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1. Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer

Author:
Czerniak, Bogdan A.,   et al.   ; Robertson, A. Gordon; Kim, Jaegil; Al-Ahmadie, Hikmat; Bellmunt, Joaquim; Guo, Guangwu; Cherniack, Andrew D.; Hinoue, Toshinori; Laird, Peter W.; Hoadley, Katherine A.; Akbani, Rehan; Castro, Mauro A.A.; Gibb, Ewan A.; Kanchi, Rupa S.; Gordenin, Dmitry A.; Shukla, Sachet A.; Sanchez-Vega, Francisco; Hansel, Donna E.; Reuter, Victor E.; Su, Xiaoping; de Sa Carvalho, Benilton; Chagas, Vinicius S.; Mungall, Karen L.; Sadeghi, Sara; Pedamallu, Chandra Sekhar; Lu, Yiling; Klimczak, Leszek J.; Zhang, Jiexin; Choo, Caleb; Ojesina, Akinyemi I.; Bullman, Susan; Leraas, Kristen M.; Lichtenberg, Tara M.; Wu, Catherine J.; Schultz, Nicholaus; Getz, Gad; Meyerson, Matthew; Mills, Gordon B.; McConkey, David J.; Weinstein, John N.; Kwiatkowski, David J.; Lerner, Seth P.;     Show all 42 Authors
Source:
Cell 2017 v.171 pp. 540-556.e25
ISSN:
0092-8674
Subject:
carcinoma; gene expression; genes; histology; messenger RNA; microRNA; mutagenesis; non-coding RNA; urinary bladder neoplasms
Abstract:
... We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the overall mutational load was associated with APOBEC-signature mutagenesis. Clustering by mutation signature identified a high-mutation subset with 75% 5-year survival. mRNA expression clustering refined prior clustering ...
DOI:
10.1016/j.cell.2017.09.007
PubMed:
28988769
PubMed Central:
PMC5687509

2. Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia

Author:
Czerniak, Bogdan,   et al.   ; Lee, Sangkyou; Jeong, Joon; Majewski, Tadeusz; Scherer, Steven E.; Kim, Mi-Sook; Tuziak, Tomasz; Tang, Kuang S.; Baggerly, Keith; Grossman, Herbert Barton; Zhou, Jain-Hua; Shen, Lanlan; Bondaruk, Jolanta; Ahmed, Saira S.; Samanta, Susmita; Spiess, Philippe; Wu, Xifeng; Filipek, Slawomir; McConkey, David; Bar-Eli, Menashe; Issa, Jean-Pierre; Benedict, William F.;     Show all 22 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.34 pp. 13732-13737
ISSN:
0027-8424
Subject:
cell viability; chromosome mapping; evolution; genes; homozygosity; humans; methylation; point mutation; urinary bladder neoplasms
Abstract:
... We used human bladder cancer as a model system and the whole-organ histologic and genetic mapping strategy to identify clonal genetic hits associated with growth advantage, tracking the evolution of bladder cancer from intraurothelial precursor lesions. Six putative chromosomal regions critical for clonal expansion of intraurothelial neoplasia and development of bladder cancer were identified by u ...
DOI:
10.1073/pnas.0701771104
PubMed:
17702869
PubMed Central:
PMC1949496