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- Mei, Leixia, et al. Show all 8 Authors
- Journal of materials chemistry B 2019 v.7 no.3 pp. 469-476
- analgesia; antineoplastic agents; biocompatibility; cytotoxicity; dose response; drug delivery systems; drug therapy; hydrogels; ions; nanofibers; nonsteroidal anti-inflammatory agents; pain; peptides; prostatic neoplasms; toxicity testing; viscoelasticity; zinc
- ... Herein, we report supramolecular hydrogelators made of forky peptides and nonsteroidal anti-inflammatory drugs (NSAID). Two zinc ions (ZIs)-responsive short peptide dendrons (E₃FID and E₃FNP) modified by NSAID (indometacinand naproxen) were designed and synthesized successfully. These novel small molecule hydrogelators can self-assemble in water to form stable supramolecular nanofibers/hydrogels. ...
- Mei, Leixia, et al. Show all 9 Authors
- Journal of materials chemistry B 2016 v.4 no.36 pp. 6043-6051
- P-glycoproteins; carbon; drug delivery systems; drug therapy; etoposide; irradiation; ligands; monoclonal antibodies; multiple drug resistance; near infrared radiation; neoplasms; oxidation; photothermotherapy; polyethylene glycol; synergism
- ... Multidrug resistance (MDR) is a major obstacle to cancer chemotherapy due to the overexpression of P-glycoprotein (P-gp). Herein, etoposide (ETO) was loaded onto oxidized carbon nanohorns (oxCNHs), which were modified by polyethylene glycol (PEG) and further functionalized with the targeting ligand P-gp monoclonal antibody (PA) in an attempt to overcome MDR. The obtained drug delivery system (ETO@ ...