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- Loeffen, Willie, et al. Show all 3 Authors
- Archives of virology 2013 v.158 no.2 pp. 325-339
- Classical swine fever virus; acute course; bioinformatics; calcitriol; chronic diseases; cytotoxicity; death; enzymes; gene expression regulation; genes; hematologic tests; humans; inflammation; interferons; kidneys; lupus erythematosus; macrophages; microarray technology; monocytes; swine; tempering; transcription (genetics); tryptophan
- ... Infection of pigs with CSFV can lead to either acute disease, resulting in death or recovery, or chronic disease. The mechanisms by which CSFV manipulates the pig’s first line of defence to establish a chronic infection are poorly understood. Therefore, pigs were infected with moderately virulent CSFV, and whole blood was collected on a regular basis during a period of 18 days. Using whole-genome ...
- Loeffen, Willie, et al. Show all 4 Authors
- Veterinary microbiology 2011 v.147 no.3-4 pp. 262-273
- Classical swine fever virus; chronic diseases; death; excretion; monitoring; polymerase chain reaction; reproduction; reverse transcription; swine; swine housing; virus transmission; viruses
- ... Infection with moderately virulent strains of classical swine fever virus (CSFV) can lead to different courses of disease: either (sub)acute, resulting in death or recovery, or chronic disease. The virus excretion dynamics between these courses are quite dissimilar, but it is not known if this also results in differences in virus transmission. In this study, the excretion and transmission dynamics ...