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1. Polymerization-Induced Self-Assembly Generating Vesicles with Adjustable pH-Responsive Release Performance

Author:
Pan, Cai-Yuan,   et al.   ; Xu, Xiao-Fei; Zhang, Wen-Jian; Hong, Chun-Yan;     Show all 4 Authors
Source:
Macromolecules 2019 v.52 no.5 pp. 1965-1975
ISSN:
1520-5835
Subject:
copolymerization; drugs; hydrophobicity; pH; polymers; therapeutics
Abstract:
... Stimuli-responsive polymeric vesicles have attracted great attention in drug delivery due to their intrinsic hollow structures and “on demand” release of drugs upon environmental stimuli. The drug-release kinetics from polymeric vesicles, which is usually dependent on the stimuli-responsive behaviors of the polymeric vesicle, has great impacts on the therapeutic efficacy. Over the past decade, pol ...
DOI:
10.1021/acs.macromol.9b00144

2. Photo-responsive camptothecin-based polymeric prodrug coated silver nanoparticles for drug release behaviour tracking via the nanomaterial surface energy transfer (NSET) effect

Author:
Pan, Cai-Yuan,   et al.   ; Li, Jiao-Yang; Qiu, Liang; Xu, Xiao-Fei; Hong, Chun-Yan; Zhang, Wen-Jian;     Show all 6 Authors
Source:
Journal of materials chemistry 2018 v.6 no.11 pp. 1678-1687
ISSN:
2050-7518
Subject:
composite polymers; drug delivery systems; drugs; energy transfer; fluorescence; in vitro studies; nanoparticles; nanosilver; polymerization
Abstract:
... A hybrid drug delivery system was successfully fabricated by attaching a camptothecin (CPT)-based polymeric prodrug onto the surface of silver nanoparticles (AgNPs). PEG was employed as a macro-RAFT agent in RAFT polymerization to synthesize a branched star copolymer, to which CPT is linked through the photo-responsive o-nitrobenzyl linkage. In vitro tests indicate that the fluorescence of CPT in ...
DOI:
10.1039/c7tb02998e

3. Silver Nanoparticles Covered with pH-Sensitive Camptothecin-Loaded Polymer Prodrugs: Switchable Fluorescence “Off” or “On” and Drug Delivery Dynamics in Living Cells

Author:
Pan, Cai-Yuan,   et al.   ; Qiu, Liang; Li, Jia-Wei; Hong, Chun-Yan;     Show all 4 Authors
Source:
ACS applied materials & interfaces 2017 v.9 no.46 pp. 40887-40897
ISSN:
1944-8252
Subject:
cytotoxicity; drug delivery systems; drugs; energy transfer; fluorescence; human cell lines; in vitro studies; lysosomes; nanoparticles; nanosilver; neoplasms; pH; polymerization; polymers
Abstract:
... A unique drug delivery system, in which silver nanoparticles (AgNPs) are covered with camptothecin (CPT)-based polymer prodrug, has been developed, and the polymer prodrug, in which the CPT is linked to the polymer side chains via an acid-labile β-thiopropionate bond, is prepared by RAFT polymerization. For poly(2-(2-hydroxyethoxy)ethyl methacrylate-co-methacryloyloxy-3-thiahexanoyl-camptothecin)@ ...
DOI:
10.1021/acsami.7b14070

4. Efficient Fabrication of Photosensitive Polymeric Nano-objects via an Ingenious Formulation of RAFT Dispersion Polymerization and Their Application for Drug Delivery

Author:
Pan, Cai-Yuan,   et al.   ; Zhang, Wen-Jian; Hong, Chun-Yan;     Show all 3 Authors
Source:
Biomacromolecules 2017 v.18 no.4 pp. 1210-1217
ISSN:
1526-4602
Subject:
coumarin; dimerization; drugs; hydrophilicity; hydrophobicity; irradiation; micelles; photosensitivity; polymerization
Abstract:
... An ingenious formulation of RAFT dispersion polymerization based on photosensitive monomers of 2-nitrobenzyl methacrylate (NBMA) and 7-(2-methacryloyloxy-ethoxy)-4-methyl-coumarin (CMA) is reported herein. Various morphologies, such as spherical micelle, nanoworm, lamella, and vesicle, are fabricated at up to 20% solids content. Photoinduced cleavage of the NBMA moieties and dimerization of the co ...
DOI:
10.1021/acs.biomac.6b01887

5. Fabrication of Reductive-Responsive Prodrug Nanoparticles with Superior Structural Stability by Polymerization-Induced Self-Assembly and Functional Nanoscopic Platform for Drug Delivery

Author:
Pan, Cai-Yuan,   et al.   ; Zhang, Wen-Jian; Hong, Chun-Yan;     Show all 3 Authors
Source:
Biomacromolecules 2016 v.17 no.9 pp. 2992-2999
ISSN:
1526-4602
Subject:
composite polymers; diameter; drug delivery systems; drug therapy; drugs; encapsulation; nanoparticles; neoplasms; polymerization; toxicity
Abstract:
... A highly efficient strategy, polymerization-induced self-assembly (PISA) for fabrication of the polymeric drug delivery systems in cancer chemotherapy is reported. Diblock prodrug copolymer, PEG-b-P(MEO₂MA-co-CPTM) was used as the macro-RAFT agent to fabricate prodrug nanoparticles through PISA. The advantages of fabricating intelligent drug delivery system via this approach are as following: (1) ...
DOI:
10.1021/acs.biomac.6b00819

6. Unimolecular micelles of camptothecin-bonded hyperbranched star copolymers via β-thiopropionate linkage: synthesis and drug delivery

Author:
Pan, Cai-Yuan,   et al.   ; Qiu, Liang; Liu, Qing; Hong, Chun-Yan;     Show all 4 Authors
Source:
Journal of materials chemistry B 2015 v.4 no.1 pp. 141-151
ISSN:
2050-7518
Subject:
composite polymers; drugs; micelles; neoplasm cells; pH; polymerization
Abstract:
... In order to develop pH- and redox-responsive unimolecular micelles composed of camptothecin (CPT)-conjugated hyperbranched star copolymers via acid-labile β-thiopropionate linkage, a new monomer, methacryloyloxy-3-thiohexanoyl–CPT, is synthesized through conjugation of CPT with methacrylate via β-thiopropionate linkage, and then used in synthesis of the CPT-conjugated hyperbranched star copolymers ...
DOI:
10.1039/c5tb01905b

7. A Unique Aliphatic Tertiary Amine Chromophore: Fluorescence, Polymer Structure, and Application in Cell Imaging

Author:
Pan, Cai-Yuan,   et al.   ; Sun, Miao; Hong, Chun-Yan;     Show all 3 Authors
Source:
Journal of the American Chemical Society 2012 v.134 no.51 pp. 20581-20584
ISSN:
1520-5126
Subject:
cytotoxicity; drugs; fluorescence; fluorescent dyes; image analysis; photoluminescence; polymers; tertiary amines; vapors
Abstract:
... Although photoluminescence of tertiary aliphatic amines has been extensively studied, the usage of this fundamental chromophore as a fluorescent probe for various applications has unfortunately not been realized because their uncommon fluorescence is easily quenched, and strong fluorescence has been observed only in vapor phase. The objective of this study is how to retain the strong fluorescence ...
DOI:
10.1021/ja310236m