISSN:
1532-2750
Subject:
blood pressure; body weight; buprenorphine; cardiomyopathy; cats; clinical examination; dexmedetomidine; echocardiography; heart rate; pulmonary artery; screening; sedation
Abstract:
... Sedative agents are occasionally used to enable echocardiographic examination when screening cats for heart disease, such as hypertrophic cardiomyopathy (HCM). Owing to their haemodynamic effects, sedative agents may alter echocardiographic measurements. The aim of the study was to evaluate the effects of the sedative combination dexmedetomidine and buprenorphine on echocardiographic variables, bl ...
DOI:
10.1177/1098612X17720327

24. Evaluation of add on effect of carvedilol on standard protocol of digoxin, frusemide and benazepril in the management of dilated cardiomyopathy in dogs

Author:
Akhilesh Kumar; Sahadeb Dey; Abhishek Chandra Saxena; Sumit Mahajan
Source:
Indian journal of animal research 2018 v.52 no.4 pp. 583-590
ISSN:
0976-0555
Subject:
angiotensin-converting enzyme inhibitors; animal research; beta-adrenergic antagonists; blood serum; cardiac output; cardiomyopathy; clinical examination; digoxin; dogs; echocardiography; electrocardiography; furosemide; protocols; quality of life; therapeutics
Abstract:
... This is a prospective, controlled, randomized clinical trial in canine patients with overt Dilated Cardiomyopathy (DCM). We hypothesized that the addition of the third generation beta-blocker carvedilol to the standard treatment of diuretic (furosemide), inotropic support (digoxin) and ACE-inhibitor (benazepril) would have beneficial effects over cardiac function and quality of life (QoL) that wou ...
DOI:
10.18805/ijar. B-3377

25. Symmetric Dimethylarginine in Cats with Hypertrophic Cardiomyopathy and Diabetes Mellitus

Author:
R. Langhorn; I.N. Kieler; J. Koch; L.B. Christiansen; L.R. Jessen
Source:
Journal of veterinary internal medicine 2018 v.32 no.1 pp. 57-63
ISSN:
0891-6640
Subject:
algorithms; analysis of variance; blood pressure; blood serum; cardiomyopathy; case-control studies; cats; clinical examination; comorbidity; diabetes mellitus; echocardiography; kidney diseases; renal function; thyroxine; urinalysis
Abstract:
... BACKGROUND: Symmetric dimethylarginine (SDMA) has been increasingly used as a marker of early chronic kidney disease (CKD) in cats, but little is known about the influence of comorbidities on SDMA in this species. HYPOTHESIS: Hypertrophic cardiomyopathy (HCM) and diabetes mellitus (DM), independently of CKD, are associated with changes in serum SDMA. ANIMALS: Ninety‐four cats (17 with CKD, 40 with ...
DOI:
10.1111/jvim.14902
PubMed:
29230874
PubMed Central:
PMC5787200

26. A prospective evaluation of oral Yunnan Baiyao therapy on thromboelastographic parameters in apparently healthy cats

Author:
Jeffrey E. Patlogar; Colleen Tansey; Melissa Wiebe; Gabrielle C. Hybki; Todd Trostel; Lisa A. Murphy; Reid K. Nakamura
Source:
Journal of veterinary emergency and critical care 2019 v.29 no.6 pp. 611-615
ISSN:
1479-3261
Subject:
adults; adverse effects; anemia; blood sampling; cardiomyopathy; cats; clinical examination; echocardiography; erythrocyte count; fibrinogen; hospitals; mediastinum; prospective studies; therapeutics; vomiting; China
Abstract:
... OBJECTIVE: To determine the effect of Yunnan Baiyao (YB) on hemostatic parameters measured by thromboelastography (TEG) in apparently healthy cats administered 1 capsule of YB orally twice daily for 1 week. DESIGN: Prospective study of client‐owned cats at a small animal specialty hospital. SETTING: One private referral center. ANIMALS: Twenty client‐owned adult cats were prospectively enrolled. I ...
DOI:
10.1111/vec.12895

27. Common pathogenic mechanism in patients with dropped head syndrome caused by different mutations in the MYH7 gene

Author:
Yulia Surikova; Alexandra Filatova; Margarita Polyak; Mikhail Skoblov; Elena Zaklyazminskaya
Source:
Gene 2019 v.697 pp. 159-164
ISSN:
0378-1119
Subject:
adulthood; amino acid sequences; biopsy; cardiomyopathy; cell lines; clinical examination; complementary DNA; electromyography; exons; head; histopathology; males; medical history; messenger RNA; muscles; muscular diseases; mutants; mutation; patients; phenotype; plasmids; sequence analysis
Abstract:
... Mutations in the MYH7 gene are the source of an allelic series of diseases, including various cardiomyopathies and skeletal myopathies that usually manifest in adulthood. We observed a 1.5 y.o. male patient with congenital weaknesses of the axial muscles, “dropped head” syndrome, and dilated cardiomyopathy. The clinical evaluation included medical history, an echocardiogram, electromyography, and ...
DOI:
10.1016/j.gene.2019.02.011

28. Holter monitoring demonstrates that ventricular arrhythmias are common in cats with decompensated and compensated hypertrophic cardiomyopathy

Author:
U. Bartoszuk; B.W. Keene; M. Baron Toaldo; N. Pereira; N. Summerfield; J. Novo Matos; T.M. Glaus
Source:
veterinary journal 2019 v.243 pp. 21-25
ISSN:
1090-0233
Subject:
blood serum; cardiomyopathy; cat diseases; cats; clinical examination; death; echocardiography; heart rate; monitoring; prognosis; radiography; tachycardia; troponin I
Abstract:
... Arrhythmias can complicate cardiac disease in cats and are a potential cause of sudden death. The aim of this study was to evaluate the presence and nature of cardiac arrhythmias, and the potential correlation between plasma serum troponin I (cTnI) concentrations and the presence or severity of arrhythmias in cats with decompensated (dHCM) and compensated hypertrophic cardiomyopathy (cHCM). Forty ...
DOI:
10.1016/j.tvjl.2018.11.005

29. Absolute Erythrocytosis in a Sunda Wrinkled Hornbill (Aceros corrugatus)

Author:
Jon Romano; Terry W. Campbell; Krystan R. Grant; Christine Montgomery; Sushan Han
Source:
Journal of avian medicine and surgery 2020 v.34 no.2 pp. 192-197
ISSN:
1082-6742
Subject:
Aceros; atherosclerosis; birds; blood; body condition; carcinoma; cardiomyopathy; cell biology; clinical examination; heart; hematopoiesis; histopathology; hypertrophy; hypoxia; lungs; males; medicine; necropsy; polycythemia; prognosis; radiography; surgery; ultrasonography; uremia
Abstract:
... A captive, 22-year-old, intact male Sunda wrinkled hornbill (Aceros corrugatus) was presented for an acute onset of open-mouth breathing and bilaterally drooped wings. An external physical examination revealed a moderately thin body condition, marked respiratory effort, and a significant heart murmur. Diagnostic blood testing revealed moderate azotemia and persistent erythrocytosis, initially docu ...
DOI:
10.1647/1082-6742-34.2.192

30. Detection of congestive heart failure by Doppler echocardiography in cats with hypertrophic cardiomyopathy

Author:
Michelle N. Rohrbaugh; Karsten E. Schober; Jaylyn D. Rhinehart; John D. Bonagura; Amy Habing; Vedat Yildiz
Source:
Journal of veterinary internal medicine 2020 v.34 no.3 pp. 1091-1101
ISSN:
0891-6640
Subject:
blood serum; cardiomyopathy; clinical examination; cohort studies; echocardiography; heart failure; natriuretic peptides; radiography; respiratory rate; veterinary medicine
Abstract:
... BACKGROUND: Left‐sided congestive heart failure (CHF) is characterized by increased filling pressures and related Doppler echocardiographic (DE) filling patterns. HYPOTHESIS: Doppler echocardiographic variables of left ventricular filling derived from transmitral flow, pulmonary vein flow, and tissue Doppler can be used to detect CHF in cats with hypertrophic cardiomyopathy (HCM). ANIMALS: Forty‐s ...
DOI:
10.1111/jvim.15777

31. Diagnosis and Management of Dilated Cardiomyopathy (DCM) in a Dog

Author:
Dipanjan Mondal; P. Mukherjee; J. Mukherjee
Source:
Intas polivet 2020 v.21 no.1 pp. 183-184
ISSN:
2249-8796
Subject:
Golden Retriever; cardiomyopathy; carnitine; clinical examination; dietary supplements; dogs; dyspnea; exercise; heart; tachypnea; taurine
Abstract:
... A ten years old Golden Retriever dog was presented with history of dyspnea, inappetence and exercise intolerance since last one month. Physical examination revealed tachypnea and cardiac murmurs. Hematological values were normal. Vertebral heart score revealed increased cardiac silhouette which was subsequently confirmed in ECG. The animal was treated with ACE inhibitors, diuretics and cardiac ion ...

32. Effect of feline characteristics on plasma N‐terminal‐prohormone B‐type natriuretic peptide concentration and comparison of a point‐of‐care test and an ELISA test

Author:
Sofia Hanås; Bodil S. Holst; Katja Höglund; Jens Häggström; Anna Tidholm; Ingrid Ljungvall
Source:
Journal of veterinary internal medicine 2020 v.34 no.3 pp. 1187-1197
ISSN:
0891-6640
Subject:
blood chemistry; blood pressure; cardiomyopathy; cats; clinical examination; echocardiography; females; hematology; males; natriuretic peptides; point-of-care systems; veterinary medicine
Abstract:
... BACKGROUND: Increased plasma concentration of N‐terminal‐prohormone B‐type natriuretic peptide (NT‐proBNP) can be detected in cats with cardiac disease. Potential effects of feline characteristics on NT‐proBNP concentration may influence clinical usefulness. OBJECTIVES: To evaluate potential effects of feline characteristics on NT‐proBNP plasma concentration and to compare NT‐proBNP plasma concent ...
DOI:
10.1111/jvim.15754

33. Lack of Association of IL6 polymorphism with the susceptibility to Chagas disease in Latin American populations

Author:
Mariana Strauss; Desiré Casares-Marfil; Alexia Alcaraz; Miriam Palma-Vega; Pau Bosch-Nicolau; María Silvina Lo Presti; Israel Molina; Clara Isabel González; Javier Martín; Marialbert Acosta-Herrera; Chagas Genetics CYTED Network
Source:
Acta tropica 2020 v.210 pp. 105546
ISSN:
0001-706X
Subject:
Chagas disease; Trypanosoma cruzi; cardiomyopathy; clinical examination; interleukin-6; meta-analysis; seroprevalence; Argentina; Bolivia; Colombia; Peru
Abstract:
... The aim of the present study was to analyze IL6 rs1800795 genetic variant in the susceptibility to Trypanosoma cruzi infection and in the development of chronic Chagas cardiomyopathy (CCC), in five independent Latin American cohorts. A total of 3,087 individuals from Latin American countries (Argentina, Bolivia, Peru, and two cohorts from Colombia) were studied. In all cohorts, patients were class ...
DOI:
10.1016/j.actatropica.2020.105546

34. Sleeping hearts: 12 years after a follow up study on cardiac findings due to sleeping sickness

Author:
Anna Blum; Junior Mudji; Leticia Grize; Christian Burri; Michael J. Zellweger; Johannes Blum
Source:
One health 2020 v.11 pp. 100182
ISSN:
2352-7714
Subject:
African trypanosomiasis; Chagas disease; Protozoa; cardiomyopathy; clinical examination; complications (disease); electric potential difference; heart failure; humans; villages; Cameroon; Democratic Republic of the Congo
Abstract:
... Both American Trypanosomiasis (Chagas disease) and Human African Trypanosomiasis (HAT) are diseases caused by single-celled flagellate protozoan parasites. While cardiac complications such as conduction problems and heart failure are very common in Chagas disease there is little known about the long-term effects of Human African Trypanosomiasis (HAT) on cardiac sequelae in Sub-Saharan Africa, wher ...
DOI:
10.1016/j.onehlt.2020.100182

35. Successful management of ventricular fibrillation and ventricular tachycardia using defibrillation and intravenous amiodarone therapy in a cat

Author:
Noa Berlin; Dan G. Ohad; Igal Maiorkis; Efrat Kelmer
Source:
Journal of veterinary emergency and critical care 2020 v.30 no.4 pp. 474-480
ISSN:
1479-3261
Subject:
cardiac arrest; cardiomyopathy; cardiopulmonary resuscitation; clinical examination; echocardiography; electrocardiography; intravenous injection; lidocaine; males; patients; tachycardia
Abstract:
... OBJECTIVE: To describe the successful management of ventricular fibrillation (VF) and ventricular tachycardia (VT) using cardiopulmonary resuscitation, including defibrillation, followed by continuous rate infusion of IV amiodarone, in a cat with cardiac arrest secondary to tachyarrhythmia. CASE SUMMARY: A 12‐year‐old previously healthy neutered male Scottish Fold cat presented following an acute ...
DOI:
10.1111/vec.12960

36. Tolerance of torasemide in cats with congestive heart failure: a retrospective study on 21 cases (2016–2019)

Author:
Camille Poissonnier; Sarra Ghazal; Peggy Passavin; Maria-Paz Alvarado; Solène Lefort; Emilie Trehiou-Sechi; Vittorio Saponaro; Alix Barbarino; Julia Delle Cave; Charlie-Rose Marchal; Boris Depré; Etienne Vannucci; Renaud Tissier; Patrick Verwaerde; Valérie Chetboul
Source:
BMC veterinary research 2020 v.16 no.1 pp. 339
ISSN:
1746-6148
Subject:
adverse effects; age; ascites; cardiomyopathy; cats; clinical examination; data collection; death; disease course; dogs; dosage; dyspnea; echocardiography; edema; furosemide; heart failure; humans; medical records; objectives; population; prospective studies; retrospective studies; sole; veterinary medicine
Abstract:
... BACKGROUND: In dogs with congestive heart failure (CHF), the efficacy of torasemide, a loop diuretic, has been demonstrated. However, unlike in dogs and humans little has been described about the use of torasemide in the cat with spontaneous CHF. The objectives of this retrospective study were therefore to describe the therapeutic use of oral torasemide in cats with spontaneous CHF, document its p ...
DOI:
10.1186/s12917-020-02554-6

37. Acute and severe haemorrhage following pentosan polysulfate injection in a Cornish Rex

Author:
Miranda X Tong; Jessica F Romine; Michael R Hardcastle
Source:
Journal of feline medicine and surgery open reports 2021 v.7 no.2 pp. 20551169211058650
ISSN:
2055-1169
Subject:
anemia; arthritis; blood transfusion; cardiomyopathy; cats; clinical examination; coumarin; edema; fluid therapy; glucosamine; heart failure; hematocrit; hemorrhage; liver; males; medicine; neck; patients; sodium; subcutaneous injection; thorax
Abstract:
... A 14-year-old male castrated Cornish Rex cat was referred for lethargy progressing rapidly to collapse in the hours following a subcutaneous injection of a product containing 100 mg/ml pentosan polysulfate sodium and 168 mg/ml glucosamine. Physical examination revealed the cat to be in hypotensive shock with swelling and interstitial oedema around the cranial thorax and caudal cervical regions wit ...
DOI:
10.1177/20551169211058650

38. Canine thoracic radiographic images as an educational dataset for distance learning and research on vertebral heart score

Author:
Cesar Augusto Flores Dueñas; Soila Maribel Gaxiola Camacho; Martin Francisco Montaño Gómez; Rafael Villa Angulo; Idalia Enríquez Verdugo; Tomás Rentería Evangelista; José Ascención Pérez Corrales; Miguel Ángel Rodríguez Gaxiola
Source:
Data in Brief 2021 v.36 pp. 107040
ISSN:
2352-3409
Subject:
body length; cardiomyopathy; clinical examination; data collection; dogs; females; heart; hospitals; males; patients; radiography; radiology; research institutions; veterinary medicine; Mexico
Abstract:
... Distance learning is a rapidly spreading form of education worldwide and it plays a crucial role to provide access to millions of people in developing countries. However, the benefits of online learning extend far beyond and became increasingly popular also in medical schools, including veterinary medicine [1,2]. In these new teaching settings, high-quality, validated and easily accessible multime ...
DOI:
10.1016/j.dib.2021.107040

39. Feasibility of a Combined Mobile-Health Electrocardiographic and Rapid Diagnostic Test Screening for Chagas-Related Cardiac Alterations

Author:
Michele Spinicci; Carlo Fumagalli; Niccolò Maurizi; Enrico Guglielmi; Mimmo Roselli; Herlan Gamboa; Marianne Strohmeyer; Veronica Poma; Roberto Vargas; Iacopo Olivotto; Alessandro Bartoloni
Source:
Microorganisms 2021 v.9 no.9 pp. -
ISSN:
2076-2607
Subject:
Chagas disease; Trypanosoma cruzi; X-radiation; cardiomyopathy; chest; clinical examination; death; electrocardiography; multivariate analysis; risk; systolic blood pressure; telemedicine; villages; wireless technology; Bolivia
Abstract:
... Background: Chronic Chagas cardiomyopathy (CChC) is the most common cause of death related to Chagas disease (CD). The aim of this study was to assess the feasibility of a combined rapid diagnostic test (RDT) and electrocardiographic (ECG) screening in a remote rural village of the Bolivian Chaco, with a high prevalence of CChC. Methods: Consecutive healthy volunteers > 15 years were enrolled in t ...
DOI:
10.3390/microorganisms9091889

40. Histologic comparison in two Doberman pinschers with a dilated cardiomyopathy phenotype

Author:
K.T. Sykes; A.B. Saunders; A.R. Hoffmann; B.F. Porter
Source:
Journal of veterinary cardiology 2021 v.33 pp. 1-5
ISSN:
1760-2734
Subject:
Chagas disease; Trypanosoma cruzi; amastigotes; cardiomyopathy; clinical examination; echocardiography; electrocardiography; fibrosis; histology; histopathology; inflammation; insect vectors; myocarditis; myocardium; parasites; phenotype; toxicity
Abstract:
... Idiopathic dilated cardiomyopathy (DCM) is a common acquired cardiac disease in large breed dogs with a high prevalence in Doberman pinschers. It is characterized histologically by attenuated wavy fibers and fatty infiltration with degeneration. The phenotypic appearance of DCM includes ventricular dilation with systolic dysfunction and ventricular arrhythmias. These changes can be caused by other ...
DOI:
10.1016/j.jvc.2020.10.001

41. Pathogenic variants in plakophilin-2 gene (PKP2) are associated with better survival in arrhythmogenic right ventricular cardiomyopathy

Author:
Elżbieta K. Biernacka; Karolina Borowiec; Maria Franaszczyk; Małgorzata Szperl; Alessandra Rampazzo; Olgierd Woźniak; Marta Roszczynko; Witold Śmigielski; Anna Lutyńska; Piotr Hoffman
Source:
Journal of applied genetics 2021 v.62 no.4 pp. 613-620
ISSN:
1234-1983
Subject:
cardiomyopathy; clinical examination; death; echocardiography; electrocardiography; genes; genotype-phenotype correlation; heart failure; heart transplant; high performance liquid chromatography; medical history; mutation; phenotype; prognosis
Abstract:
... Arrhythmogenic right ventricular cardiomyopathy (ARVC) is mainly caused by mutations in genes encoding desmosomal proteins. Variants in plakophilin-2 gene (PKP2) are the most common cause of the disease, associated with conventional ARVC phenotype. The study aims to evaluate the prevalence of PKP2 variants and examine genotype–phenotype correlation in Polish ARVC cohort. All 56 ARVC patients fulfi ...
DOI:
10.1007/s13353-021-00647-y

42. Proteomic characterization of serum proteins from Atlantic salmon (Salmo salar L.) from an outbreak with cardiomyopathy syndrome

Author:
Janina Z. Costa; Jorge del Pozo; Kevin McLean; Neil Inglis; Philippe Sourd; Andrei Bordeianu; Kim D. Thompson
Source:
Journal of fish diseases 2021 v.44 no.11 pp. 1697-1709
ISSN:
0140-7775
Subject:
Salmo salar; aquaculture; biomarkers; blood serum; carbonate dehydratase; cardiomyopathy; clinical examination; creatine kinase; early diagnosis; ferroxidase; fibrinogen; fibronectins; glycogen; lactate dehydrogenase; myocarditis; phosphorylase; protein content; proteomics; salmon; viruses; vitamin A
Abstract:
... Cardiomyopathy syndrome (CMS), caused by piscine myocarditis virus (PMCV), is a serious challenge to Atlantic salmon (Salmo salar L.) aquaculture. Regrettably, husbandry techniques are the only tool to manage CMS outbreaks, and no prophylactic measures are available at present. Early diagnosis of CMS is therefore desirable, preferably with non‐lethal diagnostic methods, such as serum biomarkers. T ...
DOI:
10.1111/jfd.13488

43. Risk indictors in cats with preclinical hypertrophic cardiomyopathy: a prospective cohort study

Author:
Vicky A Ironside; Philip R Tricklebank; Adrian Boswood
Source:
Journal of feline medicine and surgery 2021 v.23 no.2 pp. 149-159
ISSN:
1532-2750
Subject:
blood; blood pressure; cardiomyopathy; cats; clinical examination; cohort studies; death; echocardiography; heart failure; medicine; natriuretic peptides; patients; risk; surgery
Abstract:
... This study aimed to identify indicators of the risk of progression of preclinical hypertrophic cardiomyopathy (HCM). This was a prospective cohort study following a population of cats with preclinical HCM. Cats serially underwent physical examination, blood pressure measurement, blood sampling and echocardiography. Development of congestive heart failure (CHF), arterial thromboembolism (ATE) or su ...
DOI:
10.1177/1098612X20938651

44. SCN5A gene variants as potential markers of the progression of chronic chagasic cardiac alterations

Author:
Romina Laura Blasco; Mariana Strauss; Daniela Alejandra Velázquez López; Sandra Tabares; Adela Sembaj; Héctor Walter Rivarola; Patricia Adriana Paglini; María Silvina Lo Presti
Source:
Parasitology international 2021 v.80 pp. 102213
ISSN:
1383-5769
Subject:
Chagas disease; Trypanosoma cruzi; alleles; antibodies; cardiomyopathy; clinical examination; disease progression; electrocardiography; genetic factors; genotype; parasitology; patients; polymorphism; seroprevalence; sodium channels
Abstract:
... Host genetic factors have been proposed as determinants of the variable progression of Chagas disease (ChD). Two polymorphisms, H558R and A572D, of the voltage-gated sodium channel α-subunit SCN5A gene were studied in chagasic patients in order to determine their contribution to the susceptibility to the development and/or to the progression of the cardiovascular disease. A total of 104 patients w ...
DOI:
10.1016/j.parint.2020.102213

45. The Feline Cardiomyopathies: 1. General concepts

Author:
Mark D Kittleson; Etienne Côté
Source:
Journal of feline medicine and surgery 2021 v.23 no.11 pp. 1009-1027
ISSN:
1532-2750
Subject:
adults; biomarkers; cardiomyopathy; cats; clinical examination; death; disease severity; dyspnea; echocardiography; edema; heart; heart failure; medicine; mixed breeds; natriuretic peptides; pain; paralysis; phenotype; point-of-care systems; prognosis; radiography; surgery; tachypnea; ultrasonics
Abstract:
... The feline cardiomyopathies are the most prevalent type of heart disease in adult domestic cats. Several forms have been identified (see Parts 2 and 3), with hypertrophic cardiomyopathy (HCM) being the most common. Clinically the cardiomyopathies are often indistinguishable. Cats with subclinical cardiomyopathy may or may not have characteristic physical examination findings (eg, heart murmur, gal ...
DOI:
10.1177/1098612X211021819

46. Variants in MHY7 Gene Cause Arrhythmogenic Cardiomyopathy

Author:
Valentina Ferradini; Luca Parca; Annamaria Martino; Chiara Lanzillo; Elisa Silvetti; Leonardo Calò; Stefano Caselli; Giuseppe Novelli; Manuela Helmer-Citterich; Federica Carla Sangiuolo; Ruggiero Mango
Source:
Genes 2021 v.12 no.6 pp. -
ISSN:
2073-4425
Subject:
cardiomyopathy; clinical examination; computer simulation; genes; genetic heterogeneity; muscle strength; mutation; myosin heavy chains; necropsy; pathogenesis; phenotype; sarcomeres; syncope; tachycardia
Abstract:
... Background: Arrhythmogenic Cardiomyopathy (ACM) is a disease of the cardiac muscle, characterized by frequent ventricular arrhythmias and functional/ structural abnormalities, mainly of the right ventricle. To date, 20 different genes have been associated with ACM and the majority of them encode for desmosomal proteins. In this study, we describe the characterization of two novel variants in MHY7 ...
DOI:
10.3390/genes12060793

47. Prediction of clinically important acquired cardiac disease without an echocardiogram in large breed dogs using a combination of clinical, radiographic and electrocardiographic variables

Author:
S. Wesselowski; S.G. Gordon; N. Meddaugh; A.B. Saunders; J. Häggström; K. Cusack; B.W. Janacek; D.J. Matthews
Source:
Journal of veterinary cardiology 2022 v.40 pp. 126-141
ISSN:
1760-2734
Subject:
cardiomyopathy; clinical examination; echocardiography; electrocardiography; heart; prediction; radiography
Abstract:
... Large breed (LB) dogs develop dilated cardiomyopathy (DCM) and myxomatous mitral valve disease (MMVD). Echocardiography is required for a definitive diagnosis but is not always available. Our objective was to assess the clinical utility of thoracic radiographs alone and in combination with physical examination and electrocardiography findings for the prediction of clinically important DCM or MMVD ...
DOI:
10.1016/j.jvc.2021.07.003

48. Prospective clinical trial evaluating spironolactone in Doberman pinschers with congestive heart failure due to dilated cardiomyopathy

Author:
A. Laskary; S. Fonfara; H. Chambers; M.L. O'Sullivan
Source:
Journal of veterinary cardiology 2022 v.40 pp. 84-98
ISSN:
1760-2734
Subject:
aldosterone; antagonists; atrial fibrillation; cardiomyopathy; clinical examination; death; echocardiography; euthanasia; heart failure; placebos; prospective studies; quality of life; questionnaires; radiography; spironolactone; therapeutics
Abstract:
... Whether the aldosterone antagonist spironolactone has beneficial survival effects in dogs with dilated cardiomyopathy (DCM) is not known. The primary objective of the study was to evaluate the effect of spironolactone, when added to conventional therapy, on survival time in Doberman pinschers with congestive heart failure (CHF) due to DCM. Sixty-seven client-owned Doberman pinschers with CHF due t ...
DOI:
10.1016/j.jvc.2021.06.001

49. Prospective evaluation of the combined value of physical examination and biomarker variables in screening for preclinical dilated cardiomyopathy in Doberman Pinschers

Author:
S.G. Gordon; S. Wesselowski; A.H. Estrada; L. Braz-Ruivo; N. Morris; J. Häggström; M.R. O'Grady; E. Malcolm
Source:
Journal of veterinary cardiology 2022 v.40 pp. 69-83
ISSN:
1760-2734
Subject:
biomarkers; cardiomyopathy; clinical examination; heart; natriuretic peptides; prediction
Abstract:
... Screening to assess likelihood of preclinical dilated cardiomyopathy (PC-DCM) prior to advanced diagnostic tests in Doberman Pinschers (DP) is desirable. To investigate the combined value of physical examination (PE), N-terminal pro B-type natriuretic peptide (NTproBNP) and cardiac troponin I (cTnI) for identifying PC-DCM in DP. All dogs underwent: PE, echocardiogram, 3-min ECG and cardiac biomark ...
DOI:
10.1016/j.jvc.2022.01.004