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1. Modulatory Role of Vaginal-Isolated Lactococcus lactis on the Expression of miR-21, miR-200b, and TLR-4 in CAOV-4 Cells and In Silico Revalidation

Author:
Yalda Rahbar Saadat; Mohammad Mostafa Pourseif; Sepideh Zununi Vahed; Abolfazl Barzegari; Yadollah Omidi; Jaleh Barar
Source:
Probiotics and antimicrobial proteins 2020 v.12 no.3 pp. 1083-1096
ISSN:
1867-1306
Subject:
4',6-diamidino-2-phenylindole; DNA; Lactococcus lactis; Toll-like receptor 4; animal ovaries; apoptosis; biomarkers; computer simulation; databases; flow cytometry; gene expression regulation; genes; microRNA; microarray technology; molecular biology; neoplasm cells; ovarian neoplasms; probiotics; protein-protein interactions; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; staining; vagina; women
Abstract:
... Ovarian cancer (OC) is a leading cause of death among women worldwide. Various evidences suggest that oncomiRs and Toll-like receptor 4 (TLR-4) signaling pathways appear to be key players in the initiation and progression of OC. It seems there exists a continuous intercommunication between cancer cells and normal microbiota of the vagina. The biological impacts of vaginal isolated lactococcus lact ...
DOI:
10.1007/s12602-019-09596-9

2. Structure and expression of the long noncoding RNA gene MIR503 in humans and non-human primates

Author:
Ramesh Choudhari; Barbara Yang; Peter Rotwein; Shrikanth S. Gadad
Source:
Molecular and cellular endocrinology 2020 v.510 pp. 110819
ISSN:
0303-7207
Subject:
Primates; RNA splicing; X chromosome; animal ovaries; databases; exons; gene expression; genomics; human physiology; humans; messenger RNA; neoplasms; non-coding RNA; testes; tissues; transcription (genetics)
Abstract:
... Recent technical and other advances in genomics provide unique opportunities to improve our understanding of human physiology and disease predisposition through a detailed analysis of gene structure and expression by examining data in public genome and gene-expression repositories. Yet, the vast majority of human genes remain understudied. This is particularly true of genes for long noncoding RNAs ...
DOI:
10.1016/j.mce.2020.110819

3. TEX19 promotes ovarian carcinoma progression and is a potential target for epitope vaccine immunotherapy

Author:
Zhaoxu Xu; Haichao Tang; Tianshu Zhang; Mingli Sun; Qiang Han; Jiao Xu; Minjie Wei; Zhaojin Yu
Source:
Life sciences 2020 v.241 pp. 117171
ISSN:
0024-3205
Subject:
Internet; Western blotting; animal ovaries; bioactive properties; biomarkers; carcinogenesis; computer software; databases; epitopes; humans; immunotherapy; loss-of-function mutation; lymph nodes; ovarian neoplasms; patients; peptides; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; small interfering RNA; testes; vaccines
Abstract:
... Testis Expressed 19 (TEX19) is one of cancer/testis antigens identified in recent years and is related to the oncogenesis and progress of several cancers. This study aimed to reveal the role of TEX19 in ovarian cancer (OC) and searched for potential candidate epitope peptides of TEX19 to facilitate clinical application. TEX19 levels were evaluated by immunohistochemistry (IHC) in 98 human ovarian ...
DOI:
10.1016/j.lfs.2019.117171

4. Comparing early embryo morphokinetics with time-lapse microscopy in patients with low and normal ovarian response to ovarian stimulation

Author:
Evaggelia Alexopoulou; Anja Pinborg; Esben Budtz-Jørgensen; Anne Zedeler
Source:
Reproductive Biology 2019 v.19 no.2 pp. 127-132
ISSN:
1642-431X
Subject:
animal ovaries; anti-Mullerian hormone; cell cycle; databases; embryology; human reproduction; microscopy; oocytes; patients; retrospective studies; risk; rolling
Abstract:
... In this retrospective study, patients undergoing ovarian stimulation were allocated into two groups (47 normal responders (NR) vs 47 low responders (LR)) according to the number of aspirated oocytes and their Anti-Müllerian hormone (AMH). 171 oocytes were retrieved from the LR group and 447 oocytes from the NR group. The oocytes were studied regarding the early embryo morphokinetic parameters and ...
DOI:
10.1016/j.repbio.2019.03.002

5. Effects of cinnamon on controlling metabolic parameters of polycystic ovary syndrome: A systematic review and meta-analysis

Author:
Fatemeh Heydarpour; Niloofar Hemati; Amir Hadi; Sajjad Moradi; Elham Mohammadi; Mohammad Hosein Farzaei
Source:
Journal of ethnopharmacology 2020 v.254 pp. 112741
ISSN:
0378-8741
Subject:
amenorrhea; animal ovaries; blood glucose; blood serum; body mass index; body weight; cholesterol; cinnamon; common cold; databases; diarrhea; fasting; fever; flatulence; headache; insulin; meta-analysis; patients; polycystic ovary syndrome; randomized clinical trials; statistical models; systematic review; traditional medicine; triacylglycerols
Abstract:
... Cinnamon as a traditional medicine has been widely used in various disorders such as headache, toothache, common cold, diarrhea, flatulence, fever, amenorrhea frigidity. However, the effect of cinnamon supplementation on metabolic parameters of polycystic ovary syndrome (PCOS) patients has not been fully assessed.Clinical trials have shown contradictory effects of cinnamon supplementation on metab ...
DOI:
10.1016/j.jep.2020.112741

6. Genetic epidemiology of ovarian cancer in the 22 Arab countries: A systematic review

Author:
Nadin Younes; Hatem Zayed
Source:
Gene 2019 v.684 pp. 154-164
ISSN:
0378-1119
Subject:
Arabs; animal ovaries; breast neoplasms; databases; epidemiological studies; genes; mutation; ovarian neoplasms; patients; systematic review; tumor suppressor proteins; Arab countries; Saudi Arabia; Sudan
Abstract:
... Ovarian cancer (OC) is a common disease among Arabs, with one of the highest incidences in the world. OC is underdiagnosed, underreported, and mostly reported with breast cancer. This study aimed to conduct a systematic review to estimate the published knowledge about the genetic epidemiology of OC in the 22 Arab countries. Therefore, we systematically searched seven literature databases (Web of s ...
DOI:
10.1016/j.gene.2018.10.044

7. Identification and characterization of microRNAs in the gonad of Trachinotus ovatus using Solexa sequencing

Author:
Pingping He; Pinyuan Wei; Xiaohan Chen; Yong Lin; Jinxia Peng
Source:
Comparative biochemistry and physiology 2019 v.30 pp. 312-320
ISSN:
1744-117X
Subject:
Trachinotus ovatus; animal ovaries; databases; females; gender differences; gene expression regulation; high-throughput nucleotide sequencing; males; microRNA; parents; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; selection methods; sexual maturity; testes; transcriptome
Abstract:
... The Trachinotus ovatus (T. ovatus) reach sexual maturity as late as 4–5 years, and there are no obvious morphology differences between males and females, even at maturity, making the selection of male and female parents for selective breeding difficult. To examine the potential regulatory mechanism of sexual differentiation, we conducted a microRNAs (miRNAs) analysis on the ovaries and testes of T ...
DOI:
10.1016/j.cbd.2019.03.010

8. Inferior fertility and higher concentrations of anti-Müllerian hormone in dairy cows with longer anogenital distance

Author:
V. Akbarinejad; F. Gharagozlou; M. Vojgani; E. Shourabi; M.J.M. Makiabadi
Source:
Domestic animal endocrinology 2019 v.68 pp. 47-53
ISSN:
0739-7240
Subject:
androgens; animal ovaries; anti-Mullerian hormone; blood serum; calving; conception rate; dairy cows; databases; estrus; female fertility; herds; lactation; maternal exposure; repeat breeder; reproductive performance
Abstract:
... Anogenital distance (AGD), which is an indicator of prenatal androgen exposure, has been reported to have high variability and negative association with fertility in dairy cows. Prenatal exposure to androgens could influence the development of primordial follicles and size of ovarian reserve, which is related to reproduction. However, the relationship between AGD and size of ovarian reserve has no ...
DOI:
10.1016/j.domaniend.2019.01.011

9. Regulation effect and mechanism of Sheng-Hua-Tang on female reproductive system: From experimental transcriptomic analysis to clinical applications

Author:
Jung-Miao Li; Chung-Chih Liao; Hui-Chi Huang; Cheng-Li Lin; Hsin-Yi Lo; Chien-Yun Hsiang; Tin-Yun Ho
Source:
Journal of ethnopharmacology 2020 v.249 pp. 112431
ISSN:
0378-8741
Subject:
animal ovaries; brain; breasts; clinical trials; databases; females; gene expression; genes; hemorrhage; herbal medicines; menstrual cycle; mice; microarray technology; oral administration; pain; traditional medicine; transcriptomics; uterine contraction; uterus; women
Abstract:
... Sheng-Hua-Tang (SHT) is commonly used to treat female illnesses, especially postpartum conditioning. However, its effects and mechanisms on female reproductive system remain unclear. The aim of the present study was to investigate the effect of SHT on female brain-ovary-uterus axis from bench to clinic.Mice were administrated SHT (200 mg/kg) orally for seven consecutive days. Brain, ovary, and ute ...
DOI:
10.1016/j.jep.2019.112431

10. The Study of the Expression of CGB1 and CGB2 in Human Cancer Tissues

Author:
Piotr Białas; Aleksandra Śliwa; Anna Szczerba; Anna Jankowska
Source:
Genes 2020 v.11 no.9 pp. -
ISSN:
2073-4425
Subject:
adenocarcinoma; animal ovaries; bladder; carcinosarcoma; databases; endometrium; germ cells; human chorionic gonadotropin; humans; loci; lungs; messenger RNA; multigene family; pregnancy; protein products; pseudogenes; rectum; squamous cell carcinoma; testes; thymoma; transcription (genetics); trophoblast
Abstract:
... Human chorionic gonadotropin (hCG) is a well-known hormone produced by the trophoblast during pregnancy as well as by both trophoblastic and non-trophoblastic tumors. hCG is built from two subunits: α (hCGα) and β (hCGβ). The hormone-specific β subunit is encoded by six allelic genes: CGB3, CGB5, CGB6, CGB7, CGB8, and CGB9, mapped to the 19q13.32 locus. This gene cluster also encompasses the CGB1 ...
DOI:
10.3390/genes11091082

11. The effect of probiotics, prebiotics, and synbiotics on hormonal and inflammatory indices in women with polycystic ovary syndrome: a systematic review and meta-analysis

Author:
Sevda Gholizadeh Shamasbi; Solmaz Ghanbari-Homayi; Mojgan Mirghafourvand
Source:
European journal of nutrition 2020 v.59 no.2 pp. 433-450
ISSN:
1436-6207
Subject:
animal ovaries; antioxidant activity; chi-square distribution; chronic diseases; clinical trials; confidence interval; databases; early diagnosis; endocrine diseases; glutathione; malondialdehyde; meta-analysis; nitric oxide; patients; placebos; polycystic ovary syndrome; prasterone; prebiotics; probiotics; sex hormone-binding globulin; statistical models; systematic review; testosterone; women
Abstract:
... INTRODUCTION: Polycystic ovary syndrome (PCOS) is among the most prevalent endocrine disorders in women and can lead to many other disorders and chronic diseases. Thus, early diagnosis and treatment of this syndrome is important. Using probiotics, prebiotics, and synbiotics supplementations to treat PCOS seems appropriate because of their useful effects and low complications. AIMS: To assess the e ...
DOI:
10.1007/s00394-019-02033-1

12. A full-length transcriptome of Sepia esculenta using a combination of single-molecule long-read (SMRT) and Illumina sequencing

Author:
Jinyong Zhang; Changlin Liu; Muchun He; Zilong Xiang; Yanan Yin; Shufang Liu; ZhiMeng Zhuang
Source:
Marine genomics 2019 v.43 pp. 54-57
ISSN:
1874-7787
Subject:
Sepia; animal ovaries; brain; databases; developmental stages; genomics; messenger RNA; microsatellite repeats; muscles; overfishing; reproduction; sequence analysis; spawning; transcriptome
Abstract:
... As an economically important cephalopods species, wild-caught Sepia esculenta fishery has suffered a server decline due to over-fishing and ocean environmental damage. To restore this seriously declining fishery resource, we should understand the genetic foundation and molecular mechanism of spawning, reproduction and mortal of golden cuttlefish. In this study, we generated the full-length transcr ...
DOI:
10.1016/j.margen.2018.08.008

13. De novo transcriptome analysis of eyestalk reveals ovarian maturation related genes in Macrobrachium rosenbergii

Author:
Qun Jiang; Yue Min; Hui Yang; Wenlong Wan; Xiaojun Zhang
Source:
Aquaculture 2019 v.505 pp. 280-288
ISSN:
0044-8486
Subject:
Macrobrachium rosenbergii; adults; animal ovaries; aquaculture; breeding; cDNA libraries; complementary DNA; databases; financial economics; freshwater crustaceans; gene expression; gene expression regulation; industry; insulin; juveniles; messenger RNA; neurohormones; neurotransmitter receptors; peptides; signal transduction; transcriptomics; transforming growth factor beta; unigenes
Abstract:
... Macrobrachium rosenbergii is a commercially important freshwater crustacean species cultured across the world. The economic benefit of M. rosenbergii industry is closely related with gamete quality which unfortunately is unstable in artificial breeding. Improving gamete quality might be achieved through a better understanding of ovarian maturation, but the molecular mechanism is still unclear. Thi ...
DOI:
10.1016/j.aquaculture.2019.02.073

14. Differential expression of microRNAs in recombinant Chinese hamster ovary cells treated with sodium butyrate using digital RNA counting

Author:
Sung-Min Lim; Sun-Hye Park; Joo-Hyoung Lee; Sun Hong Kim; Jee Yon Kim; Jeong-Ki Min; Gyun Min Lee; Yeon-Gu Kim
Source:
Journal of biotechnology 2018 v.283 pp. 37-42
ISSN:
0168-1656
Subject:
Chinese hamsters; animal ovaries; cell culture; databases; gene expression regulation; messenger RNA; mice; microRNA; protein synthesis; quantitative polymerase chain reaction; recombinant proteins; reverse transcriptase polymerase chain reaction; sodium butyrate; transcriptomics
Abstract:
... Sodium butyrate (NaBu) is an efficient supplement for increasing recombinant protein production in Chinese hamster ovary (CHO) cell culture. To elucidate the effects of NaBu on miRNA expression profile in recombinant CHO (rCHO) cells, differentially expressed miRNAs in NaBu-treated rCHO cells were assessed by NanoString nCounter analysis. This result showed that eight mature mouse miRNAs (let-7b, ...
DOI:
10.1016/j.jbiotec.2018.07.018

15. Ecotoxicological potential of the biocides terbutryn, octhilinone and methylisothiazolinone: Underestimated risk from biocidal pathways?

Author:
Simon Kresmann; Arokia Hansel Rajan Arokia; Christoph Koch; Bernd Sures
Source:
Science of the total environment 2018 v.625 pp. 900-908
ISSN:
0048-9697
Subject:
Chinese hamsters; Daphnia magna; Oncorhynchus mykiss; animal ovaries; aquatic environment; biocides; cell lines; cleaning agents; coatings; databases; ecotoxicology; environmental assessment; household products; households; industry; leaching; liver; median effective concentration; models; pollution; risk; risk assessment; terbutryn
Abstract:
... The use of biocides by industry, agriculture and households increased throughout the last two decades. Many new applications with known substances enriched the variety of biocidal pollution sources for the aquatic environment. While agriculture was the major source for a long time, leaching from building facades and preservation of personal care and cleaning products was identified as new sources ...
DOI:
10.1016/j.scitotenv.2017.12.280

16. The Effects of Probiotics or Synbiotics Supplementation in Women with Polycystic Ovarian Syndrome: a Systematic Review and Meta-Analysis of Randomized Clinical Trials

Author:
Javad Heshmati; Farnaz Farsi; Somaye Yosaee; Maryam Razavi; Mahroo Rezaeinejad; Elham Karimie; Mahdi Sepidarkish
Source:
Probiotics and antimicrobial proteins 2019 v.11 no.4 pp. 1236-1247
ISSN:
1867-1306
Subject:
animal ovaries; blood glucose; cholesterol; confidence interval; databases; dietary supplements; fasting; high density lipoprotein; insulin; insulin resistance; low density lipoprotein; meta-analysis; polycystic ovary syndrome; probiotics; randomized clinical trials; systematic review; triacylglycerols; women
Abstract:
... We searched bibliographic databases from inception through May 2018 to evaluate the effect of probiotics (or synbiotics) supplementation in women suffering from polycystic ovary syndrome (PCOS). Seven trials involving 236 women with PCOS and 235 controls were included in the meta-analysis. Comparing with the control group, probiotics (or synbiotics) may improve Quantitative insulin sensitivity che ...
DOI:
10.1007/s12602-018-9493-9

17. In Silico Computational Transcriptomics Reveals Novel Endocrine Disruptors in Largemouth Bass (Micropterus salmoides)

Author:
Danilo Basili; Ji-Liang Zhang; John Herbert; Kevin Kroll; Nancy D. Denslow; Christopher J. Martyniuk; Francesco Falciani; Philipp Antczak
Source:
Environmental science & technology 2018 v.52 no.13 pp. 7553-7565
ISSN:
1520-5851
Subject:
Micropterus salmoides; animal ovaries; databases; dynamic models; endocrine-disrupting chemicals; environmental science; estradiol; females; fish communities; gene expression; gene expression regulation; genes; gonadosomatic index; liver; males; ovarian development; prediction; quantitative polymerase chain reaction; quercetin; transcription (genetics); transcriptomics; vitellogenin
Abstract:
... In recent years, decreases in fish populations have been attributed, in part, to the effect of environmental chemicals on ovarian development. To understand the underlying molecular events we developed a dynamic model of ovary development linking gene transcription to key physiological end points, such as gonadosomatic index (GSI), plasma levels of estradiol (E2) and vitellogenin (VTG), in largemo ...
DOI:
10.1021/acs.est.8b02805

18. Integrated microarray meta-analysis identifies miRNA-27a as an oncogene in ovarian cancer by inhibiting FOXO1

Author:
Zhonghao Wang; Gaili Ji; Qian Wu; Shu Feng; Yanhua Zhao; Zhongwei Cao; Chuanmin Tao
Source:
Life sciences 2018 v.210 pp. 263-270
ISSN:
0024-3205
Subject:
animal ovaries; cell proliferation; data collection; databases; gain-of-function mutation; luciferase; meta-analysis; microRNA; microarray technology; neoplasm cells; oncogenes; ovarian neoplasms; patients
Abstract:
... Survival of ovarian cancer patients is generally poor, partly because most of them are already at an advanced stage when diagnosed. The purpose of this study was to screen prognostic miRNAs for ovarian cancer, and to explore the underlying mechanisms.Integrated meta-analysis of miRNA microarrays retrieved from public repositories was employed to identify clinically significant miRNAs involved in o ...
DOI:
10.1016/j.lfs.2018.08.043

19. Microarray analysis of obese women with polycystic ovary syndrome for key gene screening, key pathway identification and drug prediction

Author:
Lina Wei; Chunlei Xin; Wenjuan Wang; Cuifang Hao
Source:
Gene 2018 v.661 pp. 85-94
ISSN:
0378-1119
Subject:
Bayesian theory; DNA-directed DNA polymerase; DNA-directed RNA polymerase; adrenergic receptors; androgen receptors; animal ovaries; bioinformatics; calcium signaling; data collection; databases; drugs; gene expression; genes; metabolism; microarray technology; obesity; ornithine decarboxylase; patients; polycystic ovary syndrome; prediction; protein-protein interactions; screening; serotonin receptors; spironolactone; women
Abstract:
... This study aimed to screen key genes and pathways involved in obese polycystic ovary syndrome (PCOS), and predict drugs for treatment of obese PCOS via bioinformatics approaches.Microarray dataset GSE10946 were downloaded from the Gene Expression Omnibus database, including 7 cumulus cell samples from obese PCOS patients and 6 lean control samples. Differentially expressed genes (DEGs) between obe ...
DOI:
10.1016/j.gene.2018.03.079

20. Prognostic significance of β-catenin expression in patients with ovarian cancer: A meta-analysis

Author:
Huideng Long; Ganxiong Li; Xiaoman Wen; Yanmin Lv; Min Zhang; Yuanfeng Wei; Wenting Xie; Peng Zhong; Lijuan Pang
Source:
Gene 2018 v.678 pp. 270-279
ISSN:
0378-1119
Subject:
animal ovaries; beta catenin; computer software; cytoplasm; databases; immunohistochemistry; managers; meta-analysis; ovarian neoplasms; patients; prognosis
Abstract:
... The purpose of this study was to evaluate the impact of β-catenin immunohistochemical expression on the prognostic of ovarian cancer (OC) for that β-catenin could be responsible for the development and progress of OC.We searched various databases to identify eligible studies, and Review Managers 5.2 software was fulfilled in the meta-analysis.A total of 11 studies were defined and composed in 1858 ...
DOI:
10.1016/j.gene.2018.08.047