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- Ganguli, Nirmalya, et al. Show all 6 Authors
- Applied microbiology and biotechnology 2018 v.102 no.14 pp. 6221-6234
- beta-casein; biopharmaceuticals; bioreactors; buffaloes; cost effectiveness; epithelial cells; gene expression; genetically modified organisms; germ cells; humans; interferon-gamma; lactation; mammary glands; membrane fusion; milk; nucleic acids; protein synthesis; risk; therapeutics; transgenes; transgenesis
- ... Protein expression in the milk of transgenic farmed animals offers a cost-effective system for producing therapeutics. However, transgenesis in farmed animals is not only cumbersome but also involves risk of potential hazard by germline gene integration, due to interruptions caused by the transgene in the native genome. Avoiding germline gene integration, we have delivered buffalo β-casein promote ...
- Ganguli, Nirmalya, et al. Show all 11 Authors
- Cell and tissue research 2018 v.371 no.2 pp. 351-363
- DNA microarrays; Sertoli cells; cell division; follicle-stimulating hormone; germ cells; infancy; male fertility; males; mice; monkeys; puberty; spermatogenesis; testosterone; transcriptome; transgenic animals
- ... Testicular Sertoli cells make a niche for the division and differentiation of germ cells. Sertoli cells respond to increased follicle-stimulating hormone (FSH) and testosterone (T) levels at the onset of puberty by producing paracrine factors which affect germ cells and trigger robust onset of spermatogenesis. Such paracrine support to germ cells is absent during infancy, despite Sertoli cells bei ...