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1. Arrhythmogenic right ventricular cardiomyopathy in dogs

Author:
S.M. Cunningham; L. Dos Santos
Source:
Journal of veterinary cardiology 2022 v.40 pp. 156-169
ISSN:
1760-2734
Subject:
English bulldog; cardiomyopathy; death; dogs; epigenetics; heart failure; models; mutation; myocardium; pathogenesis; pathophysiology; people; prognosis; syncope
Abstract:
... Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited myocardial disease seen in dogs, cats, and humans. A common entity in Boxers and the related English bulldog, the disease is characterized by fatty or fibrofatty replacement of the myocardium, ventricular arrhythmias, and the potential for syncope or sudden death. In some individuals, concomitant left ventricular involvement re ...
DOI:
10.1016/j.jvc.2021.07.001

2. Impact of diabetic retinopathy on prognosis of patients with heart failure with preserved ejection fraction

Author:
Y. Yang; Y. Zhou; Y. Cao; Y. Dong; C. Liu; W. Zhu
Source:
Nutrition, metabolism, and cardiovascular diseases 2022 pp. -
ISSN:
0939-4753
Subject:
aldosterone; antagonists; cardiac output; death; diabetic retinopathy; heart failure; metabolism; myocardial infarction; nutrition; prognosis; regression analysis; risk factors
Abstract:
... Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus (DM), and could increase the risks of adverse cardiovascular events among DM patients. Since heart failure with preserved ejection fraction (HFpEF) and DM often coexist, our present study aimed to explore the associations of DR with adverse outcomes in HFpEF patients. We conducted this study in a l ...
DOI:
10.1016/j.numecd.2022.04.020

3. Ischemic Cardiomyopathy versus Non-Ischemic Dilated Cardiomyopathy in Patients with Reduced Ejection Fraction— Clinical Characteristics and Prognosis Depending on Heart Failure Etiology (Data from European Society of Cardiology Heart Failure Registries)

Author:
Agata Tymińska; Krzysztof Ozierański; Paweł Balsam; Cezary Maciejewski; Anna Wancerz; Emil Brociek; Michał Marchel; Maria G. Crespo-Leiro; Aldo P. Maggioni; Jarosław Drożdż; Grzegorz Opolski; Marcin Grabowski; Agnieszka Kapłon-Cieślicka
Source:
Biology 2022 v.11 no.2 pp. -
ISSN:
2079-7737
Subject:
aldosterone; atrial fibrillation; cardiomyopathy; death; heart failure; prognosis; therapeutics
Abstract:
... Personalized management involving heart failure (HF) etiology is crucial for better prognoses for HF patients. This study aimed to compare patients with ischemic cardiomyopathy (ICM) and patients with non-ischemic dilated cardiomyopathy (NIDCM) in terms of baseline characteristics and prognosis. We assessed 895 patients with HF with reduced left ventricular ejection fraction participating in the P ...
DOI:
10.3390/biology11020341

4. Mendelian randomization analysis of vitamin D in the secondary prevention of hypertensive-diabetic subjects: role of facilitating blood pressure control

Author:
Yap-Hang Chan; C. Mary Schooling; Jie V. Zhao; Shiu-Lun Au Yeung; Jo Jo Hai; G. Neil Thomas; Kar-Keung Cheng; Chao-Qiang Jiang; Yuen-Kwun Wong; Ka-Wing Au; Clara S. Tang; Chloe Y. Y. Cheung; Aimin Xu; Pak-Chung Sham; Tai-Hing Lam; Karen Siu-Ling Lam; Hung-Fat Tse
Source:
Genes & nutrition 2022 v.17 no.1 pp. 1
ISSN:
1555-8932
Subject:
blood pressure; blood serum; death; heart failure; hypertension; myocardial infarction; noninsulin-dependent diabetes mellitus; risk; stroke
Abstract:
... BACKGROUND: Vitamin D (Vit-D) promotes vascular repair and its deficiency is closely linked to the development of type 2 diabetes mellitus (T2DM) and hypertension. Whether genetially predicted vitamin D status (serological 25-hydroxyvitamin D [25(OH)D]) confers secondary protection against cardiovascular diseases (CVD) among high-risk hypertensive-diabetic subjects was unknown. METHODS: This is a ...
DOI:
10.1186/s12263-022-00704-z

5. Myocarditis and pericarditis: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data

Author:
S. Kristen Sexson Tejtel; Flor M. Munoz; Iyad Al-Ammouri; Fabio Savorgnan; Rama K. Guggilla; Najwa Khuri-Bulos; Lee Phillips; Renata J.M. Engler
Source:
Vaccine 2022 v.40 no.10 pp. 1499-1511
ISSN:
0264-410X
Subject:
acute course; cardiomyopathy; data collection; death; heart failure; hypersensitivity; monitoring; myocarditis; myocardium; necrosis; pericarditis; pericardium; relative risk; smallpox; vaccination; vaccines
Abstract:
... Myocarditis and/or pericarditis (also known as myopericarditis) are inflammatory diseases involving the myocardium (with non-ischemic myocyte necrosis) and/or the pericardial sac. Myocarditis/pericarditis (MPC) may present with variable clinical signs, symptoms, etiologies and outcomes, including acute heart failure, sudden death, and chronic dilated cardiomyopathy. Possible undiagnosed and/or sub ...
DOI:
10.1016/j.vaccine.2021.11.074

6. Prospective clinical trial evaluating spironolactone in Doberman pinschers with congestive heart failure due to dilated cardiomyopathy

Author:
A. Laskary; S. Fonfara; H. Chambers; M.L. O'Sullivan
Source:
Journal of veterinary cardiology 2022 v.40 pp. 84-98
ISSN:
1760-2734
Subject:
aldosterone; antagonists; atrial fibrillation; cardiomyopathy; clinical examination; death; echocardiography; euthanasia; heart failure; placebos; prospective studies; quality of life; questionnaires; radiography; spironolactone; therapeutics
Abstract:
... Whether the aldosterone antagonist spironolactone has beneficial survival effects in dogs with dilated cardiomyopathy (DCM) is not known. The primary objective of the study was to evaluate the effect of spironolactone, when added to conventional therapy, on survival time in Doberman pinschers with congestive heart failure (CHF) due to DCM. Sixty-seven client-owned Doberman pinschers with CHF due t ...
DOI:
10.1016/j.jvc.2021.06.001

7. A genome-wide analysis of cardiac lesions of pigs that die during transport: Is heart failure of in-transit-loss pigs associated with a heritable cardiomyopathy?

Author:
Katherine Zurbrigg; Francesca Bertolini; Muhammed Walugembe; Toni Van Dreumel; David Alves; Robert Friendship; Terry L. O'Sullivan; Max F. Rothschild
Source:
Canadian journal of veterinary research 2021 v.85 no.2 pp. 119-126
ISSN:
0830-9000
Subject:
cardiomyopathy; death; genome-wide association study; genotyping; heart failure; hypertrophy; single nucleotide polymorphism; slaughterhouses; veterinary medicine; Ontario
Abstract:
... While heart failure is a primary cause of death for many in-transit-loss (ITL) pigs, the underlying cause of these deaths is not known. Cardiomyopathies are considered a common cause of heart failure in humans and often have a genetic component. The objective of this study was to determine if genes associated with cardiomyopathies could be identified in ITL pigs. Samples from the hearts of pigs th ...

8. Arrhythmogenic right ventricular cardiomyopathy in Bulldogs: Evaluation of clinical and histopathologic features, progression, and outcome in 71 dogs (2004–2016)

Author:
S.L. Holdt; N.K. Peckens; S. Rosenthal; R. Cober
Source:
Journal of veterinary cardiology 2022 v.40 pp. 170-183
ISSN:
1760-2734
Subject:
arrhythmia; blood; cardiomyopathy; confidence interval; death; genes; genetic analysis; heart failure; histopathology; mixed breeds; mortality; mutation; syncope
Abstract:
... This study aimed to characterize the clinical and histopathological features of arrhythmogenic right ventricular cardiomyopathy (ARVC) in English Bulldogs, American Bulldogs, and Bulldog-type mixed breed dogs and assess affected Bulldogs for a striatin gene mutation previously reported in Boxers with ARVC. Seventy-one Bulldogs fit the inclusion criteria. Genetic analysis was performed on five dogs ...
DOI:
10.1016/j.jvc.2021.10.003

9. Attributing hypertensive life expectancy loss to ambient heat exposure: A multicenter study in eastern China

Author:
Rubing Pan; Hao Zheng; Zhen Ding; Zhiwei Xu; Hung Chak Ho; Mohammad Zahid Hossain; Cunrui Huang; Weizhuo Yi; Jian Song; Jian Cheng; Hong Su
Source:
Environmental research 2022 v.208 pp. 112726
ISSN:
0013-9351
Subject:
adverse effects; air; climate change; death; geocoding; heart; heart failure; heat; hospitals; hypertension; kidney diseases; longevity; mortality; ozone; particulates; people; rain; research; risk; summer; temperature; China
Abstract:
... Ambient high temperature is a worldwide trigger for hypertension events. However, the effects of heat exposure on hypertension and years of life lost (YLL) due to heat remain largely unknown. We conducted a multicenter study in 13 cities in Jiangsu Province, China, to investigate 9727 individuals who died from hypertension during the summer months (May to September) between 2016 and 2017. Meteorol ...
DOI:
10.1016/j.envres.2022.112726

10. Blocking TNF signaling may save lives in COVID-19 infection

Author:
Vitaly Ablamunits; Christopher Lepsy
Source:
Molecular biology reports 2022 v.49 no.3 pp. 2303-2309
ISSN:
0301-4851
Subject:
COVID-19 infection; blood; death; heart failure; insulin resistance; interleukin-6; lungs; molecular biology; mortality; phosphotransferases (kinases); signal transduction; vaccination
Abstract:
... Global vaccination effort and better understanding of treatment strategies provided a ray of hope for improvement in COVID-19 pandemic, however, in many countries, the disease continues to collect its death toll. The major pathogenic mechanism behind severe cases associated with high mortality is the burst of pro-inflammatory cytokines TNF, IL-6, IFNγ and others, resulting in multiple organ failur ...
DOI:
10.1007/s11033-022-07166-x

11. Cardiac fibrosis and curcumin: a novel perspective on this natural medicine

Author:
Fatemeh Sadoughi; Jamal Hallajzadeh; Liaosadat Mirsafaei; Zatollah Asemi; Mahdi Zahedi; Mohammad Ali Mansournia; Bahman Yousefi
Source:
Molecular biology reports 2021 v.48 no.11 pp. 7597-7608
ISSN:
0301-4851
Subject:
Oriental traditional medicine; antioxidants; curcumin; death; fibrosis; heart failure; inflammation; mechanical stress; molecular biology; myocardium; oxidative stress; statistics; therapeutics; turmeric
Abstract:
... BACKGROUND: According to WHO statistics, cardiovascular disease are the leading causes of death in the world. One of the main factors which is causing heart failure, systolic and diastolic dysfunction, and arrythmias is a condition named cardiac fibrosis. This condition is defined by the accumulation of fibroblast-produced ECM in myocardium layer of the heart. OBJECTIVE: Accordingly, the current r ...
DOI:
10.1007/s11033-021-06768-1

12. Clinical and Echocardiographic Findings in an Aged Population of Cavalier King Charles Spaniels

Author:
Jorge Prieto Ramos; Andrea Corda; Simon Swift; Laura Saderi; Gabriel De La Fuente Oliver; Brendan Corcoran; Kim M. Summers; Anne T. French
Source:
Animals 2021 v.11 no.4 pp. -
ISSN:
2076-2615
Subject:
body weight; death; echocardiography; elderly; gender; heart failure
Abstract:
... Myxomatous mitral valve disease (MMVD) is the most common cardiac disease in dogs. It varies from dogs without clinical signs to those developing left-sided congestive heart failure, leading to death. Cavalier King Charles Spaniels (CKCSs) are particularly susceptible to MMVD. We hypothesised that within the elderly CKCS population, there is a sub-cohort of MMVD-affected dogs that do not have card ...
DOI:
10.3390/ani11040949

13. Clinical efficacy of a benazepril and spironolactone combination in dogs with congestive heart failure due to myxomatous mitral valve disease: The BEnazepril Spironolactone STudy (BESST)

Author:
Melissa Coffman; Emilie Guillot; Thomas Blondel; Catherine Garelli‐Paar; Shuo Feng; Susanne Heartsill; Clarke E. Atkins
Source:
Journal of veterinary internal medicine 2021 v.35 no.4 pp. 1673-1687
ISSN:
0891-6640
Subject:
antagonists; death; edema; euthanasia; furosemide; heart failure; mineralocorticoid receptors; people; risk; spironolactone; veterinary medicine
Abstract:
... BACKGROUND: The renin‐angiotensin‐aldosterone system (RAAS), when chronically activated, is harmful and RAAS‐suppressive drugs are beneficial in the treatment of congestive heart failure (CHF). Mineralocorticoid receptor antagonists are widely used in the treatment of CHF in people. HYPOTHESIS/OBJECTIVES: To determine if a mineralocorticoid receptor antagonist (spironolactone) is beneficial and sa ...
DOI:
10.1111/jvim.16155

14. Comparison of modes of action between fish, cell and mitochondrial toxicity based on toxicity correlation, excess toxicity and QSAR for class-based compounds

Author:
Shuo Wang; Xiao Zhang; Bingxin Gui; Xiaotian Xu; Limin Su; Yuan H. Zhao; Christopher J. Martyniuk
Source:
Toxicology 2022 v.470 pp. 153155
ISSN:
0300-483X
Subject:
apoptosis; binomial distribution; blood pressure; cytotoxicity; death; energy; fish; heart failure; hydrogen; hydrophobicity; ionization; mitochondria; quantitative structure-activity relationships; toxicology; van der Waals forces
Abstract:
... Mitochondria are significant targets in cells for many environmental chemicals. Mitochondrial damage and dysfunction can lead to apoptosis and death of fish. The objectives of this study were to compare the modes of action (MOAs) between fish, cell and mitochondrial toxicity. To achieve the goal, toxicity correlation, excess toxicity and quantitative structure–activity relationship (QSAR) were inv ...
DOI:
10.1016/j.tox.2022.153155

15. Double-layered adhesive microneedle bandage based on biofunctionalized mussel protein for cardiac tissue regeneration

Author:
Soomee Lim; Tae Yoon Park; Eun Young Jeon; Kye Il Joo; Hyung Joon Cha
Source:
Biomaterials 2021 v.278 pp. 121171
ISSN:
0142-9612
Subject:
adhesion; bandages; biocompatible materials; cardiomyocytes; death; extracellular matrix; fibroins; half life; heart failure; models; mortality; mussels; myocardial infarction; peptides; rats; therapeutics; tissue repair; vascular endothelial growth factors
Abstract:
... Heart failure following myocardial infarction (MI), the primary cause of mortality worldwide, is the consequence of cardiomyocyte death or dysfunction. Clinical efforts involving the delivery of growth factors (GFs) and stem cells with the aim of regenerating cardiomyocytes for the recovery of structural and functional integrity have largely failed to deliver, mainly due to short half-lives and ra ...
DOI:
10.1016/j.biomaterials.2021.121171

16. Echocardiographic assessment of dilated cardiomyopathy in dogs

Author:
J.D. Bonagura; L.C. Visser
Source:
Journal of veterinary cardiology 2022 v.40 no. pp. 15-50
ISSN:
1760-2734
Subject:
aorta; biomarkers; body size; cardiomyopathy; death; dogs; echocardiography; electrocardiography; etiology; heart failure; phenotype
Abstract:
... Dilated cardiomyopathy (DCM) is a frequent cause of cardiac disability, congestive heart failure (CHF), and arrhythmic death in dogs. The etiology of DCM is usually idiopathic/genetic, but some causes of a DCM phenotype are reversible. The disease is classified into preclinical (occult) and clinical (overt) stages; the latter stems from heart failure with reduced ejection fraction. DCM is further ...
DOI:
10.1016/j.jvc.2021.08.004

17. Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double‐blind, randomized, nonpivotal, exploratory field study

Author:
Karsten E. Schober; John E. Rush; Virginia Luis Fuentes; Tony Glaus; Nuala J. Summerfield; Kathy Wright; Linda Lehmkuhl; Gerhard Wess; Margaret P. Sayer; Joao Loureiro; John MacGregor; Nicole Mohren
Source:
Journal of veterinary internal medicine 2021 v.35 no.2 pp. 789-800
ISSN:
0891-6640
Subject:
cardiomyopathy; confidence interval; death; drug therapy; furosemide; heart failure; odds ratio; placebos; veterinary medicine
Abstract:
... BACKGROUND: The benefits of pimobendan in the treatment of congestive heart failure (CHF) in cats with hypertrophic cardiomyopathy (HCM) have not been evaluated prospectively. HYPOTHESIS/OBJECTIVES: To investigate the effects of pimobendan in cats with HCM and recent CHF and to identify possible endpoints for a pivotal study. We hypothesized that pimobendan would be well‐tolerated and associated w ...
DOI:
10.1111/jvim.16054

18. Efficacy of hypophysectomy for the treatment of hypersomatotropism‐induced diabetes mellitus in 68 cats

Author:
Joe Fenn; Patrick J. Kenny; Christopher J. Scudder; Katarina Hazuchova; Ruth Gostelow; Robert C. Fowkes; Yaiza Forcada; David B. Church; Stijn J. M. Niessen
Source:
Journal of veterinary internal medicine 2021 v.35 no.2 pp. 823-833
ISSN:
0891-6640
Subject:
L-thyroxine; blood serum; cohort studies; cortisol; death; diabetes mellitus; electrolytes; glycemic control; heart failure; hypoglycemia; hypophysectomy; insulin; insulin-like growth factor I; remission; veterinary medicine
Abstract:
... BACKGROUND: Hypersomatotropism (HST) is an increasingly recognized endocrinopathy in cats and is mostly described associated with diabetes mellitus (DM). OBJECTIVES: To evaluate the efficacy and safety of transsphenoidal hypophysectomy in treating HST and DM in cats. ANIMALS: Sixty‐eight client‐owned cats with HST and DM treated by transsphenoidal hypophysectomy. METHODS: Retrospective cohort stud ...
DOI:
10.1111/jvim.16080

19. Focused Cardiac Ultrasound Examination as a Tool for Diagnosis of Infective Endocarditis and Myocarditis in Dogs and Cats

Author:
Olga Szaluś-Jordanow; Marta Stabińska-Smolarz; Michał Czopowicz; Agata Moroz; Marcin Mickiewicz; Andrzej Łobaczewski; Dorota Chrobak-Chmiel; Magdalena Kizerwetter-Świda; Magdalena Rzewuska; Rafał Sapierzyński; Michał Grzegorczyk; Anna Świerk; Tadeusz Frymus
Source:
Animals 2021 v.11 no.11 pp. -
ISSN:
2076-2615
Subject:
Enterococcus; Staphylococcus epidermidis; anorexia; ascites; death; endocarditis; fever; fibrosis; heart failure; histopathology; inflammation; methicillin-resistant Staphylococcus aureus; mixed infection; myocarditis; pericardium; thoracic cavity; ultrasonics
Abstract:
... Symptoms of infective endocarditis (IE) and myocarditis are usually nonspecific and include fever, apathy, and loss of appetite. This condition can lead to severe heart failure with ascites or/and fluid in the thoracic cavity or/and in the pericardial sac. We describe infective endocarditis and myocarditis in 3 dogs and 4 cats. In all animals, the initial diagnosis was performed on the basis of a ...
DOI:
10.3390/ani11113162

20. Galectin-3 interferes with tissue repair and promotes cardiac dysfunction and comorbidities in a genetic heart failure model

Author:
Fani Vlachou; Aimilia Varela; Konstantina Stathopoulou; Konstantinos Ntatsoulis; Evgenia Synolaki; Harris Pratsinis; Dimitris Kletsas; Paschalis Sideras; Constantinos H. Davos; Yassemi Capetanaki; Stelios Psarras
Source:
Cellular and molecular life sciences 2022 v.79 no.5 pp. 250
ISSN:
1420-682X
Subject:
apoptosis; biomarkers; cardiac output; cardiomyocytes; cardiomyopathy; color; death; desmin; fibroblasts; fibrosis; galectins; heart failure; inflammation; lung function; lungs; macrophages; models; pathogenesis; protective effect; tissue repair
Abstract:
... Galectin-3, a biomarker for heart failure (HF), has been associated with myocardial fibrosis. However, its causal involvement in HF pathogenesis has been questioned in certain models of cardiac injury-induced HF. To address this, we used desmin-deficient mice (des⁻/⁻), a model of progressive HF characterized by cardiomyocyte death, spontaneous inflammatory responses sustaining fibrosis, and galect ...
DOI:
10.1007/s00018-022-04266-6

21. Genotype-Phenotype Correlation in Hypertrophic Cardiomyopathy: New Variant p.Arg652Lys in MYH7

Author:
Guido Antoniutti; Fiama Giuliana Caimi-Martinez; Jorge Álvarez-Rubio; Paula Morlanes-Gracia; Jaume Pons-Llinares; Blanca Rodríguez-Picón; Elena Fortuny-Frau; Laura Torres-Juan; Damian Heine-Suner; Tomas Ripoll-Vera
Source:
Genes 2022 v.13 no.2 pp. -
ISSN:
2073-4425
Subject:
active sites; cardiomyopathy; death; genes; genetic disorders; genotype-phenotype correlation; heart failure; hypertrophy; mutation; observational studies; risk
Abstract:
... Hypertrophic cardiomyopathy (HCM) is a genetic disease characterised by increased left ventricle (LV) wall thickness caused by mutations in sarcomeric genes. Finding a causal mutation can help to better assess the proband’s risk, as it allows the presence of the mutation to be evaluated in relatives and the follow-up to be focused on carriers. We performed an observational study of patients with H ...
DOI:
10.3390/genes13020320

22. Impact of serum uric acid levels on cardiovascular events and quality of life in patients with chronic coronary syndromes: Insights from a contemporary, prospective, nationwide registry

Author:
Leonardo De Luca; Michele M. Gulizia; Domenico Gabrielli; Jennifer Meessen; Luisa Mattei; Maurizio D'Urbano; Furio Colivicchi; Pier L. Temporelli; Claudio Borghi; Giovambattista Desideri; the START Investigators
Source:
Nutrition, metabolism, and cardiovascular diseases 2022 v.32 no.2 pp. 393-401
ISSN:
0939-4753
Subject:
blood serum; death; hazard ratio; heart failure; hospitals; hyperuricemia; metabolic diseases; metabolism; mortality; myocardial infarction; nutrition; quality of life; uric acid
Abstract:
... Hyperuricemia is a metabolic disorder that has been associated with adverse cardiovascular (CV) events. Using the data from a nationwide, prospective registry on patients with chronic coronary syndromes (CCS), we assessed the impact of serum uric acid (SUA) levels on quality of life (QoL) and major adverse CV events (MACE), a composite of CV death and hospitalization for myocardial infarction, hea ...
DOI:
10.1016/j.numecd.2021.09.034

23. LMNA Mutation in a Family with a Strong History of Sudden Cardiac Death

Author:
Laura Keil; Filip Berisha; Dorit Knappe; Christian Kubisch; Moneef Shoukier; Paulus Kirchhof; Larissa Fabritz; Yorck Hellenbroich; Rixa Woitschach; Christina Magnussen
Source:
Genes 2022 v.13 no.2 pp. -
ISSN:
2073-4425
Subject:
cardiomyopathy; case studies; death; exons; females; heart failure; heart transplant; heterozygosity; mutation; patients
Abstract:
... We report a family with heterozygous deletion of exons 3–6 of the LMNA gene. The main presentation of affected family members was characterized by ventricular and supraventricular arrhythmias, atrioventricular (AV) block and sudden cardiac death (SCD) but also by severe dilative cardiomyopathy (DCM). We report on two siblings, a 36-year-old female and her 40-year-old brother, who suffer from heart ...
DOI:
10.3390/genes13020169

24. Lack of Association between Inadequate Micronutrient Intake and Prognosis in Outpatients with Heart Failure

Author:
Núbia Rafaella Soares Moreira Torres; Fernanda Lambert de Andrade Freire; Raquel Costa Silva Dantas-Komatsu; Eduardo Paixão da Silva; Salomão Israel Monteiro Lourenço Queiroz; Niethia Regina Dantas de Lira; Rosiane Viana Zuza Diniz; Severina Carla Vieira Cunha Lima; Lucia Fatima Campos Pedrosa; Márcia Marília Gomes Dantas Lopes; Karine Cavalcanti Maurício Sena-Evangelista
Source:
Nutrients 2022 v.14 no.4 pp. -
ISSN:
2072-6643
Subject:
calcium; cohort studies; copper; death; elderly; hazard ratio; heart failure; magnesium; mathematical models; nutrient deficiencies; nutrient intake; prognosis; risk
Abstract:
... Inadequate nutrient intake can lead to worse outcomes in patients with heart failure (HF). This prospective cohort study aimed to assess the prevalence of inadequate micronutrient intake and their association with prognosis in 121 adult and elderly outpatients with HF. Habitual micronutrient intake was evaluated using 24-h dietary recalls (minimum 2 and maximum 6). Participants were grouped into m ...
DOI:
10.3390/nu14040788

25. Long-term nitrogen dioxide exposure and cause-specific mortality in the U.S. Medicare population

Author:
Ki-Do Eum; Trenton James Honda; Bingyu Wang; Fatemeh Kazemiparkouhi; Justin Manjourides; Vivian C. Pun; Virgil Pavlu; Helen Suh
Source:
Environmental research 2022 v.207 pp. 112154
ISSN:
0013-9351
Subject:
air quality; cerebrovascular disorders; death; hazard ratio; heart failure; lung neoplasms; mortality; myocardial ischemia; nitrogen dioxide; pneumonia; research; socioeconomic status
Abstract:
... Since 1971, the annual National Ambient Air Quality Standard (NAAQS) for nitrogen dioxide (NO₂) has remained at 53 ppb, the impact of long-term NO₂ exposure on mortality is poorly understood. We examined associations between long-term NO₂ exposure (12-month moving average of NO₂) below the annual NAAQS and cause-specific mortality among the older adults in the U.S. Cox proportional-hazard models w ...
DOI:
10.1016/j.envres.2021.112154

26. Metabolomics based mechanistic insights to vasorelaxant and cardioprotective effect of ethanolic extract of Citrullus lanatus (Thunb.) Matsum. & Nakai. seeds in isoproterenol induced myocardial infraction

Author:
Fatima Saqib; Muqeet Wahid; Arwa Abdulkreem AL-Huqail; Hanadi Talal Ahmedah; Nicusor Bigiu; Marius Irimie; Marius Moga; Romina Alina Marc (Vlaic); Oana Lelia Pop; Liana Maria Chicea
Source:
Phytomedicine 2022 v.100 pp. 154069
ISSN:
0944-7113
Subject:
Citrullus lanatus; antihypertensive effect; blood pressure; blood serum; cardiomyocytes; cardioprotective effect; death; developed countries; gene expression; heart failure; hypertrophy; isoproterenols; metabolomics; morbidity; myocardial infarction; therapeutics; vasoconstriction; vasodilation; vasodilator agents
Abstract:
... Cardiovascular diseases (CVDs) are a significant cause of morbidity and death in the current world, posing a challenge to both developing and industrialized nation's health systems. Citrullus lanatus (Thunb.) Matsum. & Nakai. seeds have long been utilized to supplement and enhance health and treat cardiovascular illnesses. However, its treatments for CVDs are still unknown. More research is requir ...
DOI:
10.1016/j.phymed.2022.154069

27. Mitral valvuloplasty with left atrial appendage closure and pacemaker implantation in a dog with severe myxomatous mitral valve degeneration: a case report

Author:
Tomohiko Yoshida; Ryosuke Namiki; Katsuhiro Matsuura
Source:
BMC veterinary research 2022 v.18 no.1 pp. 184
ISSN:
1746-6148
Subject:
arrhythmia; cardiac arrest; case studies; castration; death; dogs; echocardiography; electrocardiography; heart failure; males; pancreatitis; patients; risk; thrombosis; veterinary clinics
Abstract:
... BACKGROUND: Mitral valvuloplasty (MVP) has been widely recognized as a treatment option for myxomatous mitral valve disease (MMVD). However, postoperative complications such as thromboembolism, arrhythmia, and pancreatitis in some cases have resulted in death. We treated a dog with severe MMVD complicated by impaired sinus function with MVP and pacemaker implantation. Also, due to an intrinsic pro ...
DOI:
10.1186/s12917-022-03284-7

28. Mutual effects of fine particulate matter, nitrogen dioxide, and fireworks on cause-specific acute cardiovascular mortality: A case-crossover study in communities affected by aircraft noise

Author:
Apolline Saucy; Kees de Hoogh; Danielle Vienneau; Louise Tangermann; Beat Schäffer; Jean-Marc Wunderli; Nicole Probst-Hensch; Martin Röösli
Source:
Environmental pollution 2021 v.291 pp. 118066
ISSN:
0269-7491
Subject:
adults; air; air pollution; aircraft; airports; death; heart failure; morbidity; mortality; nitrogen dioxide; odds ratio; particulates; stroke; temperature; Switzerland
Abstract:
... Ambient air pollution is the leading cause of environmental mortality and morbidity worldwide. However, the individual contributions to acute mortality of traffic-related air pollutants such as nitrogen dioxide (NO₂) and fine particulate matter (PM₂.₅) are still debated. We conducted a time-stratified case-crossover study for a population located around Zurich airport in Switzerland, including 24, ...
DOI:
10.1016/j.envpol.2021.118066

29. Myocardial protein aggregates in pet guinea pigs

Author:
Teresa Southard; Kathleen Kelly; Anibal G. Armien
Source:
Veterinary pathology 2022 v.59 no.1 pp. 157-163
ISSN:
1544-2217
Subject:
actin; animal pathology; death; desmin; edema; electron microscopy; euthanasia; females; heart failure; heat shock proteins; immune response; immunohistochemistry; macrophages; males; microtubules; myosin; necropsy; organelles; retrospective studies; skeletal muscle; ubiquitin
Abstract:
... A retrospective study of guinea pigs submitted for necropsy revealed intracytoplasmic inclusions in the cardiomyocytes of 26 of 30 animals. The inclusions were found with approximately the same frequency in male and female guinea pigs and were slightly more common in older animals. In most cases, the animals did not have clinical signs or necropsy findings suggestive of heart failure, and the caus ...
DOI:
10.1177/03009858211042586

30. Myocardium-specific Isca1 knockout causes iron metabolism disorder and myocardial oncosis in rat

Author:
Yahao Ling; Xinlan Yang; Xu Zhang; Feifei Guan; Xiaolong Qi; Wei Dong; Mengdi Liu; Jiaxin Ma; Xiaoyu Jiang; Kai Gao; Jing Li; Wei Chen; Shan Gao; Xiang Gao; Shuo Pan; Jizheng Wang; Yuanwu Ma; Dan Lu; Lianfeng Zhang
Source:
Life sciences 2022 v.297 pp. 120485
ISSN:
0024-3205
Subject:
CRISPR-Cas systems; antigens; cardiomyocytes; death; echocardiography; energy; epithelium; fluorescent antibody technique; heart failure; histopathology; iron absorption; magnetism; metabolic diseases; mitochondria; models; pathogenesis; phenotype; precipitin tests; rats; therapeutics
Abstract:
... Multiple mitochondrial dysfunction (MMD) can lead to complex damage of mitochondrial structure and function, which then lead to the serious damage of various metabolic pathways including cerebral abnormalities. However, the effects of MMD on heart, a highly mitochondria-dependent tissue, are still unclear. In this study, we use iron-sulfur cluster assembly 1 (Isca1), which has been shown to cause ...
DOI:
10.1016/j.lfs.2022.120485

31. Necropsy findings in a cat with diabetes mellitus and heart failure

Author:
Melanie J Dobromylskyj; Christopher JL Little
Source:
Journal of feline medicine and surgery open reports 2021 v.7 no.2 pp. 20551169211055383
ISSN:
2055-1169
Subject:
ascites; cardiomyopathy; case studies; cats; death; diabetes mellitus; echocardiography; epidemiology; fibrosis; furosemide; heart failure; inflammation; males; medicine; microscopy; myocardium; necropsy; surgery; vena cava
Abstract:
... A 7-year-old male neutered domestic shorthair cat, previously diagnosed and treated for diabetes mellitus (DM), subsequently presented in heart failure (HF). Echocardiography revealed biatrial and biventricular dilation with poor myocardial function, and a left atrial-to-aortic ratio of 1.95:1. There was caudal vena cava dilation, hepatomegaly and ascites. The HF was treated with furosemide for 5 ...
DOI:
10.1177/20551169211055383

32. Nuanxinkang protects against ischemia/reperfusion-induced heart failure through regulating IKKβ/IκBα/NF-κB-mediated macrophage polarization

Author:
Xin Dong; Jialin Jiang; Zhijun Lin; Ruijia Wen; Ling Zou; Tong Luo; Zhuoji Guan; Xuan Li; Linhai Wang; Lu Lu; Huan Li; Yusheng Huang; Zhongqi Yang; Junyan Wang; Xiaohan Ye; Xiaohua Hong; Lingjun Wang; Shaoxiang Xian; Zixin Chen
Source:
Phytomedicine 2022 v.101 pp. 154093
ISSN:
0944-7113
Subject:
apoptosis; cardiac output; death; echocardiography; enzyme-linked immunosorbent assay; fibrosis; flow cytometry; heart failure; inflammation; interleukin-4; ischemia; lipopolysaccharides; macrophages; mice; phosphorylation; plasmids; temporal variation; transfection
Abstract:
... Heart failure (HF) is a leading cause of death worldwide. Nuanxinkang (NXK) is an effective Chinese herbal formula used in treating HF, but its underlying potential mechanisms have not been fully elucidated. To explore the protective activities of NXK in ischemia/reperfusion (IR)-induced HF through modulating the ratio of proinflammatory (M1) and anti-inflammatory (M2) macrophage populations and l ...
DOI:
10.1016/j.phymed.2022.154093

33. PUFA Supplementation and Heart Failure: Effects on Fibrosis and Cardiac Remodeling

Author:
Francesca Oppedisano; Rocco Mollace; Annamaria Tavernese; Micaela Gliozzi; Vincenzo Musolino; Roberta Macrì; Cristina Carresi; Jessica Maiuolo; Maria Serra; Antonio Cardamone; Maurizio Volterrani; Vincenzo Mollace
Source:
Nutrients 2021 v.13 no.9 pp. -
ISSN:
2072-6643
Subject:
G-protein coupled receptors; antioxidants; blood serum; brain; death; deformation; dietary supplements; docosahexaenoic acid; eicosapentaenoic acid; erythropoietin; fibroblasts; fibrosis; free fatty acids; heart; heart failure; hemodynamics; inflammation; interleukin-1; myocardial infarction; natriuretic peptides; norepinephrine; omega-3 fatty acids; risk; surveys; therapeutics
Abstract:
... Heart failure (HF) characterized by cardiac remodeling is a condition in which inflammation and fibrosis play a key role. Dietary supplementation with n-3 polyunsaturated fatty acids (PUFAs) seems to produce good results. In fact, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have anti-inflammatory and antioxidant properties and different cardioprotective mechanisms. In particular, fo ...
DOI:
10.3390/nu13092965

34. Possibility as role of ginseng and ginsenosides on inhibiting the heart disease of COVID-19: A systematic review

Author:
Mohammad Amjad Hossain; Jong-Hoon Kim
Source:
Journal of Ginseng Research 2022 v.46 no.3 pp. 321-330
ISSN:
1226-8453
Subject:
COVID-19 infection; Panax; Severe acute respiratory syndrome coronavirus 2; antioxidants; blood flow; blood pressure; death; ginsenosides; heart; heart failure; mortality; myocardial infarction; pneumonia; research; risk; systematic review; China
Abstract:
... Coronavirus has been spreading rapidly around the world since it broke out in China in 2019. Respiratory diseases caused by coronavirus infection cause various diseases ranging from asymptomatic subclinical infections to severe pneumonia and cardiovascular complications, leading to death. In this regard, natural products are being studied to prevent various diseases caused by COVID-19. In current ...
DOI:
10.1016/j.jgr.2022.01.003

35. Prevalence and prognostic implications of malnutrition as defined by GLIM criteria in elderly patients with heart failure

Author:
Susumu Hirose; Yuya Matsue; Kentaro Kamiya; Nobuyuki Kagiyama; Masaru Hiki; Taishi Dotare; Tsutomu Sunayama; Masaaki Konishi; Hiroshi Saito; Kazuya Saito; Yuki Ogasahara; Emi Maekawa; Takeshi Kitai; Kentaro Iwata; Kentaro Jujo; Hiroshi Wada; Takatoshi Kasai; Shin-ichi Momomura; Tohru Minamino
Source:
Clinical nutrition 2021 v.40 no.6 pp. 4334-4340
ISSN:
0261-5614
Subject:
clinical nutrition; confidence interval; death; elderly; hazard ratio; heart; heart failure; hospitals; information networks; leadership; malnutrition; mortality; nutrition risk assessment; prevalence; prognosis
Abstract:
... Although the Global Leadership Initiative on Malnutrition (GLIM) proposed a consensus scheme for diagnosing malnutrition in adults in clinical settings globally, the prevalence and prognostic value of malnutrition defined by GLIM criteria have yet to be evaluated in elderly patients with heart failure. This study aimed to determine the prevalence and prognostic implication of malnutrition as defin ...
DOI:
10.1016/j.clnu.2021.01.014

36. Prognostic utility of the prognostic nutritional index combined with serum sodium level in patients with heart failure

Author:
Lang Zhao; Xuemei Zhao; Pengchao Tian; Lin Liang; Boping Huang; Liyan Huang; Jiayu Feng; Yuhui Zhang; Jian Zhang
Source:
Nutrition, metabolism, and cardiovascular diseases 2022 pp. -
ISSN:
0939-4753
Subject:
absorption; blood serum; confidence interval; death; heart failure; hospitals; hyponatremia; intestines; lymphocyte count; males; malnutrition; metabolism; models; mortality; nutrition assessment; nutritional status; prediction; risk; serum albumin; sodium; China
Abstract:
... Both malnutrition and hyponatremia (serum sodium <135 mmol/L) can be induced by the impaired absorption function of the edematous intestinal wall caused by heart failure (HF) and are prognostic factors of mortality in HF. However, little is known about the interrelationship of nutritional status and hyponatremia in mortality risk prediction in HF. This study enrolled 2882 HF patients were admitted ...
DOI:
10.1016/j.numecd.2022.04.004

37. Role of Epicardial Adipose Tissue in Cardiovascular Diseases: A Review

Author:
Michał Konwerski; Aleksandra Gąsecka; Grzegorz Opolski; Marcin Grabowski; Tomasz Mazurek
Source:
Biology 2022 v.11 no.3 pp. -
ISSN:
2079-7737
Subject:
COVID-19 infection; adiponectin; adipose tissue; atherosclerosis; atrial fibrillation; coronary artery disease; death; diabetes mellitus; energy; free fatty acids; gene expression regulation; heart failure; hypothermia; mechanical stress; metabolic syndrome; obesity; pericardium; prognosis; therapeutics; visceral fat
Abstract:
... Cardiovascular diseases (CVDs) are the leading causes of death worldwide. Epicardial adipose tissue (EAT) is defined as a fat depot localized between the myocardial surface and the visceral layer of the pericardium and is a type of visceral fat. EAT is one of the most important risk factors for atherosclerosis and cardiovascular events and a promising new therapeutic target in CVDs. In health cond ...
DOI:
10.3390/biology11030355

38. Sarcopenia in patients after an episode of acute decompensated heart failure: An underdiagnosed problem with serious impact

Author:
Romain Eschalier; Grégoire Massoullié; Yves Boirie; Marie Blanquet; Aurélien Mulliez; Pierre-Louis Tartière; Stefan Anker; Marie-Claire D'Agrosa Boiteux; Ruddy Richard; Frédéric Jean; Nicolas Combaret; Géraud Souteyrand; Clément Riocreux; Bruno Pereira; Pascal Motreff; Pelle Stolt; Patrick Rossignol; Guillaume Clerfond
Source:
Clinical nutrition 2021 v.40 no.6 pp. 4490-4499
ISSN:
0261-5614
Subject:
clinical nutrition; confidence interval; cross-sectional studies; death; functional status; gait; heart failure; longitudinal studies; mortality; muscle tissues; patients; prevalence; risk; sarcopenia; walking
Abstract:
... Sarcopenia is a multifactorial syndrome resulting in a decrease in both muscle mass and function. Little is known about the prevalence and prognostic impact of sarcopenia in patients with acutely decompensated chronic heart failure (ADHF). We aimed to evaluate the prevalence (main endpoint) and impact of sarcopenia on ADHF patients.140 ADHF patients were enrolled between November 2014 and Septembe ...
DOI:
10.1016/j.clnu.2020.12.033

39. Severe Spontaneous Atherosclerosis in two Korat Breed Cats is Comparable to Human Atherosclerosis

Author:
Veera Karkamo; Niina Airas; Jere Lindén; Karoliina Hagner; Mikko I. Mäyränpää; Petri T. Kovanen; Antti Sukura; Ilona Kareinen
Source:
Journal of comparative pathology 2021 v.188 pp. 52-61
ISSN:
0021-9975
Subject:
adulthood; atherosclerosis; cholesterol; death; domestic animals; genetic predisposition to disease; heart failure; histopathology; humans; mortality; necropsy
Abstract:
... Atherosclerosis is a chronic inflammatory vascular disease and the leading cause of mortality in humans worldwide. In most domestic animal species, however, primary atherosclerosis is of little clinical relevance. Cats are considered to be atheroresistant and, to our knowledge, spontaneous atherosclerosis has not been reported in cats. Here we report the clinical and histopathological findings in ...
DOI:
10.1016/j.jcpa.2021.08.006

40. Small molecule STING inhibition improves myocardial infarction remodeling

Author:
Lavinia Rech; Mahmoud Abdellatif; Maria Pöttler; Verena Stangl; Nishani Mabotuwana; Sean Hardy; Peter P. Rainer
Source:
Life sciences 2022 v.291 pp. 120263
ISSN:
0024-3205
Subject:
DNA; autoimmunity; cardiomyocytes; cell death; death; fibrosis; heart failure; hypertrophy; infarction; inflammation; interferons; mice; models; mortality; myocardial infarction; palmitoylation
Abstract:
... Myocardial infarction (MI) is a major global cause of death. Massive cell death leads to inflammation, which is necessary for ensuing wound healing. Extensive inflammation, however, promotes infarct expansion and adverse remodeling. The DNA sensing receptor cyclic GMP-AMP synthase and its downstream signaling effector stimulator of interferon genes (cGAS-STING) is central in innate immune reaction ...
DOI:
10.1016/j.lfs.2021.120263

41. Structural Brain Changes Associated with Overweight and Obesity

Author:
Erick Gómez-Apo; Alejandra Mondragón-Maya; Martina Ferrari-Díaz; Juan Silva-Pereyra
Source:
Journal of obesity 2021 v.2021 pp. -
ISSN:
2090-0716
Subject:
adipocytes; adipose tissue; apoptosis; blood-brain barrier; cerebellum; chemokines; cognition; death; diabetes; digestive system; dysbiosis; heart failure; hypertension; inflammation; macrophages; malnutrition; metabolic syndrome; microangiopathy; neuroglia; neurons; obesity; people; rats; renal failure; secretion
Abstract:
... Obesity is a global health problem with a broad set of comorbidities, such as malnutrition, metabolic syndrome, diabetes, systemic hypertension, heart failure, and kidney failure. This review describes recent findings of neuroimaging and two studies of cell density regarding the roles of overnutrition-induced hypothalamic inflammation in neurodegeneration. These studies provided consistent evidenc ...
DOI:
10.1155/2021/6613385

42. TUG1 knockdown suppresses cardiac fibrosis after myocardial infarction

Author:
Qingsong Sun; Man Luo; Zhiwei Gao; Xiang Han; Zhuan Yan; Shouxiang Xie; Hongmei Zhao; Hong Sun
Source:
Mammalian genome 2021 v.32 no.6 pp. 435-442
ISSN:
0938-8990
Subject:
Western blotting; cardiac output; cell viability; collagen; death; fibroblasts; fibrosis; genome; heart failure; microRNA; myocardial infarction
Abstract:
... Cardiac fibrosis is involved in myocardial remodeling following acute myocardial infarction (AMI), which can result in heart failure, arrhythmias and even sudden cardiac death. Investigating the molecular mechanisms of cardiac fibrosis in acute myocardial infarction (AMI) is essential for better understanding this pathology. The current study aims to investigate the effect of TUG1 on cardiac fibro ...
DOI:
10.1007/s00335-021-09895-z

43. The Feline Cardiomyopathies: 2. Hypertrophic cardiomyopathy

Author:
Mark D Kittleson; Etienne Côté
Source:
Journal of feline medicine and surgery 2021 v.23 no.11 pp. 1028-1051
ISSN:
1532-2750
Subject:
biomarkers; blood flow; cardiomyopathy; cats; death; echocardiography; heart; heart failure; hypertension; hyperthyroidism; males; medicine; prognosis; risk; surgery
Abstract:
... Hypertrophic cardiomyopathy (HCM) is the most common form of feline cardiomyopathy observed clinically and may affect up to approximately 15% of the domestic cat population, primarily as a subclinical disease. Fortunately, severe HCM, leading to heart failure or arterial thromboembolism (ATE), only occurs in a small proportion of these cats. Domestic cats of any age from 3 months upward, of either ...
DOI:
10.1177/1098612X211020162

44. The Role of NRF2 in Obesity-Associated Cardiovascular Risk Factors

Author:
Jorge Gutiérrez-Cuevas; Marina Galicia-Moreno; Hugo Christian Monroy-Ramírez; Ana Sandoval-Rodriguez; Jesús García-Bañuelos; Arturo Santos; Juan Armendariz-Borunda
Source:
Antioxidants 2022 v.11 no.2 pp. -
ISSN:
2076-3921
Subject:
Lewis acids; adipose tissue; atherosclerosis; atrial fibrillation; coronary artery disease; cytokines; death; diabetes; genes; heart failure; hyperglycemia; hyperlipidemia; hypertension; inflammation; lipid metabolism; macrophages; morbidity; mortality; obesity; oxidative stress; pathogenesis; reactive oxygen species; therapeutics
Abstract:
... The raising prevalence of obesity is associated with an increased risk for cardiovascular diseases (CVDs), particularly coronary artery disease (CAD), and heart failure, including atrial fibrillation, ventricular arrhythmias and sudden death. Obesity contributes directly to incident cardiovascular risk factors, including hyperglycemia or diabetes, dyslipidemia, and hypertension, which are involved ...
DOI:
10.3390/antiox11020235

45. The Roles of S100A4 and the EGF/EGFR Signaling Axis in Pulmonary Hypertension with Right Ventricular Hypertrophy

Author:
Maria Laggner; Philipp Hacker; Felicitas Oberndorfer; Jonas Bauer; Thomas Raunegger; Christian Gerges; Tamás Szerafin; Jürgen Thanner; Irene Lang; Nika Skoro-Sajer; Hendrik Jan Ankersmit; Bernhard Moser
Source:
Biology 2022 v.11 no.1 pp. -
ISSN:
2079-7737
Subject:
biomarkers; death; etiology; heart; heart failure; histopathology; hypertension; hypertrophy; lungs; patients; pulmonary artery
Abstract:
... Pulmonary hypertension (PH) is characterized by increased pulmonary arterial pressure caused by the accumulation of mesenchymal-like cells in the pulmonary vasculature. PH can lead to right ventricular hypertrophy (RVH) and, ultimately, heart failure and death. In PH etiology, endothelial-to-mesenchymal transition (EndMT) has emerged as a critical process governing the conversion of endothelial ce ...
DOI:
10.3390/biology11010118

46. The predictive value of clinical, radiographic, echocardiographic variables and cardiac biomarkers for assessing risk of the onset of heart failure or cardiac death in dogs with preclinical myxomatous mitral valve disease enrolled in the DELAY study

Author:
M. Borgarelli; L. Ferasin; K. Lamb; D. Chiavegato; C. Bussadori; G. D'Agnolo; F. Migliorini; M. Poggi; R.A. Santilli; E. Guillot; C. Garelli-Paar; R. Toschi Corneliani; F. Farina; A. Zani; M. Dirven; P. Smets; C. Guglielmini; P. Oliveira; M. Di Marcello; F. Porciello; S. Crosara; P. Ciaramella; D. Piantedosi; S. Smith; S. Vannini; E. Dall’Aglio; P. Savarino; C. Quintavalla; M. Patteson; J. Silva; C. Locatelli; M. Baron Toaldo
Source:
Journal of veterinary cardiology 2021 v.36 pp. 77-88
ISSN:
1760-2734
Subject:
biomarkers; brain; confidence interval; death; echocardiography; hazard ratio; heart failure; models; natriuretic peptides; radiography; risk
Abstract:
... To identify the predictive value on time to onset of heart failure (HF) or cardiac death of clinical, radiographic, and echocardiographic variables, as well as cardiac biomarkers N-terminal pro brain natriuretic peptide (NT-proBNP) and cardiac troponin I in dogs with preclinical myxomatous mitral valve disease (MMVD).One hundred sixty-eight dogs with preclinical MMVD and left atrium to aortic root ...
DOI:
10.1016/j.jvc.2021.04.009

47. Tongxinluo capsule as supplementation and cardiovascular endpoint events in patients with coronary heart disease: A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials

Author:
Jiayu Lv; Shixu Liu; Shasha Guo; Jialiang Gao; Qingqiao Song; Xiangning Cui
Source:
Journal of ethnopharmacology 2022 v.289 pp. 115033
ISSN:
0378-8741
Subject:
Oriental traditional medicine; adjuvants; blood; coronary disease; databases; death; heart failure; herbal medicines; meta-analysis; mortality; myocardial infarction; placebos; risk; sample size; systematic review; China
Abstract:
... Tongxinluo Capsule(TXLC) is a well-known traditional Chinese medicine prescription with effects of tonifying Qi and activating blood based on the Chinese herbal medicine theory that has been recommended as routine adjuvant treatment in patients with coronary heart disease (CHD) in China. Aim of the study: This meta-analysis aimed to evaluate the efficacy and safety of TXLC as supplementation in th ...
DOI:
10.1016/j.jep.2022.115033

48. Trehalose induces B cell autophagy to alleviate myocardial injury via the AMPK/ULK1 signalling pathway in acute viral myocarditis induced by Coxsackie virus B3

Author:
Bin Wei; Feiyu Lu; Qing Kong; Yanlan Huang; Kai Huang; Weifeng Wu
Source:
international journal of biochemistry & cell biology 2022 v.146 pp. 106208
ISSN:
1357-2725
Subject:
B-lymphocytes; Enterovirus; autophagosomes; autophagy; death; heart failure; mice; myocarditis; phosphorylation; protective effect; trehalose
Abstract:
... Viral myocarditis (VMC) is the main cause of sudden acute heart failure and cardiac death in adolescents; however, treatment for VMC is limited. Trehalose is a natural non-reductive disaccharide that protects against cardiovascular diseases by inducing autophagy. The protective effect of trehalose on VMC and the specific mechanism remains unclear. In this study, we established a VMC mouse model, t ...
DOI:
10.1016/j.biocel.2022.106208

49. A review on herbal Nrf2 activators with preclinical evidence in cardiovascular diseases

Author:
Abu Mohammad Syed; Chetan Ram; Upadhyayula Suryanarayana Murty; Bidya Dhar Sahu
Source:
Phytotherapy research 2021 v.35 no.9 pp. 5068-5102
ISSN:
0951-418X
Subject:
death; heart failure; hypertrophy; leucine zipper; oxidative stress; phytotherapy; reactive oxygen species; research; smooth muscle; transcription factors
Abstract:
... Cardiovascular diseases (CVDs) are an ever‐growing problem and are the most common cause of death worldwide. The uncontrolled production of reactive oxygen species (ROS) and the activation of ROS associated with various cell signaling pathways with oxidative cellular damage are the most common pathological conditions connected with CVDs including endothelial dysfunction, hypercontractility of vasc ...
DOI:
10.1002/ptr.7137

50. ACVIM consensus statement guidelines for the classification, diagnosis, and management of cardiomyopathies in cats

Author:
Virginia Luis Fuentes; Jonathan Abbott; Valérie Chetboul; Etienne Côté; Philip R. Fox; Jens Häggström; Mark D. Kittleson; Karsten Schober; Joshua A. Stern
Source:
Journal of veterinary internal medicine 2020 v.34 no.3 pp. 1062-1077
ISSN:
0891-6640
Subject:
cardiomyopathy; death; etiology; heart failure; longevity; phenotype; risk; veterinary medicine
Abstract:
... Cardiomyopathies are a heterogeneous group of myocardial disorders of mostly unknown etiology, and they occur commonly in cats. In some cats, they are well‐tolerated and are associated with normal life expectancy, but in other cats they can result in congestive heart failure, arterial thromboembolism or sudden death. Cardiomyopathy classification in cats can be challenging, and in this consensus s ...
DOI:
10.1111/jvim.15745

51. An ultrasensitive heart-failure BNP biosensor using B/N co-doped graphene oxide gel FET

Author:
I. Novodchuk; M. Kayaharman; I.R. Ausri; R. Karimi; X.S. Tang; I.A. Goldthorpe; E. Abdel-Rahman; J. Sanderson; M. Bajcsy; M. Yavuz
Source:
Biosensors & bioelectronics 2021 v.180 pp. 113114
ISSN:
0956-5663
Subject:
biomarkers; biosensors; death; detection limit; epidermal growth factor receptors; gels; graphene oxide; heart failure; humans; natriuretic peptides; transistors
Abstract:
... Heart failure (HF) is the number one cause of death in the world. B-type natriuretic peptide (BNP) is a recognized biomarker for HF and can be used for early detection. Field effect transistor (FET) biosensors have the ability to sense BNP in much shorter times than conventional clinical studies. The lowest limit of detection (LOD) of state-of-the-art HF FET biosensors is 100 fM and detection rang ...
DOI:
10.1016/j.bios.2021.113114

52. Bifenazate exposure induces cardiotoxicity in zebrafish embryos

Author:
Jinze Ma; Yong Huang; Yuyang Peng; Zhaopeng Xu; Ziqin Wang; Xiaobei Chen; Shuling Xie; Ping Jiang; Keyuan Zhong; Huiqiang Lu
Source:
Environmental pollution 2021 v.274 pp. 116539
ISSN:
0269-7491
Subject:
Danio rerio; acaricides; adenosinetriphosphatase; antioxidants; astaxanthin; bifenazate; blood; calcium; cardiotoxicity; death; gene expression; heart; heart failure; models; oxidative stress; pollution; toxicity
Abstract:
... Bifenazate is a novel acaricide for selective foliar spraying and is widely used to control mites in agricultural production. However, its toxicity to aquatic organisms is unknown. Here, a zebrafish model was used to study bifenazate toxicity to aquatic organisms. Exposure to bifenazate was found to cause severe cardiotoxicity in zebrafish embryos, along with disorders in the gene expression relat ...
DOI:
10.1016/j.envpol.2021.116539

53. COVID-19: Multiorgan Dissemination of SARS-CoV-2 Is Driven by Pulmonary Factors

Author:
Akmaljon Odilov; Alexey Volkov; Adhamjon Abdullaev; Tatiana Gasanova; Tatiana Lipina; Igor Babichenko
Source:
Viruses 2021 v.14 no.1 pp. -
ISSN:
1999-4915
Subject:
COVID-19 infection; RNA; Severe acute respiratory syndrome coronavirus 2; blood serum; brain; death; heart failure; liver; lymph; myocardium; pathogenesis; risk; spleen; viral load
Abstract:
... Multi-organ failure is one of the common causes of fatal outcome in COVID-19 patients. However, the pathogenetic association of the SARS-CoV-2 viral load (VL) level with fatal dysfunctions of the lungs, liver, kidneys, heart, spleen and brain, as well as with the risk of death in COVID-19 patients remains poorly understood. SARS-CoV-2 VL in the lungs, heart, liver, kidneys, brain, spleen and lymph ...
DOI:
10.3390/v14010039

54. Cardiac disease in the Spix Macaw (Cyanopsitta spixii): two cases

Author:
MPN de Carvalho; MPV Cunha; T Knöbl; CS Cirqueira; RN Dias‐Neto; PP Serafini; JL Catão‐Dias; J Díaz‐Delgado
Source:
Australian veterinary journal 2021 v.99 no.9 pp. 402-407
ISSN:
0005-0423
Subject:
Acinetobacter; Cyanopsitta spixii; Pantoea; adults; atherosclerosis; birds; cardiomyocytes; cerebrum; death; endocarditis; ex situ conservation; heart failure; myocarditis; poultry; septicemia; thrombosis
Abstract:
... Cardiovascular disease in avian species, other than poultry, is being increasingly reported. In psittacine birds, atherosclerosis and congestive heart failure are the leading cardiovascular diseases, often resulting in multiorgan dysfunction and demise. The Spix's macaw (Cyanopsitta spixii) is arguably the most endangered psittacine species worldwide. We aimed to describe the gross and microscopic ...
DOI:
10.1111/avj.13097

55. Chagas Cardiomyopathy: From Romaña Sign to Heart Failure and Sudden Cardiac Death

Author:
Antonia Pino-Marín; Germán José Medina-Rincón; Sebastian Gallo-Bernal; Alejandro Duran-Crane; Álvaro Ignacio Arango Duque; María Juliana Rodríguez; Ramón Medina-Mur; Frida T. Manrique; Julian F. Forero; Hector M. Medina
Source:
Pathogens 2021 v.10 no.5 pp. -
ISSN:
2076-0817
Subject:
Chagas disease; burden of disease; cardiomyopathy; death; dysautonomia; gastrointestinal system; globalization; health services; heart failure; host-parasite relationships; pathogenesis; public health; therapeutics; urbanization; Latin America; South America
Abstract:
... Despite nearly a century of research and accounting for the highest disease burden of any parasitic disease in the Western Hemisphere, Chagas disease (CD) is still a challenging diagnosis, primarily due to its poor recognition outside of Latin America. Although initially considered endemic to Central and South America, globalization, urbanization, and increased migration have spread the disease wo ...
DOI:
10.3390/pathogens10050505

56. Dietary and supplemental antioxidant intake and risk of major adverse cardiovascular events in older men: The concord health and ageing in men project

Author:
Arpita Das; Robert G. Cumming; Vasi Naganathan; Fiona Blyth; David G. Le Couteur; David J. Handelsman; Louise M. Waite; Rosilene V.R. Ribeiro; Stephen J. Simpson; Vasant Hirani
Source:
Nutrition, metabolism, and cardiovascular diseases 2021 v.31 no.4 pp. 1102-1112
ISSN:
0939-4753
Subject:
Australians; antioxidants; ascorbic acid; death; elderly; heart failure; men; myocardial infarction; nutrient deficiencies; nutrient intake; senescence (aging); stroke; vitamin A; vitamin E; vitamin-mineral supplements; zinc; Australia
Abstract:
... The role of antioxidant intake in cardiovascular disease remains inconclusive. This study evaluates the association between antioxidant intake and the risk of major adverse cardiovascular events (MACE) among older Australian men.794 men aged ≥75 years participated in the 3rd wave of the Concord Health and Ageing in Men Project. Dietary adequacy of antioxidant intake was assessed by comparing parti ...
DOI:
10.1016/j.numecd.2020.11.032

57. Effects of Bergamot Polyphenols on Mitochondrial Dysfunction and Sarcoplasmic Reticulum Stress in Diabetic Cardiomyopathy

Author:
Jessica Maiuolo; Cristina Carresi; Micaela Gliozzi; Vincenzo Musolino; Federica Scarano; Anna Rita Coppoletta; Lorenza Guarnieri; Saverio Nucera; Miriam Scicchitano; Francesca Bosco; Stefano Ruga; Maria Caterina Zito; Roberta Macri; Antonio Cardamone; Maria Serra; Rocco Mollace; Annamaria Tavernese; Vincenzo Mollace
Source:
Nutrients 2021 v.13 no.7 pp. -
ISSN:
2072-6643
Subject:
Mediterranean diet; antioxidants; calcium; cardiomyocytes; cardiomyopathy; cell death; cell viability; death; dietary supplements; energy metabolism; fruits; heart failure; mitochondria; nutritional support; olive oil; polyphenols; red meat; sarcoplasmic reticulum
Abstract:
... Cardiovascular disease is the leading cause of death and disability in the Western world. In order to safeguard the structure and the functionality of the myocardium, it is extremely important to adequately support the cardiomyocytes. Two cellular organelles of cardiomyocytes are essential for cell survival and to ensure proper functioning of the myocardium: mitochondria and the sarcoplasmic retic ...
DOI:
10.3390/nu13072476

58. Endoplasmic Reticulum Stress Promotes iNOS/NO and Influences Inflammation in the Development of Doxorubicin-Induced Cardiomyopathy

Author:
Ashim K. Bagchi; Akshi Malik; Gauri Akolkar; Davinder S. Jassal; Pawan K. Singal
Source:
Antioxidants 2021 v.10 no.12 pp. -
ISSN:
2076-3921
Subject:
apoptosis; cardiomyocytes; cardiomyopathy; caspases; death; doxorubicin; endoplasmic reticulum; endoplasmic reticulum stress; heart failure; inflammation; mitochondria; unfolded protein response
Abstract:
... Doxorubicin (Dox) is known to cause heart failure in some cancer patients. Despite extensive studies over the past half century, the subcellular basis of Dox-induced cardiomyopathy (DIC) is still elusive. Earlier, we suggested that Dox causes a delayed activation of unfolded protein response (UPR) which may promote mitochondrial Bax activity leading to cardiomyocyte death. As a follow up, using NO ...
DOI:
10.3390/antiox10121897

59. Genetics of canine myxomatous mitral valve disease

Author:
M. J. O’Brien; N. J. Beijerink; C. M. Wade
Source:
Animal genetics 2021 v.52 no.4 pp. 409-421
ISSN:
0268-9146
Subject:
Cavalier King Charles Spaniel; animal genetics; death; disease severity; dogs; genomics; heart failure; heart valve diseases; longevity; mortality
Abstract:
... Myxomatous mitral valve disease (MMVD) is the most common heart disease and cause of cardiac death in domestic dogs. MMVD is characterised by slow progressive myxomatous degeneration from the tips of the mitral valves onwards with subsequent mitral valve regurgitation, and left atrial and ventricular dilatation. Although the disease usually has a long asymptomatic period, in dogs with severe disea ...
DOI:
10.1111/age.13082

60. Harnessing the Benefits of Endogenous Hydrogen Sulfide to Reduce Cardiovascular Disease

Author:
Kevin M. Casin; John W. Calvert
Source:
Antioxidants 2021 v.10 no.3 pp. -
ISSN:
2076-3921
Subject:
cardiomyopathy; death; exercise; fasting; heart failure; hydrogen sulfide; therapeutics
Abstract:
... Cardiovascular disease is the leading cause of death in the U.S. While various studies have shown the beneficial impact of exogenous hydrogen sulfide (H₂S)-releasing drugs, few have demonstrated the influence of endogenous H₂S production. Modulating the predominant enzymatic sources of H₂S—cystathionine-β-synthase, cystathionine-γ-lyase, and 3-mercaptopyruvate sulfurtransferase—is an emerging and ...
DOI:
10.3390/antiox10030383

61. Heart rhythm characterization during sudden cardiac death in dogs

Author:
R. Santilli; V. Saponaro; L. Carlucci; M. Perego; S. Battaia; M. Borgarelli
Source:
Journal of veterinary cardiology 2021 v.38 pp. 18-30
ISSN:
1760-2734
Subject:
cardiac arrest; cardiomyopathy; databases; death; dogs; echocardiography; heart; heart failure; myocarditis; retrospective studies; tachycardia
Abstract:
... Inherited or acquired arrhythmic disorders and cardiac disease have been associated with sudden cardiac death (SCD) in dogs. The electrical mechanism related to death in most of these cases is unknown. This retrospective study aimed to describe arrhythmic events in dogs that experienced SCD during Holter monitoring.Nineteen client-owned dogs that experienced SCD during Holter examination were incl ...
DOI:
10.1016/j.jvc.2021.09.005

62. High Plasma Docosahexaenoic Acid Associated to Better Prognoses of Patients with Acute Decompensated Heart Failure with Preserved Ejection Fraction

Author:
Naoaki Matsuo; Toru Miyoshi; Atsushi Takaishi; Takao Kishinoue; Kentaro Yasuhara; Masafumi Tanimoto; Yukari Nakano; Nobuhiko Onishi; Masayuki Ueeda; Hiroshi Ito
Source:
Nutrients 2021 v.13 no.2 pp. -
ISSN:
2072-6643
Subject:
arachidonic acid; death; docosahexaenoic acid; eicosapentaenoic acid; heart failure; mortality; nutrition risk assessment; nutritional status; prognosis; regression analysis; retrospective studies; therapeutics
Abstract:
... The clinical relevance of polyunsaturated fatty acids (PUFAs) in heart failure remains unclear. The aim of this study was to investigate the association between PUFA levels and the prognosis of patients with heart failure with preserved ejection fraction (HFpEF). This retrospective study included 140 hospitalized patients with acute decompensated HFpEF (median age 84.0 years, 42.9% men). The patie ...
DOI:
10.3390/nu13020371

63. Hyperuricemia as a prognostic marker for long-term outcomes in patients with myocardial infarction with nonobstructive coronary arteries

Author:
Wenjian Ma; Side Gao; Sizhuang Huang; Jiansong Yuan; Mengyue Yu
Source:
Nutrition & metabolism 2021 v.18 no.1 pp. 107
ISSN:
1743-7075
Subject:
blood serum; confidence interval; coronary artery disease; death; hazard ratio; heart failure; hyperuricemia; metabolism; myocardial infarction; prognosis; regression analysis; risk assessment; risk factors; stroke; uric acid
Abstract:
... BACKGROUND: Hyperuricemia (HUA) has been proved as a predictor of worse outcomes in patients with coronary artery disease. Here, we investigated the prognostic value of HUA in a distinct population with myocardial infarction with nonobstructive coronary arteries (MINOCA). METHODS: A total of 1179 MINOCA patients were enrolled and divided into HUA and non-HUA groups. HUA was defined as a serum uric ...
DOI:
10.1186/s12986-021-00636-2

64. Impact of Inadequate Calorie Intake on Mortality and Hospitalization in Stable Patients with Chronic Heart Failure

Author:
Yoshikuni Obata; Naoya Kakutani; Shintaro Kinugawa; Arata Fukushima; Takashi Yokota; Shingo Takada; Taisuke Ono; Takeshi Sota; Yoshiharu Kinugasa; Masashige Takahashi; Hisashi Matsuo; Ryuichi Matsukawa; Ichiro Yoshida; Isao Yokota; Kazuhiro Yamamoto; Miyuki Tsuchihashi-Makaya
Source:
Nutrients 2021 v.13 no.3 pp. -
ISSN:
2072-6643
Subject:
death; eating habits; energy expenditure; energy intake; heart failure; malnutrition; mortality; regression analysis; risk
Abstract:
... Malnutrition is highly prevalent in patients with heart failure (HF), but the precise impact of dietary energy deficiency on HF patients’ clinical outcomes is not known. We investigated the associations between inadequate calorie intake and adverse clinical events in 145 stable outpatients with chronic HF who had a history of hospitalization due to worsening HF. To assess the patients’ dietary pat ...
DOI:
10.3390/nu13030874

65. Impact of obesity on adverse in-hospital outcomes in patients undergoing percutaneous mitral valve edge-to-edge repair using MitraClip® procedure - Results from the German nationwide inpatient sample

Author:
Karsten Keller; Lukas Hobohm; Martin Geyer; Felix Kreidel; Mir A. Ostad; Carl J. Lavie; Mareike Lankeit; Stavros Konstantinides; Thomas Münzel; Ralph Stephan von Bardeleben
Source:
Nutrition, metabolism, and cardiovascular diseases 2020 v.30 no.8 pp. 1365-1374
ISSN:
0939-4753
Subject:
data analysis; death; embolism; females; heart failure; heart valve diseases; metabolism; mortality; obesity; patients; renal failure
Abstract:
... The number of percutaneous edge-to-edge mitral regurgitation (MR) valve repairs with MitraClip® implantations increased exponentially in recent years. Studies have suggested an obesity survival paradox in patients with cardiovascular diseases. We investigated the influence of obesity on adverse in-hospital outcomes in patients with MitraClip® implantation.We analyzed data on characteristics of pat ...
DOI:
10.1016/j.numecd.2020.04.009

66. Impact of triglyceride-glucose index on long-term cardiovascular outcomes in patients with myocardial infarction with nonobstructive coronary arteries

Author:
Side Gao; Wenjian Ma; Sizhuang Huang; Xuze Lin; Mengyue Yu
Source:
Nutrition, metabolism, and cardiovascular diseases 2021 v.31 no.11 pp. 3184-3192
ISSN:
0939-4753
Subject:
coronary artery disease; death; heart failure; insulin resistance; metabolism; myocardial infarction; prognosis; regression analysis; risk assessment; risk factors; stroke
Abstract:
... Triglyceride-glucose (TyG) index has been reported as a novel surrogate marker of insulin resistance and a risk factor in patients with coronary artery disease. We aimed to investigate the prognostic value of TyG index in a distinct entity with myocardial infarction with nonobstructive coronary arteries (MINOCA).A total of 1179 MINOCA patients were recruited and divided according to tertile levels ...
DOI:
10.1016/j.numecd.2021.07.027

67. Insulin-like growth factor-1 short-period therapy improves cardiomyopathy stimulating cardiac progenitor cells survival in obese mice

Author:
Daniela Andrade; Genilza Oliveira; Luciana Menezes; Ana Lúcia Nascimento; Simone Carvalho; Ana Carolina Stumbo; Alessandra Thole; Érica Garcia-Souza; Anibal Moura; Laís Carvalho; Erika Cortez
Source:
Nutrition, metabolism, and cardiovascular diseases 2020 v.30 no.1 pp. 151-161
ISSN:
0939-4753
Subject:
Western diets; animal disease models; apoptosis; calcium; cardiomyocytes; cardiomyopathy; cardioprotective effect; death; fibrosis; gap junctions; heart failure; insulin-like growth factor I; laboratory animals; metabolism; mice; mortality; obesity; stem cells; subcutaneous injection
Abstract:
... Cardiovascular diseases are the main cause of mortality in obesity. Despite advanced understanding, the mechanisms that regulate cardiac progenitor cells (CPC) survival in pathological conditions are not clear. Low IGF-1 plasma levels are correlated to obesity, cardiomyopathy and CPC death, so this work aimed to investigate IGF-1 therapeutic potential on cardiomyopathy and its relationship with th ...
DOI:
10.1016/j.numecd.2019.09.001

68. Intravenous administration of allogeneic Wharton jelly-derived mesenchymal stem cells for treatment of dogs with congestive heart failure secondary to myxomatous mitral valve disease

Author:
Vicky K. Yang; Dawn M. Meola; Airiel Davis; Bruce Barton; Andrew M. Hoffman
Source:
American journal of veterinary research 2021 v.82 no.6 pp. 487-493
ISSN:
0002-9645
Subject:
biomarkers; blood serum; cardiac output; clinical trials; death; dogs; drugs; echocardiography; euthanasia; heart failure; intravenous injection; karyotyping; mesenchymal stromal cells; monocytes; placebos; veterinary medicine
Abstract:
... OBJECTIVE To evaluate whether mesenchymal stem cells (MSCs) can be safely administered IV to dogs with congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD) to improve cardiac function and prolong survival time. ANIMALS 10 client-owned dogs with CHF secondary to MMVD. PROCEDURES Dogs with an initial episode of CHF secondary to MMVD were enrolled in a double-blind, plac ...
DOI:
10.2460/ajvr.82.6.487

69. KLF15 Loss-of-Function Mutation Underlying Atrial Fibrillation as well as Ventricular Arrhythmias and Cardiomyopathy

Author:
Ning Li; Ying-Jia Xu; Hong-Yu Shi; Chen-Xi Yang; Yu-Han Guo; Ruo-Gu Li; Xing-Biao Qiu; Yi-Qing Yang; Min Zhang
Source:
Genes 2021 v.12 no.3 pp. -
ISSN:
2073-4425
Subject:
atrial fibrillation; bioinformatics; cardiomyopathy; death; electrophysiology; genes; genetic heterogeneity; heart failure; heterozygosity; loss-of-function mutation; mutants; pathogenesis; pedigree; penetrance; stroke; transcription (genetics); transcription factors; transcriptional activation
Abstract:
... Atrial fibrillation (AF) represents the most common type of clinical cardiac arrhythmia and substantially increases the risks of cerebral stroke, heart failure and death. Accumulating evidence has convincingly demonstrated the strong genetic basis of AF, and an increasing number of pathogenic variations in over 50 genes have been causally linked to AF. Nevertheless, AF is of pronounced genetic het ...
DOI:
10.3390/genes12030408

70. Key considerations in the approach to congenital heart disease in dogs and cats

Author:
A. B. Saunders
Source:
journal of small animal practice 2021 v.62 no.8 pp. 613-623
ISSN:
0022-4510
Subject:
adulthood; death; disease diagnosis; heart; heart failure; morbidity; small animal practice
Abstract:
... Congenital heart disease is an important subset of all cardiovascular disease in dogs and cats that is present at birth and most often detected in young animals but can be diagnosed in adulthood. The range of abnormalities that can occur during development of the heart is vast incorporating simple and complex defects, varying degrees of severity and clinical presentations that include heart failur ...
DOI:
10.1111/jsap.13360

71. Liquid silicone embolism syndrome (SES) in lungs and liver – A case report

Author:
Annika Nebel; Florian Veit; Anne Weber; Walter Martz; Gabriele Lasczkowski; Reinhard Dettmeyer
Source:
Forensic science international 2021 v.325 pp. 110872
ISSN:
0379-0738
Subject:
abdominal fat; blood; case studies; clothing; death; embolism; forensic sciences; gels; heart failure; injection site; liquids; liver; lungs; penis; polydimethylsiloxane; scrotum; urine
Abstract:
... Silicone embolism syndrome (SES) is a well known complication after injection of silicone gel as well as liquid silicone. Rarely, men use physiologic salt solution or liquid silicone injected into the subcutaneous tissue of the scrotum, the penis, the upper genital or the inguinal region. Those men, who call themselves “siliconers”, want to get a larger penis and scrotum, also visible when wearing ...
DOI:
10.1016/j.forsciint.2021.110872

72. Mediterranean, DASH, and Alternate Healthy Eating Index Dietary Patterns and Risk of Death in the Physicians’ Health Study

Author:
Yash R. Patel; Jeremy M. Robbins; J. Michael Gaziano; Luc Djoussé
Source:
Nutrients 2021 v.13 no.6 pp. -
ISSN:
2072-6643
Subject:
Dietary Approaches to Stop Hypertension diet; atrial fibrillation; coronary disease; death; diabetes; energy; exercise; food frequency questionnaires; hazard ratio; heart failure; hypertension; males; mortality; regression analysis; risk
Abstract:
... Objective: Our primary objective was to examine the associations of the Mediterranean (MED), the Dietary Approaches to Stop Hypertension (DASH), and the Alternate Healthy Eating Index (AHEI) diet with total mortality. Our secondary objective was to examine the association of these three dietary patterns with cardiovascular disease (CVD) and cancer mortality. Research: Design and Methods: We prospe ...
DOI:
10.3390/nu13061893

73. Modulations of Cardiac Functions and Pathogenesis by Reactive Oxygen Species and Natural Antioxidants

Author:
Sun-Hee Woo; Joon-Chul Kim; Nipa Eslenur; Tran Nguyet Trinh; Long Nguyen Hoàng Do
Source:
Antioxidants 2021 v.10 no.5 pp. -
ISSN:
2076-3921
Subject:
calcium; cardiomyocytes; cell growth; death; electron transport chain; heart failure; homeostasis; hypertension; infarction; inflammation; mitochondria; nitric oxide synthase; pathogenesis; reactive oxygen species
Abstract:
... Homeostasis in the level of reactive oxygen species (ROS) in cardiac myocytes plays a critical role in regulating their physiological functions. Disturbance of balance between generation and removal of ROS is a major cause of cardiac myocyte remodeling, dysfunction, and failure. Cardiac myocytes possess several ROS-producing pathways, such as mitochondrial electron transport chain, NADPH oxidases, ...
DOI:
10.3390/antiox10050760

74. Molecular Mechanisms Associated with ROS-Dependent Angiogenesis in Lower Extremity Artery Disease

Author:
Greg Hutchings; Łukasz Kruszyna; Mariusz J. Nawrocki; Ewa Strauss; Rut Bryl; Julia Spaczyńska; Bartłomiej Perek; Marek Jemielity; Paul Mozdziak; Bartosz Kempisty; Michał Nowicki; Zbigniew Krasiński
Source:
Antioxidants 2021 v.10 no.5 pp. -
ISSN:
2076-3921
Subject:
angiogenesis; apoptosis; atherosclerosis; blood; cell differentiation; death; endothelium; heart; heart failure; humans; medicine; morbidity; mortality; myocardial infarction; pain; quality of life; reactive oxygen species; therapeutics
Abstract:
... Currently, atherosclerosis, which affects the vascular bed of all vital organs and tissues, is considered as a leading cause of death. Most commonly, atherosclerosis involves coronary and peripheral arteries, which results in acute (e.g., myocardial infarction, lower extremities ischemia) or chronic (persistent ischemia leading to severe heart failure) consequences. All of them have a marked unfav ...
DOI:
10.3390/antiox10050735

75. Molecular Remodeling of Cardiac Sinus Node Associated with Acute Chagas Disease Myocarditis

Author:
Héctor O. Rodríguez-Angulo; Diana Colombet-Naranjo; María C. Maza; Cristina Poveda; Alfonso Herreros-Cabello; Iván Mendoza; Juan C. Perera; Juan D. Goyo; Núria Gironès; Manuel Fresno
Source:
Microorganisms 2021 v.9 no.11 pp. -
ISSN:
2076-2607
Subject:
Chagas disease; death; heart failure; isoproterenols; myocarditis; risk
Abstract:
... Chagas disease principally affects Latin-American people, but it currently has worldwide distribution due to migration. Death among those with Chagas disease can occur suddenly and without warning, even in those who may not have evidence of clinical or structural cardiac disease and who are younger than 60 years old. HCN4 channels, one of the principal elements responsible for pacemaker currents, ...
DOI:
10.3390/microorganisms9112208

76. Molecular correction of Duchenne muscular dystrophy by splice modulation and gene editing

Author:
Britt Hanson; Matthew J.A. Wood; Thomas C. Roberts
Source:
RNA biology 2021 v.18 no.7 pp. 1048-1062
ISSN:
1555-8584
Subject:
death; drugs; dystrophin; excision; exons; heart; heart failure; immunogenicity; muscles; muscular dystrophy; nephrotoxicity; oligonucleotides; patients
Abstract:
... Duchenne muscular dystrophy (DMD) is a currently incurable X-linked neuromuscular disorder, characterized by progressive muscle wasting and premature death, typically as a consequence of cardiac failure. DMD-causing mutations in the dystrophin gene are highly diverse, meaning that the development of a universally-applicable therapy to treat all patients is very challenging. The leading therapeutic ...
DOI:
10.1080/15476286.2021.1874161

77. Natural ingredients from Chinese materia medica for pulmonary hypertension

Author:
Jia-Rui ZHANG; Xuan OUYANG; Chi HOU; Qi-Feng YANG; Yingjun Wu; Wen-Ju LU; Chun-Li LIU; Kai YANG; Nan-Shan ZHONG; Jian WANG; Yu-Qin CHEN
Source:
Chinese journal of natural medicines 2021 v.19 no.11 pp. 801-814
ISSN:
1875-5364
Subject:
alternative medicine; death; heart failure; homeopathic drugs; hypertension; lungs; prognosis; pulmonary artery
Abstract:
... Pulmonary hypertension (PH) is a severe pathophysiological condition characterized by pulmonary artery remodeling and continuous increases in pulmonary artery pressure, which may eventually develop to right heart failure and death. Although newly discovered and incredible treatment strategies in recent years have improved the prognosis of PH, limited types of effective and economical drugs for PH ...
DOI:
10.1016/S1875-5364(21)60092-4

78. Non-coding RNAs: The key detectors and regulators in cardiovascular disease

Author:
Linwen Zhu; Ni Li; Lebo Sun; Dawei Zheng; Guofeng Shao
Source:
Genomics 2021 v.113 no.1 pp. 1233-1246
ISSN:
0888-7543
Subject:
DNA; arrhythmia; atherosclerosis; circular RNA; death; early diagnosis; fibrosis; gene expression; genomics; heart failure; hypertension; hypertrophy; microRNA; myocardial infarction; non-coding RNA; pulmonary artery
Abstract:
... Cardiovascular disease (CVD) is an important cause of disease-related death worldwide. One of its main pathological bases is imbalances in gene expression. Non-coding RNAs are a class of transcripts that do not encode proteins. They include microRNA (miRNA), long noncoding RNA (lncRNA) and circular RNA (circRNA). They have important biological functions such as regulating transcription and transla ...
DOI:
10.1016/j.ygeno.2020.10.024

79. Oxidative Stress Markers and Modified Model for End-Stage Liver Disease Are Associated with Outcomes in Patients with Advanced Heart Failure Receiving Bridged Therapy with Continuous-Flow Left Ventricular Assist Devices

Author:
Bożena Szyguła-Jurkiewicz; Wioletta Szczurek-Wasilewicz; Mariusz Gąsior; Izabela Copik; Justyna Małyszek-Tumidajewicz; Michał Skrzypek; Ewa Romuk; Michał Zembala; Marian Zembala; Piotr Przybyłowski
Source:
Antioxidants 2021 v.10 no.11 pp. -
ISSN:
2076-3921
Subject:
albumins; antioxidant activity; bilirubin; blood serum; creatinine; death; heart failure; liver diseases; models; oxidants; oxidative stress; risk; stroke; therapeutics; thrombosis
Abstract:
... Left ventricular assist device (LVAD) is well established as an alternative treatment for end-stage heart failure (HF) patients. The aim of the study was to determine the prognostic value of oxidative stress markers and the modified Model for End-Stage Liver Disease (modMELD) in patients receiving bridged therapy with continuous-flow LVAD. We prospectively analyzed 36 end-stage HF patients who rec ...
DOI:
10.3390/antiox10111813

80. Paroxysmal high-grade second-degree and persistent third-degree atrioventricular block in cats

Author:
I. Spalla; G.W. Smith; Y.-M. Chang; V. Luis Fuentes; D.J. Connolly
Source:
Journal of veterinary cardiology 2021 v.36 pp. 20-31
ISSN:
1760-2734
Subject:
arrhythmia; death; echocardiography; heart failure; hospitals; mortality; patients; retrospective studies; risk factors; tachypnea
Abstract:
... Both paroxysmal high-grade second-degree and persistent third-degree atrioventricular block (AVB) are recognised in cats. Our aim was to document the presentation, echocardiographic data, comorbidities and outcome in affected cats from a single referral hospital, including those that underwent epicardial pacemaker implantation (EPI).This retrospective study included 64 cats diagnosed with persiste ...
DOI:
10.1016/j.jvc.2021.04.003

81. Pathogenic variants in plakophilin-2 gene (PKP2) are associated with better survival in arrhythmogenic right ventricular cardiomyopathy

Author:
Elżbieta K. Biernacka; Karolina Borowiec; Maria Franaszczyk; Małgorzata Szperl; Alessandra Rampazzo; Olgierd Woźniak; Marta Roszczynko; Witold Śmigielski; Anna Lutyńska; Piotr Hoffman
Source:
Journal of applied genetics 2021 v.62 no.4 pp. 613-620
ISSN:
1234-1983
Subject:
cardiomyopathy; clinical examination; death; echocardiography; electrocardiography; genes; genotype-phenotype correlation; heart failure; heart transplant; high performance liquid chromatography; medical history; mutation; phenotype; prognosis
Abstract:
... Arrhythmogenic right ventricular cardiomyopathy (ARVC) is mainly caused by mutations in genes encoding desmosomal proteins. Variants in plakophilin-2 gene (PKP2) are the most common cause of the disease, associated with conventional ARVC phenotype. The study aims to evaluate the prevalence of PKP2 variants and examine genotype–phenotype correlation in Polish ARVC cohort. All 56 ARVC patients fulfi ...
DOI:
10.1007/s13353-021-00647-y

82. Ranolazine protects against diabetic cardiomyopathy by activating the NOTCH1/NRG1 pathway

Author:
Xi Chen; Long Ren; Xing Liu; Xi Sun; Chaorun Dong; Yanan Jiang; Ying Qin; Huan Qu; Jinfeng Jiao; Shuo Wang; Yunlong Bai; Baofeng Yang
Source:
Life sciences 2020 v.261 pp. 118306
ISSN:
0024-3205
Subject:
B-cell lymphoma; Western blotting; apoptosis; arrhythmia; aspartic acid; blood glucose; cardiomyopathy; caspase-3; death; diabetic complications; echocardiography; flow cytometry; heart failure; neurotrophins; weight loss
Abstract:
... Diabetic cardiomyopathy (DCM) is a common diabetes complication that can cause arrhythmia, heart failure, and even sudden death. Ranolazine is an antianginal agent used to treat chronic stable angina and has been demonstrated as an effective treatment for many cardiovascular diseases. However, the mechanism by which ranolazine alleviates DCM is unclear, motivating this study investigating the effe ...
DOI:
10.1016/j.lfs.2020.118306

83. Remote sensing natural time analysis of heartbeat data by means of a portable photoplethysmography device

Author:
G. Baldoumas; D. Peschos; G. Tatsis; V. Christofilakis; S. K. Chronopoulos; P. Kostarakis; P. A. Varotsos; N. V. Sarlis; E. S. Skordas; A. Bechlioulis; L. K. Michalis; K. K. Naka
Source:
International journal of remote sensing 2021 v.42 no.6 pp. 2292-2302
ISSN:
1366-5901
Subject:
death; electrocardiography; entropy; heart; heart failure; heart rate; radar; support vector machines; wireless technology
Abstract:
... Very recent work reported that patients can monitor their heartbeat at home and specify their heart conditions by means of a millimetre wave radar, but there exist serious limitations because the radar sensor is sensitive to significant body motions that cause Doppler frequency shifts. Such limitations do not exist when using a recently constructed portable photoplethysmography (PPG) electronic de ...
DOI:
10.1080/2150704X.2020.1847351

84. Risk indictors in cats with preclinical hypertrophic cardiomyopathy: a prospective cohort study

Author:
Vicky A Ironside; Philip R Tricklebank; Adrian Boswood
Source:
Journal of feline medicine and surgery 2021 v.23 no.2 pp. 149-159
ISSN:
1532-2750
Subject:
blood; blood pressure; cardiomyopathy; cats; clinical examination; cohort studies; death; echocardiography; heart failure; medicine; natriuretic peptides; patients; risk; surgery
Abstract:
... This study aimed to identify indicators of the risk of progression of preclinical hypertrophic cardiomyopathy (HCM). This was a prospective cohort study following a population of cats with preclinical HCM. Cats serially underwent physical examination, blood pressure measurement, blood sampling and echocardiography. Development of congestive heart failure (CHF), arterial thromboembolism (ATE) or su ...
DOI:
10.1177/1098612X20938651

85. Serum Levels of Dihomo-Gamma (γ)-Linolenic Acid (DGLA) Are Inversely Associated with Linoleic Acid and Total Death in Elderly Patients with a Recent Myocardial Infarction

Author:
Dennis Winston T. Nilsen; Peder Langeland Myhre; Are Kalstad; Erik Berg Schmidt; Harald Arnesen; Ingebjørg Seljeflot
Source:
Nutrients 2021 v.13 no.10 pp. -
ISSN:
2072-6643
Subject:
blood serum; body mass index; cod liver oil; death; diabetes mellitus; elderly; hazard ratio; heart failure; hypertension; kidney diseases; linoleic acid; myocardial infarction; omega-6 fatty acids; phospholipids; regression analysis; risk; stroke
Abstract:
... Dihomo-gamma-linolenic acid (DGLA) is an n-6 polyunsaturated fatty acid (PUFA) derived from linoleic acid (LA). The LA:DGLA ratio reflects conversion from LA to DGLA. Low levels of DGLA in serum have been related to poor outcome in myocardial infarction (MI) patients. Aims: To assess the association of DGLA and LA:DGLA with total death as a primary aim and incident cardiovascular events as a secon ...
DOI:
10.3390/nu13103475

86. Soluble ST2 proteins in male cachectic patients with chronic heart failure

Author:
Grzegorz Sobieszek; Tomasz Powrózek; Andrzej Jaroszyński; Aneta Skwarek-Dziekanowska; Mansur Rahnama-Hezavah; Teresa Małecka-Massalska
Source:
Nutrition, metabolism, and cardiovascular diseases 2021 v.31 no.3 pp. 886-893
ISSN:
0939-4753
Subject:
biomarkers; body composition; cachexia; correlation; death; detection; guidelines; heart failure; males; metabolism; monitoring; mortality; nutrition; patients; prediction; proteins; risk; screening; testing
Abstract:
... Until now, there are lack of established clinical factors allowing management of chronic heart failure (CHF) patients being at risk of cardiac cachexia (CC). The changes in soluble protein ST2 (sST2) concentrations suggest a valuable and prognostic usefulness of this biomarker in monitoring patients with CHF, especially those who potentially are prompt to develop CC. The aim of this study was to a ...
DOI:
10.1016/j.numecd.2020.11.014

87. The Association between Nutritional Status and In-Hospital Mortality among Patients with Acute Coronary Syndrome—A Result of the Retrospective Nutritional Status Heart Study (NSHS)

Author:
Michał Czapla; Piotr Karniej; Raúl Juárez-Vela; Katarzyna Łokieć
Source:
Nutrients 2020 v.12 no.10 pp. -
ISSN:
2072-6643
Subject:
death; diabetes; exhibitions; heart; heart failure; history; hospitals; hypertension; infarction; length; low density lipoprotein; malnutrition; medical records; mortality; myocardial infarction; nutrients; nutritional status; overweight; patients; people; prognosis; retrospective studies; risk; risk screening; stroke; Poland
Abstract:
... Background: Nutritional status is related to the prognosis and the length of hospitalization of individuals with myocardial infarction. This study aimed to assess the effects of nutritional status on in-hospital mortality in patients with acute coronary syndrome. Methods: We performed a retrospective study of 1623 medical records of patients admitted to the cardiology department of the University ...
DOI:
10.3390/nu12103091

88. The Association between Nutritional Status and In-Hospital Mortality among Patients with Heart Failure—A Result of the Retrospective Nutritional Status Heart Study 2 (NSHS2)

Author:
Michał Czapla; Raúl Juárez-Vela; Katarzyna Łokieć; Piotr Karniej
Source:
Nutrients 2021 v.13 no.5 pp. -
ISSN:
2072-6643
Subject:
body mass index; cholesterol; death; heart; heart failure; hospitals; low density lipoprotein; malnutrition; mortality; nutrition risk assessment; nutritional status; overweight; prognosis; retrospective studies; risk; underweight; Poland
Abstract:
... Background: A nutritional status is related to the prognosis and length of hospitalisation of patients with heart failure (HF). This study aims to assess the effect of nutritional status on in-hospital mortality in patients with heart failure. Methods: We conducted a retrospective study and analysis of medical records of 1056 patients admitted to the cardiology department of the University Clinica ...
DOI:
10.3390/nu13051669

89. The Association between Nutritional Status and In-Hospital Mortality of COVID-19 in Critically-Ill Patients in the ICU

Author:
Michał Czapla; Raúl Juárez-Vela; Vicente Gea-Caballero; Stanisław Zieliński; Marzena Zielińska
Source:
Nutrients 2021 v.13 no.10 pp. -
ISSN:
2072-6643
Subject:
COVID-19 infection; body mass index; death; heart failure; hospitals; hypertension; mortality; nutrition risk assessment; nutritional status; overweight; patients; potassium; retrospective studies; risk; Poland
Abstract:
... Background: Coronavirus disease 2019 (COVID-19) has become one of the leading causes of death worldwide. The impact of poor nutritional status on increased mortality and prolonged ICU (intensive care unit) stay in critically ill patients is well-documented. This study aims to assess how nutritional status and BMI (body mass index) affected in-hospital mortality in critically ill COVID-19 patients ...
DOI:
10.3390/nu13103302

90. The Feline Cardiomyopathies: 1. General concepts

Author:
Mark D Kittleson; Etienne Côté
Source:
Journal of feline medicine and surgery 2021 v.23 no.11 pp. 1009-1027
ISSN:
1532-2750
Subject:
adults; biomarkers; cardiomyopathy; cats; clinical examination; death; disease severity; dyspnea; echocardiography; edema; heart; heart failure; medicine; mixed breeds; natriuretic peptides; pain; paralysis; phenotype; point-of-care systems; prognosis; radiography; surgery; tachypnea; ultrasonics
Abstract:
... The feline cardiomyopathies are the most prevalent type of heart disease in adult domestic cats. Several forms have been identified (see Parts 2 and 3), with hypertrophic cardiomyopathy (HCM) being the most common. Clinically the cardiomyopathies are often indistinguishable. Cats with subclinical cardiomyopathy may or may not have characteristic physical examination findings (eg, heart murmur, gal ...
DOI:
10.1177/1098612X211021819

91. The efficacy of Chinese herbal medicines on acute coronary syndrome with renal insufficiency after percutaneous coronary intervention

Author:
Da-Wu Zhang; Shao-Li Wang; Pei-Li Wang; Jian-Peng Du; Zhu-Ye Gao; Cheng-Long Wang; Hao Xu; Da-Zhuo Shi
Source:
Journal of ethnopharmacology 2020 v.248 pp. 112354
ISSN:
0378-8741
Subject:
Angelica sinensis; Oriental traditional medicine; Panax quinquefolius; apoptosis; blood serum; coronary artery disease; creatinine; death; energy metabolism; glomerular filtration rate; heart failure; herbal medicines; leaves; myocardial infarction; patients; relative risk; renal failure; rhizomes; risk reduction; saponins; stroke; therapeutics
Abstract:
... Fufang Chuanxiong capsule consists of Angelica sinensis radix and Chuanxiong rhizome, which are used in the traditional Chinese medicine for the treatment of coronary artery disease, and Xinyue capsule is composed of panax quinquefolius saponin extracted from leaves and stems of Panax quinquefolium L, which has the functions of anti-myocardial ischemia, improving myocardial energy metabolism and i ...
DOI:
10.1016/j.jep.2019.112354

92. Trypanosoma cruzi infection in a bat-eared fox (Otocyon megalotis) with severe focally extensive suppurative myocarditis

Author:
Marc Andrew Charles Silpa; Felipe Rodriguez; Drury Reavill; Ethan Biswell; Kenneth Waldrup; Rosa A. Maldonado
Source:
Journal of exotic pet medicine 2021 v.39 pp. 81-84
ISSN:
1557-5063
Subject:
Chagas disease; Trypanosoma cruzi; cardiomyopathy; death; females; foxes; heart; heart failure; histopathology; medicine; megacolon; megaesophagus; myocarditis; necropsy; parasites
Abstract:
... Chagas disease is a parasitic illness caused by Trypanosoma cruzi. This is an intracellular parasite that can cause cardiomyopathy, megaesophagus and megacolon in the chronic phase of the disease. One of the characteristics is sudden death due to heart failure. In this study, a 15-month-old, intact female bat-eared fox (Otocyon megalotis) kept in a private collection presented for sudden death wit ...
DOI:
10.1053/j.jepm.2021.08.020

93. Adherence to Mediterranean diet and prognosis in older patients scheduled to undergo cardiac resynchronization therapy

Author:
Alberto Dominguez-Rodriguez; Pablo Avanzas; Pedro Abreu-Gonzalez; Nestor Baez-Ferrer; Francisco J. Martín-Sanchez; Óscar Mirò
Source:
Nutrition, metabolism, and cardiovascular diseases 2020 v.30 no.1 pp. 77-83
ISSN:
0939-4753
Subject:
Mediterranean diet; cohort studies; death; diet study techniques; heart failure; heart transplant; metabolism; patients; prognosis; questionnaires
Abstract:
... Adherence to the Mediterranean diet (MedDiet) has been associated with prolonged survival in older individuals. However, it is unknown whether adherence to MedDiet is associated with the prognosis in older patients scheduled to undergo cardiac resynchronization therapy (CRT). The aim of this study was to evaluate the association between adherence to the MedDiet and clinical outcomes at 12 months f ...
DOI:
10.1016/j.numecd.2019.08.002

94. Adipositas Cordis in Two Cats with Sudden Death

Author:
F. Parisi; T. Vezzosi; J.A. Mercado Saldaña; A. Poli
Source:
Journal of comparative pathology 2020 v.176 pp. 151-155
ISSN:
0021-9975
Subject:
adipose tissue; cardiomyopathy; cat diseases; cats; death; fibrosis; heart failure; histopathology; inflammation; medicine; myocardium; necrosis; staining; veterinary medicine
Abstract:
... Adipositas cordis (AC) is a rare cardiomyopathy characterized by fatty infiltration of the myocardium without signs of tissue destruction or inflammation. Its diagnosis is challenging and requires histopathological examination. This study describes such cardiomyopathy in two cats that died suddenly. In both cases, anatomopathological examination showed gross lesions indicative of acute heart failu ...
DOI:
10.1016/j.jcpa.2020.03.001

95. Alcohol Consumption and Risk of Cardiovascular Disease, Cancer and Mortality: A Prospective Cohort Study (OR17-07-19)

Author:
Xinyuan Zhang; Yan Liu; Shanshan Li; Alice Lichtenstein; Shuohua Chen; Aijun Xing; Yanxiu Wang; Shouling Wu; Xiang Gao
Source:
Current developments in nutrition 2019 v.3 no.Supplement_1 pp. -
ISSN:
2475-2991
Subject:
adults; alcohol drinking; alcoholic beverages; atrial fibrillation; blood glucose; chronic diseases; cohort studies; confidence interval; death; dose response; drug therapy; ethanol; heart failure; lifestyle; medical records; men; mortality; myocardial infarction; neoplasms; nutrition risk assessment; obesity; socioeconomic status; stroke
Abstract:
... Studies regarding whether light to moderate alcohol consumption is associated with a lower risk of cardiovascular diseases (CVD) have generated mixed results. Further, few studies have comprehensively examined the potential impact of alcohol consumption on diverse disease outcomes. The current study aimed to prospectively investigate dose-response association between alcohol consumption and risk o ...
DOI:
10.1093/cdn/nzz039.OR17-07-19

96. Association between Preoperative Nutritional Status and Clinical Outcomes of Patients with Coronary Artery Disease Undergoing Percutaneous Coronary Intervention

Author:
Su-Chan Chen; Ya-Ling Yang; Cheng-Hsueh Wu; Shao-Sung Huang; Wan Leong Chan; Shing-Jong Lin; Chia-Yu Chou; Jaw-Wen Chen; Ju-Pin Pan; Min-Ji Charng; Ying-Hwa Chen; Tao-Cheng Wu; Tse-Min Lu; Pai-Feng Hsu; Po-Hsun Huang; Hao-Min Cheng; Chin-Chou Huang; Shih-Hsien Sung; Yenn-Jiang Lin; Hsin-Bang Leu
Source:
Nutrients 2020 v.12 no.5 pp. -
ISSN:
2072-6643
Subject:
comorbidity; coronary artery disease; death; drug therapy; heart failure; kidney diseases; mace; malnutrition; methodology; myocardial infarction; nutrients; nutritional status; patients; prediction; risk characterization; risk factors; taxonomic revisions
Abstract:
... Background: Malnutrition is associated with poor outcomes in patients with cancer, heart failure and chronic kidney disease. This study aimed to investigate the predictive value of the Controlling Nutritional Status (CONUT) score in coronary artery disease (CAD) patients. Methods: We recruited a cohort of 3118 patients with CAD undergoing percutaneous coronary intervention (PCI) from 2005 to 2015. ...
DOI:
10.3390/nu12051295

97. Association between particulate matter air pollution and cardiovascular disease mortality in Lanzhou, China

Author:
Tingting Wu; Yuan Ma; Xuan Wu; Ming Bai; Yu Peng; Weiting Cai; Yongxiang Wang; Jing Zhao; Zheng Zhang
Source:
Environmental science and pollution research 2019 v.26 no.15 pp. 15262-15272
ISSN:
1614-7499
Subject:
air pollutants; air pollution; atmospheric pressure; cerebrovascular disorders; death; heart; heart failure; humidity; mortality; myocardial ischemia; nitrogen dioxide; nonlinear models; particulates; regression analysis; sulfur dioxide; temperature; China
Abstract:
... Ambient particulate matter (PM) pollution has been linked to elevated mortality, especially from cardiovascular diseases. However, evidence on the effects of particulate matter pollution on cardiovascular mortality is still limited in Lanzhou, China. This research aimed to examine the associations of daily mean concentrations of ambient air pollutants (PM₂.₅, PMC, and PM₁₀) and cardiovascular mort ...
DOI:
10.1007/s11356-019-04742-w

98. Autopsy findings in death due to Eisenmenger syndrome: A medico-legal case of road traffic accident

Author:
Pankaj Suresh Ghormade; Jai Prakash Soni; Bedanta Sarma; Shreemantha Kumar Dash
Source:
Forensic science international 2020 v.2 pp. 100040
ISSN:
2665-9107
Subject:
accidents; brain; death; edema; fibula; forensic sciences; heart failure; history; necropsy; patients; tibia; traffic
Abstract:
... Fatal road traffic accident cases constitute a major portion of the medicolegal post-mortem workload at most of the institutes and autopsy in these cases sometime reveals important underlying cardiac or brain pathology which represents the actual cause of death. In such cases, history of the road traffic accident may merely be the confounding factor to complicate the pre-existing organ pathology. ...
DOI:
10.1016/j.fsir.2019.100040

99. Contrast echocardiography for detecting bidirectional shunting in a rabbit with an atrial septal defect

Author:
Chung-Chun Yang; Shiun-Long Lin; I-Ping Chan
Source:
Journal of exotic pet medicine 2020 v.34 pp. 53-56
ISSN:
1557-5063
Subject:
blood flow; death; echocardiography; females; heart; heart failure; medicine; microbubbles; patients; rabbits; spaying
Abstract:
... Background: Primum atrial septal defect (ASD) has not been diagnosed in rabbit, considering the lack of information about the same. Congestive heart failure secondary to septal defect at an early age, which eventually resulted in death has been documented in two rabbits. Case description: In the present case, cardiomegaly was discovered incidentally in a 3-year-old female dwarf pet rabbit prior to ...
DOI:
10.1053/j.jepm.2020.04.007

100. Correlation between neutrophil count and prognosis in STEMI patients with chronic renal dysfunction: a retrospective cohort study

Author:
Yuhan Cao; Cong Fu; Xin Wang; Chaojun Yu
Source:
Open life sciences 2019 v.14 no.1 pp. 659-665
ISSN:
2391-5412
Subject:
cohort studies; confidence interval; death; hazard ratio; heart failure; inflammation; mortality; myocardial infarction; neutrophils; prognosis; risk
Abstract:
... Neutrophil is a key element in inflammation and stress disease, which are associated with poor clinical outcomes in various cardiac diseases. However, the clinical availability of neutrophil in patients with ST-elevation myocardial infarction (STEMI) and chronic renal dysfunction has not been known. Accordingly, we designed this retrospective cohort study to evaluate the differences of major adver ...
DOI:
10.1515/biol-2019-0075