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1. pH-sensitive polymeric cisplatin-ion complex with styrene-maleic acid copolymer exhibits tumor-selective drug delivery and antitumor activity as a result of the enhanced permeability and retention effect B Biointerfaces

Author:
Saisyo, Atsuyuki; Nakamura, Hideaki; Fang, Jun; Tsukigawa, Kenji; Greish, Khaled; Furukawa, Hiroyuki; Maeda, Hiroshi
Source:
Colloids and surfaces 2016 v.138 pp. 128-137
ISSN:
0927-7765
Subject:
normal distribution,   etc   ; adverse effects; antineoplastic activity; cisplatin; colloids; composite polymers; cytotoxicity; drug therapy; electrophoresis; light scattering; mice; micelles; neoplasms; pH; particle size; permeability; pharmacokinetics; tissues; weight loss;     Show all 19 Subjects
Abstract:
... Cisplatin (CDDP) is widely used to treat various cancers. However, its distribution to normal tissues causes serious adverse effects. For this study, we synthesized a complex of styrene-maleic acid copolymer (SMA) and CDDP (SMA–CDDP), which formed polymeric micelles, to achieve tumor-selective drug delivery based on the enhanced permeability and retention (EPR) effect. SMA–CDDP is obtained by regu ...
DOI:
10.1016/j.colsurfb.2015.11.032