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- Liu Bin; Zheng Ying; Wang Tong-Dan; Xu Han-Zhang; Xia Li; Zhang Jian; Wu Ying-Li; Chen Guo-Qiang; Wang Li-Shun
- Journal of Proteome Research 2012 v.11 no.3 pp. 1773-1781
- F-box proteins; cell lines; databases; glycoproteins; liquid chromatography; mass spectrometry; mutants; proteomics; ubiquitin-protein ligase; ubiquitination
- ... FBOX6 ubiquitin ligase complex is involved in the endoplasmic reticulum-associated degradation pathway by mediating the ubiquitination of glycoproteins. FBXO6 interacts with the chitobiose in unfolded N-glycoprotein, pointing glycoproteins toward E2 for ubiquitination. Although the glycoprotein-recognizing mechanism of FBXO6 is well documented, its bona fide interacting glycoproteins are largely u ...