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1. Tanshinone IIB, a primary active constituent from Salvia miltiorrhiza, exerts neuroprotective effect via inhibition of neuronal apoptosis in vitro

Author:
Xue, Charlie Changli,   et al.   ; Yu, Xue-Qing; Zhou, Zhi-Wei; Li, Chun-Guang; Zhou, Shu-Feng;     Show all 5 Authors
Source:
Phytotherapy research 2008 v.22 no.6 pp. 846-850
ISSN:
0951-418X
Subject:
DNA; Salvia miltiorrhiza; apoptosis; caspase-3; cytotoxicity; in vitro studies; myocardial ischemia; neurons; neuroprotective effect; proteins; rats; roots; stroke
Abstract:
... Tanshinone IIB (TSB) is a major active constituent of the roots of Salvia miltiorrhiza (Danshen) widely used in the treatment of stroke and coronary heart disease in Asian countries. This study investigated the in vitro neuroprotective effects of TSB and the underlying mechanism. Co-treatment with TSB significantly inhibited the cytotoxicity and apoptosis of rat cortical neurons induced by stauros ...
DOI:
10.1002/ptr.2404

2. Rapid synthesis of NADPH responsive CdSe quantum dots from selenium nanoparticles

Author:
Lv, Changli,   et al.   ; Zhou, Mengcheng; Liu, Bingxin; Chen, Zhijun; Shen, Jiacong;     Show all 5 Authors
Source:
RSC advances 2014 v.4 no.105 pp. 61133-61136
ISSN:
2046-2069
Subject:
NADP (coenzyme); ambient temperature; bovine serum albumin; cadmium; cytotoxicity; glutathione; nanoparticles; quantum dots; selenium
Abstract:
... Herein we developed a new approach for CdSe quantum dots (QDs) synthesis. These bovine serum albumin (BSA) and glutathione (GSH) conjugated CdSe QDs (BSA–GSH–CdSe QDs) are of low cytotoxicity and NADPH responsive. The whole synthetic process can be completed within 8 minutes at room temperature. ...
DOI:
10.1039/c4ra11312h

3. In vitro and in vivo studies on the degradation of high-purity Mg (99.99wt.%) screw with femoral intracondylar fractured rabbit model

Author:
Zhao, Changli,   et al.   ; Han, Pei; Cheng, Pengfei; Zhang, Shaoxiang; Ni, Jiahua; Zhang, Yuanzhuang; Zhong, Wanrun; Hou, Peng; Zhang, Xiaonong; Zheng, Yufeng; Chai, Yimin;     Show all 11 Authors
Source:
Biomaterials 2015 v.64 pp. 57-69
ISSN:
0142-9612
Subject:
X-radiation; alkaline phosphatase; bone density; bone formation; bone marrow; cell viability; corrosion; cytotoxicity; gene expression; genes; humans; in vivo studies; magnesium; messenger RNA; micro-computed tomography; models; osteopontin; rabbits; scanning electron microscopy; stem cells; toxic substances
Abstract:
... High-purity magnesium (HP Mg) takes advantage in no alloying toxic elements and slower degradation rate in lack of second phases and micro-galvanic corrosion. In this study, as rolled HP Mg was fabricated into screws and went through in vitro immersion tests, cytotoxicity test and bioactive analysis. The HP Mg screws performed uniform corrosion behavior in vitro, and its extraction promoted cell v ...
DOI:
10.1016/j.biomaterials.2015.06.031

4. Cytotoxic Kendomycins Containing the Carbacylic Ansa Scaffold from the Marine-Derived Verrucosispora sp. SCSIO 07399

Author:
Sun, Changli,   et al.   ; Zhang, Shanwen; Xie, Qing; Tian, Xin-Peng; Gui, Chun; Qin, Xiangjing; Zhang, Hua; Ju, Jianhua;     Show all 8 Authors
Source:
Journal of natural products 2019 v.82 no.12 pp. 3366-3371
ISSN:
1520-6025
Subject:
Gram-positive bacteria; Verrucosispora; X-ray diffraction; antibacterial properties; cytotoxicity; derivatization; human cell lines; inhibitory concentration 50; minimum inhibitory concentration; neoplasm cells; spectral analysis
Abstract:
... Three new kendomycin analogues, kendomycins B–D (1–3), were discovered from the marine-derived actinomycete Verrucosispora sp. SCSIO 07399. The structures of 1–3 were elucidated using diverse spectroscopic data analyses, X-ray crystallography, and semisynthetic derivatization. In vitro antimicrobial assays revealed that 1–3 all display good antibacterial activities against six Gram-positive bacter ...
DOI:
10.1021/acs.jnatprod.9b00654

5. Antitubercular Ilamycins from Marine-Derived Streptomyces atratus SCSIO ZH16 ΔilaR

Author:
Sun, Changli,   et al.   ; Liu, Zhiyong; Zhu, Xiangcheng; Fan, Zhiying; Huang, Xuanmei; Wu, Qiaoling; Zheng, Xiaohong; Qin, Xiangjing; Zhang, Tianyu; Zhang, Hua; Ju, Jianhua; Ma, Junying;     Show all 12 Authors
Source:
Journal of natural products 2020 v.83 no.5 pp. 1646-1657
ISSN:
1520-6025
Subject:
Human immunodeficiency virus; Mycobacterium tuberculosis; Streptomyces atratus; X-ray diffraction; amino acids; antineoplastic activity; bioassays; cytotoxicity; death; drugs; human cell lines; minimum inhibitory concentration; multiple drug resistance; mutants; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; pathogens; structure-activity relationships; tuberculosis
Abstract:
... Tuberculosis (TB) ranks as the leading cause of death from a single infectious agent (ranking more lethal than HIV/AIDS) over the course of the past decade. More concerning is that reports of multi-drug-resistant (MDR) and extensively drug-resistant (XDR) strains of TB have been dramatically increasing. It continues to become ever more clear that novel anti-TB drugs with improved efficacies and re ...
DOI:
10.1021/acs.jnatprod.0c00151