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- Diaz-San Segundo, Fayna, et al. Show all 4 Authors
- ARS USDA Submissions 2014 pp. 1
- Foot-and-mouth disease virus; Human adenovirus C; animals; cell-mediated immunity; disease prevention; foot-and-mouth disease; gene induction; genetic vectors; immune response; in vivo studies; interferons; vaccination; viral antigens; viruses
- ... Foot-and-mouth disease virus (FMDV) infects cloven-hoofed animals and causes a highly contagious disease that rapidly spreads among many susceptible species. Vaccination with an inactivated whole virus antigen in formulation with adjuvant, or with a replication-defective human adenovirus 5 (Ad5) able to deliver FMDV empty capsids have proven to be effective strategies to control disease in 7 days. ...
- Diaz-San Segundo, Fayna, et al. Show all 8 Authors
- Journal of Interferon and Cytokine Research 2012 v.32 no.10 pp. 462
- Foot-and-mouth disease virus; animal diseases; cell culture; disease control; double-stranded RNA; foot-and-mouth disease; gene expression; gene induction; genes; immunity; interferon-alpha; mononuclear leukocytes; oligonucleotides; swine; therapeutics; vaccines
- ... Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hoofed animals. Vaccines require approximately 7 days to induce protection, thus prior to this time vaccinated animals are still susceptible to the disease. Our group has previously shown that swine inoculated with 1x10^11 focus forming units (FFU) of a replication-defective human adenovirus containing the gene for po ...
- Diaz-San Segundo, Fayna, et al. Show all 10 Authors
- Journal of virology 2013 v.87 no.10 pp. 5447
- Foot-and-mouth disease virus; Venezuelan equine encephalitis virus; cattle; death; encephalitis; gene induction; genes; green fluorescent protein; horses; humans; immunization; interferons; lethal dose; livestock and meat industry; mice; replicon; swine; viruses
- ... We have previously shown that delivery of the porcine type I interferon gene (poIFN-α/β) with a replication-defective human adenovirus vector (adenovirus 5 [Ad5]) can sterilely protect swine challenged with foot-and-mouth disease virus (FMDV) 1 day later. However, the need of relatively high doses of Ad5 limits the applicability of such a control strategy in the livestock industry. Venezuelan equi ...
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