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- Brown, James B., et al. Show all 18 Authors
- Molecular ecology 2018 v.27 no.4 pp. 886-897
- Daphnia magna; abiotic stress; cell communication; environmental impact; gene expression regulation; genes; genetic background; genotype-environment interaction; habitats; keystone species; metabolism; stress response; transcription (genetics)
- ... Natural habitats are exposed to an increasing number of environmental stressors that cause important ecological consequences. However, the multifarious nature of environmental change, the strength and the relative timing of each stressor largely limit our understanding of biological responses to environmental change. In particular, early response to unpredictable environmental change, critical to ...
- Brown, James B., et al. Show all 5 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2011 v.108 no.50 pp. 19867-19872
- algorithms; computer software; exons; expressed sequence tags; genes; linear models; messenger RNA; probability; statistical models
- ... Since the inception of next-generation mRNA sequencing (RNA-Seq) technology, various attempts have been made to utilize RNA-Seq data in assembling full-length mRNA isoforms de novo and estimating abundance of isoforms. However, for genes with more than a few exons, the problem tends to be challenging and often involves identifiability issues in statistical modeling. We have developed a statistical ...
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- Brown, James B, et al. Show all 11 Authors
- Genome biology 2012 v.13 no.9 pp. 2910
- DNA; artificial intelligence; binding sites; genes; humans; statistical models; transcription factors
- ... BACKGROUND: Transcription factors function by binding different classes of regulatory elements. The Encyclopedia of DNA Elements (ENCODE) project has recently produced binding data for more than 100 transcription factors from about 500 ChIP-seq experiments in multiple cell types. While this large amount of data creates a valuable resource, it is nonetheless overwhelmingly complex and simultaneousl ...
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