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1. Pathway analysis in blood cells of pigs infected with classical swine fever virus: comparison of pigs that develop a chronic form of infection or recover

Author:
Loeffen, Willie,   et al.   ; Hulst, Marcel; Weesendorp, Eefke;     Show all 3 Authors
Source:
Archives of virology 2013 v.158 no.2 pp. 325-339
ISSN:
0304-8608
Subject:
Classical swine fever virus; acute course; bioinformatics; calcitriol; chronic diseases; cytotoxicity; death; enzymes; gene expression regulation; genes; hematologic tests; humans; inflammation; interferons; kidneys; lupus erythematosus; macrophages; microarray technology; monocytes; swine; tempering; transcription (genetics); tryptophan
Abstract:
... Infection of pigs with CSFV can lead to either acute disease, resulting in death or recovery, or chronic disease. The mechanisms by which CSFV manipulates the pig’s first line of defence to establish a chronic infection are poorly understood. Therefore, pigs were infected with moderately virulent CSFV, and whole blood was collected on a regular basis during a period of 18 days. Using whole-genome ...
DOI:
10.1007/s00705-012-1491-8
PubMed:
23053521

2. Transmission of classical swine fever virus depends on the clinical course of infection which is associated with high and low levels of virus excretion

Author:
Loeffen, Willie,   et al.   ; Weesendorp, Eefke; Backer, Jantien; Stegeman, Arjan;     Show all 4 Authors
Source:
Veterinary microbiology 2011 v.147 no.3-4 pp. 262-273
ISSN:
0378-1135
Subject:
Classical swine fever virus; chronic diseases; death; excretion; monitoring; polymerase chain reaction; reproduction; reverse transcription; swine; swine housing; virus transmission; viruses
Abstract:
... Infection with moderately virulent strains of classical swine fever virus (CSFV) can lead to different courses of disease: either (sub)acute, resulting in death or recovery, or chronic disease. The virus excretion dynamics between these courses are quite dissimilar, but it is not known if this also results in differences in virus transmission. In this study, the excretion and transmission dynamics ...
DOI:
10.1016/j.vetmic.2010.06.032
PubMed:
20674195