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- Lewis, P.A., et al. Show all 7 Authors
- Veterinary ophthalmology 2007 v.10 no.s1 pp. 28-37
- dogs; dog diseases; glaucoma; pathogenesis; glycoproteins; biochemical mechanisms; mutation; bioaccumulation; epidemiological studies; eyes; tissue distribution; Beagle; genetic disorders; inheritance (genetics); animal models; histopathology; immunohistochemistry; immunocytochemistry
- ... The presence of myocilin was investigated in a colony of Beagles, a canine model for inherited primary open-angle glaucoma (POAG). The myocilin protein was localized in the normal and glaucomatous canine eyes by immunohistochemistry and immunocytochemistry. Paraffin- and plastic-embedded specimens from the anterior uveas of 10 Beagles with inherited glaucoma (3 months to 13 years old) and 6 age-ma ...
- Lewis, P.A., et al. Show all 5 Authors
- Veterinary ophthalmology 2003 v.6 no.3 pp. 205-209
- Beagle; actin; antibodies; arteries; disease course; dogs; glaucoma; heart; immunoglobulins; immunohistochemistry; microfilaments; muscle fibers; myocytes; peroxidase; rabbits; rats; smooth muscle; streptavidin
- ... Purpose: To date, our knowledge of the canine trabecular meshwork (TM) with regard to contractility is incomplete. It is important to understand the potential contractile capability within the TM and possible changes associated with spontaneous hypertensive glaucoma. To that end we have examined the presence of actin, including smooth muscle (SM) actin, in the normal and glaucomatous canine iridoc ...