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- Ogino, Shuichi, et al. Show all 7 Authors
- Biomaterials 2018 v.161 pp. 270-278
- angiogenesis; binding capacity; collagen; endothelial cells; evolution; medicine; myocardial infarction; myocardium; therapeutics; vascular endothelial growth factors
- ... To enhance the therapeutic effect of growth factors, a powerful strategy is to direct their localization to damaged sites. To treat skin wounds and myocardial infarction, we selected vascular endothelial growth factor (VEGF) carrying binding affinity to collagen. A simple conjugation of a reported collagen-binding sequence and VEGF did not increase the collagen-binding affinity, indicating that th ...