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- Doerge, D.R., et al. Show all 3 Authors
- Journal of agricultural and food chemistry 1999 v.47 no.9 pp. 3764-3770
- diet; quantitative analysis; soybeans; genistein; daidzein; rats; mass spectrometry; blood; liquid chromatography
- ... Genistein is the principal soy isoflavone to which the putative beneficial effects of soy consumption have been attributed; however, the possibility of adverse biological effects (e.g., estrogenic, antithyroid) has also been raised. This paper describes development and validation of a simple and sensitive analytical method for the determination of genistein in the blood of rats receiving dietary g ...
- Doerge, D.R., et al. Show all 5 Authors
- Journal of agricultural and food chemistry 2002 v.50 no.17 pp. 4783-4790
- genistein; formononetin; metabolism; liver; microsomes; cytochrome P-450; enzyme activity; metabolites; humans; rats
- ... Biochanin A and formononetin are abundant in legumes. These proestrogenic isoflavones can be converted by 4'-O-demethylation to the more potent phytoestrogens genistein and daidzein. Incubation of biochanin A or formononetin with human liver microsomes resulted in 4'-O-demethylation and the production of additional metabolites. Three new hydroxylated formononetin derivatives, 6,7-dihydroxy-4'-meth ...