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- Dou, Tongyi, et al. Show all 10 Authors
- Analytical chemistry 2019 v.91 no.9 pp. 5638-5645
- Danio rerio; biotransformation; carboxylesterase; cell membranes; fluorescence; fluorescent dyes; humans; hydrolysis; optical properties; screening; substrate specificity
- ... Rational design of practical probes with excellent specificity and improved optical properties for a particular enzyme is always a big challenge. Herein, a practical and highly specific fluorescent probe for carboxylesterase 1 (CES1) was rationally designed using meso-carboxyl-BODIPY as the basic fluorophore based on the substrate preference and catalytic properties of CES1. Following molecular do ...