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... The aim of the present study was to investigate the direct action of the phyto-oestrogen genistein (Gen) on vascular endothelial behaviour, either in the presence or absence of proinflammatory agents. In rat aortic endothelial cell (EC) cultures, 24 h of treatment with Gen significantly increased cell proliferation in a wide range of concentration (0·001–10 nm). This mitogenic action was prevented ...
... In the mammalian ovary, the microvasculature in the thecal layer of follicles is associated with follicular development. Apelin and its receptor, APJ, are expressed in the tissues and organs which include the vasculature. The aims of the present study were to examine the mRNA expression of apelin and the APJ receptor in granulosa cells and theca tissue of bovine follicles and the effects of steroi ...
animal proteins; linseed; signal transduction; dietary supplements; estradiol; mechanism of action; biomarkers; gene expression; apoptosis; human cell lines; messenger RNA; hormone receptors; mice; lignans; cell proliferation; hulls; protein synthesis; dosage; biochemical pathways; animal models; diet therapy; breast neoplasms
Abstract:
... Previous studies have shown that dietary flaxseed (FS) can reduce the growth of established human breast tumors in athymic mice with low circulating estrogen concentrations. In this study, we determined the effect of FS compared with pure lignan at the level it is present in FS [secoisolariciresinol diglucoside (SDG)] and to the lignan-rich fraction [FS hull (FH)] on human breast tumor growth and ...
... To determine if molecular markers typically associated with ultraviolet exposure could be detected in canine ocular hemangiomas (HA) and hemangiosarcomas (HSA). Paraffin-embedded samples of canine ocular HA (n = 6) and HSA (n = 6) were examined for the presence of p53, p21, p16, cyclin D, PCNA, pAkt, telomerase, and estrogen receptor (ER)-α using immunohistochemistry. p53 and cyclin D protein were ...
... A method allowing simultaneous genotyping of two loci: pre-implantation protein 3 (prei3) and estrogen receptor (ESR) was presented. In multiplex PCR amplification, two amplicons were simultaneously produced a 294bp fragment of prei3 gene and a 121bp fragment of ESR gene and were then subjected to ''one-tube'' restriction enzyme digestion with MspI and PvuII. A total of 92 sows from the 4th dam li ...
... Milk yield is reduced by pregnancy, and the present experiment was conducted to study the biological basis for the negative effect of pregnancy on milk yield. A total of 16 dairy cows were fed at either a normal or a low feeding level (eight cows per treatment), and half of them were inseminated after approximately 3 months of lactation and the other half were not inseminated. Mammary biopsies wer ...
... It has been widely accepted that mammalian females are born with a non-renewing, finite pool of oocytes that will be continuously cleared by atresia, with only a small proportion of them reaching ovulation. Apoptosis regulates this mass germ cell death, especially through the balance between pro- and anti-apoptotic proteins encoded by the BCL-2 gene family. The caviomorph rodent Lagostomus maximus ...
mammary neoplasms (animal); dogs; women; dog diseases; human diseases; breast neoplasms; immunohistochemistry; biomarkers; cell proliferation; animal proteins; cell differentiation; apoptosis; estrogens; hormone receptors; gene expression; females; menopause; animal models; carcinogenesis
Abstract:
... Mammary tumours are the most common neoplasms in humans and canines. Human and canine mammary tumours share several important epidemiological, clinicopathological and biochemical features. Development of mammary tumours involves accumulation of mutant cells caused by excessive proliferation and insufficient apoptosis or dysregulation of cellular differentiation. The present study was therefore des ...
women; men; menopause; hypercholesterolemia; high protein diet; soy protein; animal proteins; isoflavones; protein intake; estrogenic properties; hormone secretion; estrogens; androgens; nutritional intervention
Abstract:
... Consumption of soy protein has been associated with altered risk of developing endocrine-regulated cancers. This study was designed to assess the independent effect of soy relative to animal protein and soy-derived isoflavones on circulating estrogen and androgen concentrations in post-menopausal women and older men. Forty-two subjects (> 50 yr) with low-density lipoprotein cholesterol levels of g ...