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You searched for: Author "Isupov, Michail N." Remove constraint Author: "Isupov, Michail N." Subject crystal structure Remove constraint Subject: crystal structure Subject Fasciola hepatica Remove constraint Subject: Fasciola hepatica
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1. The Fasciola hepatica thioredoxin: High resolution structure reveals two oxidation states

Author:
Isupov, Michail N.,   et al.   ; Line, Kirsty; Garcia-Rodriguez, Esther; Maggioli, Gabriela; Parra, Francisco; Littlechild, Jennifer A.;     Show all 6 Authors
Source:
Molecular and biochemical parasitology 2008 v.161 no.1 pp. 44-48
ISSN:
0166-6851
Subject:
Fasciola hepatica; active sites; crystal structure; cysteine; disulfide bonds; hosts; humans; oxidation; protein structure
Abstract:
... The Fasciola hepatica thioredoxin protein structure has been determined to 1.45Å resolution. This is the first example of a single crystal structure to show the active site cysteine residues in both the reduced and disulfide oxidised form. Consistent with this observation the process of oxidation appears to require very little rearrangement of the surrounding protein structure. The F. hepatica thi ...
DOI:
10.1016/j.molbiopara.2008.06.009