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- Amster-Choder, Orna, et al. Show all 2 Author
- Current opinion in microbiology 2016 v.33 pp. 83-90
- RNA; bacteria; cytoskeleton; gene expression; organelles; signal transduction
- ... Bacterial cells are intricately organized, despite the lack of membrane-bounded organelles. The extremely crowded cytoplasm promotes macromolecular self-assembly and formation of distinct subcellular structures, which perform specialized functions. For example, the cell poles act as hubs for signal transduction complexes, thus providing a platform for the coordination of optimal cellular responses ...
- Choder, Mordechai, et al. Show all 4 Authors
- Journal of Molecular Biology 2013 v.425 pp. 3750-3775
- eukaryotic cells; evolution; gene expression; half life; homeostasis; messenger RNA; regulator genes; regulon
- ... mRNA concentration depends on the balance between transcription and degradation rates. On both sides of the equilibrium, synthesis and degradation show, however, interesting differences that have conditioned the evolution of gene regulatory mechanisms. Here, we discuss recent genome-wide methods for determining mRNA half-lives in eukaryotes. We also review pre- and posttranscriptional regulons tha ...
- Choder, Mordechai, et al. Show all 10 Authors
- Cell 2013 v.153 pp. 1000-1011
- cytoplasm; gene expression; gene expression regulation; messenger RNA; yeasts
- ... Maintaining proper mRNA levels is a key aspect in the regulation of gene expression. The balance between mRNA synthesis and decay determines these levels. We demonstrate that most yeast mRNAs are degraded by the cytoplasmic 5′-to-3′ pathway (the “decaysome”), as proposed previously. Unexpectedly, the level of these mRNAs is highly robust to perturbations in this major pathway because defects in va ...