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You searched for: Author "Hoshii, Takayuki" Remove constraint Author: "Hoshii, Takayuki" Subject genes Remove constraint Subject: genes
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1. A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response

Author:
Hoshii, Takayuki,   et al.   ; Cifani, Paolo; Feng, Zhaohui; Huang, Chun-Hao; Koche, Richard; Chen, Chun-Wei; Delaney, Christopher D.; Lowe, Scott W.; Kentsis, Alex; Armstrong, Scott A.;     Show all 10 Authors
Source:
Cell 2018 v.172 pp. 1007-1021.e17
ISSN:
0092-8674
Subject:
DNA damage; apoptosis; cell viability; chromatin; cyclins; gene expression; genes; histones; interphase; lysine; methylation; methyltransferases; mutagenesis; myeloid leukemia; screening
Abstract:
... MLL/SET methyltransferases catalyze methylation of histone 3 lysine 4 and play critical roles in development and cancer. We assessed MLL/SET proteins and found that SETD1A is required for survival of acute myeloid leukemia (AML) cells. Mutagenesis studies and CRISPR-Cas9 domain screening show the enzymatic SET domain is not necessary for AML cell survival but that a newly identified region termed ...
DOI:
10.1016/j.cell.2018.01.032

2. Association of a murine leukaemia stem cell gene signature based on nucleostemin promoter activity with prognosis of acute myeloid leukaemia in patients

Author:
Hoshii, Takayuki,   et al.   ; Ali, Mohamed A.E.; Naka, Kazuhito; Yoshida, Akiyo; Fuse, Kyoko; Kasada, Atsuo; Tadokoro, Yuko; Ueno, Masaya; Ohta, Kumiko; Kobayashi, Masahiko; Takahashi, Chiaki; Hirao, Atsushi;     Show all 12 Authors
Source:
Biochemical and biophysical research communications 2014 v.450 pp. 837-843
ISSN:
0006-291X
Subject:
binding proteins; cell cycle; gene expression regulation; genes; green fluorescent protein; guanosine triphosphate; humans; leukemia; messenger RNA; mice; models; patients; prognosis; stem cells
Abstract:
... Acute myeloid leukaemia (AML) is a heterogeneous neoplastic disorder in which a subset of cells function as leukaemia-initiating cells (LICs). In this study, we prospectively evaluated the leukaemia-initiating capacity of AML cells fractionated according to the expression of a nucleolar GTP binding protein, nucleostemin (NS). To monitor NS expression in living AML cells, we generated a mouse AML m ...
DOI:
10.1016/j.bbrc.2014.06.066