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- Doerge, D.R., et al. Show all 3 Authors
- Journal of agricultural and food chemistry 1999 v.47 no.9 pp. 3764-3770
- diet; quantitative analysis; soybeans; genistein; daidzein; rats; mass spectrometry; blood; liquid chromatography
- ... Genistein is the principal soy isoflavone to which the putative beneficial effects of soy consumption have been attributed; however, the possibility of adverse biological effects (e.g., estrogenic, antithyroid) has also been raised. This paper describes development and validation of a simple and sensitive analytical method for the determination of genistein in the blood of rats receiving dietary g ...
- Doerge, D.R., et al. Show all 6 Authors
- Journal of agricultural and food chemistry 2004 v.52 no.21 pp. 6623-6632
- metabolism; humans; medicinal properties; formononetin; cytochrome P-450; Trifolium pratense; genistein; daidzein; liver microsomes; enzyme inhibition
- ... Biochanin A and formononetin are the predominant isoflavones in red clover. In a previous study (J. Agric. Food Chem. 2002, 50, 4783-4790), it was demonstrated that human liver microsomes converted biochanin A and formononetin to genistein and daidzein. This paper now shows CYP1B1-catalyzed O-demethylation of biochanin A and formononetin to produce genistein and daidzein, respectively, which inhib ...