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1. Polymerization-Induced Self-Assembly Generating Vesicles with Adjustable pH-Responsive Release Performance

Author:
Pan, Cai-Yuan,   et al.   ; Xu, Xiao-Fei; Zhang, Wen-Jian; Hong, Chun-Yan;     Show all 4 Authors
Source:
Macromolecules 2019 v.52 no.5 pp. 1965-1975
ISSN:
1520-5835
Subject:
copolymerization; drugs; hydrophobicity; pH; polymers; therapeutics
Abstract:
... Stimuli-responsive polymeric vesicles have attracted great attention in drug delivery due to their intrinsic hollow structures and “on demand” release of drugs upon environmental stimuli. The drug-release kinetics from polymeric vesicles, which is usually dependent on the stimuli-responsive behaviors of the polymeric vesicle, has great impacts on the therapeutic efficacy. Over the past decade, pol ...
DOI:
10.1021/acs.macromol.9b00144

2. Silver Nanoparticles Covered with pH-Sensitive Camptothecin-Loaded Polymer Prodrugs: Switchable Fluorescence “Off” or “On” and Drug Delivery Dynamics in Living Cells

Author:
Pan, Cai-Yuan,   et al.   ; Qiu, Liang; Li, Jia-Wei; Hong, Chun-Yan;     Show all 4 Authors
Source:
ACS applied materials & interfaces 2017 v.9 no.46 pp. 40887-40897
ISSN:
1944-8252
Subject:
cytotoxicity; drug delivery systems; drugs; energy transfer; fluorescence; human cell lines; in vitro studies; lysosomes; nanoparticles; nanosilver; neoplasms; pH; polymerization; polymers
Abstract:
... A unique drug delivery system, in which silver nanoparticles (AgNPs) are covered with camptothecin (CPT)-based polymer prodrug, has been developed, and the polymer prodrug, in which the CPT is linked to the polymer side chains via an acid-labile β-thiopropionate bond, is prepared by RAFT polymerization. For poly(2-(2-hydroxyethoxy)ethyl methacrylate-co-methacryloyloxy-3-thiahexanoyl-camptothecin)@ ...
DOI:
10.1021/acsami.7b14070

3. Unimolecular micelles of camptothecin-bonded hyperbranched star copolymers via β-thiopropionate linkage: synthesis and drug delivery

Author:
Pan, Cai-Yuan,   et al.   ; Qiu, Liang; Liu, Qing; Hong, Chun-Yan;     Show all 4 Authors
Source:
Journal of materials chemistry B 2015 v.4 no.1 pp. 141-151
ISSN:
2050-7518
Subject:
composite polymers; drugs; micelles; neoplasm cells; pH; polymerization
Abstract:
... In order to develop pH- and redox-responsive unimolecular micelles composed of camptothecin (CPT)-conjugated hyperbranched star copolymers via acid-labile β-thiopropionate linkage, a new monomer, methacryloyloxy-3-thiohexanoyl–CPT, is synthesized through conjugation of CPT with methacrylate via β-thiopropionate linkage, and then used in synthesis of the CPT-conjugated hyperbranched star copolymers ...
DOI:
10.1039/c5tb01905b