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- Williamson, Seth, et al. Show all 5 Authors
- Analytical and bioanalytical chemistry 2018 v.410 no.28 pp. 7395-7404
- blood serum; breasts; carbon; desorption; glycomics; glycoproteins; glycosylation; human diseases; humans; ionization; magnetism; models; nanocomposites; polysaccharides; protein folding; signal transduction; spectroscopy
- ... More than 50% of all known proteins are glycosylated, which is critical for many biological processes such as protein folding and signal transduction. Glycosylation has proven to be associated with different mammalian diseases such as breast and liver cancers. Therefore, characterization of glycans is highly important to facilitate a better understanding of the development and progression of many ...
- Williamson, Seth D., et al. Show all 10 Authors
- Electrophoresis 2018 v.39 no.24 pp. 3063-3081
- chemical bonding; derivatization; electrophoresis; glycomics; glycosylation; ionization; mass spectrometry; physicochemical properties; polysaccharides; proteins
- ... The diversification of the chemical properties and biological functions of proteins is attained through posttranslational modifications, such as glycosylation. Glycans, which are covalently attached to proteins, play a vital role in cell activities. The microheterogeneity and complexity of glycan structures associated with proteins make comprehensive glycomic analysis challenging. However, recent ...