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1. Phytochemical screening, antibacterial, anti-biofilm and quorum sensing inhibiting activity of Alpinia nigra leaf extract against infectious pathogen Pseudomonas aeruginosa PAO1

Author:
Manish Kumar Gupta; Rashmi Singh; Latha Rangan
Source:
Food control 2023 v.143 pp. 109327
ISSN:
0956-7135
Subject:
Alpinia nigra; Chromobacterium violaceum; Pseudomonas aeruginosa; antibiotics; antimicrobial properties; bacteria; bacterial infections; biofilm; cell death; computer simulation; ethyl acetate; extracellular matrix; fluorescence microscopy; food safety; gene expression; growth curves; leaf extracts; pathogens; people; phytochemicals; quorum sensing; therapeutics
Abstract:
... The recurrent cycles of several bacterial diseases are an endorsement of the formation of biofilms that are intractable to antibiotic therapy. Biofilm-associated diseases have affected millions of people worldwide and are unassailable due to frequent changes of surface antigens and gene expression. Therefore, there is a need to find out an alternative approach to cure biofilm infections. Plant-der ...
DOI:
10.1016/j.foodcont.2022.109327

2. A simple integrated microfluidic platform for the research of hydrogels containing gradients in cell density induced breast cancer electrochemotherapy

Author:
Xuexia Lin; Chenjing Wang; Feixiang Fang; Shufeng Zhou
Source:
Talanta 2023 v.253 pp. 123920
ISSN:
0039-9140
Subject:
agarose; breast neoplasms; cell adhesion; cell culture; cytotoxicity; drugs; electroporation; extracellular matrix; hydrogels; hydrophobicity; indium tin oxide; metastasis; neoplasm cells; prognosis; toxicity testing
Abstract:
... Cell density is important for tumour metastasis, treatment and prognosis. Characterizing changes in cell density for electrochemotherapy (ECT) can reveal sub-populations in pathological states, and adjust treatment program. In this work, a simple and convenient microfluidic platform was developed to study the effect cell density on ECT by integrating the improved cell gradient generator, cell cult ...
DOI:
10.1016/j.talanta.2022.123920

3. 1α,25-dihydroxyvitamin D reduction of MCF10A-ras cell viability in extracellular matrix detached conditions is dependent on regulation of pyruvate carboxylase

Author:
Madeline P. Sheeley; Violet A. Kiesel; Chaylen Andolino; Nadia A. Lanman; Shawn S. Donkin; Stephen D. Hursting; Michael K. Wendt; Dorothy Teegarden
Source:
Journal of nutritional biochemistry 2022 v.109 pp. 109116
ISSN:
0955-2863
Subject:
aspartic acid; breast neoplasms; cell viability; citrates; extracellular matrix; glutamic acid; glutamine; malates; metabolites; metastasis; neoplasm cells; neoplasm progression; protein synthesis; pyruvate carboxylase
Abstract:
... An emerging hallmark of cancer is cellular metabolic reprogramming to adapt to varying cellular environments. Throughout the process of metastasis cancer cells gain anchorage independence which confers survival characteristics when detached from the extracellular matrix (ECM). Previous work demonstrates that the bioactive metabolite of vitamin D, 1α,25-dihydroxyvitamin D (1,25[OH]₂D), suppresses c ...
DOI:
10.1016/j.jnutbio.2022.109116

4. 2-Alkyl-anthraquinones inhibit Candida albicans biofilm via inhibiting the formation of matrix and hyphae

Author:
Yuanyuan Song; Ziqi Wang; Yijing Long; Yang Mao; Feng Jiang; Yuanyuan Lu
Source:
Research in microbiology 2022 v.173 no.6-7 pp. 103955
ISSN:
0923-2508
Subject:
Candida albicans; anthraquinones; biofilm; extracellular matrix; glycosides; hyphae; microbiology; research; transcriptomics; virulence
Abstract:
... Candida albicans can form biofilm on biotic and abiotic surfaces of medical implants to cause superficial and systemic infections under specific condition. The formation of hyphae and matrix of C. albicans are considered as probable virulence factors. We assessed the inhibitory activities of 26 anthraquinones against C. albicans biofilm formation, which were substituted by different functional gro ...
DOI:
10.1016/j.resmic.2022.103955

5. 20(S)- Protopanaxadiol suppresses hepatic stellate cell activation via WIF1 demethylation-mediated inactivation of the Wnt/β-catenin pathway

Author:
Chunxue Li; Yating Zhan; Rongrong Zhang; Qiqi Tao; Zhichao Lang; Jianjian Zheng
Source:
Journal of Ginseng Research 2022 pp. -
ISSN:
1226-8453
Subject:
DNA methyltransferase; Panax; carbon tetrachloride; collagen; demethylation; drugs; extracellular matrix; liver; liver cirrhosis; methylation; research; therapeutics
Abstract:
... 20(S)-protopanaxadiol (PPD), one of the main components of ginseng, has anti-inflammatory, anti-estrogenic, and anti-tumor activities. It is known that activated hepatic stellate cells (HSCs) are the primary producers of extracellular matrix (ECM) in the liver, and the Wnt/β-catenin pathway participates in the activation of HSCs. We aimed to explore whether PPD inhibits liver fibrosis is associate ...
DOI:
10.1016/j.jgr.2022.05.005

6. 3D Culture Modeling of Metastatic Breast Cancer Cells in Additive Manufactured Scaffolds

Author:
Afroditi Nanou; Ivan Lorenzo-Moldero; Kyriakos D. Gazouleas; Barbara Cortese; Lorenzo Moroni
Source:
ACS applied materials & interfaces 2022 v.14 no.24 pp. 28389-28402
ISSN:
1944-8252
Subject:
adhesion; breast neoplasms; cell culture; collagen; drugs; extracellular matrix; fibronectins; human cell lines; metastasis; phenotype; polystyrenes; sowing; tissue culture
Abstract:
... Cancer biology research is increasingly moving toward innovative in vitro 3D culture models, as conventional and current 2D cell cultures fail to resemble in vivo cancer biology. In the current study, porous 3D scaffolds, designed with two different porosities along with 2D tissue culture polystyrene (TCP) plates were used with a model breast cancer human cell line. The 3D engineered system was ev ...
DOI:
10.1021/acsami.2c07492

7. 3D Printed Piezoelectric Wound Dressing with Dual Piezoelectric Response Models for Scar-Prevention Wound Healing

Author:
Jiachen Liang; Huajing Zeng; Liang Qiao; Hong Jiang; Qian Ye; Zhilong Wang; Bin Liu; Zengjie Fan
Source:
ACS applied materials & interfaces 2022 v.14 no.27 pp. 30507-30522
ISSN:
1944-8252
Subject:
biocompatibility; bioelectricity; cell movement; collagen; extracellular matrix; friction; hydrogels; sodium alginate; three-dimensional printing
Abstract:
... During the long process of wound defect repair, the bioelectric stimulation around the wound gradually decreases, which can cause gradual down-regulation of the wound healing cascade response, disordered deposition of collagen fibers, and abnormal remodeling of the extracellular matrix (ECM). All these combined will eventually result in delayed wound healing and scar tissue formation. To resolve t ...
DOI:
10.1021/acsami.2c04168

8. A 3D bioprinted decellularized extracellular matrix/gelatin/quaternized chitosan scaffold assembling with poly(ionic liquid)s for skin tissue engineering

Author:
Jie Xu; Huan Fang; Ya Su; Yue Kang; Deli Xu; Yuen Yee Cheng; Yi Nie; Hong Wang; Tianqing Liu; Kedong Song
Source:
International journal of biological macromolecules 2022 v.220 pp. 1253-1266
ISSN:
0141-8130
Subject:
Escherichia coli; antibacterial properties; bacterial infections; biocompatibility; biodegradation; bioprinting; cell growth; chitosan; extracellular matrix; extrusion; gelatin; hemolysis; hemostasis; hydrogen; hydrophilicity; ionic liquids; porosity; secretion
Abstract:
... Currently, a suitable bioink for 3D bioprinting and capable of mimicking the microenvironment of native skin and preventing bacterial infection remains a major challenge in skin tissue engineering. In this study, we prepared a tissue-specific extracellular matrix-based bioink, and dECM/Gel/QCS (dGQ) 3D scaffold assembling with poly(ionic liquid)s (PILs) (dGQP) was obtained by an extrusion 3D biopr ...
DOI:
10.1016/j.ijbiomac.2022.08.149

9. 3D porous scaffolds from wheat glutenin for cultured meat applications

Author:
Ning Xiang; John S.K. Yuen; Andrew J. Stout; Natalie R. Rubio; Ying Chen; David L. Kaplan
Source:
Biomaterials 2022 v.285 pp. 121543
ISSN:
0142-9612
Subject:
biocompatible materials; cattle; crosslinking; cultured meat; extracellular matrix; glutenins; mice; myoblasts; plant source protein; refrigeration; toxicity; wheat
Abstract:
... Scaffolds suitable for use in food products are crucial components for the production of cultured meat. Here, wheat glutenin, an inexpensive and abundant plant-based protein, was used to develop 3D porous scaffolds for cultured meat applications. A physical cross-linking method based on water annealing was developed for the fabrication of porous glutenin sponges and fibrous aligned scaffolds. The ...
DOI:
10.1016/j.biomaterials.2022.121543

10. A 3D-Printed Polycaprolactone/Marine Collagen Scaffold Reinforced with Carbonated Hydroxyapatite from Fish Bones for Bone Regeneration

Author:
Se-Chang Kim; Seong-Yeong Heo; Gun-Woo Oh; Myunggi Yi; Won-Kyo Jung
Source:
Marine drugs 2022 v.20 no.6 pp. -
ISSN:
1660-3397
Subject:
Fourier transform infrared spectroscopy; Paralichthys olivaceus; X-ray diffraction; bone formation; bones; collagen; extracellular matrix; fish; hydrophilicity; hydroxyapatite; mineralization; polyacrylamide gel electrophoresis; tissue repair
Abstract:
... In bone tissue regeneration, extracellular matrix (ECM) and bioceramics are important factors, because of their osteogenic potential and cell–matrix interactions. Surface modifications with hydrophilic material including proteins show significant potential in tissue engineering applications, because scaffolds are generally fabricated using synthetic polymers and bioceramics. In the present study, ...
DOI:
10.3390/md20060344

11. 3D-printed oxygen-releasing scaffolds improve bone regeneration in mice

Author:
Ashley L. Farris; Dennis Lambrechts; Yuxiao Zhou; Nicholas Y. Zhang; Naboneeta Sarkar; Megan C. Moorer; Alexandra N. Rindone; Ethan L. Nyberg; Alexander Perdomo-Pantoja; S.J. Burris; Kendall Free; Timothy F. Witham; Ryan C. Riddle; Warren L. Grayson
Source:
Biomaterials 2022 v.280 pp. 121318
ISSN:
0142-9612
Subject:
antioxidants; biocompatible materials; biodegradability; bone formation; bones; extracellular matrix; humans; hyperoxia; hypoxia; mice; osteopontin; oxygen; polyvinyl alcohol; therapeutics; tissue repair; toxicity
Abstract:
... Low oxygen (O₂) diffusion into large tissue engineered scaffolds hinders the therapeutic efficacy of transplanted cells. To overcome this, we previously studied hollow, hyperbarically-loaded microtanks (μtanks) to serve as O₂ reservoirs. To adapt these for bone regeneration, we fabricated biodegradable μtanks from polyvinyl alcohol and poly (lactic-co-glycolic acid) and embedded them to form 3D-pr ...
DOI:
10.1016/j.biomaterials.2021.121318

12. ASPN Is a Potential Biomarker and Associated with Immune Infiltration in Endometriosis

Author:
Li Wang; Jing Sun
Source:
Genes 2022 v.13 no.8 pp. -
ISSN:
2073-4425
Subject:
B-lymphocytes; T-lymphocytes; Western blotting; biomarkers; calcium; chemokines; cytotoxicity; data collection; databases; endometriosis; endometrium; endothelial cells; extracellular matrix; female genital diseases; fibroblasts; gene expression; gene expression regulation; genes; immunotherapy; metastasis; muscle contraction; patients; regression analysis; smooth muscle
Abstract:
... Objective: Endometriosis is a benign gynecological disease characterized by distant metastasis. Previous studies have discovered abnormal numbers and function of immune cells in endometriotic lesions. We aimed to find potential biomarkers of endometriosis and to explore the relationship between ASPN and the immune microenvironment of endometriosis. Methods: We obtained the GSE141549 and GSE7305 da ...
DOI:
10.3390/genes13081352

13. Aberrant interaction between mutated ADAMTSL2 and LTBP4 is associated with adolescent idiopathic scoliosis

Author:
Bowen Liu; Sen Zhao; Lian Liu; Huakang Du; Hengqiang Zhao; Shengru Wang; Yuchen Niu; Xiaoxin Li; Guixing Qiu; Zhihong Wu; Terry Jianguo Zhang; Nan Wu; Deciphering disorders Involving Scoliosis COmorbidities (DISCO) study group
Source:
Gene 2022 v.814 pp. 146126
ISSN:
0378-1119
Subject:
adolescents; etiology; extracellular matrix; fibroblasts; genes; humans; monogenic inheritance; risk; scoliosis
Abstract:
... Adolescent idiopathic scoliosis (AIS) is a complex spinal deformity with a prevalence of 1%-3%. Genetic factors have been associated with the etiology of AIS. However, previous studies mainly focused on common single nucleotide polymorphisms which confer modest disease risk. Recently, rare variants in FBN1 and other extracellular matrix genes have been implicated in AIS, suggesting a potential ove ...
DOI:
10.1016/j.gene.2021.146126

14. Accumulation and penetration behavior of hypericin in glioma tumor spheroids studied by fluorescence microscopy and confocal fluorescence lifetime imaging microscopy

Author:
Miriam C. Bassler; Tim Rammler; Frank Wackenhut; Sven zur Oven-Krockhaus; Ivona Secic; Rainer Ritz; Alfred J. Meixner; Marc Brecht
Source:
Analytical and bioanalytical chemistry 2022 v.414 no.17 pp. 4849-4860
ISSN:
1618-2642
Subject:
analytical chemistry; analytical methods; brain; extracellular matrix; fluorescence; fluorescence microscopy; glioblastoma; hypericin; photochemotherapy; photosensitizing agents
Abstract:
... Glioblastoma WHO IV belongs to a group of brain tumors that are still incurable. A promising treatment approach applies photodynamic therapy (PDT) with hypericin as a photosensitizer. To generate a comprehensive understanding of the photosensitizer-tumor interactions, the first part of our study is focused on investigating the distribution and penetration behavior of hypericin in glioma cell spher ...
DOI:
10.1007/s00216-022-04107-2

15. Activation and Inhibition of Human Matrix Metalloproteinase-9 (MMP9) by HOCl, Myeloperoxidase and Chloramines

Author:
Yihe Wang; Christine Y. Chuang; Clare L. Hawkins; Michael J. Davies
Source:
Antioxidants 2022 v.11 no.8 pp. -
ISSN:
2076-3921
Subject:
basement membrane; cysteine; extracellular matrix; fibronectins; gelatinase B; gels; histidine; humans; inflammation; laminin; lysine; methionine; myeloperoxidase; neutrophils; oxidation; plasmin; serum albumin; taurine
Abstract:
... Matrix metalloproteinase-9 (MMP9, gelatinase B) plays a key role in the degradation of extracellular-matrix (ECM) proteins in both normal physiology and multiple pathologies, including those linked with inflammation. MMP9 is excreted as an inactive proform (proMMP9) by multiple cells, and particularly neutrophils. The proenzyme undergoes subsequent processing to active forms, either enzymatically ...
DOI:
10.3390/antiox11081616

16. Adhesion and kinetics of biofilm formation and related gene expression of Listeria monocytogenes in response to nutritional stress

Author:
Yuan Wang; Linjun Sun; Lili Hu; Zhen Wang; Xiang Wang; Qingli Dong
Source:
Food research international 2022 v.156 pp. 111143
ISSN:
0963-9969
Subject:
Listeria monocytogenes; adhesion; aggression; biofilm; cell movement; extracellular matrix; food research; gene expression; malnutrition; nutrient deficiencies; nutritional status; pathogens; plankton; polymers; polysaccharides; stainless steel; temperature
Abstract:
... Listeria monocytogenes is a gram-positive pathogen, that usually adheres to stainless steel (SS), and other abiotic surfaces in food processing that undergo repeated cleaning and cause the spread of Listeria. Through the enumeration of biofilm cells, extracellular polymeric substance (EPS) component and the scanning electron microscopy (SEM) analysis of biofilms, it was found that the ratio of cel ...
DOI:
10.1016/j.foodres.2022.111143

17. Adhesion properties of cell surface proteins in Lactobacillus strains in the GIT environment

Author:
Yixing Yu; Manli Zong; Lifeng Lao; Jianzhu Wen; Daodong Pan; Zhen Wu
Source:
Food & function 2022 v.13 no.6 pp. 3098-3109
ISSN:
2042-650X
Subject:
Lactobacillus; adhesion; bile; biofilm; digestive tract; extracellular matrix; fermentation; immunity; immunoglobulins; intestines; lactic acid; mucosa; mucus; pH; probiotics
Abstract:
... As a broadly defined member of lactic acid bacteria (LAB), the Lactobacillus strain is well characterized in food fermentation and specific strains can enhance the intestinal barrier function and be recognized as the probiotic strain. In recent years, many molecules of the cell surface are thought to be related to the adhesion property in the gastrointestinal mucosa. Mucus layer-related proteins, ...
DOI:
10.1039/d1fo04328e

18. Adipose extracellular matrix deposition is an indicator of obesity and metabolic disorders

Author:
Hui-jian Chen; Xi-yue Yan; Ao Sun; Li Zhang; Jing Zhang; You-e Yan
Source:
Journal of nutritional biochemistry 2022 pp. 109159
ISSN:
0955-2863
Subject:
adipocytes; adipogenesis; blood serum; collagen; extracellular matrix; fibronectins; gene expression; glucose; high fat diet; human health; humans; insulin resistance; laminin; obesity; oleic acid; white adipose tissue
Abstract:
... Obesity and metabolic disorders are threats to human health. Extracellular matrix (ECM) is an important member of adipose microenvironment. ECM remodeling contributes to obesity and insulin resistance, but the roles of every single ECM component is still not fully understood. We observed glucose and lipids metabolic disorders in high-fat diet (HFD)-fed mice and humans with obesity. Higher levels o ...
DOI:
10.1016/j.jnutbio.2022.109159

19. Adipose mesenchymal stem cell-based tissue engineering mesh with sustained bFGF release to enhance tissue repair

Author:
Xiaotong Wu; Hong Guo; Yuanyuan Jia; Qing Wang; Jiaqi Wang; Xiuli Sun; Jianliu Wang
Source:
Biomaterials science 2022 v.10 no.12 pp. 3110-3121
ISSN:
2047-4849
Subject:
angiogenesis; animal models; biocompatibility; biocompatible materials; cell proliferation; collagen; elderly; extracellular matrix; fibroblast growth factor 2; fibroins; immunomodulators; polypropylenes; quality of life; therapeutics; tissue repair
Abstract:
... Pelvic organ prolapse (POP) harms the quality of life of elderly patients. Transvaginal polypropylene mesh repair for POP was a frequently reported complication and was banned by the FDA in 2019. New therapeutic strategies are urgently required, and tissue engineering technology could be a novel therapy. Here, we developed a tissue engineering mesh out of three components: silk fibroin (SF) knitte ...
DOI:
10.1039/d1bm01893k

20. Aftermath of AGE-RAGE Cascade in the pathophysiology of cardiovascular ailments

Author:
Rufaida Wasim; Tarique Mahmood; Mohd. Haris Siddiqui; Farogh Ahsan; Arshiya Shamim; Aditya Singh; Mohammad Shariq; Saba Parveen
Source:
Life sciences 2022 v.307 pp. 120860
ISSN:
0024-3205
Subject:
basement membrane; crosslinking; etiology; extracellular matrix; glycation; heart failure; inflammation; nutrition; oxidative stress; pathogenesis; pathophysiology; transcription factor NF-kappa B
Abstract:
... Amidst several pathophysiological cascades, Advanced Glycation End products (AGEs) have been identified as a pivotal aetiology behind the pathogenesis and progression of cardiovascular disorders, by inducing oxidative stress and inflammation of myocardial and vascular tissues. Non-enzymatic glycation of reducing sugars with amino acids in proteins, lipids, and nucleic acids produce AGEs, which are ...
DOI:
10.1016/j.lfs.2022.120860