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- Molander, Marianne; Staerk, Dan; Mørck Nielsen, Hanne; Brandner, Johanna M.; Diallo, Drissa; Kusamba Zacharie, Chifundera; van Staden, Johannes; Jäger, Anna K.
- Journal of ethnopharmacology 2015 v.165 pp. 1-8
- Grewia mollis, etc ; Dichrostachys cinerea; Paullinia pinnata; Tamarindus indica; antiserum; cell movement; cytotoxicity; enzymes; ethanol; models; mortality; necrosis; plant extracts; snake bites; therapeutics; tissue repair; traditional medicine; venoms; Sub-Saharan Africa; Show all 19 Subjects
- ... Snakebite envenomation causes 5000–10,000 mortalities and results in more than 5–15,000 amputations in sub-Saharan Africa alone every year. The inaccessibility of antiserum therapy is a vast problem, and only about 2.5% of the actual need for antiserum in Africa is covered. Numerous plants have shown in vitro inhibitory activity against one or more of the hydrolytic enzymes involved in snakebite-i ...
- Molander, Marianne; Nielsen, Line; Søgaard, Søren; Staerk, Dan; Rønsted, Nina; Diallo, Drissa; Chifundera, Kusamba Zacharie; van Staden, Johannes; Jäger, Anna K.
- Journal of ethnopharmacology 2014 v.157 pp. 171-180
- Grewia mollis, etc ; Bauhinia thonningii; Bitis arietans; Combretum; Lannea; Naja; Strychnos; active ingredients; antiserum; bioassays; enzyme inhibition; enzyme inhibitors; ethanol; hyaluronoglucosaminidase; inhibitory concentration 50; mortality; necrosis; patients; phospholipase A2; plant anatomy; polyphenols; proteinases; snake bites; snakes; traditional medicine; Democratic Republic of the Congo; Mali; South Africa; Show all 28 Subjects
- ... Snakebite envenomation, every year, causes estimated 5–10,000 mortalities and results in more than 5–15,000 amputations in sub-Saharan Africa alone. Antiserum is not easily accessible in these regions or doctors are simply not available, thus more than 80% of all patients seek traditional practitioners as first-choice. Therefore it is important to investigate whether the plants used in traditional ...