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1. Pyridoxal-5′-phosphate-dependent enzymes involved in biotin biosynthesis: Structure, reaction mechanism and inhibition Proteins and proteomics

Author:
Mann, Stéphane; Ploux, Olivier
Source:
Biochimica et biophysica acta 2011 v.1814 no.11 pp. 1459-1466
ISSN:
1570-9639
Subject:
serine C-palmitoyltransferase,   etc   ; 5-aminolevulinate synthase; Mycobacterium tuberculosis; acylation; antibiotics; biosynthesis; biotin; crystal structure; decarboxylation; enzyme inactivation; herbicides; microorganisms; pyridoxal; transamination;     Show all 14 Subjects
Abstract:
... The four last steps of biotin biosynthesis, starting from pimeloyl-CoA, are conserved among all the biotin-producing microorganisms. Two enzymes of this pathway, the 8-amino-7-oxononanoate synthase (AONS) and the 7,8-diaminopelargonic acid aminotransferase (DAPA AT) are dependent on pyridoxal-5′-phosphate (PLP). This review summarizes our current understanding of the structure, reaction mechanism ...
DOI:
10.1016/j.bbapap.2010.12.004