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- Doerge, D.R., et al. Show all 5 Authors
- Journal of agricultural and food chemistry 2002 v.50 no.17 pp. 4783-4790
- genistein; formononetin; metabolism; liver; microsomes; cytochrome P-450; enzyme activity; metabolites; humans; rats
- ... Biochanin A and formononetin are abundant in legumes. These proestrogenic isoflavones can be converted by 4'-O-demethylation to the more potent phytoestrogens genistein and daidzein. Incubation of biochanin A or formononetin with human liver microsomes resulted in 4'-O-demethylation and the production of additional metabolites. Three new hydroxylated formononetin derivatives, 6,7-dihydroxy-4'-meth ...
- Doerge, D.R., et al. Show all 6 Authors
- Journal of agricultural and food chemistry 2004 v.52 no.21 pp. 6623-6632
- metabolism; humans; medicinal properties; formononetin; cytochrome P-450; Trifolium pratense; genistein; daidzein; liver microsomes; enzyme inhibition
- ... Biochanin A and formononetin are the predominant isoflavones in red clover. In a previous study (J. Agric. Food Chem. 2002, 50, 4783-4790), it was demonstrated that human liver microsomes converted biochanin A and formononetin to genistein and daidzein. This paper now shows CYP1B1-catalyzed O-demethylation of biochanin A and formononetin to produce genistein and daidzein, respectively, which inhib ...