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- Ziegler, Andreas, et al. Show all 3 Authors
- Phytotherapy research 2010 v.24 no.3 pp. 466-468
- Ames test; Salmonella typhimurium; Symphytum officinale; allantoin; carcinogenicity; comfrey; contusions; drugs; genes; genotoxicity; hepatotoxicity; mammals; mutagenicity; mutation; pyrrolizidine alkaloids; roots; rosmarinic acid
- ... Comfrey (Symphytum officinale L.) root is traditionally used for the topical treatment of contusions, strains and sprains. Besides allantoin and rosmarinic acid, which are discussed as pharmacologically active principles, the drug contains pyrrolizidine alkaloids (PAs) known for their hepatotoxic, carcinogenic and mutagenic properties. The topical herbal medicinal products Kytta-Salbe® f and Kytta ...