Jump to Main Content
- Paltsev, Mikhail A., et al. Show all 8 Authors
- Biochemical and biophysical research communications 2018 v.506 no.4 pp. 854-861
- cell lines; dermis; gene expression; genes; hyperkeratosis; hyperplasia; inflammation; interleukin-1beta; interleukin-6; keratinocytes; messenger RNA; mice; polycyclic aromatic hydrocarbons; retinoic acid; skin lesions; tetrachlorodibenzo-p-dioxin; therapeutics; toxicity; toxicology; viability
- ... Exposure to toxic halogenated polyaromatic hydrocarbons, of which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most potent, induces diverse skin pathologies in humans, including chloracne, hyperkeratosis, hamartomas, etc. While the toxic effects of TCDD have been extensively studied, effective approaches to their treatment are still lacking. Retinoids are commonly used in therapy of acneiform ...