Subject term: extracellular matrix and cell adhesion

1. 3,4-Methylenedioxy-β-nitrostyrene inhibits adhesion and migration of human triple-negative breast cancer cells by suppressing β1 integrin function and surface protein disulfide isomerase

Author:: I-Hua Chen; Fang-Rong Chang; Yang-Chang Wu; Po-Hsiung Kung; Chin-Chung Wu
Source:: Biochimie 2015 v.110 pp. 81-92
ISSN:: 0300-9084
Subject:: CD29 antigen; Western blotting; actin; adhesion; antineoplastic agents; breast neoplasms; cell adhesion; cell viability; confocal microscopy; extracellular matrix; immigration; metastasis; neoplasm cells; non-specific protein-tyrosine kinase; phosphorylation; protein disulfide-isomerase; surface proteins; thiols
Abstract:: ... Triple negative breast cancer (TNBC) exhibits an aggressive clinical course by high metastatic potential. It is known that integrin-mediated cell adhesion and migration are important for cancer metastasis. In the present study, a synthetic compound, 3, 4-methyenedioxy-β-nitrostyrene (MNS), significantly inhibited adhesion of TNBC cell lines to different extracellular matrix (ECM) components. The a ...
DOI:: 10.1016/j.biochi.2015.01.006
: https://doi.org/10.1016/j.biochi.2015.01.006

2. 3D Microcontact Printing for Combined Chemical and Topographical Patterning on Porous Cell Culture Membrane

Author:: Justyna Borowiec; Joerg Hampl; Sukhdeep Singh; Sebastian Haefner; Karin Friedel; Patrick Mai; Dana Brauer; Florian Ruther; Liliana Liverani; Aldo R. Boccaccini; Andreas Schober
Source:: ACS applied materials & interfaces 2018 v.10 no.26 pp. 22857-22865
ISSN:: 1944-8252
Subject:: adhesion; antibodies; cell culture; extracellular matrix; geometry; materials science; microstructure; proteins; staining
Abstract:: ... Micrometer-scale biochemical or topographical patterning is commonly used to guide the cell attachment and growth, but the ability to combine these patterns into an integrated surface with defined chemical and geometrical characteristics still remains a technical challenge. Here, we present a technical solution for simultaneous construction of 3D morphologies, in the form of channels, on porous me ...
DOI:: 10.1021/acsami.8b06585
: https://doi.org/10.1021/acsami.8b06585

3. 3D Scaffolds with Different Stiffness but the Same Microstructure for Bone Tissue Engineering

Author:: Chen Guobao; Dong Chanjuan; Yang Li; Lv Yonggang
Source:: ACS Applied Materials & Interfaces 2015 v.7 no.29 pp. 15790-15802
ISSN:: 1944-8252
Subject:: adhesion; angiogenesis; bone formation; bones; cell adhesion; cell differentiation; cell viability; coatings; collagen; extracellular matrix; hydroxyapatite; mechanical properties; micro-computed tomography; microstructure; osteoblasts; porosity; rats; stem cells; tissue engineering
Abstract:: ... A growing body of evidence has shown that extracellular matrix (ECM) stiffness can modulate stem cell adhesion, proliferation, migration, differentiation, and signaling. Stem cells can feel and respond sensitively to the mechanical microenvironment of the ECM. However, most studies have focused on classical two-dimensional (2D) or quasi-three-dimensional environments, which cannot represent the re ...
DOI:: 10.1021/acsami.5b02662
: https://doi.org/10.1021/acsami.5b02662

4. 3D multi-layered fibrous cellulose structure using an electrohydrodynamic process for tissue engineering

Author:: Minseong Kim; GeunHyung Kim
Source:: Journal of colloid and interface science 2015 v.457 pp. 180-187
ISSN:: 0021-9797
Subject:: biobased products; biochemical pathways; cell adhesion; cellulose; cellulosic fibers; electric field; extracellular matrix; fibroblasts; geometry; humans; nanofibers; tissue engineering; topology
Abstract:: ... Micro/nanofibrous structures have been applied widely in various tissue-engineering applications because the topological structures are similar to the extracellular matrix (ECM), which encourages a high degree of cell adhesion and growth. However, it has been difficult to produce a three-dimensional (3D) fibrous structure using controllable macro-pores. Recently, cellulose has been considered a hi ...
DOI:: 10.1016/j.jcis.2015.07.007
: https://doi.org/10.1016/j.jcis.2015.07.007

5. 3D-Bioprinted Difunctional Scaffold for In Situ Cartilage Regeneration Based on Aptamer-Directed Cell Recruitment and Growth Factor-Enhanced Cell Chondrogenesis

Author:: Zhen Yang; Tianyuan Zhao; Cangjian Gao; Fuyang Cao; Hao Li; Zhiyao Liao; Liwei Fu; Pinxue Li; Wei Chen; Zhiqiang Sun; Shuangpeng Jiang; Zhuang Tian; Guangzhao Tian; Kangkang Zha; Tingting Pan; Xu Li; Xiang Sui; Zhiguo Yuan; Shuyun Liu; Quanyi Guo
Source:: ACS applied materials & interfaces 2021 v.13 no.20 pp. 23369-23383
ISSN:: 1944-8252
Subject:: biodegradability; bioprinting; cartilage; cell adhesion; chondrogenesis; extracellular matrix; gelatin; oligonucleotides; polymers; rabbits; strength (mechanics); therapeutics
Abstract:: ... Articular cartilage (AC) lesions are fairly common but remain an obstacle for clinicians and researchers due to their poor self-healing capacity. Recently, a promising therapy based on the recruitment of autologous mesenchymal stem cells (MSCs) has been developed for the regeneration of full-thickness cartilage defects in the knee joint. In this study, a 3D-bioprinted difunctional scaffold was dev ...
DOI:: 10.1021/acsami.1c01844
: https://doi.org/10.1021/acsami.1c01844

6. A Citrus Extract Containing Flavanones Represses Plasminogen Activator Inhibitor-1 (PAI-1) Expression and Regulates Multiple Inflammatory, Tissue Repair, and Fibrosis Genes in Human Colon Fibroblasts

Author:: Gimenez-Bastida, Juan A.; Martinez-Florensa, Mario; Espin, Juan-Carlos; Tomas-Barberan, Francisco A.; Garcia-Conesa, Maria-Teresa
Source:: Journal of agricultural and food chemistry 2009 v.57 no.19 pp. 9305-9315
ISSN:: 0021-8561
Subject:: anti-inflammatory activity; metalloproteinases; plant extracts; cell adhesion; extracellular matrix; flavanones; tissue repair; fibrosis; gene expression; gene expression regulation; colon; transcription factors; human cell lines; messenger RNA; tumor necrosis factor-alpha; in vitro studies; monocytes; inflammation; oranges; plasminogen activator; fibroblasts
Abstract:: ... The consumption of flavonoid-rich Citrus extracts has been associated with multiple beneficial effects including anti-inflammatory properties, but the potential effects on the inflammatory responses in the gut have not been thoroughly investigated. We used microarrays to search for molecular changes induced in human colon fibroblasts in response to the exposure to a flavanone-rich bitter orange ex ...
DOI:: 10.1021/jf901983g
PubMed:: 19728713
: https://doi.org/10.1021/jf901983g

7. A Lymphocyte Serine Protease Granzyme A Causes Detachment of a Small-Intestinal Epithelial Cell Line (IEC-6)

Author:: Hirofumi HIRAYASU; Yumiko YOSHIKAWA; Satoshi TSUZUKI; Tohru FUSHIKI
Source:: Bioscience, biotechnology, and biochemistry 2008 v.72 no.9 pp. 2294-2302
ISSN:: 1347-6947
Subject:: adhesion; apoptosis; biotechnology; cell lines; collagen; cytotoxicity; deformation; epithelial cells; extracellular matrix; fibronectins; laminin; rats; serine proteinases; small intestine
Abstract:: ... Granzyme A (GzmA) is a serine protease (trypsin-like specificity) produced in cytotoxic lymphocytes. This enzyme is believed to enter virus-infected cells and growing tumors and induce apoptosis, but the roles of GzmA expressed in lymphocytes scattered through the epithelial layer of the normal small intestine are unknown. In the present study, recombinant rat GzmA (rGzmA) was found to cause morph ...
DOI:: 10.1271/bbb.80140
: https://doi.org/10.1271/bbb.80140

8. A Multi-Omics Approach Identifies Key Regulatory Pathways Induced by Long-Term Zinc Supplementation in Human Primary Retinal Pigment Epithelium

Author:: Eszter Emri; Elod Kortvely; Sascha Dammeier; Franziska Klose; David Simpson; EYE-RISK Consortium; Anneke I. den Hollander; Marius Ueffing; Imre Lengyel
Source:: Nutrients 2020 v.12 no.10 pp. -
ISSN:: 2072-6643
Subject:: cell adhesion; cell culture; clinical trials; databases; decline; dietary mineral supplements; electrical resistance; epithelium; extracellular matrix; genes; humans; macular degeneration; microvilli; multiomics; nutrients; oxidative stress; pigmentation; protein secretion; proteins; proteome; stress response; transcriptome; zinc
Abstract:: ... In age-related macular degeneration (AMD), both systemic and local zinc levels decline. Elevation of zinc in clinical studies delayed the progression to end-stage AMD. However, the molecular pathways underpinning this beneficial effect are not yet identified. In this study, we used differentiated primary human fetal retinal pigment epithelium (RPE) cultures and long-term zinc supplementation to ca ...
DOI:: 10.3390/nu12103051
: https://doi.org/10.3390/nu12103051

9. A Novel Method to Produce Immobilised Biomolecular Concentration Gradients to Study Cell Activities: Design and Modelling

Author:: Giovanni Vozzi; Tommaso Lenzi; Francesca Montemurro; Carla Pardini; Francesca Vaglini; Arti Ahluwalia
Source:: Molecular biotechnology 2012 v.50 no.2 pp. 99-107
ISSN:: 1073-6085
Subject:: cell adhesion; image analysis; hydrocolloids; sowing; models; collagen; fluorescein; extracellular matrix
Abstract:: ... It is well known that many cell functions are activated by chemical signals with a time and space-dependent profile. To mimic these profiles in vitro, it is necessary to develop a system that is able to generate concentration gradients with a resolution similar to that perceived by cells, which is around nanomolar with a spatial resolution of a few tens of microns. Many devices capable of generati ...
DOI:: 10.1007/s12033-011-9411-9
PubMed:: 21544696
: https://doi.org/10.1007/s12033-011-9411-9

10. A Programmable Toolkit to Dynamically Signal Cells Using Peptide Strand Displacement

Author:: Kyle D. Riker; Margaret L. Daly; Micah J. Papanikolas; Tengyue Jian; Stephen J. Klawa; Jacqueline (Yalin) S. Shin (Sahin); Dingyuan Liu; Anamika Singh; A. Griffin Miller; Ronit Freeman
Source:: ACS applied materials & interfaces 2021 v.13 no.18 pp. 21018-21029
ISSN:: 1944-8252
Subject:: extracellular matrix; fibroblasts; integrins; ligands; peptides; periodicity
Abstract:: ... The native extracellular matrix communicates and interacts with cells by dynamically displaying signals to control their behavior. Mimicking this dynamic environment in vitro is essential in order to unravel how cell–matrix interactions guide cell fate. Here, we present a synthetic platform for the temporal display of cell-adhesive signals using coiled-coil peptides. By designing an integrin-engag ...
DOI:: 10.1021/acsami.1c03370
: https://doi.org/10.1021/acsami.1c03370

11. A Secreted Disulfide Catalyst Controls Extracellular Matrix Composition and Function

Author:: Tal Ilani; Assaf Alon; Iris Grossman; Ben Horowitz; Elena Kartvelishvily; Sidney R. Cohen; Deborah Fass
Source:: Science 2013 v.341 no.6141 pp. 74-76
ISSN:: 0036-8075
Subject:: catalysts; catalytic activity; cell adhesion; disulfide bonds; endoplasmic reticulum; extracellular matrix; humans; laminin; neoplasms; protein folding; stress response
Abstract:: ... Form and Function The contribution of disulfide bonding to oxidative protein folding and assembly, quality control, and stress responses in the endoplasmic reticulum (ER) are widely recognized. In contrast, catalysis of disulfide bond formation downstream of the ER is uncharted territory. QSOX, a Golgi-localized or secreted disulfide catalyst, was identified in the 1970s and was more recently show ...
DOI:: 10.1126/science.1238279
: https://doi.org/10.1126/science.1238279

12. A Simple Approach for an Eggshell-Based 3D-Printed Osteoinductive Multiphasic Calcium Phosphate Scaffold

Author:: Dadhich Prabhash; Das Bodhisatwa; Pal Pallabi; Srivas Pavan K.; Dutta Joy; Ray Sabyasachi; Dhara Santanu
Source:: ACS applied materials 2016 v.8 no.19 pp. 11910-11924
ISSN:: 1944-8252
Subject:: apatite; cell adhesion; cell differentiation; chitosan; egg shell; extracellular matrix; extrusion; gene expression; mechanical properties; osteocalcin; phosphoric acid; physicochemical properties; porosity; secretion; surface area; wastes
Abstract:: ... Natural origin bioceramics are widely used for bone grafts. In the present study, an eggshell-derived bioceramic scaffold is fabricated by 3D printing as a potential bone-graft analogue. The eggshell, a biological waste material, was mixed with a specific ratio of phosphoric acid and chitosan to form a precursor toward the fabrication of an osteoinductive multiphasic calcium phosphate scaffold via ...
DOI:: 10.1021/acsami.5b11981
: https://doi.org/10.1021/acsami.5b11981

13. A gene expression-based comparison of cell adhesion to extracellular matrix and RGD-terminated monolayers

Author:: Courtney J. Sobers; Sarah E. Wood; Milan Mrksich
Source:: Biomaterials 2015 v.52 pp. 385-394
ISSN:: 0142-9612
Subject:: adhesion; biocompatible materials; cell adhesion; cell culture; extracellular matrix; gene expression; genes; models; transcription (genetics)
Abstract:: ... This work uses global gene expression analysis to compare the extent to which model substrates presenting peptide adhesion motifs mimic the use of conventional extracellular matrix protein coated substrates for cell culture. We compared the transcriptional activities of genes in cells that were cultured on matrix-coated substrates with those cultured on self-assembled monolayers presenting either ...
DOI:: 10.1016/j.biomaterials.2015.02.045
PubMed:: 25818445
PubMed Central:: PMC4379455
: https://doi.org/10.1016/j.biomaterials.2015.02.045

14. A guide to the composition and functions of the extracellular matrix

Author:: Nikos K. Karamanos; Achilleas D. Theocharis; Zoi Piperigkou; Dimitra Manou; Alberto Passi; Spyros S. Skandalis; Demitrios H. Vynios; Véronique Orian‐Rousseau; Sylvie Ricard‐Blum; Christian E.H. Schmelzer; Laurent Duca; Madeleine Durbeej; Nikolaos A. Afratis; Linda Troeberg; Marco Franchi; Valentina Masola; Maurizio Onisto
Source:: FEBS journal 2021 v.288 no.24 pp. 6850-6912
ISSN:: 1742-464X
Subject:: angiogenesis; autophagy; cell adhesion; cell proliferation; disease progression; elastin; extracellular matrix; glycosidases; human health; hyaluronic acid; immunity; integrins; laminin; metalloproteinases; organogenesis; proteoglycans; therapeutics
Abstract:: ... Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that provides structural support for the cells and tissues. Accumulated knowledge clearly demonstrated over the last decade that ECM plays key regulatory roles since it orchestrates cell signaling, functions, properties and morphology. Extracellularly secreted as well as cell‐bound factors are among the major members o ...
DOI:: 10.1111/febs.15776
: https://doi.org/10.1111/febs.15776

15. A liquid culture cancer spheroid model reveals low PI3K/Akt pathway activity and low adhesiveness to the extracellular matrix

Author:: Natsuki Abe‐Fukasawa; Rina Watanabe; Yuki Gen; Taito Nishino; Nobue Itasaki
Source:: FEBS journal 2021 v.288 no.19 pp. 5650-5667
ISSN:: 1742-464X
Subject:: adhesion; antineoplastic agents; cell adhesion; extracellular matrix; liquids; metastasis; migratory behavior; models; neoplasms; plasma membrane; viability; xenotransplantation
Abstract:: ... Three‐dimensional (3D) cultures of cancer cells in liquid without extracellular matrix (ECM) offer in vitro models for metastasising conditions such as those in vessels and effusion. However, liquid culturing is often hindered by cell adhesiveness, which causes large cell clumps. We previously described a liquid culture material, LA717, which prevents nonclonal cell adhesion and subsequent clumpin ...
DOI:: 10.1111/febs.15867
: https://doi.org/10.1111/febs.15867

16. A novel BSA immobilizing manner on modified titanium surface ameliorates osteoblast performance

Author:: O.P. Gomes; G.S. Feltran; M.R. Ferreira; C.S. Albano; W.F. Zambuzzi; P.N. Lisboa-Filho
Source:: Colloids and surfaces 2020 v.190 pp. 110888
ISSN:: 0927-7765
Subject:: X-ray photoelectron spectroscopy; adsorption; bioassays; biocompatibility; biocompatible materials; bovine serum albumin; cell adhesion; extracellular matrix; films (materials); genes; hydroxylation; moieties; osteoblasts; radio waves; titanium; titanium dioxide
Abstract:: ... Surface modification of medical and dental devices, to improve their biocorrosion resistance and biocompatibility, can be achieved with the multidisciplinary field of biomaterials. Nanostructured titanium dioxide (TiO₂) has been employed as surface modifier of titanium-based biomaterials because it can prevent the failure of the devices due to wear mechanisms. Moreover, this oxide surface is mostl ...
DOI:: 10.1016/j.colsurfb.2020.110888
: https://doi.org/10.1016/j.colsurfb.2020.110888

17. A novel approach to prepare a tissue engineering decellularized valve scaffold with poly(ethylene glycol)–poly(ε-caprolactone)

Author:: Zhigang Zhu; Jianliang Zhou; Jingli Ding; Jianjun Xu; Haijun Zhong; Shuijin Lei
Source:: RSC advances 2016 v.6 no.17 pp. 14427-14438
ISSN:: 2046-2069
Subject:: DNA; adhesion; biocompatibility; blood platelets; cell adhesion; collagen; deoxycholic acid; elastin; extracellular matrix; hemolysis; histology; mechanical properties; octoxynol; swine; tissue engineering; ultrastructure; water content
Abstract:: ... The objective of this study was to explore the feasibility of preparing a decellularized valve scaffold with methoxy poly(ethylene glycol)–poly(ε-caprolactone) (MPEG–PCL). This is the first report of applying MPEG–PCL to decellularize porcine aortic valves (PAVs). We evaluated its decellularization activity versus two commonly used agents (Triton X-100 and sodium deoxycholate (SD)) in terms of his ...
DOI:: 10.1039/c5ra22808e
: https://doi.org/10.1039/c5ra22808e

18. A novel culture platform for fast proliferation of human annulus fibrosus cells

Author:: Li Xiao; Mengmeng Ding; Osama Saadoon; Eric Vess; Andrew Fernandez; Ping Zhao; Li Jin; Xudong Li
Source:: Cell and tissue research 2017 v.367 no.2 pp. 339-350
ISSN:: 0302-766X
Subject:: Western blotting; actin; adhesion; cell adhesion; cell proliferation; collagen; cost effectiveness; dose response; extracellular matrix; fibronectins; fluorescent antibody technique; focal adhesions; gelatin; gelatinase A; gelatinase B; gene expression; glycosaminoglycans; humans; in vitro culture; intervertebral disks; messenger RNA; microscopy; phenotype; protein synthesis; proteoglycans; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; staining; tissue engineering
Abstract:: ... Tissue engineering provides a promising approach to treat degenerative disc disease, which usually requires a large quantity of seed cells. A simple and reliable in vitro culture system to expand seed cells in a timely fashion is necessary to implement the application clinically. Here, we sought to establish a cost-effective culture system for expanding human annulus fibrosus cells using extracell ...
DOI:: 10.1007/s00441-016-2497-4
PubMed:: 27623803
PubMed Central:: PMC5269443
: https://doi.org/10.1007/s00441-016-2497-4

19. A quartz crystal microbalance based study reveals living cell loading rate via [formula omitted] integrins

Author:: Kshitij Amar; Ian I. Suni; Farhan Chowdhury
Source:: Biochemical and biophysical research communications 2020 pp. -
ISSN:: 0006-291X
Subject:: cell adhesion; chemical bonding; extracellular matrix; integrins; peptides; quartz; quartz crystal microbalance; research
Abstract:: ... Cellular interactions with the microenvironment are mediated by ligand-receptor bonds. Such ligand-receptor bond dynamics is known to be heavily dependent on the loading rate. However, the physiologically-relevant loading rate of living cells remains unknown. Here, using a quartz crystal microbalance (QCM), we developed a bulk-force sensing platform to semi-quantitatively detect the rate of cellul ...
DOI:: 10.1016/j.bbrc.2020.01.149
: https://doi.org/10.1016/j.bbrc.2020.01.149

20. A vascular injury model using focal heat-induced activation of endothelial cells

Author:: J. L. Sylman; D. T. Artzer; K. Rana; K. B. Neeves
Source:: Integrative biology 2015 v.7 no.7 pp. 801-814
ISSN:: 1757-9708
Subject:: antibodies; blood coagulation factors; blood platelets; cell adhesion; endothelial cells; extracellular matrix; finite element analysis; heat; microelectrodes; models; platelet activation; secretion; temperature
Abstract:: ... Endothelial cells (EC) both inhibit and promote platelet function depending on their activation state. Quiescent EC inhibit platelet activation by constitutive secretion of platelet inhibitors. Activated EC promote platelet adhesion by secretion of von Willebrand factor (vWF). EC also secrete an extracellular matrix that support platelet adhesion when exposed following vascular injury. Previous st ...
DOI:: 10.1039/c5ib00108k
PubMed:: 26087748
PubMed Central:: PMC4494879
: https://doi.org/10.1039/c5ib00108k

21. AT14A mediates the cell wall–plasma membrane–cytoskeleton continuum in Arabidopsis thaliana cells

Author:: Bing Lü; Juan Wang; Yu Zhang; Hongcheng Wang; Jiansheng Liang; Jianhua Zhang
Source:: Journal of experimental botany 2012 v.63 no.11 pp. 4061-4069
ISSN:: 0022-0957
Subject:: Arabidopsis thaliana; actin; adhesion; animals; cell adhesion; cell walls; cellulose; extracellular matrix; fluorescent antibody technique; green fluorescent protein; integrins; microfilaments; microtubules; mutants; phenotype; plasma membrane; plasmolysis
Abstract:: ... AT14A has a small domain that has sequence similarities to integrins from animals. Integrins serve as a transmembrane linker between the extracellular matrix and the cytoskeleton, which play critical roles in a variety of biological processes. Because the function of AT14A is unknown, Arabidopsis thaliana AT14A, which is a transmembrane receptor for cell adhesion molecules and a middle member of t ...
DOI:: 10.1093/jxb/ers063
PubMed:: 22456678
PubMed Central:: PMC3398443
: https://doi.org/10.1093/jxb/ers063

22. Abrogated Cell Contact Guidance on Amino-Functionalized Microgrooves

Author:: Mörke Caroline; Rebl Henrike; Finke Birgit; Dubs Manuela; Nestler Peter; Airoudj Aissam; Roucoules Vincent; Schnabelrauch Matthias; Körtge Andreas; Anselme Karine; Helm Christiane A.; Nebe J. Barbara
Source:: ACS Applied Materials & Interfaces 2017 v.9 no.12 pp. 10461-10471
ISSN:: 1944-8252
Subject:: adhesion; argon (noble gases); atmospheric pressure; cell adhesion; cell physiology; coatings; extracellular matrix; geometry; integrins; microrelief; osteoblasts; oxygen; polymerization; titanium
Abstract:: ... Topographical and chemical features of biomaterial surfaces affect the cell physiology at the interface and are promising tools for the improvement of implants. The dominance of the surface topography on cell behavior is often accentuated. Striated surfaces induce an alignment of cells and their intracellular adhesion-mediated components. Recently, it could be demonstrated that a chemical modifica ...
DOI:: 10.1021/acsami.6b16430
: https://doi.org/10.1021/acsami.6b16430

23. Acetylcholinesterase in cell adhesion, neurite growth and network formation

Author:: Paraoanu, Laura E.; Layer, Paul G.
Source:: FEBS journal 2008 v.275 no.4 pp. 618-624
ISSN:: 1742-464X
Subject:: acetylcholinesterase; cell adhesion; cell communication; extracellular matrix; mice; neural networks; neurodegenerative diseases; neurodevelopment; protein-protein interactions; receptors; stress response; tissues
Abstract:: ... The expression of acetylcholinesterase is not restricted to cholinergically innervated tissues and relates to both neurotransmission and multiple biological aspects, including neural development, stress response and neurodegenerative diseases. Therefore, the classical function of acetylcholinesterase has to be distinguished from its non-classical, e.g. enzymatic from non-enzymatic, functions. Here ...
DOI:: 10.1111/j.1742-4658.2007.06237.x
: https://doi.org/10.1111/j.1742-4658.2007.06237.x

24. Active loading graphite/hydroxyapatite into the stable hydroxyethyl cellulose scaffold nanofibers for artificial cornea application

Author:: Davood Kharaghani; Debarun Dutta; Kitty K. K. Ho; Ke-Qin Zhang; Wei Kai; Xuehong Ren; Mark D. P. Willcox; Ick Soo Kim
Source:: Cellulose 2020 v.27 no.6 pp. 3319-3334
ISSN:: 0969-0239
Subject:: cell adhesion; cellulose; cornea; crosslinking; epithelial cells; extracellular matrix; glutaraldehyde; graphene; humans; hydrogels; hydroxyapatite; nanofibers; polyvinyl alcohol; tissue engineering
Abstract:: ... The design of biocompatible porous scaffolds that encourage cell adhesion for corneal tissue engineering applications continues to be challenging. In addition to porous hydrogels, nanofibers that can simulate the extracellular matrix structure for cell adhesion would be beneficial. Graphite and nano-hydroxyapatite (nHA) are two bioactive materials that have been used to improve cell adhesion in sc ...
DOI:: 10.1007/s10570-020-02999-w
: https://doi.org/10.1007/s10570-020-02999-w

25. Adhesion of fibroblast cells on thin films representing surfaces of polymeric scaffolds of human urethra rationalized by molecular models of integrin binding: cell adhesion on polymeric scaffolds for regenerative medicine

Author:: Simona Braccini; Gianni Pecorini; Federica Chiellini; Dusan Bakos; Stanislav Miertus; Vladimir Frecer
Source:: Journal of biotechnology 2020 v.324 pp. 233-238
ISSN:: 0168-1656
Subject:: adhesion; biocompatible materials; biodegradability; biotechnology; cell adhesion; cell lines; cell proliferation; extracellular matrix; fibroblasts; glass; glycolic acid; humans; integrins; mechanics; medicine; mice; solvents; transmembrane proteins; urethra
Abstract:: ... This work combines experimental and computational study of Balb/3T3 clone A31 mouse embryo fibroblasts cell line adhesion and proliferation on fourteen different polymeric surfaces prepared from poly(dioxanone) (PDO), poly(glycolic acid) (PGA), poly(hydroxybutyrate) (PHB), and poly(L-lactic acid) (PLA), and their 1:1 mixtures. The study was done with the aim to explore the attractive interactions ...
DOI:: 10.1016/j.jbiotec.2020.11.001
: https://doi.org/10.1016/j.jbiotec.2020.11.001

26. Adhesion profile and differentiation capacity of human adipose tissue derived mesenchymal stem cells grown on metal ion (Zn, Ag and Cu) doped hydroxyapatite nano-coated surfaces

Author:: R. Beklem Bostancioglu; Mevlut Gurbuz; Ayse Gul Akyurekli; Aydin Dogan; A. Savas Koparal; A. Tansu Koparal
Source:: Colloids and surfaces 2017 v.155 pp. 415-428
ISSN:: 0927-7765
Subject:: DNA; actin; adhesion; adipose tissue; air; alizarin; alkaline phosphatase; biocompatibility; bone formation; cell adhesion; cell viability; colloids; copper; culture media; cytoskeleton; extracellular matrix; fluorescent antibody technique; genes; glass; humans; hydroxyapatite; metal ions; microarray technology; scanning electron microscopy; silver; spray deposition; staining; stem cells; zinc
Abstract:: ... Accelerated Mesenchymal Stem Cells (MSCs) condensation and robust MSC-matrix and MSC-MSC interactions on nano-surfaces may provide critical factors contributing to such events, likely through the orchestrated signal cascades and cellular events modulated by the extracellular matrix. In this study, human adipose tissue derived mesenchymal stem cells (hMSC)', were grown on metal ion (Zn, Ag and Cu) ...
DOI:: 10.1016/j.colsurfb.2017.04.015
: https://doi.org/10.1016/j.colsurfb.2017.04.015

27. Advanced gellan gum-based glycol chitosan hydrogel for cartilage tissue engineering biomaterial

Author:: Sumi Lee; Joo Hee Choi; Ain Park; Mina Rim; Jina Youn; Wonchan Lee; Jeong Eun Song; Gilson Khang
Source:: International journal of biological macromolecules 2020 v.158 pp. 452-460
ISSN:: 0141-8130
Subject:: biocompatibility; biocompatible materials; biodegradability; biopolymers; cartilage; cell adhesion; chitosan; chondrogenesis; extracellular matrix; gellan gum; histology; hydrogels; in vitro studies; mechanical properties; models; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; tissue engineering; viability assays; water solubility; weight loss
Abstract:: ... Gellan gum (GG), a nature-derived polysaccharide, is one of the materials widely used in cartilage tissue engineering (TE). Glycol chitosan (GC), a derivative of chitosan, is a water-soluble natural polymer that has excellent biocompatibility and biodegradability as well as cell adhesion. Herein, GG was physically blended with GC to enhance the mechanical properties and microenvironment of the GG ...
DOI:: 10.1016/j.ijbiomac.2020.04.135
: https://doi.org/10.1016/j.ijbiomac.2020.04.135

28. Aire knockdown in medullary thymic epithelial cells affects Aire protein, deregulates cell adhesion genes and decreases thymocyte interaction

Author:: Nicole Pezzi; Amanda Freire Assis; Larissa Cotrim Cotrim-Sousa; Gabriel Sarti Lopes; Maritza Salas Mosella; Djalma Sousa Lima; Karina F. Bombonato-Prado; Geraldo Aleixo Passos
Source:: Molecular Immunology 2016 v.77 pp. 157-173
ISSN:: 0161-5890
Subject:: T-lymphocytes; antigens; cell adhesion; coculture; epithelial cells; extracellular matrix; gene expression; genes; messenger RNA; mice; thymocytes; transcription factors; transcriptomics
Abstract:: ... We demonstrate that even a partial reduction of Aire mRNA levels by siRNA-induced Aire knockdown (Aire KD) has important consequences to medullary thymic epithelial cells (mTECs). Aire knockdown is sufficient to reduce Aire protein levels, impair its nuclear location, and cause an imbalance in large-scale gene expression, including genes that encode cell adhesion molecules. These genes drew our at ...
DOI:: 10.1016/j.molimm.2016.08.003
: https://doi.org/10.1016/j.molimm.2016.08.003

29. Alginate-based hydrogels with improved adhesive properties for cell encapsulation

Author:: Bapi Sarker; Julia Rompf; Raquel Silva; Nadine Lang; Rainer Detsch; Joachim Kaschta; Ben Fabry; Aldo R. Boccaccini
Source:: International journal of biological macromolecules 2015 v.78 pp. 72-78
ISSN:: 0141-8130
Subject:: biocompatible materials; cell adhesion; crosslinking; extracellular matrix; gelatin; hydrocolloids; mechanical properties; microencapsulation; mixing; physicochemical properties
Abstract:: ... Hydrogel-based biomaterials are ideal scaffolding matrices for microencapsulation, but they need to be modified to resemble the mechanical, structural and chemical properties of the native extracellular matrix. Here, we compare the mechanical properties and the degradation behavior of unmodified and modified alginate hydrogels in which cell adhesive functionality is conferred either by blending or ...
DOI:: 10.1016/j.ijbiomac.2015.03.061
: https://doi.org/10.1016/j.ijbiomac.2015.03.061

30. Alternagin-C, an alpha2beta1 integrin ligand, attenuates collagen-based adhesion, stimulating the metastasis suppressor 1 expression in triple-negative breast tumor cells

Author:: Milene Nóbrega de Oliveira Moritz; Bruna Carla Casali; Uliana Sbeguen Stotzer; Patty Karina dos Santos; Heloisa Sobreiro Selistre-de-Araujo
Source:: Toxicon 2022 v.210 pp. 1-10
ISSN:: 0041-0101
Subject:: Bothrops; adhesion; angiogenesis; breast neoplasms; breasts; cell adhesion; cell lines; cell movement; collagen; disease course; extracellular matrix; gene expression; inflammation; integrins; ligands; metalloproteinases; metastasis; neoplasm cells; neoplasm progression; risk; snake venoms; snakes
Abstract:: ... Triple-negative breast cancer has an aggressive clinical course and its treatment has been challenging due to high metastatic risk. Molecular targets have been sought to provide better strategies for this type of cancer. Integrins are cell adhesion receptors involved in tumor progression and α₂β₁ integrin, a collagen receptor, has a key role in breast metastasis. Disintegrins, a family of proteins ...
DOI:: 10.1016/j.toxicon.2022.02.001
: https://doi.org/10.1016/j.toxicon.2022.02.001

31. Alternative splicing of Ikaros regulates the FUT4/LeX-α5β1 integrin-FAK axis in acute lymphoblastic leukemia

Author:: Lijun Yi; Qinghua Hu; Jing Zhou; Zhiqiang Liu; Hong Li
Source:: Biochemical and biophysical research communications 2019 v.510 no.1 pp. 128-134
ISSN:: 0006-291X
Subject:: adhesion; alternative splicing; cell adhesion; drug resistance; drug therapy; epitopes; extracellular matrix; fibronectins; glycosylation; induced mutation; integrins; lymphocytic leukemia; monitoring; neoplasm cells; prognosis; relapse; signal transduction; transcription (genetics)
Abstract:: ... Unveiling the mechanism of the relapse of acute lymphoblastic leukemia (ALL) is the key to improve the prognosis of ALL and remains a huge challenge. Glycan-based interactions play a vital role in immune surveillance, cell-cell adhesion and cell-matrix interaction, contributing to treatment failure in tumor. However, the glycan essential for leukemia development and its upstream regulatory mechani ...
DOI:: 10.1016/j.bbrc.2019.01.064
: https://doi.org/10.1016/j.bbrc.2019.01.064

32. Ameliorative effect of methylthiouracil on TGFBIp-induced septic responses

Author:: Byeongjin Jung; Sae-Kwang Ku; Jong-Sup Bae
Source:: Biochemical and biophysical research communications 2015 v.463 pp. 661-666
ISSN:: 0006-291X
Subject:: adhesion; anti-inflammatory activity; cell adhesion; cell movement; drugs; extracellular matrix; human diseases; human umbilical vein endothelial cells; humans; methylthiouracil; mice; neutrophils; permeability; proteins; screening; sepsis (infection); signal transduction; transforming growth factor beta
Abstract:: ... The screening of bioactive compound libraries can be an effective approach for repositioning FDA-approved drugs or discovering new treatments for human diseases. Transforming growth factor β-induced protein (TGFBIp) is an extracellular matrix protein whose expression in several cell types is greatly increased by TGF-β. TGFBIp is released by human umbilical vein endothelial cells (HUVECs), and func ...
DOI:: 10.1016/j.bbrc.2015.05.120
: https://doi.org/10.1016/j.bbrc.2015.05.120

33. Amphiphilic beads as depots for sustained drug release integrated into fibrillar scaffolds

Author:: Akhilesh K. Gaharwar; Silvia M. Mihaila; Ashish A. Kulkarni; Alpesh Patel; Andrea Di Luca; Rui L. Reis; Manuela E. Gomes; Clemens van Blitterswijk; Lorenzo Moroni; Ali Khademhosseini
Source:: Journal of controlled release 2014 v.187 pp. 66-73
ISSN:: 0168-3659
Subject:: alkaline phosphatase; bone formation; cell adhesion; composite polymers; dexamethasone; encapsulation; extracellular matrix; humans; hydrophobicity; mineralization; models; stem cells; tissue engineering; tissue repair
Abstract:: ... Native extracellular matrix (ECM) is a complex fibrous structure loaded with bioactive cues that affects the surrounding cells. A promising strategy to mimicking native tissue architecture for tissue engineering applications is to engineer fibrous scaffolds using electrospinning. By loading appropriate bioactive cues within these fibrous scaffolds, various cellular functions such as cell adhesion, ...
DOI:: 10.1016/j.jconrel.2014.04.035
PubMed:: 24794894
PubMed Central:: PMC4079754
: https://doi.org/10.1016/j.jconrel.2014.04.035

34. Amyloid Fibrils: Versatile Biomaterials for Cell Adhesion and Tissue Engineering Applications

Author:: Subhadeep Das; Reeba S. Jacob; Komal Patel; Namrata Singh; Samir K. Maji
Source:: Biomacromolecules 2018 v.19 no.6 pp. 1826-1839
ISSN:: 1526-4602
Subject:: amyloid; apoptosis; biobased products; biocompatible materials; cell adhesion; extracellular matrix; focal adhesions; human diseases; signal transduction; tissue engineering; toxicity
Abstract:: ... Extracellular matrices (ECM) play an enormous role in any living system, controlling various factors and eventually fates of cells. ECM regulates cell fate by providing constant exogenous signals altering intracellular signal transduction for diverse pathways including proliferation, migration, differentiation, and apoptosis. Biomaterial scaffolds are designed to mimic the natural extracellular ma ...
DOI:: 10.1021/acs.biomac.8b00279
: https://doi.org/10.1021/acs.biomac.8b00279

35. An Epigenetic Signature is Associated with Serum 25‐Hydroxyvitamin D in Colorectal Cancer Tumors

Author:: Hatim Boughanem; Andrea G. Izquierdo; Pablo Hernández‐Alonso; Isabel Arranz‐Salas; Felipe F. Casanueva; Francisco J. Tinahones; Ana B. Crujeiras; Manuel Macias‐Gonzalez
Source:: Molecular nutrition & food research 2021 v.65 no.18 pp. e2100125
ISSN:: 1613-4125
Subject:: DNA methylation; blood serum; cAMP-dependent protein kinase; cell adhesion; colorectal neoplasms; epigenetics; extracellular matrix; food research; genes; loci; models; vitamin D
Abstract:: ... INTRODUCTION: Vitamin D has been widely associated with colorectal cancer (CRC) through different insights. This study aims to explore the association between serum 25‐hydroxyvitamin D (25(OH)D) and the global DNA methylation in tumor from CRC patients. METHODS AND RESULTS: A genome‐wide DNA methylation analysis is conducted in 20 CRC patients under categorical (10 patients have 25(OH)D <30 ng mL⁻ ...
DOI:: 10.1002/mnfr.202100125
: https://doi.org/10.1002/mnfr.202100125

36. An Inhibitory Antibody Blocks the First Step in the Dithiol/Disulfide Relay Mechanism of the Enzyme QSOX1

Author:: Iris Grossman; Assaf Alon; Tal Ilani; Deborah Fass
Source:: Journal of Molecular Biology 2013 v.425 pp. 4366-4378
ISSN:: 0022-2836
Subject:: adenocarcinoma; catalysts; cell adhesion; cell movement; cell viability; disulfide bonds; electron transfer; extracellular matrix; fibroblasts; humans; laminin; metastasis; models; monoclonal antibodies; mutagenesis; neoplasm cells; secretion; sulfides
Abstract:: ... Quiescin sulfhydryl oxidase 1 (QSOX1) is a catalyst of disulfide bond formation that undergoes regulated secretion from fibroblasts and is over-produced in adenocarcinomas and other cancers. We have recently shown that QSOX1 is required for incorporation of particular laminin isoforms into the extracellular matrix (ECM) of cultured fibroblasts and, as a consequence, for tumor cell adhesion to and ...
DOI:: 10.1016/j.jmb.2013.07.011
: https://doi.org/10.1016/j.jmb.2013.07.011

37. An affinity-based approach to engineer laminin-presenting cell instructive microenvironments

Author:: Daniela Barros; Paula Parreira; Joana Furtado; Frederico Ferreira-da-Silva; Eduardo Conde-Sousa; Andrés J. García; M. Cristina L. Martins; Isabel Freitas Amaral; Ana Paula Pêgo
Source:: Biomaterials 2019 v.192 pp. 601-611
ISSN:: 0142-9612
Subject:: bioactive properties; cell adhesion; cell culture; coatings; epitopes; extracellular matrix; glycoproteins; gold; humans; laminin; neural stem cells; polyethylene glycol
Abstract:: ... Laminin immobilization into diverse biological and synthetic matrices has been explored to replicate the microenvironment of stem cell niches and gain insight into the role of extracellular matrix (ECM) on stem cell behavior. However, the site-specific immobilization of this heterotrimeric glycoprotein and, consequently, control over its orientation and bioactivity has been a challenge that has li ...
DOI:: 10.1016/j.biomaterials.2018.10.039
: https://doi.org/10.1016/j.biomaterials.2018.10.039

38. An artificial membrane binding protein-polymer surfactant nanocomplex facilitates stem cell adhesion to the cartilage extracellular matrix

Author:: Rosalia Cuahtecontzi Delint; Graham J. Day; William J.P. Macalester; Wael Kafienah; Wenjin Xiao; Adam W. Perriman
Source:: Biomaterials 2021 v.276 pp. 120996
ISSN:: 0142-9612
Subject:: adhesion; biocompatible materials; cartilage; cattle; cell adhesion; cell viability; collagen; cytotoxicity; electrostatic interactions; extracellular matrix; green fluorescent protein; humans; peptides; placenta; plasma membrane; polymers; stem cells; surfactants
Abstract:: ... One of the major challenges within the emerging field of injectable stem cell therapies for articular cartilage (AC) repair is the retention of sufficient viable cell numbers at the site of injury. Even when delivered via intra-articular injection, the number of stem cells retained at the target is often low and declines rapidly over time. To address this challenge, an artificial plasma membrane b ...
DOI:: 10.1016/j.biomaterials.2021.120996
: https://doi.org/10.1016/j.biomaterials.2021.120996

39. An in silico hybrid continuum-/agent-based procedure to modelling cancer development: Interrogating the interplay amongst glioma invasion, vascularity and necrosis

Author:: Jean de Montigny; Alexandros Iosif; Lukas Breitwieser; Marco Manca; Roman Bauer; Vasileios Vavourakis
Source:: Methods 2021 v.185 pp. 94-104
ISSN:: 1046-2023
Subject:: adhesion; brain; carcinogenesis; cell adhesion; cell movement; cost effectiveness; extracellular matrix; finite element analysis; glioblastoma; growth factors; models; necrosis; nutrient availability; oxygen; phenotype
Abstract:: ... This paper develops a three-dimensional in silico hybrid model of cancer, which describes the multi-variate phenotypic behaviour of tumour and host cells. The model encompasses the role of cell migration and adhesion, the influence of the extracellular matrix, the effects of oxygen and nutrient availability, and the signalling triggered by chemical cues and growth factors. The proposed in silico h ...
DOI:: 10.1016/j.ymeth.2020.01.006
: https://doi.org/10.1016/j.ymeth.2020.01.006

40. Analysis of a Blumeria graminis-Secreted Lipase Reveals the Importance of Host Epicuticular Wax Components for Fungal Adhesion and Development

Author:: Feng, Jie; Wang, Feng; Liu, Guosheng; Greenshields, David; Shen, Wenyun; Kaminskyj, Susan; Hughes, Geoff R.; Peng, Youliang; Selvaraj, Gopalan; Zou, Jitao; Wei, Yangdou
Source:: Molecular plant-microbe interactions 2009 v.22 no.12 pp. 1601-1610
ISSN:: 0894-0282
Subject:: epicuticular wax; conidia; Blumeria graminis; cell walls; extracellular matrix; expressed sequence tags; wheat; triacylglycerol lipase; appressoria; pathogenicity; hyphae; Triticum aestivum; adhesion; hydrophobicity; alkanes; protein secretion; gene expression regulation; cell adhesion
Abstract:: ... The biotrophic powdery mildew fungus Blumeria graminis releases extracellular materials to the surface of fungal infection structures that facilitate anchoring them to hydrophobic plant surfaces prior to infection; however, the chemistry of fungal adhesives and the mechanism of adhesion remain largely unclear. Expressed sequence tag analysis led to identification of a secreted lipase, Lip1, from B ...
DOI:: 10.1094/MPMI-22-12-1601
PubMed:: 19888825
: https://doi.org/10.1094/MPMI-22-12-1601

41. Analysis of integrins and vascular endothelial growth factor isoforms mRNA expression in the canine uterus during perimplantation period

Author:: D. Bukowska; B. Kempisty; M. Jackowska; M. Woźna; P. Antosik; H. Piotrowska; J. Jaśkowski
Source:: Polish journal of veterinary sciences 2011 v.14 no.2 pp. 253-258
ISSN:: 1505-1773
Subject:: bitches; blood; cell adhesion; complementary DNA; cytoskeleton; deoxyribonuclease I; embryo implantation; endometrium; extracellular matrix; gene expression; gene expression regulation; genes; integrins; messenger RNA; metabolism; metestrus; pregnancy; progesterone; quantitative analysis; receptors; transcription (genetics); vascular endothelial growth factors
Abstract:: ... Integrins are the major receptors within the extracellular matrix (ECM) that mediate several functions connected with cell life and metabolism, such as cell adhesion, migration, cytoskeletal organization, proliferation, survival, and differentiation. A vascular endothelial growth factor (VEGF) is one of the most important angiogenic factors. It has been suggested that the expression of this gene m ...
DOI:: 10.2478/v10181-011-0038-3
: https://doi.org/10.2478/v10181-011-0038-3

42. Analysis of protein-linked glycosylation in a sperm-somatic cell adhesion system

Author:: Sutton-Smith, Mark; Wong, Nyet Kui; Khoo, Kay-Hooi; Wu, Sz-Wei; Yu, Shin-Yi; Patankar, Manish S.; Easton, Richard; Lattanzio, Frank A.; Morris, Howard R.; Dell, Anne; Clark, Gary F.
Source:: Glycobiology 2007 v.17 no.6 pp. 553-567
ISSN:: 0959-6658
Subject:: cell adhesion; eggs; erythrocytes; extracellular matrix; glycosphingolipids; glycosylation; mice; oligosaccharides; oxidation; rabbits; sialic acid; somatic cells; spermatozoa; tandem mass spectrometry; zona pellucida
Abstract:: ... Murine sperm initiate fertilization by binding to the specialized extracellular matrix of their complementary eggs, known as the zona pellucida. On the basis of data reported in this study, mouse sperm also bind to rabbit erythrocytes with higher affinity than they do to murine eggs. This unusual interaction between a germ cell and a somatic cell ("sperm-somatic cell adhesion system") is also carb ...
DOI:: 10.1093/glycob/cwm025
: https://doi.org/10.1093/glycob/cwm025

43. Analysis of the behavior of 2D monolayers and 3D spheroid human pancreatic beta cells derived from induced pluripotent stem cells in a microfluidic environment

Author:: Amal Essaouiba; Rachid Jellali; Marie Shinohara; Benedikt Scheidecker; Cécile Legallais; Yasuyuki Sakai; Eric Leclerc
Source:: Journal of biotechnology 2021 v.330 pp. 45-56
ISSN:: 0168-1656
Subject:: biotechnology; c-peptide; cell adhesion; diabetes; extracellular matrix; glucagon; glucose; humans; hypoglycemic agents; insulin secretion; models
Abstract:: ... The limited availability of primary human β-cells/islets and their quality (due to donor diversity) restrict the development of in vitro models for diabetes research. Human induced pluripotent stem cells (hiPSCs) may be a promising cell-source for diabetes studies, anti-diabetic drug screening and personalized therapies. However, achieving levels of maturity/functionality that are comparable to th ...
DOI:: 10.1016/j.jbiotec.2021.02.009
: https://doi.org/10.1016/j.jbiotec.2021.02.009

44. Ancient origin of the integrin-mediated adhesion and signaling machinery

Author:: Sebé-Pedrós, Arnau; Roger, Andrew J.; Lang, Franz B.; King, Nicole; Ruiz-Trillo, Iñaki
Source:: Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.22 pp. 10142-10147
ISSN:: 0027-8424
Subject:: Animalia; adhesion; ancestry; animals; cell adhesion; cell communication; evolution; extracellular matrix; fungi; genes; genomics; integrins; protists
Abstract:: ... The evolution of animals (metazoans) from their unicellular ancestors required the emergence of novel mechanisms for cell adhesion and cell-cell communication. One of the most important cell adhesion mechanisms for metazoan development is integrin-mediated adhesion and signaling. The integrin adhesion complex mediates critical interactions between cells and the extracellular matrix, modulating sev ...
DOI:: 10.1073/pnas.1002257107
PubMed:: 20479219
PubMed Central:: PMC2890464
: https://doi.org/10.1073/pnas.1002257107

45. Anterior gradient 2 is involved in the post-transcriptional regulation of β-dystroglycan

Author:: Eunyoung Lee; Do Hee Lee
Source:: Animal cells and systems 2021 v.25 no.1 pp. 19-27
ISSN:: 2151-2485
Subject:: actin; adhesion; animals; breast neoplasms; carcinogenesis; cytoskeleton; extracellular matrix; homeostasis; protein disulfide-isomerase
Abstract:: ... Anterior gradient 2 (AGR2) is a protein disulfide isomerase over-expressed in numerous types of cancer. Although AGR2 plays a role in ER homeostasis, its function(s) in tumorigenesis is still elusive. Here we demonstrate that AGR2 is involved in the regulation of the β-subunit of dystroglycan (β-DG), a component of the multi-protein complex linking the extracellular matrix and cytoskeletal network ...
DOI:: 10.1080/19768354.2020.1871405
: https://doi.org/10.1080/19768354.2020.1871405

46. Anti-metastatic activity of the recombinant disintegrin, r-mojastin 1, from the Mohave rattlesnake

Author:: Sara Lucena; Elda E. Sanchez; John C. Perez
Source:: Toxicon 2011 v.57 no.5 pp. 794-802
ISSN:: 0041-0101
Subject:: Crotalus; adhesion; angiogenesis; antineoplastic agents; bladder; carcinoma; cell adhesion; cell growth; cell movement; death; extracellular matrix; fibronectins; fibrosarcoma; humans; melanoma; metastasis; mice; molecular weight; neoplasm cells; patients; peptides; platelet aggregation; snakes; venoms
Abstract:: ... Cancer is the uncontrollable growth of cell, which may spread to other parts of the body. The interaction of cancer cells with extracellular matrix (ECM) is essential for metastasis, which is the principal cause of death in cancer patients. Disintegrins are naturally occurring low molecular weight peptides found in the venoms of many snakes. Disintegrins were first used to inhibit platelet aggrega ...
DOI:: 10.1016/j.toxicon.2011.02.014
PubMed:: 21334359
PubMed Central:: PMC3293478
: https://doi.org/10.1016/j.toxicon.2011.02.014

47. Anti-tumor activity of staurosporine in the tumor microenvironment of cervical cancer: An in vitro study

Author:: Suresh Singh Yadav; Chandra Bhushan Prasad; Shyam Babu Prasad; Lakshmi Kant Pandey; Sunita Singh; Satyajit Pradhan; Gopeshwar Narayan
Source:: Life sciences 2015 v.133 pp. 21-28
ISSN:: 0024-3205
Subject:: adhesion; antineoplastic activity; apoptosis; cell adhesion; cell growth; cell movement; cell proliferation; cell suspension culture; dose response; enzyme inhibitors; extracellular matrix; fibronectins; in vitro studies; metalloproteinases; metastasis; neoplasm cells; protein kinases; quantitative polymerase chain reaction; staurosporine; therapeutics; uterine cervical neoplasms
Abstract:: ... The fundamental events for cancer progression and metastases include loss of cell adhesion, cell proliferation, anchorage-independent cell growth (evading anoikis), cell migration and cell invasion. All these events leading to cancer progression happen in a favorable nurturing tumor microenvironment. This study was designed to explore the anti-tumor activity of staurosporine (a nonspecific protein ...
DOI:: 10.1016/j.lfs.2015.04.019
: https://doi.org/10.1016/j.lfs.2015.04.019

48. Approaches in extracellular matrix engineering for determination of adhesion molecule mediated single cell function

Author:: Chantal E. Ayres-Sander; Anjelica L. Gonzalez
Source:: Frontiers in biology 2013 v.8 no.1 pp. 32-49
ISSN:: 1674-7984
Subject:: adhesion; bioactive properties; cadherins; cell adhesion; cell movement; cultured cells; extracellular matrix; humans; integrins; phagocytosis; tissue repair
Abstract:: ... The native extracellular matrix (ECM) and the cells that comprise human tissues are together engaged in a complex relationship; cells alter the composition and structure of the ECM to regulate the material and biologic properties of the surrounding environment while the composition and structure of the ECM modulates cellular processes that maintain healthy tissue and repair diseased tissue. This r ...
DOI:: 10.1007/s11515-012-1199-x
: https://doi.org/10.1007/s11515-012-1199-x

49. Aqueous extracts and polysaccharides from Marshmallow roots (Althea officinalis L.): Cellular internalisation and stimulation of cell physiology of human epithelial cells in vitro

Author:: Deters, Alexandra; Zippel, Janina; Hellenbrand, Nils; Pappai, Dirk; Possemeyer, Cathleen; Hensel, Andreas
Source:: Journal of ethnopharmacology 2010 v.127 no.1 pp. 62-69
ISSN:: 0378-8741
Subject:: Althaea officinalis; medicinal plants; medicinal properties; plant extracts; polysaccharides; human cell lines; in vitro studies; epithelial cells; cell physiology; roots; mucosa; mechanism of action; tissue repair; fibroblasts; cell proliferation; microarray technology; gene expression; uptake mechanisms; cell adhesion; extracellular matrix; cytokines; apoptosis
Abstract:: ... Aims: Aqueous extracts from the roots of Althea officinalis L. (Malvaceae) are widely used for treatment of irritated mucosa. The clinical proven effects are related to the presence of bioadhesive and mucilaginous polysaccharides from the rhamnogalacturonan type, leading to the physical formation of mucin-like on top of the irritated tissues. No data are available if the extracts or the polysaccha ...
DOI:: 10.1016/j.jep.2009.09.050
PubMed:: 19799989
: https://doi.org/10.1016/j.jep.2009.09.050

50. Arg-Gly-Asp-modified elastin-like polypeptide regulates cell proliferation and cell cycle proteins via the phosphorylation of Erk and Akt in pancreatic β-cell

Author:: Yeo Jin Hwang; Gwon-Soo Jung; Won Bae Jeon; Kyeong-Min Lee
Source:: Heliyon 2020 v.6 no.9 pp. e04918
ISSN:: 2405-8440
Subject:: Western blotting; adhesion; cell adhesion; cell cycle; cell proliferation; cyclins; extracellular matrix; gentian violet; insulin; insulin secretion; mitogen-activated protein kinase; phosphatidylinositol 3-kinase; phosphorylation; polypeptides; rats; transcription factors
Abstract:: ... Enhancement of β-cell proliferation plays an important role in maintaining β-cell mass and function, and in improving pancreatic β-cell survival before transplantation. Extracellular matrix (ECM) components increase the adhesion and proliferation of β-cells, and the RGD-modified elastin-like polypeptide (RGD-ELP, REP) has been described as a bioactive matrix. In this study, we investigated whether ...
DOI:: 10.1016/j.heliyon.2020.e04918
: https://doi.org/10.1016/j.heliyon.2020.e04918

51. Arginine-Presenting Peptide Hydrogels Decorated with Hydroxyapatite as Biomimetic Scaffolds for Bone Regeneration

Author:: Ghosh Moumita; Halperin-Sternfeld Michal; Grigoriants Irena; Lee Jaehun; Nam Ki Tae; Adler-Abramovich Lihi
Source:: Biomacromolecules 2017 v.18 no.11 pp. 3541-3550
ISSN:: 1526-4602
Subject:: arginine; biocompatible materials; biomimetics; bones; cell adhesion; cell viability; extracellular matrix; hydrogels; hydroxyapatite; moieties; storage modulus; strength (mechanics); tissue engineering
Abstract:: ... Hydrogels are promising candidates for biomimetic scaffolds of the extracellular matrix in tissue engineering applications. However, their use in bone tissue engineering is limited due to their low mechanical properties. In this study, we designed and synthesized multicomponent peptide-based hydrogels composed of fluorenyl-9-methoxycarbonyl diphenylalanine (FmocFF), which contributed to the rigidi ...
DOI:: 10.1021/acs.biomac.7b00876
: https://doi.org/10.1021/acs.biomac.7b00876

52. Assessment of the Effects of Surface Potential on the Kinetics of HEK293T Cell Adhesion Behavior Using a Quartz Crystal Microbalance with Dissipation Monitoring

Author:: Wei-Lun Kao; Hsun-Yun Chang; Kang-Yi Lin; Yi-Wei Lee; Jing-Jong Shyue
Source:: Journal of physical chemistry 2018 v.122 no.1 pp. 694-704
ISSN:: 1932-7455
Subject:: adhesion; biobased products; cell adhesion; electrostatic interactions; epithelial cells; extracellular matrix; fluorescent antibody technique; focal adhesions; gold; light microscopy; moieties; pseudopodia; quartz crystal microbalance; staining; viscoelasticity; zeta potential
Abstract:: ... Cell adhesion plays a key role in biomaterial development. Self-assembled monolayers (SAMs) provide a convenient and versatile means of modifying surface properties to study how environmental cues affect the cell adhesion process. Serial ζ-potential surfaces can be realized by introducing various ratios of oppositely charged functional groups on a gold surface. A quartz crystal microbalance with d ...
DOI:: 10.1021/acs.jpcc.7b11072
: https://doi.org/10.1021/acs.jpcc.7b11072

53. Bacterial cellulose nanofiber reinforced poly(glycerol-sebacate) biomimetic matrix for 3D cell culture

Author:: Baoxiu Wang; Peng Ji; Yiding Ma; Jianchun Song; Zhengwei You; Shiyan Chen
Source:: Cellulose 2021 v.28 no.13 pp. 8483-8492
ISSN:: 0969-0239
Subject:: biomimetics; biosynthesis; cell adhesion; cell culture; cell growth; cell proliferation; cell structures; cellulose; extracellular matrix; fibroblasts; mice; nanofibers
Abstract:: ... Conventional two-dimensional (2D) cell culture is dramatically different from three-dimensional (3D) in vivo environment cells experience in vivo. Here, a new kind of 3D cell culture with a biomimetic structure to natural extracellular matrix (ECM) based on bacterial cellulose (BC) nanofibers and poly(glycerol-sebacate) (PGS) was designed. The 3D PGS/BC cell culture shows a porous and nanofibrous ...
DOI:: 10.1007/s10570-021-04053-9
: https://doi.org/10.1007/s10570-021-04053-9

54. Bienzymatically crosslinked gelatin/hyaluronic acid interpenetrating network hydrogels: preparation and characterization

Author:: Zhiping Fan; Yemin Zhang; Shuo Fang; Chen Xu; Xinsong Li
Source:: RSC advances 2014 v.5 no.3 pp. 1929-1936
ISSN:: 2046-2069
Subject:: biocompatibility; biocompatible materials; biological assessment; biopolymers; cell adhesion; compression strength; crosslinking; cytotoxicity; extracellular matrix; gelatin; gelation; hyaluronic acid; hydrogels; peroxidase; protein-glutamine gamma-glutamyltransferase; rheometers; strength (mechanics); tissue engineering; tyramine; water content
Abstract:: ... Hydrogels that mimic the extracellular matrix in both composition and crosslinking chemistry have great potential in the development of tissue engineering scaffolds. Natural polymer hydrogels crosslinked by enzymes have excellent biocompatibility due to their natural origin and the mild reaction conditions, but usually suffer from a lack of mechanical strength. In order to improve the mechanical p ...
DOI:: 10.1039/c4ra12446d
: https://doi.org/10.1039/c4ra12446d

55. Bilayered nanofibrous 3D hierarchy as skin rudiment by emulsion electrospinning for burn wound management

Author:: Pallabi Pal; Prabhash Dadhich; Pavan Kumar Srivas; Bodhisatwa Das; Dhrubajyoti Maulik; Santanu Dhara
Source:: Biomaterials science 2017 v.5 no.9 pp. 1786-1799
ISSN:: 2047-4849
Subject:: Cirrhinus cirrhosus; animal models; burns (injuries); cell adhesion; coatings; collagen; cost effectiveness; emulsions; extracellular matrix; fibroblasts; keratinocytes; mixing; nanofibers; porosity; protein synthesis; scales (integument)
Abstract:: ... Mimicking skin extracellular matrix hierarchy, the present work aims to develop a bilayer skin graft comprising a porous cotton-wool-like 3D layer with membranous structure of PCL–chitosan nanofibers. Emulsion electrospinning with differential stirring periods of PCL–chitosan emulsion results in development of a bilayer 3D structure with varied morphology. The electrospun membrane has fiber diamet ...
DOI:: 10.1039/c7bm00174f
: https://doi.org/10.1039/c7bm00174f

56. Bio-active molecules modified surfaces enhanced mesenchymal stem cell adhesion and proliferation

Author:: Rezvan Mobasseri; Lingling Tian; Masoud Soleimani; Seeram Ramakrishna; Hossein Naderi-Manesh
Source:: Biochemical and biophysical research communications 2017 v.483 pp. 312-317
ISSN:: 0006-291X
Subject:: adhesion; bone marrow; cell adhesion; cell culture; cell proliferation; collagen; confocal microscopy; cultured cells; extracellular matrix; fibronectins; glass; peptides; pseudopodia; scanning electron microscopy; signal transduction; stem cells; tissue culture; tissue engineering
Abstract:: ... Surface modification of the substrate as a component of in vitro cell culture and tissue engineering, using bio-active molecules including extracellular matrix (ECM) proteins or peptides derived ECM proteins can modulate the surface properties and thereby induce the desired signaling pathways in cells. The aim of this study was to evaluate the behavior of human bone marrow mesenchymal stem cells ( ...
DOI:: 10.1016/j.bbrc.2016.12.146
: https://doi.org/10.1016/j.bbrc.2016.12.146

57. Bio-artificial tongue with tongue extracellular matrix and primary taste cells

Author:: Jung Seung Lee; Ann-Na Cho; Yoonhee Jin; Jin Kim; Suran Kim; Seung-Woo Cho
Source:: Biomaterials 2017 pp. -
ISSN:: 0142-9612
Subject:: cell adhesion; cell culture; electronic tongue; extracellular matrix; gene expression; lipids; manufacturing; models; neurons; polymers; taste; tongue; transmission electron microscopy
Abstract:: ... Artificial taste devices for tastant sensing and taste information standardization are attracting increasing attention with the exponential growth of the food and beverage industries. Despite recent developments in artificial taste sensors incorporating polymers, lipid membranes, and synthetic vesicles, current devices have limited functionality and sensitivity, and are complex to manufacture. Mor ...
DOI:: 10.1016/j.biomaterials.2017.10.019
: https://doi.org/10.1016/j.biomaterials.2017.10.019

58. Bioaccumulation and reproductive toxicity of bisphenol A in male-pregnant seahorse (Hippocampus erectus) at environmentally relevant concentrations

Author:: Yali Liu; Yongli Wu; Geng Qin; Yu Chen; Xin Wang; Qiang Lin
Source:: Science of the total environment 2021 v.753 pp. 141805
ISSN:: 0048-9697
Subject:: Hippocampus erectus; adults; apoptosis; bioaccumulation; bisphenol A; cell adhesion; environment; extracellular matrix; histology; indicator species; reproductive toxicology; toxicity; transcription (genetics); transcriptomics
Abstract:: ... Seahorses, with brood pouch in adult males, are a bioindicator species that exhibit specialized reproductive strategy of “male pregnancy”. Bisphenol A (BPA), one of the most pervasive endocrine-disrupting chemicals (EDCs), is hazardous for reproductive, immune, and neurological systems. However, no evidence of BPA toxicity to the male-pregnant animals is available. Herein, the reproductive toxicit ...
DOI:: 10.1016/j.scitotenv.2020.141805
: https://doi.org/10.1016/j.scitotenv.2020.141805

59. Bioactive films produced from self-assembling peptide amphiphiles as versatile substrates for tuning cell adhesion and tissue architecture in serum-free conditions

Author:: Ricardo M. Gouveia; Valeria Castelletto; Simon G. Alcock; Ian W. Hamley; Che J. Connon
Source:: Journal of materials chemistry B 2013 v.1 no.44 pp. 6157-6169
ISSN:: 2050-7518
Subject:: adhesion; biocompatible materials; biomimetics; blood serum; cell adhesion; cell structures; chemistry; coatings; cornea; extracellular matrix; fibroblasts; humans; manufacturing; medicine; peptides; polytetrafluoroethylene; surfactants; therapeutics; tissue engineering; viability
Abstract:: ... The development of versatile bioactive surfaces able to emulate in vivo conditions is of enormous importance to the future of cell and tissue therapy. Tuning cell behaviour on two-dimensional surfaces so that the cells perform as if they were in a natural three-dimensional tissue represents a significant challenge, but one that must be met if the early promise of cell and tissue therapy is to be f ...
DOI:: 10.1039/c3tb21031f
: https://doi.org/10.1039/c3tb21031f

60. Biodegradation-Resistant Multilayers Coated with Gold Nanoparticles. Toward a Tailor-made Artificial Extracellular Matrix

Author:: Prokopović Vladimir Z.; Vikulina Anna S.; Sustr David; Duschl Claus; Volodkin Dmitry
Source:: ACS applied materials 2016 v.8 no.37 pp. 24345-24349
ISSN:: 1944-8252
Subject:: biodegradation; cell culture; coatings; extracellular matrix; hyaluronic acid; lysozyme; models; nanogold; nanoparticles; polymers; tissue engineering
Abstract:: ... Polymer multicomponent coatings such as multilayers mimic an extracellular matrix (ECM) that attracts significant attention for the use of the multilayers as functional supports for advanced cell culture and tissue engineering. Herein, biodegradation and molecular transport in hyaluronan/polylysine multilayers coated with gold nanoparticles were described. Nanoparticle coating acts as a semipermea ...
DOI:: 10.1021/acsami.6b10095
: https://doi.org/10.1021/acsami.6b10095

61. Biofilms of Pseudomonas and Lysinibacillus Marine Strains on High-Density Polyethylene

Author:: Maiara Monteiro Oliveira; Audrey Menegaz Proenca; Eduardo Moreira-Silva; Aline Machado de Castro; Francine Melise dos Santos; Letícia Marconatto; Renata Medina-Silva
Source:: Microbial ecology 2021 v.81 no.4 pp. 833-846
ISSN:: 0095-3628
Subject:: Lysinibacillus; Pseudomonas aeruginosa; adhesion; bacterial colonization; biodegradation; biofilm; biomass; cell adhesion; durability; environmental fate; extracellular matrix; marine sediments; nanoplastics; pollution; polyethylene
Abstract:: ... Environmental pollution by plastic debris is estimated on a scale of 100 million metric tons, a portion of which is fragmented into micro- and nanoplastics. These fragments are often colonized by bacterial species in marine environments, possibly contributing to the biodegradation of such materials. However, further investigations are necessary to determine the impact of abiotic polymer weathering ...
DOI:: 10.1007/s00248-020-01666-8
: https://doi.org/10.1007/s00248-020-01666-8

62. Biofunctionalization of titanium with PEG and anti-CD34 for hemocompatibility and stimulated endothelialization

Author:: Jialong Chen; Jianjun Cao; Juan Wang; Manfred F. Maitz; Lisa Guo; Yuancong Zhao; Quanli Li; Kaiqin Xiong; Nan Huang
Source:: Journal of colloid and interface science 2012 v.368 no.1 pp. 636-647
ISSN:: 0021-9797
Subject:: adhesion; antibodies; blood platelets; cell adhesion; cell culture; coatings; extracellular matrix; macrophage activation; medical equipment; polyethylene glycol; proteins; smooth muscle; stem cells; thrombosis; titanium
Abstract:: ... Thrombosis and restenosis are the main causes of failure of cardiovascular and other blood-contacting biomedical devices. It is recognized that rapid endothelialization is a promising method for preventing these complications. Convincing evidence in vivo has further emerged that the vascular homing of endothelial progenitor cells (EPCs) contributes to rapid endothelial regeneration. This study dea ...
DOI:: 10.1016/j.jcis.2011.11.039
: https://doi.org/10.1016/j.jcis.2011.11.039

63. Biofunctionalized and self-supported polypyrrole frameworks as nanostructured ECM-like biointerfaces

Author:: Damien Lefèvre; Juliette Louvegny; Mathieu Naudin; Etienne Ferain; Christine Dupont-Gillain; Sophie Demoustier-Champagne
Source:: RSC advances 2018 v.8 no.41 pp. 22932-22943
ISSN:: 2046-2069
Subject:: biocompatible materials; cell adhesion; coatings; collagen; extracellular matrix; hyaluronic acid; nanopores; nanotubes; polymerization; porosity; pyrroles; tissues
Abstract:: ... Hybrid nanobiointerfaces were designed as an original contribution to the challenge of synthesizing nanostructured biomaterials integrating a set of cell fate-determining cues, originally provided to cells by the extracellular matrix (ECM). The produced biointerfaces consist of a stiff framework of intersected polypyrrole (PPy) nanotubes supporting a soft multilayer composed of ECM-derived biomacr ...
DOI:: 10.1039/c8ra00325d
: https://doi.org/10.1039/c8ra00325d

64. Bioinspired titanium coatings: self-assembly of collagen–alginate films for enhanced osseointegration

Author:: Danijela Gregurec; Guocheng Wang; Ricardo H. Pires; Marija Kosutic; Tanja Lüdtke; Mihaela Delcea; Sergio Enrique Moya
Source:: Journal of materials chemistry B 2016 v.4 no.11 pp. 1978-1986
ISSN:: 2050-7518
Subject:: alginates; bioactive properties; biofilm; biopolymers; cell adhesion; coatings; collagen; crosslinking; extracellular matrix; mechanical properties; osteoblasts; prostheses; titanium; titanium dioxide
Abstract:: ... Achieving long term osseointegration is fundamental to the development of successful bone implants. A key aspect for improving long term osseointegration on titania surfaces is to gain control of nano- and microscale features. The so called biological approach is applied here to modify the surface of titania by coating it with a self-assembled and chemically crosslinked biopolymer film made of alg ...
DOI:: 10.1039/c6tb00204h
: https://doi.org/10.1039/c6tb00204h

65. Biological Responses and Mechanisms of Human Bone Marrow Mesenchymal Stem Cells to Zn and Mg Biomaterials

Author:: Zhu Donghui; Su Yingchao; Young Marcus L.; Ma Jun; Zheng Yufeng; Tang Liping
Source:: ACS applied materials & interfaces 2017 v.9 no.33 pp. 27453-27461
ISSN:: 1944-8252
Subject:: alizarin; alloys; biocompatibility; biocompatible materials; bone formation; bone marrow; calcium; cell adhesion; cell communication; cell viability; collagen; cytoskeleton; extracellular matrix; genes; humans; magnesium; mechanical properties; mineralization; mitogen-activated protein kinase; osteopontin; quantitative polymerase chain reaction; receptors; staining; stem cells; zinc
Abstract:: ... Zn biomaterials attract strong attentions recently for load-bearing medical implants because of their mechanical properties similar to bone, biocompatibility, and degradability at a more matched rate to tissue healing. It has been shown previously that Zn alloys are beneficial for bone regeneration, but the supporting mechanisms have not been explored in detail. Here, we studied the biological res ...
DOI:: 10.1021/acsami.7b06654
: https://doi.org/10.1021/acsami.7b06654

66. Biological control for rice blast disease by employing detachment action with gelatinolytic bacteria

Author:: Shimoi, Saki; Inoue, Kanako; Kitagawa, Hiroko; Yamasaki, Masanori; Tsushima, Seiya; Park, Pyoyun; Ikeda, Kenichi
Source:: Biological control 2010 v.55 no.2 pp. 85-91
ISSN:: 1049-9644
Subject:: metalloproteinases; Oryza sativa; Acidovorax; cations; spore germination; extracellular matrix; cell adhesion; fungal antagonists; Magnaporthe; Chryseobacterium; ribosomal DNA; Sphingomonas; leaves; blast disease; chelating agents; host plants; disease control; collagen; enzyme activity; Pseudomonas; bacteria
Abstract:: ... We screened collagenolytic/gelatinolytic bacteria from rice leaves and soil which degraded the fungal extracellular matrix to establish a novel biological control measure inhibiting germling adhesion on the host plant surface against airborne fungal diseases such as rice blast disease Magnaporthe oryzae B. Coch. Two different screening methods, i.e., screening from the leaf-associated bacterial li ...
DOI:: 10.1016/j.biocontrol.2010.07.008
: https://doi.org/10.1016/j.biocontrol.2010.07.008

67. Biomaterials in regenerative medicine: engineering to recapitulate the natural

Author:: Robert P Keatch; Ana M Schor; Jan B Vorstius; Seth L Schor
Source:: Current opinion in biotechnology 2012 v.23 no.4 pp. 579-582
ISSN:: 0958-1669
Subject:: biocompatible materials; cell adhesion; engineering; extracellular matrix; gene expression; homeostasis; medicine
Abstract:: ... The functional significance of the extracellular matrix (ECM) has generally been defined in terms of the provision of a structural support for cell adhesion and the establishment of tissue physical integrity. Recent evidence has, however, led to a paradigm shift according to which the ECM is increasingly recognised to exert a profound influence on cell behaviour, including gene expression, migrati ...
DOI:: 10.1016/j.copbio.2012.01.017
: https://doi.org/10.1016/j.copbio.2012.01.017

68. Biomembrane-mimicking lipid bilayer system as a mechanically tunable cell substrate

Author:: Lena A. Lautscham; Corey Y. Lin; Vera Auernheimer; Christoph A. Naumann; Wolfgang H. Goldmann; Ben Fabry
Source:: Biomaterials 2014 v.35 pp. 3198-3207
ISSN:: 0142-9612
Subject:: cell adhesion; extracellular matrix; fibroblasts; glass; ligands; lipid bilayers; mechanical properties; polyacrylamide; viscoelasticity
Abstract:: ... Cell behavior such as cell adhesion, spreading, and contraction critically depends on the elastic properties of the extracellular matrix. It is not known, however, how cells respond to viscoelastic or plastic material properties that more closely resemble the mechanical environment cells encounter in the body. In this report, we employ viscoelastic and plastic biomembrane-mimicking cell substrates ...
DOI:: 10.1016/j.biomaterials.2013.12.091
PubMed:: 24439398
PubMed Central:: PMC4026006
: https://doi.org/10.1016/j.biomaterials.2013.12.091

69. Biomimetic Carbon Fiber Systems Engineering: A Modular Design Strategy To Generate Biofunctional Composites from Graphene and Carbon Nanofibers

Author:: Mohammadreza Taale; Fabian Schütt; Tian Carey; Janik Marx; Yogendra Kumar Mishra; Norbert Stock; Bodo Fiedler; Felice Torrisi; Rainer Adelung; Christine Selhuber-Unkel
Source:: ACS applied materials & interfaces 2019 v.11 no.5 pp. 5325-5335
ISSN:: 1944-8252
Subject:: adsorption; biocompatible materials; biomimetics; carbon fibers; carbon nanofibers; carbon nanotubes; cell adhesion; cell viability; ceramics; dispersions; electrical conductivity; extracellular matrix; fibroblasts; graphene; hydrolysis; microstructure; modulus of elasticity; porosity; systems engineering; vapors; zinc oxide
Abstract:: ... Carbon-based fibrous scaffolds are highly attractive for all biomaterial applications that require electrical conductivity. It is additionally advantageous if such materials resembled the structural and biochemical features of the natural extracellular environment. Here, we show a novel modular design strategy to engineer biomimetic carbon fiber-based scaffolds. Highly porous ceramic zinc oxide (Z ...
DOI:: 10.1021/acsami.8b17627
PubMed:: 30600988
PubMed Central:: PMC6369718
: https://doi.org/10.1021/acsami.8b17627

70. Biomimetic Poly(ethylene glycol)-Based Hydrogels as Scaffolds for Inducing Endothelial Adhesion and Capillary-Like Network Formation

Author:: Zhu Junmin; He Ping; Lin Lin; Jones Derek R.; Marchant Roger E.
Source:: Biomacromolecules 2012 v.13 no.3 pp. 706-713
ISSN:: 1526-4602
Subject:: adhesion; biodegradability; biomimetics; cell adhesion; collagen; collagenase; endothelial cells; extracellular matrix; humans; hydrogels; models; polyethylene glycol; tissue engineering; umbilical veins
Abstract:: ... The extracellular matrix (ECM) is an attractive model for designing synthetic scaffolds with a desirable environment for tissue engineering. Here, we report on the synthesis of ECM-mimetic poly(ethylene glycol) (PEG) hydrogels for inducing endothelial cell (EC) adhesion and capillary-like network formation. A collagen type I-derived peptide GPQGIAGQ (GIA)-containing PEGDA (GIA-PEGDA) was synthesiz ...
DOI:: 10.1021/bm201596w
PubMed:: 22296572
PubMed Central:: PMC3310151
: https://doi.org/10.1021/bm201596w

71. Biomimetic hybrid scaffold consisting of co-electrospun collagen and PLLCL for 3D cell culture

Author:: Esra Türker; Ümit Hakan Yildiz; Ahu Arslan Yildiz
Source:: International journal of biological macromolecules 2019 v.139 pp. 1054-1062
ISSN:: 0141-8130
Subject:: adsorption; aqueous solutions; biodegradation; biomimetics; cell adhesion; cell culture; cell proliferation; cell viability; collagen; extracellular matrix; fibroblasts; lactones; mice; polyvinylpyrrolidone; solvents; tissue engineering; toxicity
Abstract:: ... Electrospun collagen is commonly used as a scaffold in tissue engineering applications since it mimics the content and morphology of native extracellular matrix (ECM) well. This report describes “toxic solvent free” fabrication of electrospun hybrid scaffold consisting of Collagen (Col) and Poly(l-lactide-co-ε-caprolactone) (PLLCL) for three-dimensional (3D) cell culture. Biomimetic hybrid scaffol ...
DOI:: 10.1016/j.ijbiomac.2019.08.082
: https://doi.org/10.1016/j.ijbiomac.2019.08.082

72. Biomimetic interconnected porous keratin–fibrin–gelatin 3D sponge for tissue engineering application

Author:: Sivakumar Singaravelu; Giriprasath Ramanathan; M.D. Raja; Naveen Nagiah; P. Padmapriya; Krishnasamy Kaveri; Uma Tiruchirapalli Sivagnanam
Source:: International journal of biological macromolecules 2016 v.86 pp. 810-819
ISSN:: 0141-8130
Subject:: biocompatibility; biomimetics; cell adhesion; cell growth; cell proliferation; drugs; extracellular matrix; fibrin; fibroblasts; freeze drying; gelatin; humans; keratin; keratinocytes; mechanical properties; scanning electron microscopy; solvents; tissue engineering; tissue repair
Abstract:: ... The medicated wound dressing material with highly interconnected pores, mimicking the function of the extracellular matrix was fabricated for the promotion of cell growth. In this study, keratin (K), fibrin (F) and gelatin (G) composite scaffold (KFG-SPG) was fabricated by freeze drying technique and the mupirocin (D) drug was successfully incorporated with KFG-SPG (KFG-SPG-D) intended for tissue ...
DOI:: 10.1016/j.ijbiomac.2016.02.021
: https://doi.org/10.1016/j.ijbiomac.2016.02.021

73. Biomimetic microspheres for 3D mesenchymal stem cell culture and characterization

Author:: Sandra Clara-Trujillo; Juan Carlos Marín-Payá; Lourdes Cordón; Amparo Sempere; Gloria Gallego Ferrer; José Luis Gómez Ribelles
Source:: Colloids and surfaces 2019 v.177 pp. 68-76
ISSN:: 0927-7765
Subject:: acrylates; acrylic acid; adhesion; biomimetics; cell adhesion; cell culture; cell proliferation; coatings; colloids; composite polymers; extracellular matrix; fibronectins; hyaluronic acid; magnetism; mesenchymal stromal cells; microparticles; stem cells; swine
Abstract:: ... Stem cells reside in niches, specialized microenvironments that sustain and regulate their fate. Extracellular matrix (ECM), paracrine factors or other cells are key niche regulating elements. As the conventional 2D cell culture lacks these elements, it can alter the properties of naïve stem cells. In this work we designed a novel biomimetic microenvironment for cell culture, consisting of magneti ...
DOI:: 10.1016/j.colsurfb.2019.01.050
: https://doi.org/10.1016/j.colsurfb.2019.01.050

74. Biomimetic multifactor stimulation method for analyzing the synergism of matrix stiffness and inorganic polyphosphates on cellular behaviors

Author:: Xiaonan Zheng; Yucheng Sun; Haifang Li; Nan Li; Xueji Zhang; Jin-Ming Lin
Source:: Talanta 2022 v.241 pp. 123222
ISSN:: 0039-9140
Subject:: biomechanics; biomimetics; carcinogenesis; cell adhesion; cell culture; drugs; energy; extracellular matrix; glioma; metabolism; phagocytosis; polyphosphates; synergism
Abstract:: ... In the process of tumorigenesis and development, cancer cells must integrate and respond to complex and dynamic signals in the tumor microenvironment. Nevertheless, simulating the original biomechanical and biochemical microenvironment of different cells in vitro is a fundamental challenge in studying synergistic effects. To address this issue, we have proposed a biomimetic multi-factor stimulatio ...
DOI:: 10.1016/j.talanta.2022.123222
: https://doi.org/10.1016/j.talanta.2022.123222

75. Biomimetic nanofibrous scaffolds for bone tissue engineering

Author:: Jeremy M. Holzwarth; Peter X. Ma
Source:: Biomaterials 2011 v.32 no.36 pp. 9622-9629
ISSN:: 0142-9612
Subject:: biomimetics; cell adhesion; cell differentiation; collagen; extracellular matrix; growth factors; hydroxyapatite; separation; stem cells; tissue engineering
Abstract:: ... Bone tissue engineering is a highly interdisciplinary field that seeks to tackle the most challenging bone-related clinical issues. The major components of bone tissue engineering are the scaffold, cells, and growth factors. This review will focus on the scaffold and recent advancements in developing scaffolds that can mimic the natural extracellular matrix of bone. Specifically, these novel scaff ...
DOI:: 10.1016/j.biomaterials.2011.09.009
PubMed:: 21944829
PubMed Central:: PMC3195926
: https://doi.org/10.1016/j.biomaterials.2011.09.009

76. Bionic composite hydrogel with a hybrid covalent/noncovalent network promoting phenotypic maintenance of hyaline cartilage

Author:: Qing Wang; Xing Li; Peilei Wang; Ya Yao; Yang Xu; Yafang Chen; Yong Sun; Qing Jiang; Yujiang Fan; Xingdong Zhang
Source:: Journal of materials chemistry B 2020 v.8 no.20 pp. 4402-4411
ISSN:: 2050-7518
Subject:: animals; cartilage; cell adhesion; coculture; collagen; extracellular matrix; gene expression; hyaluronic acid; hydrogels; hydrogen; hydrophilicity; hydrophobicity; immunogenicity; peptides; phenotype; polymers; secretion; strength (mechanics)
Abstract:: ... The injectable composite hydrogel based on collagen and hyaluronic acid provided a bionic three-dimensional microenvironment and mimetic natural extracellular matrix (ECM) for the growth of cells in vivo and has been widely researched and developed for cartilage tissue engineering. Here, a novel injectable bionic hydrogel with hybrid covalent/noncovalent network derived from covalent conjugation o ...
DOI:: 10.1039/d0tb00253d
: https://doi.org/10.1039/d0tb00253d

77. Biophysical characteristics of cells cultured on cholesteryl ester liquid crystals

Author:: Chin Fhong Soon; Wan Ibtisam Wan Omar; Rebecca F. Berends; Nafarizal Nayan; Hatijah Basri; Kian Sek Tee; Mansour Youseffi; Nick Blagden; Morgan Clive Thomas Denyer
Source:: Micron 2014 v.56 pp. 73-79
ISSN:: 0968-4328
Subject:: Fourier transform infrared spectroscopy; atomic force microscopy; cell adhesion; cell culture; cell membranes; cholesterol; collagen; culture media; cultured cells; extracellular matrix; fibronectins; glass; humans; image analysis; integrins; keratinocytes; laminin; liquid crystals; physicochemical properties; surface roughness
Abstract:: ... This study aimed at examining the biophysical characteristics of human derived keratinocytes (HaCaT) cultured on cholesteryl ester liquid crystals (CELC). CELC was previously shown to improve sensitivity in sensing cell contractions. Characteristics of the cell integrin expressions and presence of extracellular matrix (ECM) proteins on the liquid crystals were interrogated using various immunocyto ...
DOI:: 10.1016/j.micron.2013.10.011
: https://doi.org/10.1016/j.micron.2013.10.011

78. Biotin–Avidin Based Universal Cell–Matrix Interaction for Promoting Three-Dimensional Cell Adhesion

Author:: Dou Xiao-Qiu; Zhang Jia; Feng Chuanliang
Source:: ACS Applied Materials & Interfaces 2015 v.7 no.37 pp. 20786-20792
ISSN:: 1944-8252
Subject:: adhesion; avidin; cell adhesion; denaturation; encapsulation; extracellular matrix; gene expression; hydrogels; nanofibers; reverse transcriptase polymerase chain reaction
Abstract:: ... To promote cell adhesion in three-dimensional (3D) extracellular matrix (ECM) is crucial for avoiding cell anoikis, which is one of the most important issues for fundamental cell biology. Herein, a biotin–avidin based universal cell–matrix interaction for different types of cells is developed in order to achieve the promoted adhesion in 3D ECM. For the purpose, biotinylated nanofibrous hydrogels a ...
DOI:: 10.1021/acsami.5b05828
: https://doi.org/10.1021/acsami.5b05828

79. Blocking Integrin Activation at the α Subunit

Author:: Nancy R. Gough
Source:: Science signaling 2011 v.4 no.198 pp. ec309
ISSN:: 1937-9145
Subject:: CD29 antigen; adhesion; antibodies; cell adhesion; cell movement; cultured cells; energy transfer; extracellular matrix; fibronectins; fluorescence; genes; keratinocytes; ligands; mice; mutation; peptides; precipitin tests; splenocytes; talin
Abstract:: ... Integrins are heterodimers of α and β subunits that control cellular adhesion to extracellular matrix proteins. The activity state of integrins is dynamically regulated to enable cells to migrate, divide, or remain stationary depending on the context and extracellular signals. Integrins can adopt three conformations—two that are inactive with low to moderate ligand affinity and one with high affin ...
DOI:: 10.1126/scisignal.4198ec309
: https://doi.org/10.1126/scisignal.4198ec309

80. Bone tissue response induced by bioactive polymer functionalized Ti6Al4V surfaces: In vitro and in vivo study

Author:: Helena P. Felgueiras; Adeline Decambron; Mathieu Manassero; Louise Tulasne; Margaret D.M. Evans; Véronique Viateau; Véronique Migonney
Source:: Journal of colloid and interface science 2017 v.491 pp. 44-54
ISSN:: 0021-9797
Subject:: bone formation; bone morphogenetic proteins; bones; cell adhesion; cell differentiation; collagen; extracellular matrix; hydroxyapatite; in vivo studies; mineralization; orthopedics; polymers; rabbits; sodium; styrene
Abstract:: ... Ti6Al4V is commonly used for orthopedic applications. This study was designed to test the potentially added benefit of Ti6Al4V functionalized with a bioactive polymer poly(sodium styrene sulfonate) both in vitro and in vivo. Cell-based assays with MC3T3-E1 osteoblast-like cells were used to measure the cell adhesion strength, cell spreading, focal contact formation, cell differentiation and the mi ...
DOI:: 10.1016/j.jcis.2016.12.023
: https://doi.org/10.1016/j.jcis.2016.12.023

81. Bottom up proteomics reveals novel differentiation proteins in neuroblastoma cells treated with 13-cis retinoic acid

Author:: Effie G. Halakos; Andrew J. Connell; Lisa Glazewski; Shuo Wei; Robert W. Mason
Source:: Journal of proteomics 2019 pp. -
ISSN:: 1874-3919
Subject:: bioinformatics; biomarkers; biosynthesis; cell adhesion; cell differentiation; collagen; extracellular matrix; metastasis; neoplasm cells; neoplasms; neurites; patients; proteome; proteomics; remission; retinoic acid; sympathetic nervous system
Abstract:: ... Neuroblastoma, a cancer of the sympathetic nervous system, is the second most common pediatric cancer. A unique feature of neuroblastoma is remission in some patients due to spontaneous differentiation of metastatic tumors. 13-cis retinoic acid (13-cis RA) is currently used in the clinic to treat neuroblastoma due to its differentiation inducing effects. In this study, we used shotgun proteomics t ...
DOI:: 10.1016/j.jprot.2019.103491
PubMed:: 31472280
PubMed Central:: PMC7079284
: https://doi.org/10.1016/j.jprot.2019.103491

82. Boundary crossing in epithelial wound healing

Author:: Fong, Eileen; Tzlil, Shelly; Tirrell, David A.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.45 pp. 19302-19307
ISSN:: 0027-8424
Subject:: Monte Carlo method; cell adhesion; cell movement; cornea; cultured cells; epithelium; extracellular matrix; humans; ligands; models; proteins; tissue repair
Abstract:: ... The processes of wound healing and collective cell migration have been studied for decades. Intensive research has been devoted to understanding the mechanisms involved in wound healing, but the role of cell-substrate interactions is still not thoroughly understood. Here we probe the role of cell-substrate interactions by examining in vitro the healing of monolayers of human corneal epithelial (HC ...
DOI:: 10.1073/pnas.1008291107
PubMed:: 20974917
PubMed Central:: PMC2984212
: https://doi.org/10.1073/pnas.1008291107

83. CD44: More than a mere stem cell marker

Author:: I. Morath; T.N. Hartmann; V. Orian-Rousseau
Source:: international journal of biochemistry & cell biology 2016 v.81 pp. 166-173
ISSN:: 1357-2725
Subject:: carcinogenesis; cell adhesion; cytokines; extracellular matrix; growth factors; hyaluronic acid; metastasis; neoplasms; osteopontin; stem cells
Abstract:: ... CD44 is a cell adhesion molecule that plays an important role in tumor progression and metastasis. The role of CD44 in tumorigenesis is due to its binding to extracellular matrix components, including hyaluronan (HA) and osteopontin (OPN), and to messenger molecules, such as growth factors present in the tumor microenvironment. HA and OPN are highly abundant in the leukemic stem cell niche and in ...
DOI:: 10.1016/j.biocel.2016.09.009
: https://doi.org/10.1016/j.biocel.2016.09.009

84. CDH11 promotes liver fibrosis via activation of hepatic stellate cells

Author:: Wanyuan Ruan; Runsang Pan; Xiaoxu Shen; Yingjie Nie; Yayun Wu
Source:: Biochemical and biophysical research communications 2019 v.508 no.2 pp. 543-549
ISSN:: 0006-291X
Subject:: adherens junctions; carcinogenesis; cell adhesion; extracellular matrix; humans; liver; liver cirrhosis; mice; neoplasms; patients; tissues; transmembrane proteins
Abstract:: ... Liver fibrosis, an important health condition associated with chronic liver injury that provides a permissive environment for cancer development, is characterized by the persistent deposition of extracellular matrix components that are mainly derived from activated hepatic stellate cells (HSCs). CDH11 belongs to a group of transmembrane proteins that are principally located in adherens junctions. ...
DOI:: 10.1016/j.bbrc.2018.11.153
: https://doi.org/10.1016/j.bbrc.2018.11.153

85. Cadherin-11 coordinates cellular migration and extracellular matrix remodeling during aortic valve maturation

Author:: Caitlin J. Bowen; Jingjing Zhou; Derek C. Sung; Jonathan T. Butcher
Source:: Developmental biology 2015 v.407 no.1 pp. 145-157
ISSN:: 0012-1606
Subject:: CD29 antigen; adulthood; cadherins; calcification; cell adhesion; cell movement; extracellular matrix; locomotion; mice; mortality; phenotype; pseudopodia; small interfering RNA; transfection
Abstract:: ... Proper remodeling of the endocardial cushions into thin fibrous valves is essential for gestational progression and long-term function. This process involves dynamic interactions between resident cells and their local environment, much of which is not understood. In this study, we show that deficiency of the cell–cell adhesion protein cadherin-11 (Cad-11) results in significant embryonic and perin ...
DOI:: 10.1016/j.ydbio.2015.07.012
PubMed:: 26188246
PubMed Central:: PMC4841269
: https://doi.org/10.1016/j.ydbio.2015.07.012

86. Calcium and 1,25-dihydroxyvitamin D₃ modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial

Author:: Petr Protiva; Swaroop Pendyala; Celeste Nelson; Leonard H Augenlicht; Martin Lipkin; Peter R Holt
Source:: American journal of clinical nutrition 2016 v.103 no.5 pp. 1224-1231
ISSN:: 1938-3207
Subject:: Western diets; adaptive immunity; biopsy; blood serum; calcium; calcium carbonate; cell adhesion; clinical trials; colon; colorectal neoplasms; cross-over studies; extracellular matrix; gene expression; gene expression regulation; genes; humans; immune response; inflammation; interferons; mucosa; protocols; vitamin status
Abstract:: ... Background: A high dietary calcium intake with adequate vitamin D status has been linked to lower colorectal cancer risk, but the mechanisms of these effects are poorly understood. Objective: The objective of this study was to elucidate the effects of a Western-style diet (WD) and supplemental calcium and/or 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] on the colorectal mucosa. Design: We conducted 2 cr ...
DOI:: 10.3945/ajcn.114.105304
PubMed:: 27009752
PubMed Central:: PMC4841933
: https://doi.org/10.3945/ajcn.114.105304

87. Canine pre-iridal fibrovascular membranes: morphologic and immunohistochemical investigations

Author:: Zarfoss, Mitzi K.; Breaux, Carrie B.; Whiteley, Herbert E.; Hamor, Ralph E.; Flaws, Jodi A.; Labelle, Philippe; Dubielzig, Richard R.
Source:: Veterinary ophthalmology 2010 v.13 no.1 pp. 4-13
ISSN:: 1463-5216
Subject:: actin; adenoma; angiogenesis; cell adhesion; collagen; dog diseases; dogs; endothelial cells; extracellular matrix; eyes; immunohistochemistry; laminin; mucins; smooth muscle; vascular endothelial growth factors
Abstract:: ... Pathologic intraocular neovascularization is a key component of many canine ophthalmic diseases such as uveitis, retinal detachment, intraocular neoplasms, and corneal perforation. The purpose of this study was to evaluate the structure of pre-iridal fibrovascular membranes (PIFMs) associated with several different disease processes and to identify specific factors associated with their developmen ...
DOI:: 10.1111/j.1463-5224.2009.00739.x
PubMed:: 20149169
: https://doi.org/10.1111/j.1463-5224.2009.00739.x

88. Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins

Author:: Erinn S. Raborn; Melissa Jamerson; Francine Marciano-Cabral; Guy A. Cabral
Source:: Life sciences 2014 v.104 no.1-2 pp. 15-23
ISSN:: 0024-3205
Subject:: CD29 antigen; Human immunodeficiency virus 1; actin; adhesion; blood-brain barrier; cannabinoid receptors; cannabinoids; cell adhesion; extracellular matrix; gels; humans; laminin; monocytes; polymerization; therapeutics
Abstract:: ... The aim of this study was to assess the effect of select cannabinoids on human immunodeficiency virus type 1 (HIV-1) transactivating (Tat) protein-enhanced monocyte-like cell adhesion to proteins of the extracellular matrix (ECM).Collagen IV, laminin, or an ECM gel was used to construct extracellular matrix layers. Human U937 monocyte-like cells were exposed to Tat in the presence of ∆⁹-tetrahydro ...
DOI:: 10.1016/j.lfs.2014.04.008
PubMed:: 24742657
PubMed Central:: PMC4089388
: https://doi.org/10.1016/j.lfs.2014.04.008

89. Cardiac outflow tract development relies on the complex function of Sox4 and Sox11 in multiple cell types

Author:: Mandy H. Paul; Richard P. Harvey; Michael Wegner; Elisabeth Sock
Source:: Cellular and molecular life sciences 2014 v.71 no.15 pp. 2931-2945
ISSN:: 1420-682X
Subject:: mechanism of action; neural crest; cell adhesion; transcription factors; humans; congenital abnormalities; cytoskeleton; mice; heart; extracellular matrix
Abstract:: ... Congenital heart defects represent the most common human birth defects and are often life-threatening. Frequently, they are caused by abnormalities of the outflow tract whose formation results from coordinated development of cells from mesodermal and neural crest origin and depends on the activity of many different transcription factors. However, place, time, and mode of action have only been anal ...
DOI:: 10.1007/s00018-013-1523-x
: https://doi.org/10.1007/s00018-013-1523-x

90. Celiac disease patient IgA antibodies induce endothelial adhesion and cell polarization defects via extracellular transglutaminase 2

Author:: Cristina Antonella Nadalutti; Ilma Rita Korponay-Szabo; Katri Kaukinen; Martin Griffin; Markku Mäki; Katri Lindfors
Source:: Cellular and molecular life sciences 2014 v.71 no.7 pp. 1315-1326
ISSN:: 1420-682X
Subject:: CD29 antigen; adhesion; angiogenesis; apoptosis; autoantibodies; celiac disease; cell adhesion; cell movement; crosslinking; endothelial cells; enzyme activity; extracellular matrix; fibronectins; immunoglobulin A; patients; phenotype; protein-glutamine gamma-glutamyltransferase; secretion; signal transduction
Abstract:: ... We have recently found that celiac disease patient serum-derived autoantibodies targeted against transglutaminase 2 interfere with several steps of angiogenesis, including endothelial sprouting and migration, though the mechanism involved remained to be fully characterized. This study now investigated the processes underlying the antiangiogenic effects exerted by celiac disease patient antibodies ...
DOI:: 10.1007/s00018-013-1455-5
: https://doi.org/10.1007/s00018-013-1455-5

91. Cell Adhesion Characteristics on Tantalum Pentoxide Gate Insulator for Cultured-Cell-Gate Field-Effect Transistor

Author:: Hiroto Satake; Toshiya Sakata
Source:: Langmuir 2021 v.37 no.24 pp. 7548-7555
ISSN:: 1520-5827
Subject:: adhesion; adsorption; biocompatibility; biosensors; blood serum; cell adhesion; chondrocytes; collagen; electrodes; extracellular matrix; proteoglycans; surface tension; tantalum oxide; transistors
Abstract:: ... Understanding the interaction between living cells and a tantalum pentoxide (Ta₂O₅) gate electrode is important for controlling cell adhesion and functions when developing a cultured-cell-gate field-effect transistor biosensor. In this study, we evaluate the cell adhesion characteristics of the Ta₂O₅ membrane without or with a polydopamine (pDA) coating for chondrocytes, which is expected as a tre ...
DOI:: 10.1021/acs.langmuir.1c01044
: https://doi.org/10.1021/acs.langmuir.1c01044

92. Cell Growth on (“Janus”) Density Gradients of Bifunctional Zeolite L Crystals

Author:: Kehr Nermin Seda; Motealleh Andisheh; Schäfer Andreas H.
Source:: ACS Applied Materials & Interfaces 2016 v.8 no.51 pp. 35081-35090
ISSN:: 1944-8252
Subject:: biopolymers; cell adhesion; cell growth; crystals; extracellular matrix; fibroblasts; glass; nanoparticles; zeolites
Abstract:: ... Nanoparticle density gradients on surfaces have attracted interest as two-dimensional material surfaces that can mimic the complex nano-/microstructure of the native extracellular matrix, including its chemical and physical gradients, and can therefore be used to systematically study cell–material interactions. In this respect, we report the preparation of density gradients made of bifunctional ze ...
DOI:: 10.1021/acsami.6b13667
: https://doi.org/10.1021/acsami.6b13667

93. Cell Selective Apoptosis Induced by Polymorphic Alteration of Self-Assembled Silica Nanowebs

Author:: Keshavarz Meysam; Tan Bo; Venkatakrishnan Krishnan
Source:: ACS Applied Materials & Interfaces 2017 v.9 no.7 pp. 6292-6305
ISSN:: 1944-8252
Subject:: apoptosis; biocompatibility; biomarkers; cell adhesion; crystal structure; drug carriers; endocytosis; energy; engineering; extracellular matrix; fibroblasts; ionization; mammals; nanoparticles; neoplasms; silica; silicon
Abstract:: ... The biocompatibility of silicon-based nanomaterials makes them suitable for biophysical and biomedical applications. However, the application of silicon-based nanomaterials has been mainly restricted to nanoparticles (NPs) as a potential drug carrier and the extracellular matrix (ECM) as a platform for cell adhesion and proliferation. Here, we introduce silica NPs self-assembled into a 3D nanoweb ...
DOI:: 10.1021/acsami.6b14836
: https://doi.org/10.1021/acsami.6b14836

94. Cell adhesion and invasion inhibitory effect of an ovarian cancer targeting peptide selected via phage display in vivo

Author:: Ximing Pu; Chuying Ma; Guangfu Yin; Fei You; Yan Wei
Source:: Biochemical and biophysical research communications 2014 v.443 pp. 858-863
ISSN:: 0006-291X
Subject:: animal ovaries; bacteriophages; cell adhesion; extracellular matrix; metastasis; neoplasm cells; ovarian neoplasms
Abstract:: ... Organ-specific metastasis is of great importance since most of the cancer deaths are caused by spread of the primary cancer to distant sites. Therefore, targeted anti-metastases therapies are needed to prevent cancer cells from metastasizing to different organs. The phage clone pc3-1 displaying peptide WSGPGVWGASVK selected by phage display had been identified which have high binding efficiency an ...
DOI:: 10.1016/j.bbrc.2013.12.058
: https://doi.org/10.1016/j.bbrc.2013.12.058

95. Cell adhesion mechanisms on laterally mobile polymer films

Author:: Andreas P. Kourouklis; Ronald V. Lerum; Harry Bermudez
Source:: Biomaterials 2014 v.35 no.17 pp. 4827-4834
ISSN:: 0142-9612
Subject:: adhesion; biomimetics; cell adhesion; composite polymers; extracellular matrix; fibroblasts; films (materials); focal adhesions; hydrophobicity; integrins; ligands; quantitative analysis
Abstract:: ... In contrast with the majority of substrates used to study cell adhesion, the natural extracellular matrix (ECM) is dynamic and remodeled over time. Here we use amphiphilic block copolymers to create self-assembled supported films with tunable lateral mobility. These films are intended to serve as partial mimics of the ECM in order to better understand cell adhesion responses, specifically in the c ...
DOI:: 10.1016/j.biomaterials.2014.02.052
: https://doi.org/10.1016/j.biomaterials.2014.02.052

96. Cell adhesion on an artificial extracellular matrix using aptamer-functionalized PEG hydrogels

Author:: Niancao Chen; Zhaoyang Zhang; Boonchoy Soontornworajit; Jing Zhou; Yong Wang
Source:: Biomaterials 2012 v.33 no.5 pp. 1353-1362
ISSN:: 0142-9612
Subject:: adhesion; biocompatible materials; cell adhesion; cell viability; extracellular matrix; hydrocolloids; mechanical properties; medicine; nucleic acids; oligonucleotides; polyethylene glycol; polymerization
Abstract:: ... The development of an artificial extracellular matrix (ECM) is important to regenerative medicine because the ECM plays complex and dynamic roles in the regulation of cell behavior. In this study, nucleic acid aptamers were applied to functionalize hydrogels for mimicking the adhesion sites of the ECM. The results showed that nucleic acid aptamers could be incorporated into polyethylene glycol (PE ...
DOI:: 10.1016/j.biomaterials.2011.10.062
: https://doi.org/10.1016/j.biomaterials.2011.10.062

97. Cell adhesion properties of neural stem cells in the chick embryo

Author:: David R. Canning; Rebecca L. Cunningham
Source:: In vitro cellular & developmental biology 2015 v.51 no.5 pp. 507-514
ISSN:: 1071-2690
Subject:: adhesion; cell adhesion; chickens; chicks; chondroitin sulfate; embryo (animal); extracellular matrix; gastrulation; in vitro studies; nervous system; stem cells
Abstract:: ... The nervous system of vertebrates is derived from an early embryonic region referred to as the neural plate. In the chick embryo, the neural plate is populated by neural stem cells specified from the epiblast shortly after the onset of gastrulation. Accompanying the formation of the plate, chondroitin sulfate glycosaminoglycans are expressed in the basal extracellular matrix. We describe in vitro ...
DOI:: 10.1007/s11626-014-9851-1
: https://doi.org/10.1007/s11626-014-9851-1

98. Cell adhesion tunes inflammatory TPL2 kinase signal transduction

Author:: Maria Vougioukalaki; Konstantina Georgila; Emmanouil I. Athanasiadis; Aristides G. Eliopoulos
Source:: Cellular and molecular life sciences 2022 v.79 no.3 pp. 156
ISSN:: 1420-682X
Subject:: cancer therapy; carcinoma; cell adhesion; cell death; extracellular matrix; fibroblasts; ligands; metastasis; mitogen-activated protein kinase kinase kinase; non-specific protein-tyrosine kinase; signal transduction; transcription (genetics); ubiquitin-protein ligase
Abstract:: ... Signaling through adhesion-related molecules is important for cancer growth and metastasis and cancer cells are resistant to anoikis, a form of cell death ensued by cell detachment from the extracellular matrix. Herein, we report that detached carcinoma cells and immortalized fibroblasts display defects in TNF and CD40 ligand (CD40L)-induced MEK-ERK signaling. Cell detachment results in reduced ba ...
DOI:: 10.1007/s00018-022-04130-7
: https://doi.org/10.1007/s00018-022-04130-7

99. Cell response on the biomimetic scaffold of silicon nano- and micro-topography

Author:: Shih-Ping Yang; Hsiang-Sheng Wen; Tzer-Min Lee; Truan-Sheng Lui
Source:: Journal of materials chemistry B 2016 v.4 no.10 pp. 1891-1897
ISSN:: 2050-7518
Subject:: biomarkers; biomimetics; cell adhesion; cell culture; cell proliferation; enzyme-linked immunosorbent assay; extracellular matrix; fibroblasts; fluorescent antibody technique; furnaces; mice; microfilaments; microrelief; nanomaterials; physicochemical properties; proteins; scanning electron microscopy; silicon; topology; vapors
Abstract:: ... Silicon scaffolds were synthesized in a low-pressure furnace via a vapor–liquid–solid (VLS) mechanism. Structural dimensions of silicon scaffolds were tunable in the synthesis to satisfy diverse requirements for cell culture applications. Cylindraceous SiNWs structurally resemble fibrous proteins in connective tissue and the extracellular matrix (ECM), which are main cell adhesion substrata in viv ...
DOI:: 10.1039/c5tb02361k
: https://doi.org/10.1039/c5tb02361k

100. Cell-ECM contact-guided intracellular polarization is mediated via lamin A/C dependent nucleus-cytoskeletal connection

Author:: Geonhui Lee; Seong-Beom Han; Dong-Hwee Kim
Source:: Biomaterials 2021 v.268 pp. 120548
ISSN:: 0142-9612
Subject:: biocompatible materials; cell adhesion; cell movement; cell polarity; cell proliferation; extracellular matrix; microtubules; organelles; signal transduction
Abstract:: ... Cell polarization plays a crucial role in dynamic cellular events, such as cell proliferation, differentiation, and directional migration in response to diverse extracellular and intracellular signals. Although it is well known that cell polarization entails highly orchestrated intracellular molecular reorganization, the underlying mechanism of repositioning by intracellular organelles in the pres ...
DOI:: 10.1016/j.biomaterials.2020.120548
: https://doi.org/10.1016/j.biomaterials.2020.120548

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1. 3,4-Methylenedioxy-β-nitrostyrene inhibits adhesion and migration of human triple-negative breast cancer cells by suppressing β1 integrin function and surface protein disulfide isomerase

2. 3D Microcontact Printing for Combined Chemical and Topographical Patterning on Porous Cell Culture Membrane

3. 3D Scaffolds with Different Stiffness but the Same Microstructure for Bone Tissue Engineering

4. 3D multi-layered fibrous cellulose structure using an electrohydrodynamic process for tissue engineering

5. 3D-Bioprinted Difunctional Scaffold for In Situ Cartilage Regeneration Based on Aptamer-Directed Cell Recruitment and Growth Factor-Enhanced Cell Chondrogenesis

6. A Citrus Extract Containing Flavanones Represses Plasminogen Activator Inhibitor-1 (PAI-1) Expression and Regulates Multiple Inflammatory, Tissue Repair, and Fibrosis Genes in Human Colon Fibroblasts

7. A Lymphocyte Serine Protease Granzyme A Causes Detachment of a Small-Intestinal Epithelial Cell Line (IEC-6)

8. A Multi-Omics Approach Identifies Key Regulatory Pathways Induced by Long-Term Zinc Supplementation in Human Primary Retinal Pigment Epithelium

9. A Novel Method to Produce Immobilised Biomolecular Concentration Gradients to Study Cell Activities: Design and Modelling

10. A Programmable Toolkit to Dynamically Signal Cells Using Peptide Strand Displacement

11. A Secreted Disulfide Catalyst Controls Extracellular Matrix Composition and Function

12. A Simple Approach for an Eggshell-Based 3D-Printed Osteoinductive Multiphasic Calcium Phosphate Scaffold

13. A gene expression-based comparison of cell adhesion to extracellular matrix and RGD-terminated monolayers

14. A guide to the composition and functions of the extracellular matrix

15. A liquid culture cancer spheroid model reveals low PI3K/Akt pathway activity and low adhesiveness to the extracellular matrix

16. A novel BSA immobilizing manner on modified titanium surface ameliorates osteoblast performance

17. A novel approach to prepare a tissue engineering decellularized valve scaffold with poly(ethylene glycol)–poly(ε-caprolactone)

18. A novel culture platform for fast proliferation of human annulus fibrosus cells

19. A quartz crystal microbalance based study reveals living cell loading rate via [formula omitted] integrins

20. A vascular injury model using focal heat-induced activation of endothelial cells

21. AT14A mediates the cell wall–plasma membrane–cytoskeleton continuum in Arabidopsis thaliana cells

22. Abrogated Cell Contact Guidance on Amino-Functionalized Microgrooves

23. Acetylcholinesterase in cell adhesion, neurite growth and network formation

24. Active loading graphite/hydroxyapatite into the stable hydroxyethyl cellulose scaffold nanofibers for artificial cornea application

25. Adhesion of fibroblast cells on thin films representing surfaces of polymeric scaffolds of human urethra rationalized by molecular models of integrin binding: cell adhesion on polymeric scaffolds for regenerative medicine

26. Adhesion profile and differentiation capacity of human adipose tissue derived mesenchymal stem cells grown on metal ion (Zn, Ag and Cu) doped hydroxyapatite nano-coated surfaces

27. Advanced gellan gum-based glycol chitosan hydrogel for cartilage tissue engineering biomaterial

28. Aire knockdown in medullary thymic epithelial cells affects Aire protein, deregulates cell adhesion genes and decreases thymocyte interaction

29. Alginate-based hydrogels with improved adhesive properties for cell encapsulation

30. Alternagin-C, an alpha2beta1 integrin ligand, attenuates collagen-based adhesion, stimulating the metastasis suppressor 1 expression in triple-negative breast tumor cells

31. Alternative splicing of Ikaros regulates the FUT4/LeX-α5β1 integrin-FAK axis in acute lymphoblastic leukemia

32. Ameliorative effect of methylthiouracil on TGFBIp-induced septic responses

33. Amphiphilic beads as depots for sustained drug release integrated into fibrillar scaffolds

34. Amyloid Fibrils: Versatile Biomaterials for Cell Adhesion and Tissue Engineering Applications

35. An Epigenetic Signature is Associated with Serum 25‐Hydroxyvitamin D in Colorectal Cancer Tumors

36. An Inhibitory Antibody Blocks the First Step in the Dithiol/Disulfide Relay Mechanism of the Enzyme QSOX1

37. An affinity-based approach to engineer laminin-presenting cell instructive microenvironments

38. An artificial membrane binding protein-polymer surfactant nanocomplex facilitates stem cell adhesion to the cartilage extracellular matrix

39. An in silico hybrid continuum-/agent-based procedure to modelling cancer development: Interrogating the interplay amongst glioma invasion, vascularity and necrosis

40. Analysis of a Blumeria graminis-Secreted Lipase Reveals the Importance of Host Epicuticular Wax Components for Fungal Adhesion and Development

41. Analysis of integrins and vascular endothelial growth factor isoforms mRNA expression in the canine uterus during perimplantation period

42. Analysis of protein-linked glycosylation in a sperm-somatic cell adhesion system

43. Analysis of the behavior of 2D monolayers and 3D spheroid human pancreatic beta cells derived from induced pluripotent stem cells in a microfluidic environment

44. Ancient origin of the integrin-mediated adhesion and signaling machinery

45. Anterior gradient 2 is involved in the post-transcriptional regulation of β-dystroglycan

46. Anti-metastatic activity of the recombinant disintegrin, r-mojastin 1, from the Mohave rattlesnake

47. Anti-tumor activity of staurosporine in the tumor microenvironment of cervical cancer: An in vitro study

48. Approaches in extracellular matrix engineering for determination of adhesion molecule mediated single cell function

49. Aqueous extracts and polysaccharides from Marshmallow roots (Althea officinalis L.): Cellular internalisation and stimulation of cell physiology of human epithelial cells in vitro

50. Arg-Gly-Asp-modified elastin-like polypeptide regulates cell proliferation and cell cycle proteins via the phosphorylation of Erk and Akt in pancreatic β-cell

51. Arginine-Presenting Peptide Hydrogels Decorated with Hydroxyapatite as Biomimetic Scaffolds for Bone Regeneration

52. Assessment of the Effects of Surface Potential on the Kinetics of HEK293T Cell Adhesion Behavior Using a Quartz Crystal Microbalance with Dissipation Monitoring

53. Bacterial cellulose nanofiber reinforced poly(glycerol-sebacate) biomimetic matrix for 3D cell culture

54. Bienzymatically crosslinked gelatin/hyaluronic acid interpenetrating network hydrogels: preparation and characterization

55. Bilayered nanofibrous 3D hierarchy as skin rudiment by emulsion electrospinning for burn wound management

56. Bio-active molecules modified surfaces enhanced mesenchymal stem cell adhesion and proliferation

57. Bio-artificial tongue with tongue extracellular matrix and primary taste cells

58. Bioaccumulation and reproductive toxicity of bisphenol A in male-pregnant seahorse (Hippocampus erectus) at environmentally relevant concentrations

59. Bioactive films produced from self-assembling peptide amphiphiles as versatile substrates for tuning cell adhesion and tissue architecture in serum-free conditions

60. Biodegradation-Resistant Multilayers Coated with Gold Nanoparticles. Toward a Tailor-made Artificial Extracellular Matrix

61. Biofilms of Pseudomonas and Lysinibacillus Marine Strains on High-Density Polyethylene

62. Biofunctionalization of titanium with PEG and anti-CD34 for hemocompatibility and stimulated endothelialization

63. Biofunctionalized and self-supported polypyrrole frameworks as nanostructured ECM-like biointerfaces

64. Bioinspired titanium coatings: self-assembly of collagen–alginate films for enhanced osseointegration

65. Biological Responses and Mechanisms of Human Bone Marrow Mesenchymal Stem Cells to Zn and Mg Biomaterials

66. Biological control for rice blast disease by employing detachment action with gelatinolytic bacteria

67. Biomaterials in regenerative medicine: engineering to recapitulate the natural

68. Biomembrane-mimicking lipid bilayer system as a mechanically tunable cell substrate

69. Biomimetic Carbon Fiber Systems Engineering: A Modular Design Strategy To Generate Biofunctional Composites from Graphene and Carbon Nanofibers

70. Biomimetic Poly(ethylene glycol)-Based Hydrogels as Scaffolds for Inducing Endothelial Adhesion and Capillary-Like Network Formation