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1. Toxic effects of fluridone on early developmental stages of Japanese Medaka (Oryzias latipes)

Author:
Jin, Jiali,   et al.   ; Kurobe, Tomofumi; Hammock, Bruce G.; Lam, Chelsea H.; Lin, Li; Teh, Swee J.;     Show all 6 Authors
Source:
The Science of the total environment 2020 v.700 pp. 134495
ISSN:
0048-9697
Subject:
Oryzias latipes; acetylcholinesterase; adverse effects; animal models; dose response; females; fish; fluridone; gene expression regulation; genes; glutathione transferase; glutathione-disulfide reductase; hatching; insulin receptor substrate proteins; larvae; males; median effective concentration; nervous system; oxidative stress; retinoic acid receptors; swimming; toxicity; transcriptomics
Abstract:
... The herbicide fluridone is intensively applied to control invasive aquatic plants globally, including in the Sacramento and San Joaquin Delta (the Delta), California, USA. Our previous study revealed that the adult stage of Delta Smelt showed acute and sub-lethal adverse effects following 6 h of exposure to environmentally relevant concentrations of fluridone. To further investigate mechanisms of ...
DOI:
10.1016/j.scitotenv.2019.134495

2. Monascus yellow, red and orange pigments from red yeast rice ameliorate lipid metabolic disorders and gut microbiota dysbiosis in Wistar rats fed on a high-fat diet

Author:
Hong, Jiali,   et al.   ; ZhouThese authors contributed equally to this study., Wenbin; Guo, Rui; Guo, Weiling; Li, Lu; Ni, Li; Sun, Jinyuan; Liu, Bin; Rao, Pingfan; Lv, Xucong;     Show all 10 Authors
Source:
Food & function 2019 v.10 no.2 pp. 1073-1084
ISSN:
2042-650X
Subject:
Clostridium; Monascus; Ruminococcus albus; animal models; bile acids; blood lipids; blood serum; cholesterol; cholesterol metabolism; dysbiosis; excretion; functional foods; gene expression; genes; high fat diet; homeostasis; hyperlipidemia; ingredients; intestinal microorganisms; laboratory animals; messenger RNA; oral administration; phylotype; pigments; rats; red yeast rice; triacylglycerols
Abstract:
... This study aimed to compare the hypolipidaemic activities of different Monascus pigments (yellow, red and orange pigments) and elucidate their possible regulatory mechanisms on lipid and cholesterol metabolism in rats fed on a high-fat diet (HFD). Results showed that oral administrations of Monascus yellow, red and orange pigments can markedly alleviate the disturbance of lipid metabolism through ...
DOI:
10.1039/c8fo02192a

3. Ma Huang Tang ameliorates bronchial asthma symptoms through the TLR9 pathway

Author:
Wang, Jiali,   et al.   ; Jiao, Jiayuan; Wu, Jiming; Guo, Yaping; Gao, Le; Liang, Honggang; Huang, Jian; Wang, Jinhui;     Show all 8 Authors
Source:
Pharmaceutical biology 2018 v.56 no.1 pp. 580-593
ISSN:
1744-5116
Subject:
Ephedra sinica; Toll-like receptor 9; animal models; asthma; breathing; computer simulation; drug therapy; eosinophils; fever; genes; immunohistochemistry; inflammation; influenza; lethal dose 50; lungs; mice; ovalbumin; patients; protein-protein interactions; sequence analysis; signal transduction; staining; tissues
Abstract:
... Context: Ma Huang Tang (MHT) has been used to treat influenza, fever, bronchial asthma, etc. as a traditional Chinese medication. However, the anti-inflammation mechanism of MHT remains unclear. Objective: The study identifies the possible mechanisms of MHT on ovalbumin (OVA)-induced acute bronchial asthma in mice. Materials and methods: First, an asthma-related protein-protein interaction (PPI) n ...
DOI:
10.1080/13880209.2018.1517184
PubMed:
30415587
PubMed Central:
PMC6237163